Perelman School of Medicine at the University of Pennsylvania

McKay Orthopaedic Research Laboratory

Liu Laboratory

Wei-Ju Louis Tseng

Wei-Ju Louis Tseng

Research Specialist
Graduate Student in Mechanical Engineering and Applied Mechanics
University of Pennsylvania

HOMETOWN
Taipei, Taiwan

EDUCATION
M.S. Biomedical Engineering, 2009, University of Michigan, Ann Arbor, MI
M.S.E. Mechanical Engineering, 2009, University of Michigan, Ann Arbor, MI
B.S. Mechanical Engineering, 2003, National Central University, Taoyuan, Taiwan

AREAS OF EXPERTISE
MicroCT Imaging and Analysis of Biological Tissues
In vivo MicroCT Imaging
Immunohistochemistry
Histomorphometry

HONERS & AWARDS
Endocrine Fellow, EFF/ASBMR Ninth Fellows Forum on Metabolic Bone Diseases, The Endocrine Fellows Foundation, Seattle, WA, October 7-8, 2015

MANUSCRIPTS

  1. Altman AR, Tseng WJ, Chandra A, Lan S, Huh BK, Luo S, Qin L, Liu XS. Quantification of skeletal growth, modeling, and remodeling by in vivo micro computed tomography. Bone. 2015; [in press]
  2. de Bakker CM, Altman AR, Tseng WJ, Tribble MB, Li C, Chandra A, Qin L, Liu XS. μCT-based, in vivo dynamic bone histomorphometry allows 3D evaluation of the early responses of bone resorption and formation to PTH and alendronate combination therapy. Bone. 2015; 73: 198-207.
  3. Rooney SI, Loro E, Sarver JJ, Peltz CD, Hast MW, Tseng WJ, Kuntz AF, Liu XS, Khurana TS, Soslowsky LJ. Exercise Protocol Induces Muscle, Tendon, and Bone Adaptations in the Rat Shoulder. Muscle, Ligaments and Tendons Journal. 2015; 4(4): 413-419.
  4. Altman AR, de Bakker CM, Tseng WJ, Chandra A, Qin L, Liu XS. Enhanced individual trabecular repair and its mechanical implications in PTH and Alendronate treated rat tibial bone. Journal of Biomechanical Engineering. 2015; 137(1).
  5. Chandra A, Lin T, Tribble MB, Zhu J, Altman AR, Tseng WJ, Zhang Y, Akintoye SO, Cengel K, Liu XS, Qin L. PTH1-34 alleviates radiotherapy-induced local bone loss by improving osteoblast and osteocyte survival. Bone. 2014; 67: 33-40.
  6. Altman AR, Tseng WJ, de Bakker CMJ, Huh BK, Chandra A, Qin L, Liu XS. A Closer Look at the Immediate Trabeculae Response to Combined Parathyroid Hormone and Alendronate Treatment. Bone. 2014; 61: 149-157.
  7. Wang B, Lai X, Price C, Thompson WR, Li W, Quabili TR, Tseng WJ, Liu XS, Zhang H, Pan J, Kirn-Safran CB, Farach-Carson MC, Wang L. Perlecan-containing pericellular matrix regulates solute transport and mechanosensing within the osteocyte lacunar-canalicular system. Journal of Bone and Mineral Research. 2014; 29(4): 878-891.
  8. Diggs AB, Bae CJ, Tseng WJ, Flanagan CL, Halloran JW, Hollister SJ. Assessing in vitro Degradation of Beta-Tricalcium Phosphate Ceramics via Micro-Computed Tomography. Key Engineering Materials. 2009; 396-398: 637-640.

ABSTRACTS

  1. Altman AR, Jeong YH, Tseng WJ, de Bakker CM, Qin L, Han L, Kim DG, Liu XS. Intermittent PTH Alleviates Abnormalities of Bone Tissue Heterogeneity Associated with Prolonged Bisphosphonate Treatment by Inducing Substantial New Bone Formation. American Society for Bone and Mineral Research Annual Meeting, Seattle, WA, October 9-12, 2015.
  2. Lin T, Chandra A, Ma X, Jia H, Tseng WJ, Cengel K, Liu XS, Qin L. Suppressing Sclerostin Activity Alleviates Radiotherapy-Induced Osteoporosis by Accelerating DNA Repair in Osteoblasts and Their Progenitors. American Society for Bone and Mineral Research Annual Meeting, Seattle, WA, October 9-12, 2015.
  3. de Bakker CM, Altman AR, Li C, Yang Y, Chang CC, Tseng WJ, Jeong YH, Kim DG, Liu XS. Reproduction Differentially Affects Cortical and Trabecular Bone and Alters Cortical Bone Stiffness and Trabecular Structure towards a Male Phenotype. American Society for Bone and Mineral Research Annual Meeting, Seattle, WA, October 9-12, 2015.
  4. Chandra A, Lin T, Tseng WJ, Zhu J, Cengel K, Xia B, Liu XS, Qin L. Activating Canonical Wnt/β-catenin Pathway Enhances DNA Repair and Promotes Cell Survival in Osteoblasts: a Novel Anabolic Treatment for Radiotherapy Associated Bone Damage. Orthopaedic Research Society Annual Meeting, Las Vegas, NV, March 24-28, 2015.
  5. Altman AR, Lott C, de Bakker CMJ, Tseng WJ, Qin L, Liu XS. Intermittent PTH after Prolonged Bisphosphonate Treatment Improves Bone Structure by Inducing Substantial New Bone Formation with Decoupled, Inhibited Bone Resorption in Ovariectomized Rats. Orthopaedic Research Society Annual Meeting, Las Vegas, NV, March 24-28, 2015.
  6. de Bakker CMJ, Li C, Altman AR, Robberts J, Tseng WJ, Liu XS. Pregnancy, Lactation, and Weaning Induce a Physiological Redistribution of Bone Mass at Multiple Skeletal Sites with Minimal Impact on Bone Quality. Orthopaedic Research Society Annual Meeting, Las Vegas, NV, March 24-28, 2015.
  7. de Bakker CMJ, Altman AR, Li C, Tribble MB, Tseng WJ, Liu XS. A Novel Image Transformation Scheme Minimizes Interpolation Artifact and Allows Reproducible Measurement of Trabecular Bone Remodeling through µCT-Based In Vivo Dynamic Bone Histomorphometry. Orthopaedic Research Society Annual Meeting, Las Vegas, NV, March 24-28, 2015.
  8. Cavalancia J, Houweling PJ, North KN, Belcher J, Tseng WJ, Barton E, Horton M, Godel J, Sciote J. Altered Mandibular Length in an Alpha-Actinin-3 Null Mouse Model. International Association for Dental Research, Boston, MA, March 11-14, 2015.
  9. Tseng WJ, de Bakker CMJ, Lin T, Tong W, Jia H, Levin LS, Qin L, Liu XS. Simultaneous Measurement of Changes in Bone Remodeling and Microvasculature in Response to Estrogen Deficiency-Induced Bone Loss and Intermittent PTH-Induced Bone Gain. American Society for Bone and Mineral Research Annual Meeting, Houston, TX, September 12-15, 2014.
  10. Altman AR, Tseng WJ, Chandra A, Qin L, Liu XS. Intermittent Parathyroid Hormone Treatment Enhances Both Cortical and Trabecular Bone Modeling in Growing Rats. American Society for Bone and Mineral Research Annual Meeting, Houston, TX, September 12-15, 2014.
  11. Altman AR, Lott C, Tseng WJ, de Bakker CMJ, Liou S-D, Lin T, Qin L, Liu XS. Intermittent PTH after Prolonged Bisphosphonate Treatment Improves Trabecular Bone Microarchitecture and Alleviates Bone Tissue Hypermineralization by Inducing Substantial New Bone Formation. American Society for Bone and Mineral Research Annual Meeting, Houston, TX, September 12-15, 2014.
  12. de Bakker CMJ, Altman AR, Li C, Tseng WJ, Liu XS. Pregnancy and Lactation Bone Loss Cause Long-Lasting Structural Deterioration of the Maternal Skeleton that Accumulates over Multiple Reproductive Cycles. American Society for Bone and Mineral Research Annual Meeting, Houston, TX, September 12-15, 2014.
  13. Lin T, Tong W, Chandra A, Hsu S-Y, Jia H, Tseng WJ, Zhu J, Liu XS, Sun D, Young W, Qin L. A Comprehensive Study of Long-Term Skeletal Changes after Spinal Cord Injury in Adult Rats. American Society for Bone and Mineral Research Annual Meeting, Houston, TX, September 12-15, 2014.
  14. Freedman BR, Tseng WJ, Fryhofer GW, Liu XS, Soslowsky LJ. Novel application of a µCT perfusion technique to evaluate Achilles tendon vessel microarchitecture in three dimensions. World Congress of Biomechanics, Boston, MA, July 6-11, 2014.
  15. Parajuli A , Gu XD, Lai X, Rogers Z, Tseng WJ, Liu XS, Kirn-Safran CB, Price C, Wang L. Diminished Disuse-induced Bone Loss in Perlecan Deficient Mice. World Congress of Biomechanics, Boston, MA, July 6-11, 2014.
  16. Tseng WJ, Lin T, de Bakker CMJ, Levin LS, Qin L, Liu XS. Changes in the Trabeculae-Vessel Function Unit in response to Estrogen Deficiency-Induced Bone Loss and Intermittent PTH-Induced Bone Gain. Orthopaedic Research Society Annual Meeting, New Orleans, LA, March 15-18, 2014.
  17. de Bakker CMJ, Allison AR, Li C, Tseng WJ, Tribble MB, Huh BK, Chandra A, Qin L, Liu XS. Alendronate and PTH Combination Therapy Stimulates Bone Formation While Inhibiting Bone Resorption Activities in the Rat Tibia: A Longitudinal, in vivo, Dynamic Bone Histomorphometry Study. Orthopaedic Research Society Annual Meeting, New Orleans, LA, March 15-18, 2014.
  18. Allison AR, Breitton K, Zhao G, Parajuli A, Tseng WJ, Wang L, Wang JHC, Liu XS. Intensive treadmill running induces bone microstructural deterioration in mouse femoral bone. Orthopaedic Research Society Annual Meeting, New Orleans, LA, March 15-18, 2014.
  19. Wang L, Parajuli A, Rogers Z, Lai X, Tseng WJ, Liu XS, Kirn-Safran CB, Price C. Reduced Perlecan Expression Attenuates Disuse Bone Loss in Mice. Orthopaedic Research Society Annual Meeting, New Orleans, LA, March 15-18, 2014.
  20. Hast MH, Yannascoli SM, Fryhofer GW, Tseng WJ, Altman AR, Liu XS, Soslowsky LJ. Overuse Following a Large Rotator Cuff Tear Alters Trabecular Bone Architecture, but Not Glenoid Curvature in a Rat Model. Orthopaedic Research Society Annual Meeting, New Orleans, LA, March 15-18, 2014.
  21. Rooney SI, Hast MI, Tseng WJ, Loro E, Liu XS, Sarver JJ, Khurana TS, Peltz CD, Soslowsky LJ. Exercise Protocol Induces Muscle, Tendon, and Bone Adaptations in the Rat Shoulder. Orthopaedic Research Society Annual Meeting, New Orleans, LA, March 15-18, 2014.
  22. Diggs AB, Tseng WJ, Winterroth F, Flanagan CL, Hollister SJ. The Effect of Composition on the Loss of Mechanical Property due to the in vivo Degradation of Calcium Phosphate Scaffolds. 5th International Conference on Mechanics of Biomaterials and Tissues. Sitges, Spain, December 8-12, 2013.
  23. Altman AR, Huh BK, Tseng WJ, Chandra A, Qin L, Liu XS. A Closer Look at the Immediate Trabeculae Response to Combined Parathyroid Hormone (PTH) and Alendronate (ALN) Treatment. American Society for Bone and Mineral Research Annual Meeting, Baltimore, MD, September 12-15, 2013.
  24. De Bakker CMJ, Altman AR, Tseng WJ, Tribble MB, Huh BK, Chandra A, Qin L, Liu XS. In Vivo Bone Dynamic Imaging Reveals Increased Bone Formation and Inhibited Bone Resorption in Rat Tibia in Response to Combined Alendronate (ALN) and PTH Treatment. American Society for Bone and Mineral Research Annual Meeting, Baltimore, MD, September 12-15, 2013.
  25. Altman AR, Breitton K, Zhao G, Huh BK, Tseng WJ, Wang JHC, Liu XS. Intensive treadmill running induces microstructural deterioration in mouse femoral trabecular bone. American Society for Bone and Mineral Research Annual Meeting, Baltimore, MD, September 12-15, 2013.
  26. Price C, Quabili T, Tseng WJ, Liu XS, Kirn-Safran C, Wang L. Osteocyte Pericellular Matrix Density Regulates Bone's Anabolic Response to Mechanical Loading. American Society for Bone and Mineral Research Annual Meeting, Baltimore, MD, September 12-15, 2013.
  27. Tseng WJ, Zhu H, Huh BK, de Bakker CMJ, Luo S, Tang J, Qin L, Liu XS. Assessment of the vascular and trabecular microstructures using micro computed tomography, vascular network perfusion, and image registration techniques. Poster Presentation. American Society of Mechanical Engineers Summer Bioengineering Conference, Sunriver, OR, June 26-29, 2013.
  28. Altman AR, Huh BK, Chandra A, Tseng WJ, Qin L, Liu XS. 3D in vivo dynamic imaging of PTH's anabolic action. Podium Presentation. American Society of Mechanical Engineers Summer Bioengineering Conference, Sunriver, OR, June 26-29, 2013.
  29. Tseng WJ, Price C, Wang L. Early Interventions in Post-Traumatic OA with Zoledronic Acid. Podium Presentation. Center of Biomedical Research 9th Annual Biomechanics Research Symposium, Newark, DE, April 23, 2012.
  30. Flanagan CL, Tseng WJ, Lin C-Y, Suarez-Gonzalez D, Murphy WL, LaMarca F, Hollister SJ. In Vivo Degradation of a Novel Poly(e-Caprolactone) Intvertebral Cage for Anterior Cervical Discectomy and Fusion in a Porcine Model. The European Chapter Meeting of the Tissue Engineering and Regenerative Medicine International Society, Galway, Ireland, June 13-16, 2010.
  31. Diggs AB, Tseng WJ, Brown SE, Flanagan CL, Hollister SJ. Assessment of Composition, Microporosity, and Macroporosity on the Ability of Calcium Phosphate Ceramic Scaffolds to Regenerate Bone. Orthopaedic Research Society Annual Meeting, New Orleans, LA, March 6-9, 2010.