Perelman School of Medicine at the University of Pennsylvania

McKay Orthopaedic Research Laboratory

Mauck Laboratory

Megan Farrell

Megan Farrell

Graduate Student in Bioengineering
University of Pennsylvania

Hometown: Archbald , Pennsylvania

Education: B.S. Biomedical Engineering, 2008, Rensselaer Polytechnic Institute

Areas of Special Interest:
Areas of scientific interest include image based analyses of functional tissue development in cartilage tissue engineered constructs, mesenchymal stem cell differentiation, and mechanobiology. When not in lab, you can find Megan working on the occasional art project, enjoying the outdoors, or eating chicken.

Publications:
Farrell MJ, Shin JI, Smith LJ, Mauck RL. Functional Consequences of Glucose and Oxygen Deprivation on Engineered Mesenchymal Stem Cell-Based Cartilage Constructs. (in review)

Farrell MJ, Fisher MB, Huang AH, Shin JI, Farrell KM, Mauck RL. Functional Properties of MSC-Based Engineered Cartilage are Unstable with Very Long Term In Vitro Culture. (in review)

Farrell MJ, Comeau ES, Mauck RL. Mesenchymal Stem Cells Produce Functional Cartilage Matrix in 3D Culture in Regions of Optimal Nutrient Supply. 2012, European Cells and Materials, 23:425-40

Erickson IE, Kestle SR, Zellars K, Farrell MJ, Kim M, Burdick JA, Mauck RL. High Stem Cell Seeding Densities in Hyaluronic Acid Hydrogels Produce Engineered Cartilage with Native Tissue Properties. 2012, Acta Biomaterialia, 8(8): 3027-34

Huang AH, Farrell MJ, Kim M, Mauck RL. Long-term Dynamic Compressive Loading Improves the Mechanical Properties of Mesenchymal Stem Cell-Laden Hydrogels. 2010, European Cells and Materials, 19:72-85.

Solorio L, Zwolinski C, Lund AW, Farrell MJ, Stegemann JP. Gelatin Microspheres Crosslinked with Genipin for Local Delivery of Growth Factors. 2010, Journal of Tissue Engineering and Regenerative Medicine, 4(7):514-23.

Book Chapters and Reviews:
Farrell MJ and Mauck RL. Advancing Articular Cartilage Repair through Engineering from Materials and Cells to Clinical Translation. In: Biomaterials and Regenerative Medicine. Ed. Ma PX. (in press)

Huang AH, Farrell MJ, Mauck RL. Mechanics and Mechanobiology of Mesenchymal Stem Cell-Based Engineered Cartilage. 2009, Journal of Biomechanics, 43(1): 128-36

Abstracts:
Farrell MJ, Cosgrove BD, Mauck RL. Micromechanical Assessment of Chondrogenic Stem Cell Heterogeneity. 60th Annual Meeting of the Orthopaedic Research Society. New Orleans, LA, March 2014. (submitted)

Cosgrove BD, Farrell MJ, Dunagin M, McLeod CM, Cote AJ, Raj A, Mauck RL. Inherent and Emergent Heterogeneity in Clonal Stem Cell Populations. 60th Annual Meeting of the Orthopaedic Research Society. New Orleans, LA, March 2014. (submitted)

Pfeifer CG, Kim M, Farrell MJ, Pacifici M, Mueller MB, Mauck RL. Attenuation of MSC Hypertrophy in 3D Culture via Treatment with a Retinoic Acid Receptor Inverse Agonist. 60th Annual Meeting of the Orthopaedic Research Society. New Orleans, LA, March 2014. (submitted)

Cosgrove BD, McLeod CM, Farrell MJ, Guvendiren M, Burdick JA, Mauck RL. Heterogeneous Traction Force Distributions in Expanded MSC Clonal Populations. Biomedical Engineering Society Meeting. Seattle, WA, September 2013.

Farrell MJ, Shin JI, Mauck RL. Functional Consequences of Glucose and Oxygen Deprivation in Engineered MSC-Based Cartilage Constructs. ASME 2013 Summer Bioengineering Conference. Sunriver, Oregon, June 2013. (podium)

Farrell MJ, Chiaro JA, Shin JI, Mauck RL. RAR Inverse Activation is Highly Pro-Chondrogenic for Stem Cell Based Cartilage Engineering. Bioengineering in Ireland 19. County Meath, Ireland, January 2013. (podium)

Farrell MJ, Fisher MB, Soegaard N, Farrell KM, Mauck RL. Mesenchymal Stem Cell-Based Cartilage is Unstable in Very Long Term In-Vitro Culture. 59th Annual Meeting of the Orthopaedic Research Society. San Antonio, TX, February 2013.

Kim M, Farrell MJ, Burdick JA, Mauck RL. Depth-Dependent Properties of a Tri-Layered Hyaluronic Acid Hydrogel Construct with Zonal Co-Culture of Chondrocytes and MSCs. 59th Annual Meeting of the Orthopaedic Research Society. San Antonio, TX, February 2013.

Farrell MJ, Farrell KM, Riggin CN, Mauck RL. Mesenchymal Stem Cell Death in Three-Dimensional Agarose Culture for Cartilage Tissue Engineering Applications: Progression, Factors, and Prevention.  Northeast Bioengineering Conference. Philadelphia, PA, March 2012.

Farrell MJ, Cosgrove BD, deVries S, Raj A, Mauck RL. Multi-Scale Analysis of Heterogeneity in Mesenchymal Stem Cell Chondrogenesis. 58th Annual Meeting of the Orthopaedic Research Society. San Francisco, CA, February 2012.

Farrell MJ, Comeau ES, Mauck RL. Dynamic Culture Improves Mechanical Functionality of MSC-Laden Tissue Engineered Constructs in a Depth-Dependent Manner. ASME 2011 Summer Bioengineering Conference. Nemacolin Woodlands Resort, PA, June 2011. (podium)

Farrell MJ, Comeau ES, Nerurkar NL, Huang AH, Mauck RL. Depth-Dependent Mechanical Properties of MSC-Laden Engineered Cartilage Constructs. 57th Annual Meeting of the Orthopaedic Research Society. Long Beach, CA, January 2011. (podium)

Farrell MJ, Comeau ES, Huang AH, Burdick JA, Mauck RL. Tunable and Depth-Dependent Mechanics of Agarose/Poly(Ethylene Glycol) Diacrylate Interpenetrating Networks. 57th Annual Meeting of the Orthopaedic Research Society. Long Beach, CA, January 2011. (podium)

Farrell MJ, Zachry TL, Mauck RL. Micromechanical Deformation of Chondrogenic Mesenchymal Stem Cells in 3D Hydrogels is Modulated by Time in Culture and Matrix Connectivity. ASME 2010 Summer Bioengineering Conference. Grande Beach Resort, Naples, Florida, June 2010.

Farrell MJ, Perreira J, Mauck RL. Micromechanical Heterogeneity of Chondrogenic Mesenchymal Stem Cell Subpopulations in 3D Culture. 56th Annual Meeting of the Orthopaedic Research Society. New Orleans, LA, March 2010.

Huang AH, Farrell MJ, Mauck RL. Dynamic Compression Initiated After Chondrogenesis Improves Mechanical Properties of Mesenchymal Stem Cell Seeded Hydrogel Constructs. 56th Annual Meeting of Orthopaedic Research Society. New Orleans, LA, March 2010.

Erickson IE, Kestle SR, Farrell MJ, Burdick JA, Mauck RL. Macromer Density Mediates Mesenchymal Stem Cell Response to Dynamic Compression in Photo-Crosslinked Hyaluronic Acid Hydrogels. 56th Annual Meeting of the Orthopaedic Research Society. New Orleans, LA, March 2010.

Huang AH, Farrell MJ, Mauck RL. Delayed Dynamic Compression Improves the Mechanical Properties of MSC-Laden Constructs. Biomedical Engineering Society Meeting. Pittsburgh, PA, October 2009.