Perelman School of Medicine at the University of Pennsylvania

McKay Orthopaedic Research Laboratory

Mauck Laboratory

Sarah Gullbrand, Ph.D.

Sarah Gullbrand

Postdoctoral Researcher
University of Pennsylvania

Hometown: Easton, CT

Education: 
Ph.D. Biomedical Engineering Rensselaer Polytechnic Institute, 2014   
B.S. Biomedical Engineering Rensselaer Polytechnic Institute, 2009

Areas of Special Interest: Intervertebral disc nutrition, translational therapeutics for intervertebral disc degeneration

Awards:
2nd Place Poster Award in Tissue Engineering and Regeneration - Philadelphia Spine Research Symposium, November 2015

Zelda and David G. Gisser Disseration Award, 2015

ISSLS Prize for Lumbar Spine Research, 2015

Best Paper in Basic Science and Socioeconomics, North American Spine Society, October 2013

National Science Foundation Graduate Research Fellowship (NSF GRFP), 2011-2014

Publications:
Gullbrand SE, Malhotra NR, Schaer TP, Zawacki Z, Martin JT, Bendigo JR, Milby AH, Dodge GR, Vresilovic EJ, Elliott DM, Mauck RL, Smith LJ. (2016) A Large Animal Model that Recapitulates the Spectrum of Human Intervertebral Disc Degeneration. Osteoarthritis and Cartilage. (Accepted)

Gullbrand SE, Peterson J, Ahlborn J, Mastropolo R, Fricker A, Roberts TT, Lawrence JP, Glennon JC, Ledet EH. ISSLS Prize Winner: Dynamic Loading-Induced Convective Transport Enhances Intervertebral Disc Nutrition. Spine, 2015; 40(15):1158-64.

Gullbrand SE, Peterson J, Mastropolo R, Roberts TT, Lawrence JP, Glennon JC, DiRisio DJ, Ledet EH. Low Rate Loading Induced Convection Enhances Net Transport into the Intervertebral Disc In Vivo. The Spine Journal, 2015; 15 (5): 1028–1033.

Gullbrand SE, Peterson J, Mastropolo R, Lawrence JP, Lopes L, Lotz J, Ledet EH. (2014). Drug-induced changes to the vertebral endplate vasculature affect transport into the intervertebral disc in vivo. J. Orthop. Res. doi: 10.1002/jor.22716.

Sanders GP, Linley SE, Sowa GA, Glennon JC, DiRisio DJ, Lawrence JP, Vanderzanden J, Lotz JC, Ledet EH. (2010). Compression on the Intervertebral Disc and Endplates of the Lumbar Spine: A Pilot Study with a Novel Animal Model. The Albany Orthopaedic Journal. 2:48-59.

Abstracts:
Gullbrand SE, Ashinsky BG, Martin JT, Pickup S, Smith LJ, Mauck RL, Smith HE. Correlations Between Quantitative T2 and T1rho MRI Parameters and Mechanics and Biochemical Content in a Rabbit Intervertebral Disc Degeneration Model. Proceedings of the 2016 Annual Meeting of the Orthopaedic Research Society. Orlando, FL. March 5-8, 2016: 10. (Podium)

Gullbrand SE, Malhotra NR, Schaer TP, Zawacki Z, Milby AH, Dodge GR, Vresilovic EJ, Elliott DM, Mauck RL, Smith LJ. Recapitulation of the Spectrum of Intervertebral Disc Degeneration in a Large Animal Model. Proceedings of the 2016 Annual Meeting of the Orthopaedic Research Society. Orlando, FL. March 5-8, 2016: 260. (Oral Poster)

Gullbrand SE, Ahlborn J, Roberts T, Glennon J, Abousayed M, Lawrence J, Ledet EH. Net Transport into the Degenerated Intervertebral Disc is Enhanced via Low Rate Loading Induced Convection In Vivo. Philadelphia Spine Research Symposium. Philadelphia, PA. October 28, 2014. (Podium)

Linley SE, Peterson J, Mastropolo R, Fricker A, Frank S, Roberts T, Lawrence J, Glennon J, DiRisio D, Ledet EH.  Mechanical Loading Rate Modulates Transport into the Cartilaginous Endplate and Intervertebral Disc. In Vivo. Proceedings of the 60th Annual Meeting of the Orthopaedic Research Society. 2014 March 15-18: New Orleans, LA: P697. (Poster).

Linley SE, Peterson J, Mastropolo R, Salamone G, Lawrence J, Lotz J, Ledet EH. The Effects of Drug-Induced Changes to the Vertebral Endplate Vasculature on Diffusion into the Nucleus Pulposus and Annulus Fibrosus. In Vivo. Proceedings of the 60th Annual Meeting of the Orthopaedic Research Society. 2014 March 15-18: New Orleans, LA: P1645. (Poster).

Linley SE, Peterson J, Mastropolo R, Frank S, Roberts T, Lawrence J, Glennon J, Ledet EH. Net Transport in the Intervertebral Disc is Dependent on Mechanical Loading Rate. Proceedings of the 28th Annual Meeting of the North American Spine Society. 2013 October 9-12; New Orleans, LA: 108. (Podium).

Linley SE, Peterson J, Mastropolo R, Lawrence J, Lopes L, Lotz J, Ledet EH. Factors Affecting Small Molecule Trans-Endplate Transport into the Intervertebral Disc. In Vivo. Proceedings of the 28th Annual Meeting of the North American Spine Society. 2013 October 9-12; New Orleans, LA: 98. (Podium).

Linley SE, Peterson J, Mastropolo R, Lawrence J, Lopes L, Lotz J, Ledet EH. The Effects of Nimodipine and Nicotine on the Intervertebral Disc Trans-Endplate Transport. Proceedings of the 59th Annual Meeting of the Orthopaedic Research Society. 2013 January 26-29; San Antonio, TX: P867. (Poster).

Linley SE, Peterson J, Mastropolo R, Roberts T, Lawrence J, Glennon J, DiRisio D, Ledet EH. Mechanical Loading Rate Modulates Intervertebral Disc Trans-Endplate Transport. Proceedings of the 59th Annual Meeting of the Orthopaedic Research Society. 2013 January 26-29; San Antonio, TX: 230. (Podium).

Linley SE, Peterson J, Mastropolo R, Roberts T, Lawrence JP, Glennon J, DiRisio D, Ledet EH. Forced Convection Enhances Net Transport to the Intervertebral Disc. In Vivo. Proceedings of the 27th Annual Meeting of the North American Spine Society. 2012 October 24-27; Dallas, TX: 139. (Podium).

Linley SE, Peterson J, Mastropolo R, Lopes L, Glennon JC, Lawrence JP, Ledet EH. The Effects of Nimodipine and Nicotine on Diffusion into the Intervertebral Disc. In Vivo. Proceedings of the 27th Annual Meeting of the North American Spine Society. 2012 October 24-27; Dallas, TX: P89. (Poster).