Perelman School of Medicine at the University of Pennsylvania

McKay Orthopaedic Research Laboratory

Mauck Laboratory

Brian Cosgrove

brian cosgrove

Graduate Student in Bioengineering
University of Pennsylvania

Hometown: Rochester, NY

Education: (2007-2011) B.S. Bioengineering, 2011, Syracuse University

Areas of Special Interest:
Brian's research interests include stem cell mechanobiology, cell-material interactions, and developmental biology. Outside of the lab, Brian enjoys photography, rock climbing, scuba diving, and all things food.

Publications:
Haupt J, McLeod CM, Cosgrove BD, A Stanley, Culbert AL, Wang L, Mauck RL, Shore EM. The ACVR1R206H FOP mutation alters progenitor cell force sensing and increases lesion stiffness during muscle repair - implications for heterotypic ossification (Submitted).

Heo SJ, Han WM, Szczesny SE, Cosgrove BD, Elliott DM, Lee DA, Duncan RL, Mauck RL. Mechanically Induced Chromatin Condensation Requires Cellular Contractility in Mesenchymal Stem Cells. Biophysical Journal, (2016).

Cosgrove BD, Mui KL, Driscoll TP, Caliari SR, Mehta KD, Assoian RK, Burdick JA, Mauck RL. N-cadherin adhesive interactions modulate mechanosensing and fate commitment of mesenchymal stem cells. Nature Materials (2016).

Caliari SR, Perepelyuk M, Cosgrove BD, Lee GY, Mauck RL, Wells RG, Burdick JA. Stiffening hydrogels for investigating the dynamics of hepatic stellate cell mechanotransduction during myofibroblast activation. Scientific Reports (2015).

Driscoll TP, Cosgrove BD, Heo S, Shurden ZE, Mauck RL. Cytoskeletal to Nuclear Strain Transfer Regulates YAP Signaling in Mesenchymal Stem Cells. Biophysical Journal (2015).

Mohanraj B, Hou C, Meloni GR, Cosgrove BD, Dodge GR, Mauck RL. A High-Throughput Mechanical Screening Device for Cartilage Tissue Engineering. Journal of Biomechanics (2014).

Abstracts:
Cosgrove BD, Mui KL, Driscoll TP, Assoian RK, Burdick JA, Mauck RL. N-Cadherin adhesive interactions modulate ECM mechanosensing and fate commitment of mesenchymal stem cells. Gordon Research Conference for Musculoskeletal Bioengineering and Biology, Andover, NH, August 8th, 2016. (Invited Podium by BDC)

Cosgrove BD, Mui KL, Driscoll TP, Assoian RK, Burdick JA, Mauck RL. N-Cadherin adhesive interactions modulate ECM mechanosensing and fate commitment of mesenchymal stem cells. SB3C Annual Meeting, National Harbor, MD, July 1st, 2016. (Podium by BDC -- PhD Competition 1st Place in Mechanics and Mechanosensing Section)

Cosgrove BD, Mui KL, Driscoll TP, Assoian RK, Burdick JA, Mauck RL. N-Cadherin Presentation Alters Rac1 Signaling to Modulate Mesenchymal Progenitor Cell Mechanosensing of Soft Tissue Microenvironments. 62nd Annual Meeting of the Orthopaedic Research Society, Orlando, FL, March 8th, 2016. (Podium by BDC)

Cosgrove BD, Mui KL, Driscoll TP, Assoian RK, Burdick JA, Mauck RL. N-Cadherin Presentation Alters Rac1 Signaling to Modulate Mesenchymal Progenitor Cell Mechanosensing of Soft Tissue Microenvironments. BMES-Cell and mOlecular Bioengineering Conference, New Orleans, LA, January 10th, 2016. (Podium by BDC)

Cosgrove, BD; Hou, C; Mohanraj, B; Dodge, GR; Mauck, RL. A Novel High-Throughput System for the Mechanical Analysis of Engineered Cartilage Constructs. 2012 World Congress on Osteoarthritis, Barcelona, Spain. April 26-29, 2012. (poster)

Cosgrove, BD; Lewis, G; Winarto, B; Wong, J; Dodge, GR; Mauck, RL. A Novel High-Throughput System for the Mechanical Analysis of Engineered Cartilage Constructs. 58th Annual Meeting of the Orthopaedic Research Society, San Francisco, CA. February 7, 2012. (podium)

Farrell, M J; Cosgrove, BD; de Vries, S; Raj, A; Mauck, RL. Multi-Scale Analysis of Heterogeneity in Mesenchymal Stem Cell Chondrogenesis. 58th Annual Meeting of the Orthopaedic Research Society, San Francisco, CA. (poster)

Erickson IE; Zellars KH; Cosgrove BD; Burdick JA; Mauck RL. Durable In Vitro Cartilage Repair and Functional Load Transmission with MSC-Seeded Hyaluronic Acid Hydrogels. 58th Annual Meeting of the Orthopaedic Research Society, San Francisco, CA. (poster)

Cosgrove, BD; Hou, C; Mohanraj, B; Dodge, GR; Mauck, RL. A Novel High-Throughput System for the Mechanical Analysis of Engineered Cartilage Constructs. Penn Center for Musculoskeletal Disorders 8th Annual Symposium, Philadelphia, PA. October 26, 2011. (poster - 2nd place biomechanics)

Awards:
2016, 1st Place PhD Competition -- SB3C Annual Meeting (originally ASME-Bioengineering Meeting)
2016, CMBE-BMES Student/Fellow Award
2015, 1st Place Poster, Penn Center for Musculoskeletal Disorder Symposium, University of Pennsylvania
2013, NIH/NIAMS Musculoskeletal Research T32 Trainee
2013, NSF Graduate Research Fellowship: Honorable Mention
2011, 2nd Place Poster, Penn Center for Musculoskeletal Disorder Symposium, University of Pennsylvania
2011, Bioengineering Founders Award, Syracuse University, for the second-highest graduating GPA
2011, Richard A. Bernard Award, for the creative application of engineering approaches towards solving the problems faced by physically handicapped individuals