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McKay Orthopaedic Research Laboratory

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Liu Laboratory

Publications

Peer Reviewed Full-Length Articles

1. Tseng WJ, Lee W, Zhao H, Liu Y, Wang W, de Bakker CMJ, Li Y, Osuna C, Tong W, Wang L, Ma X, Qin L, Liu XS. Short cyclic regimen with parathyroid hormone (PTH) results in prolonged anabolic effect relative to continuous treatment followed by discontinuation in ovariectomized rats. J Bone Miner Res. 2021 Dec 26. doi: 10.1002/jbmr.4495. 

2. Sang W, Li Y, Guignon J, Liu XS, Ural A. Structural role of osteocyte lacunae on mechanical properties of bone matrix: A cohesive finite element study. J Mech Behav Biomed Mater, 2022 Jan;125:104943. 

3. Pei S, Zhou Y, Li Y, Azar T, Wang W, Kim DG, Liu XS. Instrumented nanoindentation in musculoskeletal research. Prog Biophys Mol Biol. 2022 Jun 2:S0079-6107(22)00055-4. doi: 10.1016/j.pbiomolbio.2022.05.010

4. Wang W, Azar T, Tseng WJ, Pei S, Zhou Y, Jiang X, Dyment N, Liu XS. Distinct Responses of Modeling- and Remodeling-Based Bone Formation to the Discontinuation of Intermittent Parathyroid Hormone Treatment in Ovariectomized Rats. J Bone Miner Res. 2022 Sep 12. doi: 10.1002/jbmr.4704.

1. Han B, Li Q, Wang C, Chandrasekaran P, Zhou Y, Qin L, Liu XS, Enomoto-Iwamoto M, Kong D, Iozzo RV, Birk DE, Han L. Differentiated activities of decorin and biglycan in the progression of post-traumatic osteoarthritis. Osteoarthritis Cartilage, 2021 Aug;29(8):1181-1192.

2. Wang W, Tseng W-J, Zhao H, Azar T, Pei S, Jiang X, Dyment N, Liu XS. Activation, development, and attenuation of modeling- and remodeling-based bone formation in adult rats. Biomaterials, 2021 Jul 9;276:121015.

3. Lai X, Chung R, Li Y, Liu XS, Wang L. Lactation alters fluid flow and solute transport in maternal skeleton: A multiscale modeling study on the effects of microstructural changes and loading frequency. Bone, 2021 Oct;151:116033.

4. Li Y, de Bakker CMJ, Lai X, Zhao H, Parajuli A, Tseng W-J, Pei S, Meng T, Chung R, Wang L, Liu XS. Maternal bone adaptation to mechanical loading during pregnancy, lactation, and post-weaning recovery. Bone, 2021 Oct;151:116031.

5. Yu W, Zhong L, Yao L, Wei Y, Gui T, Li Z, Kim H, Holdreith N, Jiang X, Tong W, Dyment N, Liu XS, Yang S, Choi Y, Ahn J, Qin L. Bone marrow adipogenic lineage precursors promote osteoclastogenesis in bone remodeling and pathologic bone loss. J Clin Invest, 2021 131(2):e140214.

6. Wei Y, Sun H, Gui T, Yao L, Zhong L, Yu W, Heo S, Han L, Dyment NA, Liu XS, Zhang Y, Koyama E, Long F, Zgonis MH, Mauck RL, Ahn J, Qin L. The critical role of Hedgehog-responsive mesenchymal progenitors in meniscus development and injury repair. Elife, 2021 (10): e62917.

7. Li Y, Tseng WJ, de Bakker CMJ, Zhao H, Chung R, Liu XS. Peak trabecular bone microstructure predicts rate of estrogen-deficiency-induced bone loss in rats. Bone. 2021 Apr;145:115862.

1. Fung A, Shetye S, Li Y, Zhou Y, Liu XS, Soslowsky LJ. Pregnancy and Lactation Impair Subchondral Bone Leading to Reduced Rat Supraspinatus Tendon Failure. J Biomech Eng. 2020 Nov 1;142(11):111003.

2. Alliston T, Foucher KC, Frederick B, Hernandez CJ, Iatridis JC, Kozloff KM, Lewis KJ, Liu XS, Mercer DM, Ochia R, Queen RM, Rimnac CM, van der Meulen MCH, and Westendorf JJ. The importance of diversity, equity, and inclusion in orthopedic research, J Orthop Res, 2020 Aug;38(8):1661-1665.

3. Li Q, Han B, Wang C, Tong W, Wei Y, Tseng WJ, Han LH, Liu XS, Enomoto-Iwamoto M, Mauck RL, Qin L, Iozzo RV, Birk DE, and Han L. Decorin mediates cartilage matrix degeneration and fibrillation in post-traumatic osteoarthritis, Arthritis Rheumatol, 2020 Aug;72(8):1266-1277.

4. Parajuli A, Pei S, Zhao H, Martinez JR, Lu XL, Liu XS, Farach-Carson MC, Kirn-Safran CB, and Wang L, Trabecular bone deficit and enhanced anabolic response to re-ambulation after disuse in perlecan-deficient skeleton, Biomolecules, 2020 Jan 29;10(2).

5. Wang C, Brisson BK, Terajima M, Li Q, Hoxha K, Han B, Goldberg AM, Liu XS, Marcolongo MS, Enomoto-Iwamoto M, Yamauchi M, Volk SW, and Han L, Type III collagen is a key regulator of the collagen fibrillar structure and biomechanics of articular cartilage and meniscus, Matrix Biology, 2020 Jan;85-86:47-67.

6. Zhao H, Chang C-C, Liu Y, Yang Y, Tseng W-J, de Bakker CM, Chung R, Ghosh P, Deng L, and Liu XS, Reproducibility and radiation effect of high-resolution in vivo micro computed tomography imaging of the mouse lumbar vertebra and long bone, Annals of Biomedical Engineering, 48 (1): 157-168, 2020.

1. Han B, Li Q, Wang C, Patel P, Adams SM, Doyran B, Nia HT, Oftadeh R, Zhou S, Li CY, Liu XS, Lu XL, Enomoto-Iwamoto M, Qin L, Maruck RL, Iozzo RV, Birk D, and Han L. Decorin regulates the Aggrecan network integrity and biomechanical functions of cartilage extracellular matrix, ACS Nano, 13 (10): 11320-11333, 2019.

2. Wang L, Tower RJ, Chandra A, Yao L, Tong W, Xiong Z, Tang K, Zhang Y, Liu XS, Boerckel JD, Guo X, Ahn J, and Qin L. Periosteal mesenchymal progenitor dysfunction and extraskeletally-derived fibrosis contribute to atrophic fracture nonunion, Journal of Bone and Mineral Research, 34 (3): 520-532, 2019.

3. Liu XS, Wang L, de Bakker CMJ, and Lai X, Mechanical regulation of the maternal skeleton during reproduction and lactation, Current Osteoporosis Report, 17 (6): 375-386, 2019.

  1. de Bakker, CMJ, Zhao H, Tseng W-J, Li Y, Altman-Singles AR, Liu Y, Leavitt L, and Liu XS, Effects of Reproduction on Sexual Dimorphisms in Rat Bone Mechanics, Journal of Biomechanics, 77: 40-47, 2018
  2. de Bakker, CMJ, Li Y, Zhao H, Leavitt L, Tseng W-J, Lin T, Tong W, Qin L, and Liu XS, Structural adaptations in the rat tibia bone induced by pregnancy and lactation confer protective effects against future estrogen deficiency, Journal of Bone and Mineral Research, 33(12):2165-2176, 2018
  3. Jia H, Ma X, Wei Y, Tong W, Tower RJ, Chandra A, Wang L, Sun Z, Yang Z, Badar F, Zhang K, Tseng WJ, Kramer I, Kneissel M, Xia Y, Liu XS, Wang JHC, Han L, Enomoto-Iwamoto M, and Qin L. Loading-induced reduction in sclerostin as a mechanism of subchondral bone platesclerosis in mouse knee joints during late-stage osteoarthritis, Arthritis & Rheumatology, 70 (2):230-41, 2018
  4. Chandra A, Wang L, Young T, Zhong L, Tseng W-J, Levine MA, Cengel K, Liu XS, Zhang Y, Pignolo RJ, and Qin L. Proteasome inhibitor Bortezomib is a novel therapeutic for focal radiation-induced osteoporosis, FASEB Journal, 32(1): 52-62, 2018
  1. Jia H, Ma X, Wei Y, Tong W, Tower RJ, Chandra A, Wang L, Sun Z, Yang Z, Badar F, Zhang K, Tseng WJ, Kramer I, Kneissel M, Xia Y, Liu XS, Wang JH, Han L, Enomoto-Iwamoto M, Qin L. Subchondral bone plate sclerosis during late osteoarthritis is caused by loading-induced reduction in Sclerostin. Arthritis Rheumatol. 2017.
  2. de Bakker CMJ, Tseng WJ, Li Y, Zhao H, Altman-Singles AR, Jeong Y, Robberts J, Han L, Kim DG, X. Sherry Liu. Reproduction Differentially Affects Trabecular Bone Depending on Its Mechanical Versus Metabolic Role. J Biomech Eng. 139(11), 2017.
  3. Chandra A, Wang L, Young T, Zhong L, Tseng WJ, Levine MA, Cengel K, Liu XS, Zhang Y, Pignolo RJ, Qin L. Proteasome inhibitor bortezomib is a novel therapeutic agent for focal radiation-induced osteoporosis. FASEB J. 2017.
  4. Altman-Singles AR, Jeong Y, Tseng WJ, de Bakker CM, Zhao H, Lott C, Robberts J, Qin L, Han L, Kim DG, and Liu XS. Intermittent Parathyroid Hormone After Prolonged Alendronate Treatment Induces Substantial New Bone Formation and Increases Bone Tissue Heterogeneity in Ovariectomized Rats. Journal of Bone and Mineral Research. 2017
  5. de Bakker CMJ, Altman-Singles AR, Li Y, Tseng WJ, Li C, and Liu XS. Adaptations in the Microarchitecture and Load Distribution of Maternal Cortical and Trabecular Bone in Response to Multiple Reproductive Cycles in Rats. Journal of Bone and Mineral Research. 32(5):1014-1026, 2017.
  6. de Bakker CMJ, Tseng WJ, Li Y, Zhao H, and Liu XS. Clinical Evaluation of Bone Strength and Fracture Risk. Current Osteoporosis Reports, 15(1):32-42, 2017.
  1. Chandra A, Lin T, Young T, Tong W, Ma X, Tseng WJ, Kramer I, Kneissel M, Levine MA, Zhang Y, Cengel K, Liu XS, and Qin L. Suppression of Sclerostin alleviates radiation-induced bone loss by protecting bone forming cells and their progenitors through distinct mechanisms. Journal of Bone and Mineral Research. 2016.
  2. de Bakker CMJ, Altman AR, Li C, Tribble MB, Lott C, Tseng W-J, and Liu XS, Minimiing interpolation bias and precision error in in vivo µCT-based measurements of bone structure and dynamics. Annals of Biomedical Engineering. 2016.
  3. Zhu H, Xie F, Luo X, Qin L, Liu XS, LS Levin, and Li Q, Orthotopic forelimb allotransplantation in the rat model. Microsurgery, 2016.
  4. Zhou B, Zhang Z, Wang J, Yu YE, Liu XS, Nishiyama KK, Rubin MR, Shane E, Bilezikian JP, Guo XE. In vivo precision of digital topological skeletonization based individual trabecula segmentation (ITS) analysis of trabecular microstructure at the distal radius and tibia by HR-pQCT. Pattern Recognition Letters, 76: 83-89, 2016.
  1. Lin T, Tong W, Chandra A, Hsu S-Y, Jia H, Zhu J, Tseng W-J, Levine MA, Zhang Y, Yan S, Liu XS, Sun D, Young W, and Qin L, A comprehensive study of long-term skeletal changes after spinal cord injury in adult rats. Bone Research, 3:15028-1-9, 2015.
  2. Altman AR, Tseng WJ, de Bakker CM, Chandra A, Lan S, Huh BK, Luo S, Leonard MB, Qin L, Liu XS. Quantification of skeletal growth, modeling, and remodeling by in vivo micro computed tomography. Bone, 81: 370-9, 2015.
  3. Altman AR, de Bakker CMJ, Tseng WJ, Chandra A, Qin L, Liu XS. Enhanced individual trabecular repair and its mechanical implications in PTH and Alendronate treated rat tibial bone. Journal of Biomechanical Engineering, 137 (1): 011004-1-8, 2015.
  4. de Bakker CMJ, Altman AR, Tseng WJ, Tribble MB, Chandra A, Li C, Liu XS. µCT-Based, In Vivo Dynamic Bone Histomorphometry Allows 3D Evaluation of the Early Responses of Bone Resorption and Formation to PTH and Alendronate Combination Therapy. Bone 73: 198-207, 2015

  5. Wang J*, Zhou B*, Liu XS*, Fields AJ, Sanyal A, Shi X, Adams M, Keaveny TM, Guo XE, Trabecular plates and rods determine elastic modulus and yield strength of human trabecular bone. Bone 72: 71-80, 2015 (*authors contributed equally).

  6. Chandra A, Lin T, Zhu J, Tong W, Huo Y, Jia H, Zhang Y, Liu XS, Cengel K, Xia B, Qin L, PTH1-34 blocks radiation-induced osteoblast apoptosis by enhancing DNA repair through canonical Wnt pathway. Journal of Biological Chemistry 290 (1): 157-67, 2015.

  1. Walker MD, Shi S, Russo JJ, Liu XS, Zhou B, Zhang C, Liu G, McMahon DJ, Bilezikian JP, and Guo XE, A trabecular plate-like phenotype is overrepresented in Chinese-American versus Caucasian women, Osteoporosis International 25 (12): 2787-95, 2014.
  2. Rooney SI, Loro E, Sarver JJ, Peltz CD, Hast MW, Tseng WJ, Kuntz AF, Liu XS, Khurana TS, Soslowsky LJ. Exercise Protocol Induces Muscle, Tendon, and Bone Adaptations in the Rat Shoulder. Muscle, Ligaments and Tendons Journal 4 (4): 413-9, 2014.
  3. Chandra A, Lin T, Tribble MB, Zhu J, Altman AR, Tseng WJ, Zhang Y, Akintoye SO, Cengel K, Liu XS, and Qin L, PTH1-34 alleviates radiotherapy-induced local bone loss by improving osteoblast and osteocyte survival, Bone 67C:33-40, 2014
  4. Zhou B, Liu XS, Wang J, Lu XL, Fields AJ, and Guo XE, Dependence of mechanical properties of trabecular bone on plate-rod microstructure determined by individual trabecula segmentation (ITS), Journal of Biomechanics 47(3): 702-708, 2014
  5. Altman AR, Tseng WJ, de Bakker CMJ, Huh BK, Chandra A, Qin L, and Liu XS, A Closer Look at the Immediate Trabeculae Response to Combined Parathyroid Hormone and Alendronate Treatment, Bone 61:149-57, 2014
  6. Iyer SP, Nikkel LE, Nishiyama KK, Zhang C, McMahon, DJ, Boutroy S, Liu XS, Ratner L, Cohen DJ, Guo XE, Shane E, and Nckolas TL, Kidney transplantation with early corticosteroid withdrawal immunosuppression: paradoxical effects at the central and peripheral skeleton, Journal of the American Society of Nephrology, 25(6):1331-41, 2014
  7. Stein EM, Kepley A, Walker M, Nickolas TL, Nishiyama KK, Zhou B, Liu XS, McMahon DJ, Zhang C, Boutroy S, Cosman F, Nieves J, Guo XE, and Shane E, Skeletal structure in postmenopausal women with osteopenia and fractures is characterized by abnormal trabecular plates and cortical thinning, Journal of Bone and Mineral Research ;29(5):1101-9, 2014
  8. Wang B, Lai X, Price C, Thompson WR, Li W, Quabili TR, Tseng WJ, Liu XS, Zhang H, Pan J, Kirn-Safran CB, Farach-Carson MC, and Wang L, Perlecan-containing pericellular matrix regulates solute transport and mechanosensing within the osteocyte lacunar-canalicular system, Journal of Bone and Mineral Research, 29(4):878-91, 2014
  9. Boutroy S, Walker MD, Liu XS, McMahon DJ, Liu G, Guo XE, and Bilezikian JP, Lower cortical porosity and higher tissue mineral density in Chinese-American versus White women, Journal of Bone and Mineral Research, 29(3):551-61, 2014
  10. Peng SL*, Liu XS*, Huang S, Pan H, Zhen W, Zhou G, Luk KDK, Guo XE, and Lu WW, Intervention Timing of Strontium Treatment on Estrogen Depletion-Induced Osteoporosis in Rats: Bone Microstructure and Mechanics, Journal of Orthopaedic Research, 32(3): 477-84, 2014 (*authors contributed equally)
  11. Wang H, Ji B, Liu XS, Guo XE, Huang Y, Hwang K-C, Osteocyte-viability-based simulations of bone loss and recovery in disuse and reloading, Biomechanics and Modeling in Mechanobiology, 13(1):153-66, 2014
  1. Nickolas TL, Stein EM, Dworakowski E, Nishiyama K, Komandah-Kosseh M, Zhang CA, McMahon DJ, Liu XS, Boutroy S, Cremers S, and Shane E, Rapid cortical bone loss in patients with chronic kidney disease, Journal of Bone and Mineral Research, 28(8): 1811-20, 2013
  2. Lan S, Luo S, Huh BK, Chandra A, Altman AR, Qin L, and Liu XS, 3D Image registration is critical to ensure accurate detection of longitudinal changes in trabecular bone density, microstructure, and stiffness measurements in rat tibiae by in vivo micro computed tomography (µCT), Bone, 56(1): 83-90, 2013
  3. Cohen A, Dempster DW, Recker RR, Lappe JM, Zhou H, Wirth AJ, van Lenthe GH, Zwahlen A, Muller R, Zhao B, Guo X, Lang T, Saeed I, Liu XS, Guo XE, Cremers S, Rosen CJ, Stein EM, Nickolas TL, McMahon DJ, Young P, Shane E, Abdominal fat is associated with lower bone formation and lower trabecular bone volume in healthy premenopausal women: a transiliac bone biopsy study, Journal of Clinical Endocrinology and Metabolism, 98(6):2562-72, 2013
  4. Chandra A, Lan S, Zhu J, Siclari VA, Altman A, Cengel K, Liu XS, and Qin L, PTH prevents the adverse effects of focal radiation on bone architecture in young rats, Bone,55(2): 449-57, 2013
  5. Liu XS, Wang J, Zhou B, Stein E, Shi X, Adams M, Shane E, Guo XE, Fast trabecular bone strength predictions of HR-pQCT and individual trabeculae segmentation (ITS)-based plate and rod finite element model discriminate postmenopausal vertebral fractures, Journal of Bone and Mineral Research, 28(7): 1666-78, 2013
  6. Wang H, Liu XS, Zhou B, Wang J, Ji B, Huang Y, Hwang K-C, Guo XE, Accuracy of plate-rod microstructural finite element models of trabecular bone based on individual trabecula segmentation, Journal of Biomechanical Engineering, 135(4):44502-06, 2013
  7. Walker MD, Liu XS, Zhou B, Agarwal S, Liu G, McMahon DJ, Bilezikian JP, and Guo XE, Pre- and post-menopausal differences in bone microstructure and mechanical competence in Chinese-American and White women, Journal of Bone and Mineral Research, 28(6): 1308-18, 2013
  1. Cohen A, Lang TF, McMahon DJ, Liu XS, Guo XE, Zhang C, Stein EM, Dempster DW, Young P, Saeed I, Lappe JM, Recker RR, Shane E, Central QCT reveals lower volumetric BMD and stiffness in premenopausal women with idiopathic osteoporosis, regardless of fracture history, Journal of Clinical Endocrinology and Metabolism,97(11): 4244-52, 2012
  2. Wang H, Ji B, Liu XS, Guo, XE, Huang Y, Hwang K-C, Analysis of microstructural and mechanical alterations of trabecular bone in a simulated three-dimensional remodeling process, Journal of Biomechanics, 45(14): 2417-25, 2012
  3. Stein EM, Liu XS, Nickolas TL, Cohen A, McMahon DJ, Zhou B, Zhang C, Kamanda-Kosseh M, Cosman F, Nieves J, Guo XE, Shane E, Microarchitectural Abnormalities are More Severe in Postmenopausal Women with Vertebral Compared to Non-vertebral Fractures, Journal of Clinical Endocrinology and Metabolism, 97(10): E1918-26, 2012
  4. Liu XS, Ardeshirpour L, VanHouten JN, Shane E, and Wysolmerski JJ, Site-Specific Changes in Bone Microarchitecture, Mineralization, and Stiffness during Lactation and After Weaning in Mice, Journal of Bone and Mineral Research, 27 (4): 865-75, 2012. (Featured on the journal's cover)
  5. Liu XS, Stein EM, Zhou B, Zhang CA, Nickolas TL, Cohen A, Thomas V, McMahon DJ, Cosman F, Nieves J, Shane E, and Guo XE, Individual Trabecula Segmentation (ITS)-Based Morphological Analyses and Micro Finite Element Analysis of HR-pQCT Images Discriminate Postmenopausal Fragility Fractures Independent of DXA Measurements, Journal of Bone and Mineral Research, 27 (2):263-72, 2012.
  1. Liu XS, Shane E, McMahon DJ, and Guo XE, Individual Trabeculae Segmentation (ITS)-Based Morphological Analysis of Micro-Scale Images of Human Tibial Trabecular Bone at Limited Spatial Resolution, Journal of Bone and Mineral Research, 26 (9): 2184-93, 2011. (Featured on the journal's cover)
  2. Liu XS*, Walker MD*, McMahon DJ, Udesky J, Liu G, Bilezikian JP, and Guo XE, Better Skeletal Microstructure Helps to Explain Lower Fracture Risk among Chinese-American Women versus Caucasian Women, Journal of Bone and Mineral Research, 26 (8): 1783-92, 2011. *authors contributed equally
  3. Walker MD*, Liu XS*, Stein E, Zhou B, Bezati E, McMahon DJ, Udesky J, Liu G, Guo XE, and Bilezikian JP, Differences in Bone Microarchitecture between Postmenopausal Chinese-American and White Women, Journal of Bone and Mineral Research, 26(7): 1392-8, 2011. *authors contributed equally
  4. Peng S, Liu XS, Huang S, Li Z, Pan H, Zhen W, Luk KD, Guo XE, Lu WW, The Cross-talk between Osteoclasts and Osteoblasts in Response to Strontium Treatment: Involvement of Osteoprotegerin, Bone, 49 (6): 1290-8, 2011.
  5. Nickolas TL, Cremers S, Zhang C, Thomas V, Stein EM, Cohen A, Chauncey R, Nikkel L, Yin MT, Liu XS, Boutroy S, Staron RB, Leonard MB, McMahon DJ, Dworakowski E, and Shane E, Discriminants of Prevalent Fractures in Chronic Kidney Disease, Journal of the American Society of Nephrology, 22 (8): 1560-72, 2011.
  6. Stein EM, Liu XS, Nickolas TL, Cohen A, Thomas V, McMahon DJ, Zhang C, Cosman F, Nieves J, Greisberg J, Guo XE, and Shane E, Abnormal Microarchitecture and Stiffness in Postmenopausal Women with Ankle Fractures, Journal of Clinical Endocrinology and Metabolism, 96 (7): 2041-8, 2011.
  7. Peng SL, Liu XS, Zhou GQ, Li ZY, Keith DKL, Guo XE, and Lu WW, Osteoprogeterin Deficiency Attenuates Strontium-Mediated Inhibition of Osteoclastogenesis and Bone Resorption, Journal of Bone and Mineral Research, 26(6): 1272-82, 2011.
  8. Fields AJ, Lee GL, Liu XS, Jekir MG, Guo XE, and Keaveny TM, Influence of Vertical Trabeculae on the Compressive Strength of the Human Vertebra, Journal of Bone and Mineral Research, 26(2): 263-9, 2011.
  9. Stein EM, Liu XS, Nickolas TL, Cohen A, Thomas V, McMahon DJ, Zhang C, Cosman F, Nieves J, Guo XE, and Shane E, Abnormal Microarchitecture and Reduced Stiffness at the Radius and Tibia in Postmenopausal Women with Fractures, Journal of Bone Mineral Research, 25(12): 2296-305, 2010.
  10. Oury F, Yadav VK, Wang Y, Zhou B, Liu XS, Guo XE, Tecott LH, Schutz G, Means AR, and Karsenty G, CREB mediates brain serotonin regulation of bone mass through its expression in ventromedial hypothalamic neurons, Genes & Development, 24(20): 2330-42, 2010.
  11. Liu XS, Cohen A, Shane E, Yin PT, Stein EM, Roger H, Kokolus SL, McMahon DJ, Lappe JM, Recker RR, Lang T, and Guo XE, Bone Density, Geometry, Microstructure and Stiffness: Relationships Between Peripheral and Central Skeletal Sites Assessed by DXA, HR-pQCT, and cQCT in Premenopausal Women, Journal of Bone Mineral Research, 25(10): 2229-38, 2010.
  12. Liu XS, Zhang XH, Rajapakse CS, Wald MJ, Magland J, Sekhon KK, Adam MF, Sajda P, Wehrli FW, and Guo XE, Accuracy of High-Resolution In Vivo Micro Magnetic Resonance Imaging for Measurements of Microstructural and Mechanical Properties of Human Distal Tibial Bone, Journal of Bone Mineral Research, 25(9): 2039-50, 2010.
  13. Shi X, Liu XS, Wang X, Guo XE, and Niebur GL, Type and Orientation of Yielded Trabeculae During Overloading of Trabecular Bone Along Orthogonal Directions, Journal of Biomechanics, 43(13): 2460-6, 2010.
  14. Fang G, Ji B, Liu XS, and Guo XE, Quantification of Trabecular Bone Microdamage Using the Virtual Internal Bond Model and the Individual Trabeculae Segmentation Technique, Computer Methods in Biomechanics and Biomedical Engineering, 13(5): 605-15, 2010.
  15. Liu XS, Cohen A, Shane E, Stein E, Roger H, Kokolus SL, Yin PT, McMahon DJ, Lappe JM, Recker RR, and Guo XE, Individual Trabeculae Segmentation (ITS)-Based Morphological Analyses of High Resolution Peripheral Quantitative Computed Tomography Images Detect Abnormal Trabecular Plate and Rod Microarchitecture in Premenopausal Women with Idiopathic Osteoporosis, Journal of Bone and Mineral Research, 25(7): 1496-505, 2010. (Featured on the journal's cover)
  16. Rajapakse CS, Wald MJ, Magland J, Liu XS, Zhang XH, Wehrli FW, and Guo XE, Computational Biomechanics and Structure of the Distal Tibia from High-Resolution MRI and Micro-CT, Bone, 47 (3): 556-63, 2010.
  17. Kulak CAM, Borba VC, Jorgetti V, Reis L, Liu XS, Recker RR, Kimmel DB, Kulak Jr J, Rabelo LM, Zhou H, Guo XE, Bilezikian JP, Boguszewski CL, and Dempster DW, Skeletal Microstructural Abnormalities in Postmenopausal Women with Chronic Obstructive Pulmonary Disease, Journal of Bone Mineral Research, 25(9): 1931-40, 2010.
  18. Peng S*, Liu XS*, Wang T, Li Z, Zhou G, Luk KDK, Guo XE, and Lu WW, In Vivo Anabolic Effect of Strontium on Trabecular Bone Was Associated with Increased Osteoblastogenesis of Bone Marrow Stromal Cells, Journal of Orthopaedic Research, 28(9): 1208-14, 2010. *authors contributed equally
  19. Shi X, Liu XS, Wang X, Guo XE, and Niebur GL, Effects of trabecular type and orientation on microdamage susceptibility in trabecular bone, Bone, 46(5): 1260-6, 2010. (Featured on the journal's cover)
  20. Liu XS, Zhang XH, Sekhon KK, Adam MF, McMahon DJ, Shane E, Bilezikian JP, and Guo XE, High-Resolution Peripheral Quantitative Computed Tomography Can Assess Microstructural and Mechanical Properties of Human Distal Tibial Bone, Journal of Bone and Mineral Research, 25 (4): 746-56, 2010.
  21. Yadav VK, Balaji S, Suresh PS, Liu XS, Lu X, Li Z, Guo XE, Mann JJ, Balapure AK, Gershon MD, Medhamurthy R, Vidal M, Karsenty G, and Ducy P, Inhibition of gut-derived serotonin synthesis: a potential bone anabolic treatment, Nature Medicine, 16(3): 308-12, 2010).
  22. Shi Y, Oury F, Yadav VK, Wess J, Liu XS, Guo XE, Murshed M, and Karsenty G, Signaling through the M(3) Muscarinic Receptor Favors Bone Mass Accrual by Decreasing Sympathetic Activity, cell metabolism, 11(3): 231-8, 2010.
  23. Grayson WL, Fré°„lich M, Yeager K, Bhumiratana S, Chan ME, Cannizzaro C, Wan LQ, Liu XS, Guo XE, and Vunjak-Novakovic G, Regenerative Medicine Special Feature: Engineering Anatomically Shaped Human Bone Grafts, Proceedings of the National Academy of Science of USA, 107(8): 3299-304, 2010.
  24. Cohen A, Dempster DW, Mé»®ler R, Guo XE, Nickolas TL, Liu XS, Zhang XH, Wirth AJ, van Lenthe GH, Kohler T, McMahon DJ, Zhou H, Rubin MR, Bilezikian JP, Lappe JM, Recker RR, and Shane E, Assessment of Trabecular and Cortical Architecture and Mechanical Competence of Bone by High-Resolution Peripheral Computed Tomography: Comparison with Transilial Bone Biopsy, Osteoporosis International, 21(2): 263-73, 2010.
  25. Cohen A, Liu XS, McMahon DJ, Rogers HF, LeMaster J, Recker RR, Lappe JM, Guo XE, and Shane E, Bone Microarchitecture and Stiffness in Premenopausal Women With Idiopathic Osteoporosis, Journal of Clinical Endocrinology and Metabolism, 94(11): 4351-60, 2009.
  26. Rajapakse CS, Magland J, Zhang XH, Liu XS, Wehrli SL, Guo XE, and Wehrli FW, Implications of Noise and Resolution on Mechanical Properties of Trabecular Bone Estimated by Image-based Finite-Element Analysis, Journal of Orthopaedic Research, 27(10): 1263-71, 2009.
  27. Liu XS, Zhang XH, and Guo XE, Contributions of Trabecular Rods of Various Orientations in Determining the Elastic Properties of Human Vertebral Trabecular Bone, Bone, 45(2): 158-63, 2009. (Featured on the journal's cover)
  28. Liu XS, Bevill G, Keaveny TM, Sajda P, and Guo XE, Micromechanical Analyses of Vertebral Trabecular Bone Based on Individual Trabeculae Segmentation of Plates and Rods, Journal of Biomechanics, 42(3): 249-56, 2009.
  29. Shi Y, Yadav VK, Suda N, Liu XS, Guo XE, Myers Jr. MG, and Karsenty G, Dissociation of the Neuronal Regulation of Bone Mass and Energy Metabolism by Leptin in vivo, Proceedings of the National Academy of Sciences of USA, 105(51):20529-33, 2008.
  30. Liu XS, Huang AH, Zhang XH, Sajda P, and Guo XE, Dynamic Simulation of Three Dimensional Architectural and Mechanical Alterations in Human Trabecular Bone during Menopause, Bone, 43(2): 292-301, 2008.
  31. Zhang XH, Liu XS, Vasilic B, Wehrli FW, Benito M, Snyder PJ, and Guo XE, In Vivo 礛RI Based Finite Element and Morphological Analyses of Tibial Trabecular Bone in Eugonadal and Hypogonadal Men before and after Testosterone Treatment, Journal of Bone and Mineral Research, 23(10): 1426-34, 2008.
  32. Liu XS, Sajda P, Saha, PK, Wehrli FW, Bevill G, Keaveny TM, and Guo XE, Complete Volumetric Decomposition of Individual Trabecular Plates and Rods and Its Morphological Correlations with Anisotropic Elastic Moduli in Human Trabecular Bone, Journal of Bone and Mineral Research, 23(2): 223-35, 2008.
  33. Liu XS, Sajda P, Saha, PK, Wehrli FW, and Guo XE, Quantification of the Roles of Trabecular Microarchitecture and Trabecular Type in Determining the Elastic Modulus of Human Trabecular Bone, Journal of Bone and Mineral Research, 21(10): 1608-17, 2006.

Book Chapter

  1. Guo XE, Liu XS, and Wehrli FW, Advanced Structural Assessment of Bone Using CT and MRI, In: Orwoll E, Bilezikian JP, and Vanderschueren D (ed.) Osteoporosis in Men, ISBN-13: 978-0-12-374602-3, Academic Press, 2009.
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