Perelman School of Medicine at the University of Pennsylvania

McKay Orthopaedic Research Laboratory

Liu Laboratory

Chantal de Bakker

Chantal

Graduate Student in Bioengineering
University of Pennsylvania

HOMETOWN
Hollis, NH

EDUCATION
B.S. Biomedical Engineering, 2012, Boston University, Boston, MA

AREAS OF SPECIAL INTEREST
Imaging techniques using microCT, mechanical regulation of tissue growth, tissue remodeling.
Outside of the lab, Chantal enjoys reading, hiking, camping, traveling, and learning new languages.

HONERS & AWARDS

  1. ORS/RJOS Young Female Investigator Travel Award, March 2015
  2. Endocrine Fellow, EFF/ASBMR Eighth Fellows Forum on Metabolic Bone Diseases, The Endocrine Fellows Foundation, Houston, TX, 2014
  3. Young Investigator Travel Grant, American Society of Bone and Mineral Research, September 2014
  4. 1st Place in Tissue and Cellular Engineering Category of MS Paper Competition, World Congress of Biomechanics, July 2014
  5. ICMRS Webster Jee Young Investigator Award, 2014
  6. NSF GRFP Fellowship, 2014
  7. NSF Fellowship Honorable Mention, 2013

MANUSCRIPTS

  1. de Bakker CMJ, Altman AR, Li C, Tribble MB, Lott C, Tseng WJ, Liu XS. Minimizing Interpolation Bias and Precision Error in In Vivo μCT-based Measurements of Bone Structure and Dynamics. Ann Biomed Eng. 2016.
  2. de Bakker CMJ, Altman AR, Tseng WJ, Tribble MB, Li C, Chandra A, Qin L, Liu XS μCT-based,In Vivo Dynamic Bone Histomorphometry Allows 3D Evaluation of the Early Responses of Bone Resorption and Formation to PTH and Alendronate Combination Therapy. Bone. 2015.
  3. Altman AR, Tseng WJ, de Bakker CMJ, Chandra A, Lan S, Huh BK, Luo S, Leonard MB, Qin L, Liu XS. Quantification of Skeletal Growth, Modeling, and Remodeling by In Vivo Micro Computed Tomography. Bone. 2015.
  4. Altman AR, de Bakker CMJ, Tseng WJ, Chandra A, Qin L, Liu XS. Enhanced individual trabecular repair and its mechanical implications in PTH and Alendronate treated rat tibial bone. Journal of Biomechanical Engineering. 2015.
  5. Altman AR, Tseng WJ, de Bakker CMJ, Huh BK, Chandra A, Qin L, Liu XS. A closer look at the immediate trabeculae response to combined parathyroid hormone and alendronate treatment. Bone. 2014; 61:149-157.
  6. Hayward LNM, de Bakker CMJ, Gerstenfeld LC., Grinstaff MW, and Morgan EF. Assessment of Contrast-Enhanced Computed Tomography for Imaging of Cartilage during Fracture Healing. Journal of Orthopaedic Research. 2013; 31(4):567-573.
  7. Hayward LNM, de Bakker CMJ, Lusic H, Gerstenfeld LC, Grinstaff MW, and Morgan EF. MRT Letter: Contrast-Enhanced Computed Tomographic Imaging of Soft Callus Formation in Fracture Healing. Microscopy Research and Technique. 2012; 75(1):7-14.

ABSTRACTS

  1. de Bakker CMJ, Leavitt L, Tseng WJ, Lin T, Tong W, Qin L, Liu XS. Reproduction-Induced Changes in Maternal Trabecular Bone Microarchitecture Confer Protective Effects Against Estrogen Deficiency. American Society for Bone and Mineral Research Annual Meeting, Atlanta, GA, 2016. Submitted.
  2. Tseng WJ, Lee W, Tong W, Wang L, Ma X, Zhao H, Li Y, Chang CC, de Bakker CMJ, Qin L, Liu XS. Skeletal Responses to the Discontinuation of Intermittent Parathyroid Hormone (PTH) Treatment in Intact and Ovariectomized Rats. American Society for Bone and Mineral Research Annual Meeting, Atlanta, GA, 2016. Submitted.
  3. de Bakker CMJ, Altman AR, Tseng WJ, Leavitt L, Li C Liu XS. Reproduction Induces Adaptation of the Maternal Skeleton and Alters Patterns of Postmenopausal Bone Loss. Summer Biomechanics, Bioengineering and Biotransport Conference, National Harbor, MD, 2016. Accepted.
  4. Li Y, Peng G, Tseng WJ, de Bakker CMJ, Chandrasekaran P, Jeong YH, Kim DH, Han L, Liu XS. Effects of Reproduction and Lactation on Maternal Bone Tissue Mechanical Properties at Different Length Scales. Summer Biomechanics, Bioengineering and Biotransport Conference, National Harbor, MD, 2016. Accepted.
  5. Chang CC, Zhao H, Yang Y, de Bakker CMJ, Tseng WJ, Liu XS. Reproducibility of mouse trabecular bone microstructure at multiple skeletal sites by in vivo micro computed tomography imaging. Summer Biomechanics, Bioengineering and Biotransport Conference, National Harbor, MD, 2016. Accepted.
  6. Zhao H, Chang CC, Yang Y, Tseng WJ, de Bakker CMJ, Liu XS. Longitudinal assessment of mouse bone microstructure by in vivo mCT imaging with minimal radiation effects. Summer Biomechanics, Bioengineering and Biotransport Conference, National Harbor, MD, 2016. Accepted.
  7. de Bakker CMJ, Leavitt L, Tseng WJ, Altman AR, Lin T, Tong W, Qin L, Liu XS. Reproductive History Significantly Alters Skeletal Responses to Estrogen Deficiency Induced by Ovariectomy in Rats. Orthopaedic Research Society, Orlando, FL, 2016.
  8. de Bakker CMJ, Yang Y, Chang CC, Altman AR, Tseng WJ, Liu XS. Rat Trabecular Bone Exhibits Substantial Gender Differences Which Are Abolished after Reproduction. Orthopaedic Research Society, Orlando, FL, 2016.
  9. de Bakker CMJ, Altman AR, Li C, Yang Y, Chang CC, Tseng WJ, Jeong YH, Kim DG, Liu XS. Reproduction Differentially Affects Cortical and Trabecular Bone and Alters Cortical Bone Stiffness and Trabecular Structure towards a Male Phenotype. American Society of Bone and Mineral Research, Seattle, WA, 2015.
  10. Altman AR, Jeong YH, Tseng WJ, de Bakker CMJ, Qin L, Han L, Kim DG, Liu XS. Intermittent PTH Alleviates Abnormalities of Bone TIssue Heterogeneity Associated with Prolonged Bisphosphonate Treatment by Inducing Substantial New Bone Formation. American Society of Bone and Mineral Research, Seattle, WA, 2015.
  11. de Bakker CMJ, Li C, Altman AR, Robberts J, Tseng WJ, Liu XS. Pregnancy, lactation, and weaning induce a physiological redistribution of bone mass at multiple skeletal sites with minimal impact on bone quality. Orthopaedic Research Society, Las Vegas, 2015.
  12. de Bakker CMJ, Altman AR, Li C, Tseng WJ, Liu XS. A novel image transformation scheme minimizes interpolation artifacts and allows reproducible measurement of trabecular bone remodeling through μCT-based in vivo dynamic histomorphometry. Orthopaedic Research Society, Las Vegas, 2015.
  13. Altman AR, Lott, C, Tseng, WJ, de Bakker CMJ, Liou, SD, Lin, T, Qin L, Liu XS. Intermittent PTH after prolonged bisphosphonate treatment improves bone structure by inducing substantial new bone formation with decoupled, inhibited bone resorption in ovariectomized rats. Orthopaedic Research Society, Las Vegas, 2015.
  14. Hussein AI, Lybrand K, De Giacomo A, Tabattanon K, Hogue B, de Bakker CMJ,  Demay M, Morgan EF, Gerstenfeld LG. The Effect of Phosphate Deficiency on Callus Composition. American Society of Bone and Mineral Research, Houston, TX, 2014.
  15. de Bakker CMJ, Altman AR, Li C, Tseng WJ, Liu XS. Pregnancy and Lactation Bone Loss Cause Long-Lasting Structural Deterioration of the Maternal Skeleton that Accumulates over Multiple Reproductive Cycles. American Society of Bone and Mineral Research, Houston, TX, 2014.
  16. Tribble MB, Cohen A, de Bakker CMJ, Lappe J, Recker R, Nishiyama K, Rubin M, Bilezikian J, Shane E, Liu XS. Increased Endocortical Formation and Periosteal Resorption at the Distal Tibia in Premenopausal Women with Idiopathic Osteoporosis Treated with 18 Months of Teriparatide. American Society of Bone and Mineral Research, Houston, TX, 2014.
  17. Altman AR, Lott C, Tseng WJ, de Bakker CMJ, Liou S-D, Lin T, Qin L, Liu XS. Intermittent PTH after prolonged bisphosphonate treatment improves trabecular bone microarchitecture and alleviates bone tissue hypermineralization by inducing substantial new bone formation. American Society of Bone and Mineral Research, Houston, TX, 2014.
  18. Tseng WJ, de Bakker CMJ, Lin T, Wei T, Jia H, Levin LS, Qin L, Liu XS. Simultaneous Measurement of Changes in Bone Remodeling and Microvasculature in Response to Estrogen Deficiency-Induced Bone Loss and Intermittent PTH-Induced Bone Gain. American Society of Bone and Mineral Research, Houston, TX, 2014.
  19. de Bakker CMJ, Altman AR, Li C, Liu XS. Maternal Bone Regains Mechanical Competence after Lactation by Increasing the Thickness and Altering the Structure Type of the Remaining Trabeculae. World Congress of Biomechanics, Boston, MA, 2014.
  20. Tribble MB, Cohen A, de Bakker CMJ, Nishiyama K, Shane E, Liu XS. Increased Endocortical Formation and Periosteal Resorption in Premenopausal Women with Idiopathic Osteoporosis Treated with 18 Months of Intermittent Parathyroid Hormone. 7th World Congress of Biomechanics, Boston, MA, 2014.
  21. de Bakker CMJ, Altman AR, Li C, Liu XS. Pregnancy, Lactation, and Weaning Induce Substantial Changes in Bone Microarchitecture and Remodeling in Rat Tibiae. Orthopaedic Research Society Annual Meeting, New Orleans, LA, March 15-18, 2014.
  22. de Bakker CMJ, Altman AR, Li C, Tseng WJ, Tribble MB, Huh BK, Chandra A, Qin L, Liu XS. Alendronate and PTH Combination Therapy Stimulates Bone Formation while Inhibiting Bone Resorption Activities in the Rat Tibia: A Longitudinal, In Vivo, Dynamic Bone Histomorphometry Study. Orthopaedic Research Society Annual Meeting, New Orleans, LA, March 15-18, 2014.
  23. Altman AR, de Bakker CMJ, Chandra A, Huh BK, Qin L, Liu XS. Enhanced individual trabecular repair and its mechanical implications in PTH and alendronate treated rat tibial bone. NIRA Finalist, Poster & Podium Presentation. Orthopaedic Research Society Annual Meeting, New Orleans, LA, March 15-18, 2014.
  24. Li C, Lott C, Altman AR, de Bakker CMJ, Liu XS. Comparison between ovariectomy and lactation induced bone loss: a dynamic imaging study. Poster Presentation. Orthopaedic Research Society Annual Meeting, New Orleans, LA, March 15-18, 2014.
  25. Tseng WJ, Lin T, de Bakker CMJ, Levin LS, Qin L, Liu XS. Changes in the Trabeculae-Vessel Function Unit in response to Estrogen Deficiency-Induced Bone Loss and Intermittent PTH-Induced Bone Gain. Orthopaedic Research Society Annual Meeting, New Orleans, LA, March 15-18, 2014.
  26. Tribble MB, Cohen A, de Bakker CMJ, Nishiyama K, Shane E, Liu XS. Increased Endocortical Formation and Periosteal Resorption in Premenopausal Women with Idiopathic Osteoporosis Treated with Intermittent Parathyroid Hormone. Orthopaedic Research Society Annual Meeting, New Orleans, LA, March 15-18, 2014.
  27. Pittman J, Degiacomo A, Cusher D, de Bakker CMJ, Mroszczyk KA, Grinstaff M, Gerstenfeld LC, Morgan EF. Altered Endochondral Ossification during Fracture Healing in Response to BMP Receptor Antagonist. Orthopaedic Research Society Annual Meeting, New Orleans, LA, March 15-18, 2014.
  28. de Bakker CMJ, Altman AR, Tseng WJ, Tribble MB, Huh BK, Chandra A, Qin L, and Liu XS. In Vivo Bone Dynamic Imaging Reveals Increased Bone Formation and Inhibited Bone Resorption in Rat Tibia in Response to Combined Alendronate (ALN) and PTH Treatment. American Society for Bone and Mineral Research Annual Meeting, Baltimore, MD, 2013.
  29. Tseng WJ, Zhu H, Huh BK, de Bakker CMJ, Luo S, Tang J, Qin L, Liu XS. Assessment of the vascular and trabecular microstructures using micro computed tomography, vascular network perfusion, and image registration techniques. American Society of Mechanical Engineers Summer Bioengineering Conference, Sunriver, OR, 2013
  30. de Bakker CMJ, Mroszczyk KA, Pittman J, McDonald G, Hayward LNM, Grinstaff MW, Gerstenfeld LC, Morgan EF. Contrast-Enhanced Computed Tomography for Quantitative Assessment of Multiple Stages of Fracture Healing. Podium Presentation. Orthopaedic Research Society Annual Meeting 2013, San Antonio, TX.
  31. Hayward LNM, de Bakker CMJ, Gerstenfeld LC, Grinstaff MW, Morgan EF. Validation of Contrast-Enhanced Computed Tomography for Imaging of Cartilage in Fracture Healing. Orthopaedic Research Society Annual Meeting 2012, San Francisco, CA.
  32. de Bakker CMJ, Hayward LNM, Gerstenfeld LC, Grinstaff MW, Morgan EF. Contrast-Enhanced Computed Tomography for Non-Destructive, Quantitative Assessment of the Early Stages of Fracture Healing. ASME 2011 Summer Bioengineering Conference, Farmington, PA.
  33. Hayward LNM, de Bakker CMJ, Gerstenfeld LC, Grinstaff MW, Morgan EF. A Cationic CT Contrast Agent for Imaging of Soft Callus Formation in Fracture Healing. Orthopaedic Research Society Annual Meeting 2011, Long Beach, CA.