Perelman School of Medicine at the University of Pennsylvania

McKay Orthopaedic Research Laboratory

Mauck Laboratory

DongHwa Kim

DongHwa Kim

Post-Doctoral Fellow
University of Pennsylvania

Hometown: Busan, Korea

Education: Ph.D. Biomedical Engineering, 2011, Inje University, Korea
M.S. Biomedical Engineering, 2008, Inje University, Korea
B.S. Biomedical Engineering, 2006, Inje University, Korea

Areas of Special Interest: DongHwa Kim is from S. Korea. Her research is focused on mechanical stimulation of cells and related tissues, mesenchymal stem cell differentiation, development of bioreactors for blood vessel regeneration, and micro-physical environments on cells. Now, she is working on intervertebral disc regeneration using mesenchymal stem cells. In her spare time, she enjoys listening to music, cooking food, and traveling.

Publications:
DH Kim, SJ Heo, JW Shin. "Differentiation of mesenchymal stem cells into vascular cells under mechanical stimulation for bioengineered blood vessels," 2012, in preparation.

DH Kim, SJ Heo, SH Kim, JW Shin, SH Park, JW Shin. "Shear stress magnitude is critical in regulating the differentiation of mesenchymal stem cells, even with endothelial growth medium," 2011, Biotechnology letters, 33: 2351-2359

SH Park, JW Shin, DH Kim, SH Kim, OC Jeong, JK Kim, JW Shin. "Quantitative analyses of changes in intracellular calcium ion concentrations under flow-induced mechanical stimuli utilizing a microchip," 2011, Micro& Nano letters, 6(5): 296-300

JY Jang, SW Lee, SH Park, JW Shin, CW Mun, SH Kim, DH Kim, JW Shin. "Combinational Effects of Surface Morphology and Mechanical Straining Magnitudes on the Differentiation of Mesenchymal Stem Cells Without Using Biochemical Reagents," 2011, J. of Biomedicine and Biotechnology, Article ID 860652: 1-9

JY Han, JW Shin, SH Park, DH Kim, SH Kim, YG Kang, JW Shin. "Differentiation of Stem Cells based on Cocktail medium and Scaffold Characteristics for Osteochondral Tissue," 2011, Tissue Engineering and Regenerative Medicine, 8(2); 59-65

SH Kim, SH Park, JW Jun, DH Kim, JW Shin, JY Han, YG Kang, JW Shin. "Hydrostatic pressure can control osteogenesis and osteoclastogenesis when Stromal Cells and Osteoclast Precursor Cells are Cocultured," 2010, Tissue Engineering and Regenerative Medicine, 7(4); 383-394

JY Jeong, DH Kim, SH Park, JW Shin, JY Han, YG Kang, JW Shin. "Effects of PDMS Surface Patterns on Differentiation and Proliferation of MSCs under Intermittent Hydrostatic Pressure," 2010, Tissue Engineering and Regenerative Medicine, 7(3); 283-290

SW Lee, JY Jang, SH Park, DH Kim, JW Shin, SH Kim, JW Shin. "Study of Mesenchymal Stem Cells Co-Cultured with Endothelial Cells under Vascular Fluidic Environments," 2010, Tissue Engineering and Regenerative Medicine, 7(2); 255-261

DH Kim, SJ Heo, JW Shin, KM Park, KD Park, KS Jee. "Preparation of Thermosensitive Gelatin-Pluronic® Copolymer for Cartilage tissue engineering," 2010, Macromolecular Research, 18(4): 387-391

DH Kim, SH Kim, SJ Heo, JW Shin, SW Lee, SA Park, JW Shin. "Enhanced Differentiation of Mesenchymal Stem Cells into NP-like cells via 3D Co-culturing with Mechanical Stimulation," 2009, J. of bioscience and bioengineering, 108(1): 63-67

DH Kim, SJ Heo, JW Shin, SH Park, JW Shin. "Effects of Mechanical Stimulation on Chondrogenesis of Mesenchymal Stem Cells via 3D Co-culturing System," 2009, Tissue Engineering and Regenerative Medicine, 6(4-11); 739-745

J Wei, SJ Heo, C Liu, DH Kim, SE Kim, YT Hyun, JW Shin, JW Shin. "Preparation and characterization of bioactive calcium silicate and poly(epsilon-caprolactone) nanocomposite for bone tissue regeneration," 2009, J. of Biomedical Materials Research: Part A, 90(3): 702-712

SJ Heo, SE Kim, J Wei, DH Kim, YT Hyun, HS Yun, HK Kim, TR Yoon, SH Kim, SA Park, JW Shin, JW Shin. "Preparation and characterization of bioactive calcium silicate and PCL nanocomposite for bone tissue regeneration," 2009, Tissue Engineering, 15(5): 977-989

SJ Heo, SE Kim, J Wei, YT Hyun, HS Yun, DH Kim, JW Shin, JW Shin. " Fabrication and characterization of novel nano- and micro-HA/PCL composite scaffolds using a modified rapid prototyping process," 2009, J. of Biomedical Materials Research: Part A, 89(1): 108-116

JW Shin, YJ Lee, SJ Heo, SA Park, SH Kim, YJ Kim, DH Kim, JW Shin. "Manufacture of the multi-layered nanofibrous structures composed of polyurethane and poly(ethylene oxide) for the potential scaffolds of blood vessels," 2009, J. of Biomaterials Science: Polymer Edition, 20: 757-771

SH Ha, DH Kim, JW Shin, HC Gwak, JS Choi. "Effects of Mechanical Stimulation and Scaffolds for Nucleus Pulposus Replacement of Intervertebral Disc," 2009, J. of Korean Orthopaedic Research Society, 12(2)

J wei, SJ Heo, DH Kim, SE Kim, YT Hyun, JW Shin. "Comparison of physical, chemical and cellular responses to nano- and micro-sized calcium silicate/ poly(-caprolactone) bioactive composites," 2008, J. of the Royal Society Interface, 6;5(23): 617-630

YJ Kim, SA Park, YJ Lee, JW Shin, DH Kim, SJ Heo, KD Park, JW Shin. "The Effects of Intermittent Hydrostatic Pressure on Cell Adhesive Forces and Other Related Parameters under Various Resting Periods," 2008, J. of Biomedical Materials Research: Part B, 85(2): 353-360

DH Kim, SH Kim, SJ Heo, JW Shin, YJ Kim, SH Park, JW Jun, JW Shin. "The Differentiation of bone Marrow Stromal Cells into NP-like Cells through 3-Dimensional Co-culture System," 2008, Journal of Biomedical Engineering Research, 29(2): 159-163

KM Park, DH Kim, JW Bae, YK Joung, JW Shin, KD Park. "Injectable Chitosan-Pluronic Hydrogel Releasing Osteogenic Protein-1 for the Regeneration of Intervetebral Disc," 2008, Biomaterials research, 12(1): 24-27

JW Shin, DH Kim, SJ Heo, SH Kim, YJ Kim, JW Shin. "Effects of the Mechanical Stretch on Aligned Multi-Layered Nanofibrous Scaffolds Seeded with Smooth Muscle Cells," 2008, Journal of Biomedical Engineering Research, 29(1):52-58

SJ Heo, SE Kim, YT Hyun, DH Kim, HM Lee, YM Hwang, SA Park, JW Shin. "In Vitro Evaluation of Poly ?-Caprolactone/Hydroxyapatite Composite as Scaffolds for Bone Tissue Engineering with Human Bone Marrow Stromal Cells," 2007, Key Engineering Materials, 342-343; 369-372

SA Park, IA Kim, CR Kim, JW Shin, SJ Heo, YM Hwang, DH Kim, JW Shin. "Effects of mechanical stimuli on the cell proliferation and collagen production on the micropatterned substrate." 2006, J. Exp & Biomed. Sci, 12;224-228

Abstracts:
S.I. Chun, D.H. Kim, J.H. Cho, K.S. Hong, J.W. Shin, C.W. Mun. "Preliminary study on MR spectroscopy measurements for metabolomic change during adipogenic differentiation of human mesenchymal stem cell," International Society for Magnetic resonance in Medicine," Montreal/Canada, 2011

DH Kim, JY Han, SH Park, JW Shin, SH Kim, YG Kang, JW Shin. "The Effects of Flow-induced Shear Stress on the Differentiation of MSCs into Vascular Endothelial Cells," Termis_NA, Orlando, USA, 2010

JY Han, DH Kim, SH Park, JW Shin, SH Kim, YG Kang, JW Shin. "Preparation and Preliminary Evaluations of 3-Dimensional Hybrid Scaffolds for Osteohondral Defects utilizing Rapid Prototype Processing," Termis_NA, Orlando, USA, 2010

SH Park, JW Shin, SH Kim, DH Kim, JY Han, YG Kang, JW Shin. "Combinational effects of stimuli and co-culture on differentiation of MSCs into vascular lineages," Termis_NA, Orlando, USA, 2010

JW Shin, SH Park, SH Kim, DH Kim, JY Han, YG Kang, JW Shin. "Early Effects of Flow-induced Shear Stress on the Differentiation of Mesenchymal Stem Cells (MSCs) when Co-cultured with Smooth Muscle Cells Aligned Perpendicular to Shear stress," Termis_NA, Orlando, USA, 2010

YG Kang, JY Jeong, JY Han, DH Kim, JW Shin, SH Park, SH Kim, JW Shin. "The Effects of Intermittent Hydrostatic Pressure on the Differentiation of MSCs When Cocultured with Chondrocytes," Termis_NA, Orlando, USA, 2010

YG Kang, JW Shin, SH Park, JW Shin, DH Kim, JY Han, SH Kim. "Flow-induced Shear Stress Contributes to Long Term Maintenance of Limbal Stem Cells," Termis_NA, Orlando, USA, 2010

DH Kim, JY Han, SH Park, JW Shin, SH Kim, YG Kang, JW Shin. "The effects of shear stress on MSC differentiation into vascular endothelial cell using a Fluid flow bioreactor," ISNIT, Seoul, Korea, 2010

YG Kang, JW Shin, SH Park, JW Shin, DH Kim, JY Han, SH Kim. "Long term maintenance of Limbal Stem Cells under shear stress," ISNIT, Seoul, Korea, 2010

SI Chun, MY Jang, SY Lee, DH Kim, JH Cho, JW Shin, YI Yang, CW Mun. "Proton MR Spectroscopy Measurements for Metabolomic Changes during Adipogenic Differentiation of Muscle Derived Stem Cells," International Society for Magnetic Resonance in Medicine, Sweden, Europe, 2010

DH Kim, SJ Heo, YG Kang, SH Kim, JW Shin, SH Park, JY Han, JW Shin. "The effects of intermittent hydrostatic pressure on the differentiation of mesenchymal stem cells co-cultured with chondrocytes in alginate beads," SPRBM, Arizona, USA, 2010

JY Jeong, SW Lee, JY Jang, DH Kim, SH Park, JW Shin, JY Han, JW Shin. "The effects of PDMS surface pattern on differentiation and proliferation of MSCs under intermittent hydrostatic pressure," SPRBM, Arizona, USA, 2010

JW Shin, NR Kim, SH Park, JY Jang, DH Kim, SJ Heo, JY Han, YG Kang, SH Kim, JW Shin. "The effects of TGF-?1 and culture mediumon differentiation of human mesenchymal stem cells into cardiomyocytes," SPRBM, Arizona, USA, 2010

JY Jang, SW Lee, SH Park, JW Shin, JY Jeong, DH Kim, JY Han, JW Shin. "The effects of mechanical straining and substrate surface morphologies on differentiation of mesenchymal stem cells without biochemical reagents," SPRBM, Arizona, USA, 2010

SH Park, SH Kim, JW Shin, DH Kim, SW Lee , JY Jang , JY Jeong, JY Han, JW Shin. "The effects of fluid flow on the expressions of intracellular calcium in MG-63," SPRBM, Arizona, USA, 2010

DH Kim, KS Jee, SJ Heo, KD Park, JW Shin. "Evaluationsof the cellular responses of novel Gelatin-Pluronic thermo-sensitive hydrogel using chondrocyte," Termis 2nd World Congress, Seoul, Korea, 2009

DH Kim, SH Kim, SJ Heo, JW Shin, JW Shin. "The effect of three dimensional co-culturing system on the differentiation of BMSCs into NP-like cells," SPRBM, Miami, USA, 2008

SJ Heo, SE Kim, DH Kim, YT Hyun, SH Kim. JW Shin, JW Shin. "A novel 3-D scaffold of nano-hydroxyapatite/poly ?-caprolactone by layer manufacturing process for bone tissue engineering," SPRBM, Miami, USA, 2008

SH Kim, JW Jun, SH Park, SJ Heo, DH Kim, JW Shin, SW Lee, JY Jang, JW Shin. "Promotion of osteogenesis using a co-culture with osteoclast precursors and the loading of hydrostatic pressure," SPRBM, Miami, USA, 2008

D.H. Kim, S.H. Park, J.W. Jun, S.W. Lee, J.Y. Jang, J.Y. Jeong, S.J. Heo, J.W. Shin. "Effects of Intermittent Hydrostatic Pressure on the Chondrogenesis of Mesenchymal stem cells through 3D Co-culture," Termis_NA, San Diego, USA, 2008

S.J. Heo, S.E. Kim, D.H. Kim, S.W. Lee, T.R. Yun, J.W. Shin. "Cell and Tissue In-growth Behavior into n-HA/PCL Composite Scaffold Fabricated by LMS: Comparison with Conventional SGP Scaffolds through Animal Studies," Termis_NA, San Diego, USA, 2008

JW Jun, JW Shin, SH Park, DH Kim, SW Lee, JY Jang, JY Jung, SH Kim. "The effects of Intermittent Hydrostatic Pressure on M2-10B4 Cells in Co-Culturing System," Termis_NA, San Diego, USA, 2008

YJ Kim, DH Kim, JW Shin, SJ Heo, SH Park, SW Lee, JY Jang, JY Jeong, KS Jee, JW Shin. "The effects of intermittent hydrostatic pressure patterns: the changes in cell adhesiveness along with intracellular ca2+ concentration," Termis_AP, Taiwan, 2008

JW Shin, SJ Heo, DH Kim, YJ Kim, SH Park, SW Lee, JY Jang, JY Jeong, KS Jee, JW Shin. "Biomimetic approaches for Vascular environments with multi-layered scaffolds under mechanical stimulation," Termis_AP, Taiwan, 2008

SH Park, OC Jeong, SH Shin, DH Kim, JY Jang, SW Lee, JY Jung, KS Jee, JW Shin. "Time response of calcium (Ca2+) ion flow of MG-63 cells induced by constant shear stress in micro chip," Termis_AP, Taiwan, 2008

SA Park, JW Shin, SJ Heo, DH Kim, YM Hwang, WD Kim, JW Shin. "The effects of mechanical stretching on ligament fibroblats to the micropatterned silicone surface," Orthopeadic Research Society, Sandiego, USA, 2007

DH Go, KM Park, JW Bae, DH Kim, JW Shin, KD Park. "BMP-7 delivery using injectable chitosan hydrogel for regeneration of intervertebral disc," International symposium on recent advances in drug delivery systems, Utah, USA 2007

SJ Heo, SE Kim, YT Hyun, DH Kim, HM Lee, JW Shin, YM Hwang, JH Kim, JW Shin. "Bone tissue engineering using poly e-caprolactone/hydroxyapatite 3-D scaffolds with human bone marrow stromal cells," Asian Internationl Symposium on Biomaterials, Xiamen, CHINA, 2006

JW Shin, SA Park, JH Kim, YJ Lee, SJ Heo, YM Hwang, DH Kim, JW Shin. "Effects of multi-layered nanofibrous scaffold for smooth muscle cells," Asian Internationl Symposium on Biomaterials, Xiamen, CHINA, 2006

DH Kim, SJ Heo, JW Shin, YM Hwang, JH Kim, JW shin. "The effects of Intermittent hydrostatic pressure on MG-63 cells in three dimensional scaffolds obtained from porcine," Asian Internationl Symposium on Biomaterials, Xiamen, CHINA, 2006

YM Hwang, YJ Kim, JW Shin, DH Kim, SJ Heo, JH Kim, JW Shin. "Effects of Ca2+ on adhesive forces of CPAE cells to substrates using a quantitative force measurement system," Asian Internationl Symposium on Biomaterials, Xiamen, CHINA, 2006

SJ Heo, YT Hyun, HM Lee, DH Kim, JW Shin, YM Hwang, HS Yun, JW Shin, SE Kim. "In Vitro Evaluation of Poly(e-caprolactone)/Hydroxyapatite Composites Scaffolds By Human Bone Marrow Stromal Cells For Bone Tissue Engineering," Asian Internationl Symposium on Biomaterials, Xiamen, CHINA, 2006

Awards:
2011, Post-Doctoral Fellow by National Research Foundation of Korea (NRF) [Fostering next-generation researchers program]
2010, Travel Support Award in Society for Physical Regulation in Biology and Medicine (SPRBM)
2009, Best Poster Presentation award in 2nd World Congress of Tissue Engineering and Regenerative Medicine International Society (TERMIS)
2009, Korea Science and Engineering Foundation, S&T Graduate Scholarship
2009, Excellence award, Women in Science Engineering and Technology in Korea
2009, Certificate of commendation, Inje University (Four times)
2008, Korea, Busan Future Scientist Award 2007, Korea Baek-Yup Graduate Scholarship
2007, First place win in the annual contest of thesis proposal (Inje University)
2006 - 2009 INJE University Graduate Scholarship

Patents:
JW Shin, DH Kim "A Double-Layered Tube-type Porous Scaffold Comprising Biodegradable Polymer And Manufacturing Method Thereof, " Korea Patent Application, 10-2011-0029816, 31 Mar 2011.