Perelman School of Medicine at the University of Pennsylvania

McKay Orthopaedic Research Laboratory

Liu Laboratory

Wei-Ju Louis Tseng

Wei-Ju Louis Tseng

Research Specialist
Graduate Student in Mechanical Engineering
University of Pennsylvania

Hometown: Taipei, Taiwan

Education:
M.S. Biomedical Engineering, 2009, University of Michigan, Ann Arbor, MI
M.S.E Mechanical Engineering, 2009, University of Michigan, Ann Arbor, MI
B.S. Mechanical Engineering, 2003, National Central University, Taoyuan, Taiwan

Areas of Expertise:
MicroCT Imaging and Analysis
In vivo MicroCT Imaging
Immunohistochemistry
Histomorphometry

Manuscripts:

Altman, AR, Tseng, W-J, de Bakker, CMJ, Huh, BK, Chandra, A, Qin, L, Liu, XS. A Closer Look at the Immediate Trabeculae Response to Combined Parathyroid Hormone and Alendronate Treatment, Bone. 2014; 61: 149-157

Wang, B, Lai, X, Price, C, Thompson, WR, Li, W, Quabili, TR, Tseng, W-J, Liu, XS, Zhang, H, Pan, J, Kirn-Safran, CB, Farach-Carson, MC, Wang, L. Perlecan-containing pericellular matrix regulates solute transport and mechanosensing within the osteocyte lacunar-canalicular system. Journal of Bone and Mineral Research. 2014; 29(4): 878-891

Diggs AB, Bae CJ, Tseng W-J, Flanagan CL, Halloran JW, Hollister SJ. Assessing in vitro Degradation of Beta-Tricalcium Phosphate Ceramics via Micro-Computed Tomography. Key Engineering Materials. 2009; 396-398: 637-640

Abstracts:

Tseng, W-J, de Bakker, CMJ, Lin, T, Tong, W, Jia, H, Levin, LS, Qin, L, Liu, XS. Simultaneous Measurement of Changes in Bone Remodeling and Microvasculature in Response to Estrogen Deficiency-Induced Bone Loss and Intermittent PTH-Induced Bone Gain. American Society for Bone and Mineral Research Annual Meeting, Houston, TX, September 12-15, 2014. Submitted.

Altman, AR, Tseng, W-J, Chandra, A, Qin, L, Liu, XS. Intermittent Parathyroid Hormone Treatment Enhances Both Cortical and Trabecular Bone Modeling in Growing Rats. American Society for Bone and Mineral Research Annual Meeting, Houston, TX, September 12-15, 2014. Submitted

Altman, AR, Lott, C, Tseng, W-J, de Bakker, CMJ, Liou, S-D, Lin, T, Qin, L, Liu, XS. Intermittent PTH after Prolonged Bisphosphonate Treatment Improves Trabecular Bone Microarchitecture and Alleviates Bone Tissue Hypermineralization by Inducing Substantial New Bone Formation. American Society for Bone and Mineral Research Annual Meeting, Houston, TX, September 12-15, 2014. Submitted

de Bakker, CMJ, Altman, AR, Li, C, Tseng, W-J, Liu, XS. Pregnancy and Lactation Bone Loss Cause Long-Lasting Structural Deterioration of the Maternal Skeleton that Accumulates over Multiple Reproductive Cycles. American Society for Bone and Mineral Research Annual Meeting, Houston, TX, September 12-15, 2014. Submitted

Lin, T, Tong, W, Chandra, A, Hsu, S-Y, Jia, H, Tseng, W-J, Zhu, J, Liu, XS, Sun, D, Young, W, Qin, L. A Comprehensive Study of Long-Term Skeletal Changes after Spinal Cord Injury in Adult Rats. American Society for Bone and Mineral Research Annual Meeting, Houston, TX, September 12-15, 2014. Submitted

Freedman, BR, Tseng, W-J, Fryhofer, GW, Liu, XS, Soslowsky, LJ. Novel application of a ┬ÁCT perfusion technique to evaluate Achilles tendon vessel microarchitecture in three dimensions. World Congress of Biomechanics, Boston, MA, July 6-11, 2014.

Parajuli1, A , Gu, XD, Lai X, Rogers, Z, Tseng, W-J, Liu, XS, Kirn-Safran, CB, Price, C, Wang, L. Diminished Disuse-induced Bone Loss in Perlecan Deficient Mice. World Congress of Biomechanics, Boston, MA, July 6-11, 2014. Submitted

Tseng W-J, Lin T, de Bakker CMJ, Levin LS, Qin L, Liu XS. Changes in the Trabeculae-Vessel Function Unit in response to Estrogen Deficiency-Induced Bone Loss and Intermittent PTH-Induced Bone Gain. Orthopaedic Research Society Annual Meeting, New Orleans, LA, March 15-18, 2014.

de Bakker CMJ, Allison AR, Li C, Tseng W-J, Tribble MB, Huh BK, Chandra A, Qin L, Liu XS. Alendronate and PTH Combination Therapy Stimulates Bone Formation While Inhibiting Bone Resorption Activities in the Rat Tibia: A Longitudinal, in vivo, Dynamic Bone Histomorphometry Study. Orthopaedic Research Society Annual Meeting, New Orleans, LA, March 15-18, 2014.

Allison AR, Breitton K, Zhao G, Parajuli A, Tseng W-J, Wang L, Wang JHC, Liu XS. Intensive treadmill running induces bone microstructural deterioration in mouse femoral bone. Orthopaedic Research Society Annual Meeting, New Orleans, LA, March 15-18, 2014.

Wang L, Parajuli A, Rogers Z, Lai X, Tseng W-J, Liu XS, Kirn-Safran CB, Price C. Reduced Perlecan Expression Attenuates Disuse Bone Loss in Mice. Orthopaedic Research Society Annual Meeting, New Orleans, LA, March 15-18, 2014.

Hast MH, Yannascoli SM, Fryhofer GW, Tseng W-J, Altman AR, Liu XS, Soslowsky LJ. Overuse Following a Large Rotator Cuff Tear Alters Trabecular Bone Architecture, but Not Glenoid Curvature in a Rat Model. Orthopaedic Research Society Annual Meeting, New Orleans, LA, March 15-18, 2014.

Rooney SI, Hast MI, Tseng W-J, Loro E, Liu XS, Sarver JJ, Khurana TS, Peltz CD, Soslowsky LJ. Exercise Protocol Induces Muscle, Tendon, and Bone Adaptations in the Rat Shoulder. Orthopaedic Research Society Annual Meeting, New Orleans, LA, March 15-18, 2014.

Diggs AB, Tseng W-J, Winterroth F, Flanagan CL, Hollister SJ. The Effect of Composition on the Loss of Mechanical Property due to the in vivo Degradation of Calcium Phosphate Scaffolds. 5th International Conference on Mechanics of Biomaterials and Tissues. Submitted. Sitges, Spain, December 8-12, 2013.

Altman AR, Huh BK, Tseng W-J, Chandra A, Qin L, Liu XS. A Closer Look at the Immediate Trabeculae Response to Combined Parathyroid Hormone (PTH) and Alendronate (ALN) Treatment. American Society for Bone and Mineral Research Annual Meeting, Baltimore, MD, September 12-15, 2013.

De Bakker CMJ, Altman AR, Tseng W-J, Tribble MB, Huh BK, Chandra A, Qin L, Liu XS. In Vivo Bone Dynamic Imaging Reveals Increased Bone Formation and Inhibited Bone Resorption in Rat Tibia in Response to Combined Alendronate (ALN) and PTH Treatment. American Society for Bone and Mineral Research Annual Meeting, Baltimore, MD, September 12-15, 2013.

Altman AR, Breitton K, Zhao G, Huh BK, Tseng W-J, Wang JHC, Liu XS. Intensive treadmill running induces microstructural deterioration in mouse femoral trabecular bone. American Society for Bone and Mineral Research Annual Meeting, Baltimore, MD, September 12-15, 2013.

Price C, Quabili T, Tseng W-J, Liu XS, Kirn-Safran C, Wang L. Osteocyte Pericellular Matrix Density Regulates Bone's Anabolic Response to Mechanical Loading. American Society for Bone and Mineral Research Annual Meeting, Baltimore, MD, September 12-15, 2013.

Tseng W-J, Zhu H, Huh BK, de Bakker CMJ, Luo S, Tang J, Qin L, Liu XS. Assessment of the vascular and trabecular microstructures using micro computed tomography, vascular network perfusion, and image registration techniques. Poster Presentation. American Society of Mechanical Engineers Summer Bioengineering Conference, Sunriver, OR, June 26-29, 2013.

Altman AR, Huh BK, Chandra A, Tseng W-J, Qin L, Liu XS. 3D in vivo dynamic imaging of PTH's anabolic action. Podium Presentation. American Society of Mechanical Engineers Summer Bioengineering Conference, Sunriver, OR, June 26-29, 2013.

Tseng W-J, Price C, Wang L. Early Interventions in Post-Traumatic OA with Zoledronic Acid. Podium Presentation. Center of Biomedical Research 9th Annual Biomechanics Research Symposium, Newark, DE, April 23, 2012.

Flanagan CL, Tseng W-J, Lin C-Y, Suarez-Gonzalez D, Murphy WL, LaMarca F, Hollister SJ. In Vivo Degradation of a Novel Poly(e-Caprolactone) Intvertebral Cage for Anterior Cervical Discectomy and Fusion in a Porcine Model. The European Chapter Meeting of the Tissue Engineering and Regenerative Medicine International Society, Galway, Ireland, June 13-16, 2010.

Diggs AB, Tseng W-J, Brown SE, Flanagan CL, Hollister SJ. Assessment of Composition, Microporosity, and Macroporosity on the Ability of Calcium Phosphate Ceramic Scaffolds to Regenerate Bone. Orthopaedic Research Society Annual Meeting, New Orleans, LA, March 6-9, 2010.