Perelman School of Medicine at the University of Pennsylvania

McKay Orthopaedic Research Laboratory

Liu Laboratory

Chantal de Bakker

Chantal

Graduate Student in Bioengineering
University of Pennsylvania

Hometown: Hollis, NH

Education:
B.S. Biomedical Engineering, 2012, Boston University, Boston, MA

Areas of Special Interest: Imaging techniques using microCT, mechanical regulation of tissue growth, tissue remodeling. Outside of the lab, Chantal enjoys reading, hiking, camping, traveling, and learning new languages.

Manuscripts:

Altman AR, Tseng W-J, de Bakker CMJ, Huh BK, Chandra A, Qin L, Liu XS. A closer look at the immediate trabeculae response to combined parathyroid hormone and alendronate treatment. Bone. 2014; 61:149-157.

Hayward LNM, de Bakker CMJ, Gerstenfeld LC., Grinstaff MW, and Morgan EF. Assessment of Contrast-Enhanced Computed Tomography for Imaging of Cartilage during Fracture Healing. Journal of Orthopaedic Research. 2013; 31(4):567-573.

Hayward LNM, de Bakker CMJ, Lusic H, Gerstenfeld LC, Grinstaff MW, and Morgan EF. MRT Letter: Contrast-Enhanced Computed Tomographic Imaging of Soft Callus Formation in Fracture Healing. Microscopy Research and Technique. 2012; 75(1):7-14.

Abstracts:

de Bakker CMJ, Altman AR, Li C, Tseng W-J, Liu XS. Pregnancy and Lactation Bone Loss Cause Long-Lasting Structural Deterioration of the Maternal Skeleton that Accumulates over Multiple Reproductive Cycles. American Society of Bone and Mineral Research, Houston, TX, 2014 (submitted).

Tribble MB, Cohen A, de Bakker CMJ, Lappe J, Recker R, Nishiyama K, Rubin M, Bilezikian J, Shane E, Liu XS. Increased Endocortical Formation and Periosteal Resorption at the Distal Tibia in Premenopausal Women with Idiopathic Osteoporosis Treated with 18 Months of Teriparatide. American Society of Bone and Mineral Research, Houston, TX, 2014 (submitted).

Altman AR, Lott C, Tseng W-J, de Bakker CMJ, Liou S-D, Lin T, Qin L, Liu XS. Intermittent PTH after prolonged bisphosphonate treatment improves trabecular bone microarchitecture and alleviates bone tissue hypermineralization by inducing substantial new bone formation. American Society of Bone and Mineral Research, Houston, TX, 2014 (submitted).

Tseng W-J, de Bakker CMJ, Lin T, Wei T, Jia H, Levin LS, Qin L, Liu XS. Simultaneous Measurement of Changes in Bone Remodeling and Microvasculature in Response to Estrogen Deficiency-Induced Bone Loss and Intermittent PTH-Induced Bone Gain. American Society of Bone and Mineral Research, Houston, TX, 2014 (submitted).

de Bakker CMJ, Altman AR, Li C, and Liu XS. Maternal Bone Regains Mechanical Competence after Lactation by Increasing the Thickness and Altering the Structure Type of the Remaining Trabeculae. World Congress of Biomechanics, Boston, MA, 2014 (submitted).

Tribble MB, Cohen A, de Bakker CMJ, Nishiyama K, Shane E, Liu XS. Increased Endocortical Formation and Periosteal Resorption in Premenopausal Women with Idiopathic Osteoporosis Treated with 18 Months of Intermittent Parathyroid Hormone. 7th World Congress of Biomechanics, Boston, MA, 2014 (submitted).

de Bakker CMJ, Altman AR, Li C, and Liu XS. Pregnancy, Lactation, and Weaning Induce Substantial Changes in Bone Microarchitecture and Remodeling in Rat Tibiae. Orthopaedic Research Society Annual Meeting, New Orleans, LA, March 15-18, 2014.

de Bakker CMJ, Altman AR, Li C, Tseng W-J, Tribble MB, Huh BK, Chandra A, Qin L, and Liu XS. Alendronate and PTH Combination Therapy Stimulates Bone Formation while Inhibiting Bone Resorption Activities in the Rat Tibia: A Longitudinal, In Vivo, Dynamic Bone Histomorphometry Study. Orthopaedic Research Society Annual Meeting, New Orleans, LA, March 15-18, 2014.

Altman AR, de Bakker CMJ, Chandra A, Huh BK, Qin L, Liu XS. Enhanced individual trabecular repair and its mechanical implications in PTH and alendronate treated rat tibial bone. NIRA Finalist, Poster & Podium Presentation. Orthopaedic Research Society Annual Meeting, New Orleans, LA, March 15-18, 2014.

Li C, Lott C, Altman AR, de Bakker CMJ, Liu XS. Comparison between ovariectomy and lactation induced bone loss: a dynamic imaging study. Poster Presentation. Orthopaedic Research Society Annual Meeting, New Orleans, LA, March 15-18, 2014.

Tseng W-J, Lin T, de Bakker CMJ, Levin LS, Qin L, Liu XS. Changes in the Trabeculae-Vessel Function Unit in response to Estrogen Deficiency-Induced Bone Loss and Intermittent PTH-Induced Bone Gain. Orthopaedic Research Society Annual Meeting, New Orleans, LA, March 15-18, 2014.

Tribble MB, Cohen A, de Bakker CMJ, Nishiyama K, Shane E, Liu XS. Increased Endocortical Formation and Periosteal Resorption in Premenopausal Women with Idiopathic Osteoporosis Treated with Intermittent Parathyroid Hormone. Orthopaedic Research Society Annual Meeting, New Orleans, LA, March 15-18, 2014.

Pittman J, Degiacomo A, Cusher D, de Bakker CMJ, Mroszczyk KA, Grinstaff M, Gerstenfeld LC, Morgan EF. Altered Endochondral Ossification during Fracture Healing in Response to BMP Receptor Antagonist. Orthopaedic Research Society Annual Meeting, New Orleans, LA, March 15-18, 2014.

de Bakker CMJ, Altman AR, Tseng W-J, Tribble MB, Huh BK, Chandra A, Qin L, and Liu XS. In Vivo Bone Dynamic Imaging Reveals Increased Bone Formation and Inhibited Bone Resorption in Rat Tibia in Response to Combined Alendronate (ALN) and PTH Treatment. American Society for Bone and Mineral Research Annual Meeting, Baltimore, MD, 2013.

Tseng W-J, Zhu H, Huh BK, de Bakker CMJ, Luo S, Tang J, Qin L, Liu XS. Assessment of the vascular and trabecular microstructures using micro computed tomography, vascular network perfusion, and image registration techniques. American Society of Mechanical Engineers Summer Bioengineering Conference, Sunriver, OR, 2013

de Bakker CMJ, Mroszczyk KA, Pittman J, McDonald G, Hayward LNM, Grinstaff MW, Gerstenfeld LC, Morgan EF. Contrast-Enhanced Computed Tomography for Quantitative Assessment of Multiple Stages of Fracture Healing. Podium Presentation. Orthopaedic Research Society Annual Meeting 2013, San Antonio, TX.

Hayward LNM, de Bakker CMJ, Gerstenfeld LC, Grinstaff MW, Morgan EF. Validation of Contrast-Enhanced Computed Tomography for Imaging of Cartilage in Fracture Healing. Orthopaedic Research Society Annual Meeting 2012, San Francisco, CA.

de Bakker CMJ, Hayward LNM, Gerstenfeld LC, Grinstaff MW, Morgan EF. Contrast-Enhanced Computed Tomography for Non-Destructive, Quantitative Assessment of the Early Stages of Fracture Healing. ASME 2011 Summer Bioengineering Conference, Farmington, PA.

Hayward LNM, de Bakker CMJ, Gerstenfeld LC, Grinstaff MW, Morgan EF. A Cationic CT Contrast Agent for Imaging of Soft Callus Formation in Fracture Healing. Orthopaedic Research Society Annual Meeting 2011, Long Beach, CA.

Honors & Awards:

ICMRS Webster Jee Young Investigator Award, 2014

NSF GRFP Fellowship, 2014

NSF Fellowship Honorable Mention, 2013