Perelman School of Medicine at the University of Pennsylvania

McKay Orthopaedic Research Laboratory

Liu Laboratory

Bone Imaging and Biomechanics Journal Club

Journal Club 2015
May 27, 2015 Yihan Li

Zysset et al. (1999), "Elastic modulus and hardness of cortical and trabecular bone lamellae measured by nanoindentation in the human femur." J Biomech. 32(10):1005-1012.

Hoffler et al. (2005), "An application of nanoindentation technique to measure bone tissue Lamellae properties." J Biomech Eng. 127(7):1046-1053.

Wolfram et al. (2010), "Rehydration of vertebral trabecular bone: Influences on its anisotropy, its stiffness and the indentation work with a view to age, gender and vertebral levels." Bone. 46(2):348-354.

January 21, 2015 Wei-Ju Tseng
Yihan Li
Schwiedrzik et al., (2014), "In situ micropillar compression reveals superior strength and ductility but an absence of damage in lamellar bone ." Nat Mater. 13(7):740-747.
Journal Club 2014
July 24, 2014 Wei-Ju Tseng Tu et al. (2012) "Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading" Bone. 50:209-217.
July 15, 2014 Allison Altman Warden et al. (2013) "Reduced Gravitational Loading Does Not Account for the Skeletal Effect of Botulinum Toxin-Induced Muscle Inhibition Suggesting a Direct Effect of Muscle on Bone." Bone. 54:98-105.
June 23, 2014 Chantal de Bakker Amugongo et al. (2014) "Effects of sequential osteoporosis treatments on trabecular bone in adult rats with low bone mass." Osteoporosis Int. 25:1735- 1750.
February 18, 2014 Allison Altman Rhee Y et al. (2013), "Resorption controls bone anabolism driven by parathyroid hormone (PTH) receptor signaling in osteocytes." J Biological Chemistry. 288(41):29809-29820.
February 12, 2014 Chantal de Bakker Waarsing JH et al. (2004), "An improved segmentation method for in vivo µCT imaging." JBMR. 19(10):1640-1650.
February 5, 2014 Wei-Ju Tseng Barou O et al., (2002), "Relationships between trabecular bone remodeling and bone vascularization: a quantitative study." Bone. 30(4):604-612.
Journal Club 2013
September 24, 2013 Allison Altman Rauch F. (2012), "The dynamics of bone structural development during pubertal growth." J Musculoskelet Neuronal Interact. 12(1):1-6.
July 25, 2013 Connie Li & Carina Lott Chandra A, et al. (2013), "PTH prevents the adverse effects of focal radiation on bone architecture in young rats." Bone. 55:449-457.
July 11, 2013 Klyde Breitton Green JO et al. (2012), "Three years of alendronate treatment does not continue to decrease microstructural stresses and strains associated with trabecular microdamage initiation beyond those at 1 year" Osteoporos Int. 23:2313-2320.
June 6, 2013 Mary Beth Tribble Nickolas TL et al. (2013), "Rapid cortical bone loss in patients with chronic kidney disease" J Bone Miner Res. 28(8):1811-1820.
May 30, 2013 Allison Altman Allen MR et al. (2008), "Alendronate Reduces Bone Toughness of Ribs without Significantly Increasing Microdamage Accumulation in Dogs Following 3 Years of Daily Treatment" Calcif Tissue Int 82:354-360.
April 25, 2013 Wei-Ju Tseng Mekraldi et al. (2003), "Changes in vasoactive factors associated with altered vessel morphology in the tibial metaphysis during ovariectomy-induced bone loss in rats" Bone, 32:630-641.
April 18, 2013 Beom Kang Huh Ding W.-G. et al. (2011), "Reduced local blood supply to the tibial metaphysis is associated with ovariectomy-induced osteoporosis in mice" Connect Tissue Res. 52(1): 25-29.
March 28, 2013 Klyde Breitton Arlot ME et al. (2008), "Microarchitecture Influences Microdamage Accumulation in Human Vertebral Trabecular Bone" J Bone Miner Res. 23(10):1613-1618.
March 14, 2013 Mary Beth Tribble Macdonald HM et al. (2011), "Changes in trabecular and cortical bone microarchitecture at peripheral sites associated with 18 months of teriparatide therapy in postmenopausal women with osteoporosis" Osteoporos Int 22:357-362.
March 7, 2013 Chantal de Bakker Schulte FA et al. (2011), "In vivo micro-computed tomography allows direct three-dimensional quantification of both bone formation and bone resorption parameters using time-lapsed imaging" Bone 48:433-442.
Journal Club 2012
December 13, 2012 Allison Altman Green JO et al. (2012), "Three years of alendronate treatment does not continue to decrease microstructural stresses and strains associated with trabecular microdamage initiation beyond those at 1 year" Osteoporos Int. 23:2313-2320.
December 6, 2012 Wei-Ju Tseng Qing H et al. (2012), "Demonstration of Osteocytic Perilacunar/Canalicular Remodeling in Mice During Lactation" J Bone Miner Res. 27(5):1018-1029.
November 8, 2012 Allison Altman Tang Y et al. (2009), "TGF-beta1-induced migration of bone mesenchymal stem cells couples bone resorption with formation" Nat. Med. 15:757-765.
November 1, 2012 Allison Altman Wu XW et al. (2010), "Inhibition of Sca-1-Positive Skeletal Stem Cell Recruitment by Alendronate Blunts the Anabolic Effects of Parathyroid Hormone on Bone Remodeling" Cell Stem Cell. 7:571-580.
Kostenuik PJ et al. (2001), "OPG and PTH-(1-34) Have Additive Effects on Bone Density and Mechanical Strength in Osteopenic Ovariectomized Rats" Endocrinology, 142(10):4295-4304.
October 25, 2012 Wei-Ju Tseng Kim SW et al. (2012), "Intermittent parathyroid hormone administration converts quiescent lining cells to active osteoblasts" J Bone Miner Res. 27(10):2075-2084.
October 18, 2012 Chantal de Bakker Hayward LNM et al. (2012), "MRT Letter: Contrast-Enhanced Computed Tomographic Imaging of Soft Callus Formation in Fracture Healing" Microscopy Research and Technique, 75:7-14.
September 27, 2012 Allison Altman Kazakia RJ et al. (2008), "Assessment of bone tissue mineralization by conventional x-ray microcomputed tomography: Comparison with synchrotron radiation microcomputed tomography and ash measurements" Med Phys, 35(7):3170-3179.
September 20, 2012 Mimi Luo Prisby R et al. (2011), "Intermittent PTH(1-84) is osteoanabolic but not osteoangiogenic and relocates bone marrow blood vessels closer to bone-forming sites" J Bone Miner Res, 26(11):2583-2596.
September 13, 2012 Beom Kang Huh Fuchs RK et al. (2008), "Strontium ranelate does not stimulate bone formation in ovariectomized rats" Osteoporos Int, 19(9):1331-1341.

Bain SD et al. (2009), "Strontium ranelate improves bone strength in ovariectomized rat by positively influencing bone resistance determinants" Osteoporos Int, 20(8):1417-1428.
July 9, 2012 Allison Altman Nishiyama KK et al. (2010), "Reproducibility of bone micro-architecture measurements in rodents by in vivo micro-computed tomography is maximized with three-dimensional image registration" Bone, 46(1):155-161.