Perelman School of Medicine at the University of Pennsylvania

McKay Orthopaedic Research Laboratory

Mauck Laboratory

Tristan Driscoll

Tristan Driscoll

Graduate Student in Bioengineering
University of Pennsylvania

Hometown: Blaine, MN

Education:
2009-Present  University of Pennsylvania, Ph.D. in Bioengineering
2005-2009      University of Minnesota, B.Bm.E.

Areas of Special Interest:
Directing mesenchymal stem cell differentiation with dynamic mechanical forces. The role of the LINC complex in differentiation and mechanotransduction.

Publications:
Han WM, Heo SJ, Driscoll TP, Smith LJ, Mauck RL, Elliott DM. Macro-to microscale strain transfer in fibrous tissues is heterogeneous and tissue-specific. Biophysical Journal, 2013 Aug; 105(3):807-17.

Driscoll TP, Nakasone RH, Szczesny SE, Elliott DM, Mauck RL. Biaxial mechanics and inter-lamellar shearing of stem-cell seeded electrospun angle-ply laminates for annulus fibrosus tissue engineering. Journal of Orthopaedic Research. 2013 Jun; 31(6):864-70.

Driscoll TP, Nerurkar NL, Jacobs NT, Elliott DM, Mauck RL. Fiber angle and aspect ratio influence the shear mechanics of oriented electrospun nanofibrous scaffolds. Journal of the Mechanical Behavior of Biomedical Materials, 2011 Nov; 4(8):1627-36.

Conference Proceedings:
Driscoll, TP; Cosgrove, BD; Heo, SJ; Mauck, RL; Knockdown of LINC Complex Proteins Alters Nuclear Deformation, Cell Contractility and Mechanosensation in Mesenchymal Stem Cells. BMES Cell and Molecular Bioengineering Conference, San Diego, California, 2014. (Student/Fellow Award Podium Presentation)

Heo, SJ; Driscoll, TP; Thorpe, SD; Lee, DA; Mauck, RL; Rapid Chromatin Condensation Increases Stem Cell Nuclear Mechanics and Mechanosensitivity; 60th Annual Meeting of the Orthopaedic Research Society, New Orleans, Louisiana, 2014.

Heo, SJ; Thorpe, SD; Driscoll, TP; Hashmi, SK; Lee, DA; Mauck, RL; Rapid and Sustained Changes in Nuclear Architecture and Mechanics in Mesenchymal Stem Cells in Response to Dynamic Stretch. 60th Annual Meeting of the Orthopaedic Research Society, New Orleans, Louisiana, 2014.

Driscoll, TP; Chang, J; Keyes, T; Hast, MW; Heo, SJ; Mauck, RL; Chao, PG; Engineered Fiber Crimp Alters Scaffold Mechanics, Cell Shape, and Strain Transfer to the Nucleus. 60th Annual Meeting of the Orthopaedic Research Society, New Orleans, Louisiana, 2014.

McLeod, CM; Driscoll, TP; Farell, M; Heo, SJ; Cosgrove, BD; Mauck, RL; Mesenchymal Stem Cell Mechanobiology Is Clone Dependent. Biomedical Engineering Society, Seattle, Washington, 2013. (Podium Presentation by CMM)

Heo, SJ; Driscoll, TP; Engineering Fibrous Tissue Constructs Containing Amorphous Proteoglycan-Rich micro-Domains. Biomedical Engineering Society, Seattle, Washington, 2013.

Driscoll, TP; Heo, SJ; Shurden, ZE; Mauck, RL; Cytoskeletal Connectivity to the Nucleus Regulates MSC Nuclear Strain Transfer and Mechanotransduction. Biomedical Engineering Society, Seattle, Washington, 2013. (Podium Presentation)

Driscoll, TP; Heo, SJ; Shurden, ZE; Mauck, RL; Cytoskeletal Tension is Required for Dynamic Tensile Loading Induced Alterations in Mesenchymal Stem Cell Shape and Nuclear Connectivity. 19th Annual Conference of the Section of Bioengineering of the Royal Academy of Medicine in Ireland, Co. Meath, Ireland, 2013. (Podium Presentation by TPD, 1st Prize in Mechanobiology)

Heo, SJ; Driscoll, TP; Hashmi, S; Mauck, RL; Fibrochondrogenesis Alters Migration and Sensitizes Mesenchymal Stem Cells to Mechanical Stretch.  59th Annual Meeting of the Orthopaedic Research Society, San Antonio, TX, 2013. (Podium presentation by SJH)

Heo, SJ; Thorpe, S; Driscoll, TP; Hashmi, S; Lee, DA; Mauck, RL; Dynamic Stretch Rapidly Alters Nuclear Structure and Chromatin Condensation in Mesenchymal Stem Cells. 59th Annual Meeting of the Orthopaedic Research Society, San Antonio, TX, 2013. (Podium Presentation by SJH)

Driscoll, TP; Shurden, ZE; Heo, SJ; Mauck, RL; Cytoskeletal Tension is Required for Dynamic Tensile Loading Induced Alterations in Mesenchymal Stem Cell Shape and Nuclear Connectivity. 59th Annual Meeting of the Orthopaedic Research Society, San Antonio, TX, 2013. (Podium Presentation by TPD)

Heo, SJ; Driscoll, TP; Mauck, RL; Dynamic Tensile Loading Triggers Activation of Both TGF-beta and BMP Pathways in Mesenchymal Stem Cells. Proceedings of the ASME 2012 Summer Bioengineering Conference. Farjardo, Puerto Rico. (Podium Presentation by SJH)

Han, WM; Heo, SJ; Driscoll, TP; Mauck, RL; Elliott, DM. Micro-Scale Strain Transfer in Fiber-Reinforced Native Tissue Differs from Cell-Seeded Scaffolds. Proceedings of the ASME 2012 Summer Bioengineering Conference. Farjardo, Puerto Rico.

Driscoll, TP; Heo SJ; Mauck RL; Dynamic Tensile Loading and Altered Cell Contractility Modulate Nuclear Deformation and Cytoskeletal Connectivity. Proceedings of the ASME 2012 Summer Bioengineering Conference. Farjardo, Puerto Rico. (Podium Presentation by TPD)

Driscoll, TP; Heo SJ; Mauck RL; Dynamic Tensile Loading and Altered Cell Contractility Modulate Nuclear Deformation and Nesprin Espression. 38th Annual North East Bioengineering Conference, Philadelphia, PA. 2012. (Podium Presentation by TPD)

Heo, SJ; Driscoll TP; Zhong Z; Mauck, RL. Altered Mechanosensitivity of Fibrochondrogenic Mesenchymal Stem Cells with Modulation of Nuclear Mechanics. 58th Annual Meeting of the Orthopaedic Research Society, San Francisco, CA, 2012. (Podium Presentation by SJH)

Heo, SJ; Driscoll TP; Nerurkar, NL; Mauck, RL. Dynamic Tensile Stretch Promotes Lamin A/C Reorganization and Chromatin Condensation in Adult Stem Cells. 58th Annual Meeting of the Orthopaedic Research Society, San Francisco, CA, 2012. (Podium Presentation by TPD)

Driscoll, TP; Nakasone, RH; Szczesny; Elliott, DM; Mauck, RL. Biaxial Mechanics and Inter-lamellar Shearing of Electrospun Bilayers for Annulus Fibrosus Tissue Engineering. 58th Annual Meeting of the Orthopaedic Research Society, San Francisco, CA, 2012.

Driscoll, TP; Yang, MT; Heo, SJ; Nakasone, RH; Chen, CS; Mauck, RL. Differential Nesprin Expression with Mesenchymal Stem Cell Fibrochondrogenesis and Altered Contractility. 58th Annual Meeting of the Orthopaedic Research Society, San Francisco, CA, 2012. (Podium Presentation by TPD)

Driscoll, TP; Nakasone, RH; Szczesny, SE; Elliott, DM; Mauck, RL. Biaxial Mechanics of Electrospun Bilayers for Annulus Fibrosus Tissue Engineering. Philadelphia Spine Symposium, 2011.

Heo SJ, Nerurkar NL, Driscoll TP, Mauck RL. Differentiation and Dynamic Tensile Loading Alter Nuclear Mechanics and Mechanoreception in Mesenchymal Stem Cells. Proceedings of the ASME 2011 Summer Bioengineering Conference. Nemacolin Woodlands Resort, Famington, Pennsylvania, June 22-25, 2011. ( (Podium Presentation by TPD)

Driscoll TP, Nerurkar NL, Jacobs NT, Mauck RL, Elliott DM. Fiber Angle and Aspect Ratio Influence the Shear Mechanics of Electrospun Nanofibrous Scaffolds. Proceedings of the ASME 2011 Summer Bioengineering Conference. Nemacolin Woodlands Resort, Famington, Pennsylvania, June 22-25, 2011.

Driscoll TD, Nerurkar NL, Jacobs NT, Mauck RL, Elliott DM. Shear mechanics of electrospun scaffold for annulus fibrosus tissue engineering. 57th Annual Meeting of the Orthopaedic Research Society, Long Beach, CA, January 13 – 16, 2011.