Perelman School of Medicine at the University of Pennsylvania

McKay Orthopaedic Research Laboratory

Mauck Laboratory

Edward Bonnevie

Edward Bonnevie

Post-Doctoral Fellow
University of Pennsylvania

Hometown: Lafayette Hill, PA




Education:
Ph.D. Mechanical Engineering - Biomedical Mechanics, Cornell University, 2016
M.S. Mechanical Engineering, Cornell University, 2015
B.S. Mechanical Engineering, University of Delaware, 2011

Areas of Special Interest:
Connective Tissue Mechanobiology

Eddie is from the Philadelphia suburbs and enjoys the outdoors. In his free time, he can be found swimming, playing water polo, kayaking, windsurfing, or trying to find something new to cook.

Awards:
1. New Investigator Recognition Award, ORS (2017)
2. Finalist Student Podium Competition, SB3C (2016)
3. Sibley Prize for Excellence in Graduate Teaching Assistance (2016)
4. Sigma Xi 2nd Place Podium Competition, SGRS Conference (2015)
5. Philadelphia Section Scholarship, Society of Tribologists and Lubrication Engineers (2013)
6. NSF Graduate Research Fellowship (2012)
7. Sibley Prize for Excellence in Graduate Teaching Assistance, Honorable Mention (2012)
8. STLE Young Tribologist Award (2011)
9. NCAA D1 Academic All-American (2011)
10. NCAA D1 Academic All-District I (2011)
11. STLE Annual Meeting Poster Competition – Platinum Award (2011)
12. STLE Annual Meeting Poster Competition – Silver Award (2010)
13. CAA Scholar Athlete of the Year – Track and Field (2011)
14. CAA Scholar Athlete of the Year – Cross Country (2010)
15. University of Delaware Cross Country team captain (2010)

Publications:
1. Bonnevie, E. D., Baro, V. J., Wang, L., & Burris, D. L. (2011). In situ studies of cartilage microtribology: roles of speed and contact area. Tribology letters, 41(1), 83-95.

2. Bonnevie, E. D., Baro, V. J., Wang, L., & Burris, D. L. (2012). Fluid load support during localized indentation of cartilage with a spherical probe. Journal of biomechanics, 45(6), 1036-1041.

3. Baro, V. J., Bonnevie, E. D., Lai, X., Price, C., Burris, D. L., & Wang, L. (2012). Functional characterization of normal and degraded bovine meniscus: Rate-dependent indentation and friction studies. Bone, 51(2), 232-240.

4. Bonnevie, E.D., Puetzer, J.L., Bonassar, L.J. (2014) Enhanced boundary lubrication properties of engineered meniscus by lubricin localization with insulin-like growth factor I treatment, Journal of Biomechanics, 47(9), 2183-2188.

5. Zimmerman, B.K., Bonnevie, E.D., Park, M, Zhou, Y, Wang, L, Burris, D.L., Lu, X.L. (2015) Role of Interstitial Fluid Pressurization in TMJ Lubrication, Journal of Dental Research, 94(1), 85-92

6. Griffin D.G., Bonnevie E.D., Lachowsky, D, Hart, J, Sparks, H, Cohen, I, Moran, N, Matthews, G, Nixon, A, Bonassar , L.J. (2015) Mechanical Characterization of Matrix-Induced Autologous Chondrocyte Implantation (MACI®) Grafts in an Equine Model at 53 weeks, Journal of Biomechanics 48 (10), 1944-1949

7. Novakofski, K.D., Berg, L.C., Bronzini, I., Bonnevie, E.D., Poland, S.G., Bonassar, L.J., Fortier, L.A., (2015) Joint-dependent Response to Impact and Implications for Post-traumatic Osteoarthritis, Osteoarthritis and Cartilage, 23 (7), 1130-1137

8. Bonnevie, E.D., Delco, M.L., Fortier, L.A., Alexander, P.G., Tuan, R.S., Bonassar, L.J., (2015) Characterization of Tissue Response to Impact Loads Delivered using a Hand-Held Instrument for Studying Articular Cartilage Injury, Cartilage, 6 (4), 226-232

9. Bonnevie, E.D., Galesso, D., Secchieri, C., Cohen, I., Bonassar, L.J., (2015) Elastoviscous transitions of articular cartilage reveal a mechanism of synergy between lubricin and hyaluronic acid, PLoS One 10 (11)

10. Reesink, H.L., Bonnevie, E.D. , Liu, S, Hollander, M.J., Bonassar, L.J., Nixon, A.J., (2016) Galectin-3 Reinforces the Lubricating Boundary Layer of Articular Cartilage, Scientific Reports 6

11. Henak, C.R., Ross, K.A., Bonnevie, E.D., Kennedy, J.G., Cohen, I., Bonassar, L.J., (2016) Depth-dependent Shear Behavior of Human Ankle and Knee Cartilage, Journal of Biomechanics 49 (14), 3320-3327

12. Bonnevie, E.D., McCorry, M.C., Bonassar, L.J., (2016) Mesenchymal Stem Cells Enhance Lubrication of Engineered Meniscus Through Lubricin Localization, Biotribology, 8, 26-32

13. Bonnevie, E.D., Delco, M.L., Galesso, D., Secchieri, C., Fortier, L.A., Bonassar, L.J., (2016) Sub-Critical Impact Inhibits the Lubricating Mechanisms of Articular Cartilage, Journal of Biomechanics 53, 64-70

Abstracts:
1. Bonnevie, E.D., Baro, V.J., Wang, L., Burris, D.L., (2010) Microtribology of articular cartilage, STLE Annual Meeting, Las Vegas NV

2. Baro, V., Bonnevie, E.D., Burris, D.L., Wang, L, (2010) Effects of Fluid Flow on Indentation and Sliding Tests of Meniscus, American Society For Bone and Mineral Research Annual Meeting, Toronto ON, Canada

3. Baro, V., Bonnevie, E.D., Burris, D.L., Wang, L, (2011) Biomechanical Response of Meniscus to Contact Loading, Orthopaedic Research Society, Long Beach CA

4. Bonnevie, E.D., Baro, V.J., Wang, L., Burris, D.L., (2011) Rate Dependent Indentation Response of Articular Cartilage, STLE Annual Meeting, Atlanta GA

5. Bonnevie, E.D., Barito, L., Baro, V., Park, M., Wang, L., Burris, D.L., Lu, X.L. (2012) Mechanical Loading and Sliding Speed Dependent Frictional Coefficient of TMJ Cartilage and Disc, Orthopaedic Research Society, San Francisco CA

6. Bonnevie, E.D., Baro, V. J., Wang, L., & Burris, D. L. (2012). Effects of Indentation Rate and Contact Radius on the Local Response of Cartilage, Orthopaedic Research Society, San Francisco CA

7. Griffin, D., Lachowsky, D.J., Bonnevie, E.D., Hart, J., Sparks, H., Cohen, I., Nixon, A.J., Mathews, G., Moran, N., Bonassar, L.J. (2013) Mechanical performance of matrix-induced autologous chondrocyte implantation grafts in an equine model at 53 weeks, Orthopaedic Research Society, San Antonio TX

8. Bonnevie, E.D., Puetzer, J.L, Bonassar, L.J. (2013) IGF-I Facilitates the Formation of a Lubricin-Rich Surface Layer in Engineered Meniscus Tissue, Orthopaedic Research Society, San Antonio TX

9. Jimenez, J, Bonnevie E.D., Bonassar LJ, (2013) Characterization of Cartilage Mechanics and Wear After Trauma, BMES Annual Meeting, Seattle WA

10. Bonnevie, E.D., Bonassar, L.J. (2013) Stribeck Analysis of Articular Cartilage Lubrication: Roles of Injectable Hyaluronic Acid and Endogenous Lubricin, Combined Orthopaedic Research Societies, Venice, Italy

11. Bonnevie, E.D., Galesso D, Secchieri C, Bonassar LJ, (2014) Lubrication of Degraded Cartilage by Hyaluronic Acid, Orthopaedic Research Society Annual Meeting, New Orleans, LA

12. Bonnevie, E.D., Galesso D, Secchieri C, Bonassar LJ, (2014) Stribeck Analysis of Synovial Lubricants: Lubricating Mechanisms and Interaction of Hyaluronic Acid and Lubricin, Orthopaedic Research Society Annual Meeting, New Orleans, LA

13. Bonnevie, E.D., Galesso D, Secchieri C, Bonassar LJ, (2014) Stribeck Analysis of Synovial Lubricants: Lubricating Mechanisms and Synergy of Hyaluronic Acid and Lubricin, World Congress on Biomechanics, Boston MA

14. Bonnevie, E.D., Galesso D, Secchieri C, Bonassar LJ, (2014) Stribeck Analysis of Synovial Lubricants: Lubricating Mechanisms and Synergy of Hyaluronic Acid and Lubricin, International Conference on Biotribology, Toronto ON

15. Bonnevie, E.D., Bonassar LJ, (2014) Lubrication Mechanisms of Synovial Fluid Macromolecules: Synergy between Lubricin and Hyaluronic Acid, Gordon Research Conference on Tribology, Waltham, MA

16. Bonnevie, E.D., Galesso, D., Secchieri, C, Bonassar, L.J., (2014) Degradation-dependent Alterations in Articular Cartilage Lubrication Mechanisms, BMES Annual Meeting, San Antonio TX

17. Bonnevie, E.D., Delco, M, Fortier, L, Alexander, P, Tuan, R, Bonassar,L, (2014) Alterations of Articular Cartilage Surfaces after Mechanical Insult, BMES Annual Meeting, San Antonio TX

18. Reesink, H, Bonnevie, E.D., Liu, S, Bonassar, L, Nixon, A, (2015) Galectin-3 Enhances Cartilage Lubrication via Lubricin Binding, Orthopaedic Research Society Annual Meeting, Las Vegas NV

19. Bonnevie, E.D., Delco, M, Fortier, L, Galesso, D, Secchieri, C, Bonassar, L.J., (2015) Sub-Critical Impact Inhibits Cartilage Lubrication Mechanisms, Orthopaedic Research Society Annual Meeting, Las Vegas NV

20. Novakofski, K.D., Berg, L.C., Bronzini, I., Bonnevie, E.D., Poland, S.G., Bonassar, L.J., Fortier, L.A., (2015) Joint-dependent Response to Impact and Implications for Post-traumatic Osteoarthritis, International Cartilage Repair Society Annual Meeting, Chicago, Il

21. Bonnevie, E.D., Delco, M, Fortier, L, Galesso, D, Secchieri, C, Bonassar, L.J., (2015) Sub-Critical Impact Inhibits Cartilage Lubrication Mechanisms, Osteoarthritis Research Society International, Seattle, WA

22. Delco, M.L., Bonnevie, E.D., Szeto, H.H., Bonassar, L.J., Fortier, L.A., (2015) Acute Mitochondrial Dysfunction in Cartilage Following Mechanical Injury, Osteoarthritis Research Society International, Seattle, WA

23. Bonnevie, E.D., Galesso, D., Secchieri, C., Cohen, I., Bonassar, L.J., (2015) The Role of HA in the Lubrication of Cartilage: Synergy with Lubricin and Alterations in Degradation, International Society of Hyaluronan Sciences, Florence, Italy

24. Delco, M.L., Bonnevie E.D., L. Bonassar, J. Kennedy, R. Tuan, L.A. Fortier, (2015) Development of an Equine Model of Talocrural Post-Traumatic Osteoarthritis, TERMIS World Congress, Boston, MA

25. Delco, M.L., Bonnevie E.D., H.H. Szeto, L. Bonassar, L.A. Fortier, (2015) Acute Mitochondrial Dysfunction in Cartilage following Mechanical Injury, TERMIS World Congress, Boston, MA

26. Bonnevie, E.D., McCorry, M.C., Bonassar, L.J., (2016) Co-culture of Meniscal Fibrochondrocytes and Mesenchymal Stem Cells Enhances the Lubrication of Tissue Engineered Constructs through Lubricin Localization, ORS Annual Meeting, Orlando, FL

27. Bonnevie, E.D., Delco, M.L., Jasty, N., Bartell, L.R., Fortier, L.A., Cohen, I., Bonassar, L.J., (2016) Chondrocyte Death and Mitochondrial Dysfunction are Mediated by Lubricant and Shear Strain, ORS Annual Meeting, Orlando, FL

28. Bonnevie, E.D., Galesso, D., Secchieri, C., Cohen, I., Bonassar, L.J., (2016) ,IL-1β Inhibits the Lubricating Mechanisms of Articular Cartilage, OARSI Congress, Amsterdam, Netherlands

29. Bonnevie, E.D., Delco, M.L., Jasty, N., Bartell, L.R., Fortier, L.A., Cohen, I., Bonassar, L.J., (2016) Chondrocyte Death and Mitochondrial Dysfunction are Mediated by Cartilage Friction and Shear Strain, OARSI Congress, Amsterdam, Netherlands

30. Delco, M.L., Bonnevie E.D., H.H. Szeto, L. Bonassar, L.A. Fortier, (2016) Mitoprotection as a Strategy to Prevent Posttraumatic Osteoarthritis, OARSI Congress, Amsterdam, Netherlands

31. Bonnevie, E.D., Delco, M.L., Jasty, N., Bartell, L.R., Fortier, L.A., Cohen, I., Bonassar, L.J., (2016) Chondrocyte Death and Mitochondrial Dysfunction are Mediated by Cartilage Friction and Shear Strain, Summer Biomechanics Bioengineering and Biotransport Conference, National Harbor, MD **PhD Student Podium Competition Finalist**

32. Bonnevie, E.D., Delco, M.L., Jasty, N., Bartell, L.R., Fortier, L.A., Cohen, I., Bonassar, L.J., (2017) Chondrocyte Death, Mitochondrial Dysfunction, and Apoptosis are Mediated by Cartilage Friction and Shear Strain, ORS Annual Meeting, San Diego CA
**Winner of NIRA Podium Competition**

33. Delco, M.L., Bonnevie E.D., Alexander, P., Tuan, R.S., Bonassar, L. J, Fortier, L.A. (2017) An In Vivo Large Animal Model To Study Acute Impact-induced Cartilage Injury And The Development Of Early Posttraumatic Ankle Arthritis, ORS Annual Meeting, San Diego CA

34. Bonnevie, E.D., Elliott, D.M., Mauck, R.L. (2017) Prestress Regulates Cell Sensation of Topo-Mechanical Cue in Annulus Fibrosus Mechanobiology, SB3C Annual Meeting, Tucson, AZ