Perelman School of Medicine at the University of Pennsylvania

McKay Orthopaedic Research Laboratory

Journal Clubs

Tendon and Ligament Repair and Regeneration Journal Club

All journal clubs are scheduled at the McKay Orthopaedic Research Laboratory Conference Room (501 Stemmler Hall), unless otherwise noted.

Journal Club 2013
Journal Club 2013
October 18, 2013 Ben Freedman and Cori Riggin: Dallaudiere et al. (2013) "Acceleration of tendon healing using US guided intratendinous injection of bevacizumab: First pre-clinical study on a murine model" Eur J Radiol (Published online ahead of print). Biercevicz et al. (2013) "In Situ, Noninvasive, T2*-Weighted MRI-Derived Parameters Predict Ex Vivo Structural Properties of an Anterior Cruciate Ligament Reconstruction or Bioenhanced Primary Repair in a Porcine Model" Am J Sports Med 41:560-566.
September 20, 2013 Mike Hast and Andrey Zuskov: Yamazaki et al. (2013) "Assessment of pain-related behavior and pro-inflammatory cytokine levels in the rat rotator cuff tear model" J Orthop Res (Published online ahead of print). Zhang et al. (2012) "The effects of Dexamethasone on human patellar tendon stem cells: Implications for Dexamethasone treatment of tendon injury" J Orthop Res 31:105-110.
July 19, 2013 Lis Evans and Sarah Ilkhani-Pour: Elsaid et al. (2012) "The impact of forced joint exercise on lubricin biosynthesis from articular cartilage following ACL transection and intra-articular lubricin’s effect in exercised joints following ACL transection" Osteoarthritis and Cartilage 20:940-948. Pingel et al. (2013) "No inflammatory gene-expression response to acute exercise in human Achilles tendinopathy" Eur J Appl Physiol (Published online 16 April)
May 24, 2013 Adam Caro and Sarah Yannascoli: Friel et al. (2013) "Rotator cuff healing after continuous subacromial bupivacaine infusion: an in vivo rabbit study" J Shoulder Elbow Surg 22: 489-499. Cacao-Benedini et al. (2012) "Remobilization through stretching improves gait recovery in the rat" Acta Histochemica (Published online ahead of print).
March 29, 2013 Bri Connizzo and Steve Thomas: Rigozzi et al. (2013), "Tendon glycosaminoglycan proteoglycan sidechains promote collagen fibril sliding- AFM observations at the nanoscale" J Biomech 46:813-818. Attia et al. (2013), "Early Events of Overused Supraspinatus Tendons Involve Matrix Metalloproteinases and EMMPRIN/CD147 in the Absense of Inflammation" Am J Sports Med (Published online ahead of print).
March 1, 2013 Mike Hast and Jennica Tucker: Millard et al. (2013), "Flexing Computational Muscle: Modeling and Simulation of Musculotendon Dynamics" J Biomech Eng 135:021004-1-11. Gumucio et al. (2012), "Rotator Cuff Tear Reduces Muscle Fiber Specific Force Production and Induces Macrophage Accumulation and Autophagy" J Orthop Res 30:1963-70.
Januray 11, 2013 Elisabeth Evans and Benjamin Freedman: Medias et al. (2012), "Mechanical loading and TGF-β change the expression of multiple miRNAs in tendon fibroblasts" J Appl Physiol 113:56-62. Veres et al. (2012), "Repeated Subrupture Overload Causes Progression of Nanoscaled Descrete Plasticity Damage in Tendon Collagen Fibrils" J Orthop Res (Published online ahead of print).

Close Journal Club 2013

Journal Club 2010-12
Journal Club 2012
December 7, 2012 Adam Caro and Cori Riggin: Buchmann et al. (2012), "Refixation of the Supraspinatus Tendon in a Rat Model--Influence of Continuous Growth Factor Application on Tendon Structure" J Orthop Res, (Published online ahead of print). Chamberlain et al. (2012), "Temporal Healing in Rat Achilles Tendon: Ultrasound Correlations" Ann Biomed Eng (Published online ahead of print).
October 26, 2012 Katie Reuther and Sarah Yannascoli: Samagh et al. (2012), "MRI Quantification of Fatty Infiltration and Muscle Atrophy in a Mouse Model of Rotator Cuff Tears" J Orthop Res, (Published online ahead of print). Cuff et al. (2012), "Prospective randomized study of arthroscopic rotator cuff repair using an early versus delayed postoperative physical therapy protocol" J Shoulder Elbow Surg 21:1450-55.
September 21, 2012 Bri Connizzo and Sarah Ilkhani-Pour: Watanabe et al. (2012), "Concerted and adaptive alignment of decorin dermatan sulfate filaments in the graded organization of collagen fibrils in the equine superficial digital flexor tendon" J Anat, 220:156-63. Andersson et al. (2012), "Low level mechanical stimulation is sufficient to improve tendon healing in rats" J Appl Physiol (Published online ahead of print).
April 10, 2012 Steve Thomas and Jennica Tucker: Kaux et al. (2012), "Eccentric training improves tendon biomechanical properties: A rat model" J Orthop Res (Published online before print). Heinemeier et al. (2012), "Uphill running improves rat Achilles tendon tissue mechanical properties, and alters gene expression without inducing pathological changes" J Appl Physiol (Published online ahead of print).
Journal Club 2011
December 16, 2011 Lauren Satchell and Pramod Voleti: Lakemeier et al. (2010), "Expression of matrix metalloproteinases 1, 3, and 9 in degenerated long head biceps tendon in the presence of rotator cuff tears: an immunohistological study" BMC Musculoskelet Disord 11:271. Eliasson et al. (2012), "Achilles tendon healing in rats is improved by intermittent mechanical loading during the inflammatory phase" J Orthop Res, in press.
November 11, 2011 Kristin Miller and Katie Reuther: Liu et al. (2012), "Spatial and temporal expression of molecular markers and cell signals during normal development of the mouse patellar tendon" Tissue Eng Part A, in press. Shindle et al. (2012), "Full-thickness supraspinatus tears are associated with more synovial inflammation and tissue degeneration than partial-thickness tears" J Shoulder Elbow Surg, in press.
September 16, 2011 David Beason and J Sarver: Maeda et al. (2011), "Conversion of Mechanical Force into TGF-β-Mediated Biochemical Signals" Curr Biol 21:933-41. Ng et al. (2011), "Enforced Bipedal Downhill Running Induces Achilles Tendinosis in Rats" Connect Tissue Res, in press.
April 1, 2011 Bri Connizzo and Sarah Ilkhani-Pour: Kishore et al. (2011), "Incorporation of a decorin biomimetic enhances the mechanical properties 3 of electrochemically aligned collagen threads" Acta Biomater, in press. Duenwald et al. (2011), "Ultrasound echo is related to stress and strain in tendon" J Biomech 44:424-9.
March 18, 2011 Mark Buckley and Lydia Pathmanathan: Svensson et al. (2010), "Tensile Properties of Human Collagen Fibrils and Fascicles Are Insensitive to Environmental Salts" Biophys J 99:4020-7. Scott et al. (2011), "Scleraxis Expression Is Coordinately Regulated in a Murine Model of Patellar Tendon Injury" J Orthop Res 29:289-96.
Journal Club 2010
October 25, 2010 Ryan M. Porter, PhD, Harvard Medical School, "Proinflammatory Challenge to Chondrogenesis in situ"
July 13, 2010 Xiaowei Sherry Liu, PhD, Columbia University Medical Center, "Clinical Imaging and the Mechanical Modeling of Bone"
June 3, 2010 Evan L. Flatow, MD, The Mount Sinai School of Medicine, "Understanding Tendon Fatigue Damage"
June 1, 2010 Michael L. Sohaskey, PhD, University of California, "Novel Molecular Pathways in Skeletal Development, Homeostasis and Repair"
May 6, 2010 Frank Beier, PhD, University of Western Ontario, "TGFa Signaling in Cartilage Development and Osteoarthritis""

Close Journal Club 2010-13

Journal Club 2005-09

Journal Club 2009
2011 Xiaowei Sherry Liu, PhD, Columbia University Medical Center, "Clinical Imaging and the Mechanical Modeling of Bone"
2011 Evan L. Flatow, MD, The Mount Sinai School of Medicine, "Understanding Tendon Fatigue Damage"
2010 Michael L. Sohaskey, PhD, University of California, "Novel Molecular Pathways in Skeletal Development, Homeostasis and Repair"
2010 Michael L. Sohaskey, PhD, University of California, "Novel Molecular Pathways in Skeletal Development, Homeostasis and Repair"
Journal Club 2008
2008 Xiaowei Sherry Liu, PhD, Columbia University Medical Center, "Clinical Imaging and the Mechanical Modeling of Bone"
2008 Evan L. Flatow, MD, The Mount Sinai School of Medicine, "Understanding Tendon Fatigue Damage"
2008 Michael L. Sohaskey, PhD, University of California, "Novel Molecular Pathways in Skeletal Development, Homeostasis and Repair"
Journal Club 2007
2007 Xiaowei Sherry Liu, PhD, Columbia University Medical Center, "Clinical Imaging and the Mechanical Modeling of Bone"
2007 Evan L. Flatow, MD, The Mount Sinai School of Medicine, "Understanding Tendon Fatigue Damage"
2007 Michael L. Sohaskey, PhD, University of California, "Novel Molecular Pathways in Skeletal Development, Homeostasis and Repair"
Journal Club 2006
2006 Xiaowei Sherry Liu, PhD, Columbia University Medical Center, "Clinical Imaging and the Mechanical Modeling of Bone"
2006 Evan L. Flatow, MD, The Mount Sinai School of Medicine, "Understanding Tendon Fatigue Damage"
Journal Club 2005
2005 Michael L. Sohaskey, PhD, University of California, "Novel Molecular Pathways in Skeletal Development, Homeostasis and Repair"
2005 Michael L. Sohaskey, PhD, University of California, "Novel Molecular Pathways in Skeletal Development, Homeostasis and Repair"

Close Journal Club 2005-09

Journal Club 2001-04

Journal Club 2004
2004 Xiaowei Sherry Liu, PhD, Columbia University Medical Center, "Clinical Imaging and the Mechanical Modeling of Bone"
2004 Xiaowei Sherry Liu, PhD, Columbia University Medical Center, "Clinical Imaging and the Mechanical Modeling of Bone"
Journal Club 2003
2003 Xiaowei Sherry Liu, PhD, Columbia University Medical Center, "Clinical Imaging and the Mechanical Modeling of Bone"
2003 Xiaowei Sherry Liu, PhD, Columbia University Medical Center, "Clinical Imaging and the Mechanical Modeling of Bone"
Journal Club 2002
2002 Evan L. Flatow, MD, The Mount Sinai School of Medicine, "Understanding Tendon Fatigue Damage"
2002 Evan L. Flatow, MD, The Mount Sinai School of Medicine, "Understanding Tendon Fatigue Damage"
Journal Club 2001
2001 Michael L. Sohaskey, PhD, University of California, "Novel Molecular Pathways in Skeletal Development, Homeostasis and Repair"
2001 Michael L. Sohaskey, PhD, University of California, "Novel Molecular Pathways in Skeletal Development, Homeostasis and Repair"

Close Journal Club 2001-04

Disc and Soft Tissue Mechanics Journal Club

Tissue Engineering and Mechanobiology Journal Club

Discussion papers

Orthopaedic Molecular Biology Journal Club

Journal Club 2011-12
Journal Club 2012
February 13, 2012 Wosczyna MN, Biswas AA, Cogswell CA, Goldhamer DJ. Multipotent progenitors resident in the skeletal muscle interstitium exhibit robust BMP-dependent osteogenic activity and mediate heterotopic ossification.
January 16, 2012 Hsiao EC, Millard SM, Louie A, Huang Y, Conklin BR, Nissenson RA. Ligand-Mediated Activation of an Engineered Gs G Protein-Coupled Receptor in Osteoblasts Increases Trabecular Bone Formation.
Journal Club 2011
December 12, 2011 Shimono K, Tung WE, Macolino C, Chi AH, Didizian JH, Mundy C, Chandraratna RA, Mishina Y, Enomoto-Iwamoto M, Pacifici M, Iwamoto M. Potent inhibition of heterotopic ossification by nuclear retinoic acid receptor-gamma agonists.
November 14, 2011 Li G, Zheng B, Meszaros LB, Vella JB, Usas A, Matsumoto T, Huard J. Identification and characterization of chondrogenic progenitor cells in the fascia of postnatal skeletal muscle.
October 10, 2011 Zaiss MM, Axmann R, Zwerina J, Polzer K, Guckel E, Skapenko A, Schulze-Koops H, Horwood N, Cope A, Schett G. Treg cells suppress osteoclast formation: a new link between the immune system and bone.
September 12, 2011 Liu Y, Wang L, Fatahi R, Kronenberg M, Kalajzic I, Rowe D, Li Y, Maye P. Isolation of murine bone marrow derived mesenchymal stem cells using Twist2 Cre transgenic mice.

Close Journal Club 2011-12

Journal Club 2005-06
Journal Club 2006
February 27, 2006 Reem Kanaan, Steven Lietman, Changlin Ding, David Cooke, Michael Levine. Reduction in Gsa induces osteogenic differentiation in human mesenchymal stem cells. Clinical Orthopaedics and Related Research 434: 231-238, 2005.
January 26, 2006 David Glaser, Toshiyuki Matsuoka, Per E. Ahlberg, Nicoletta Kessaris, Palma Iannarelli, Ulla Dennehy, William D. Richardson, Andrew P. McMahon and Georgy Koentges. Neural crest origins of the neck and shoulder. Nature 436: 347-355, 2005.
December 19, 2005 Jennifer Fiori, Stephen E. Kendall, Chiara Battelli, Sarah Irwin, Jane G. Mitchell, Carlotta A. Glackin, and Joseph M. Verdi. NRAGE mediates p38 activation and neural progenitor apoptosis via the bone morphogenetic protein signaling cascade. Molecular and Cellular Biology 25(17): 7711-7724, 2005.
Journal Club 2005
November 3, 2005 Paul Billings, Didier Montarras, Jennifer Morgan, Charlotte Collins, Frederic Relaix, Stephane Zaffran, Ana Cumano, Terence Partridge, Margaret Buckingham. Direct isolation of satellite cells for skeletal muscle regeneration. Science 309: 2064-2067, 2005.
October 24, 2005 George Feldman, Laurie A. Boyer, et al (2005). Core transcriptional regulatory circuitry in human embryonic stem cells. Cell 122: 1-10.
August 11, 2005 Berangere Saucy, A. Afshan Ali, Robert S. Weinstein, Scott A. Stewart, A. Michael Parfitt, Stavros C. Manolagas, and Robert L. Jilka. Rosiglitazone causes bone loss in mice by suppressing osteoblast differentiation and bone formation. Endocrinology 146(3): 1226-1235, 2005.
April 28, 2005 Paul Billings, Trina K. Jeffery, Paul D. Upton, Richard C. Trembath and Nicholas W. Morrell. BMP4 inhibits proliferation and promotes myocyte differentiation of lung fibroblasts via Smad1 and JNK pathways. Am J Physiol Lung Cell Mol Physiol 288:L370-L378, 2005.
February 22, 2005 Reem Kanaan, Jie Liu, Julie G. Nealon and Lee S. Weinstein (2005). Distinct patterns of abnormal GNAS imprinting in familial and sporadic pseudohypoparathyroidism type 1B. Human Molecular Genetics 14 (1): 95-102.
January 25, 2005 George Feldman, Ritsert C. Jansen and Jan-Peter Nap (2004). Regulating gene expression: surprises still in store. Trends Genet 20(5):223-225. Gael Yvert, et al (2003). Trans-acting regulatory variation in Saccharomyces cerevisiae and the role of transcription factors. Nature Genetics 35(1): 57-64.

Close Journal Club 2005-06

Journal Club 2002-04
Journal Club 2004
2004 Xiaowei Sherry Liu, PhD, Columbia University Medical Center, "Clinical Imaging and the Mechanical Modeling of Bone"
20041 Evan L. Flatow, MD, The Mount Sinai School of Medicine, "Understanding Tendon Fatigue Damage"
2004 Michael L. Sohaskey, PhD, University of California, "Novel Molecular Pathways in Skeletal Development, Homeostasis and Repair"
2004 Michael L. Sohaskey, PhD, University of California, "Novel Molecular Pathways in Skeletal Development, Homeostasis and Repair"
Journal Club 2003
2003 Xiaowei Sherry Liu, PhD, Columbia University Medical Center, "Clinical Imaging and the Mechanical Modeling of Bone"
2003 Evan L. Flatow, MD, The Mount Sinai School of Medicine, "Understanding Tendon Fatigue Damage"
2003 Michael L. Sohaskey, PhD, University of California, "Novel Molecular Pathways in Skeletal Development, Homeostasis and Repair"
Journal Club 2002
2002 Xiaowei Sherry Liu, PhD, Columbia University Medical Center, "Clinical Imaging and the Mechanical Modeling of Bone"
2002 Evan L. Flatow, MD, The Mount Sinai School of Medicine, "Understanding Tendon Fatigue Damage"
2002 Michael L. Sohaskey, PhD, University of California, "Novel Molecular Pathways in Skeletal Development, Homeostasis and Repair"

Close Journal Club 2002-04