Perelman School of Medicine at the University of Pennsylvania

McKay Orthopaedic Research Laboratory

Mauck Laboratory

Deborah Gorth

Deborah Gorth

Current Position: M.D./Ph.D. Student at Jefferson University

Former Lab Position: Research Engineer

Hometown: Amherst, Maryland

Education: Sc.B. Biomedical Engineering, Brown University
Sc.M. Biomedical Engineering, Brown University

Clinical Interest: Adult reconstructive surgery

Areas of Special Interest: Intervertebral disc degeneration can debilitate individual patients and results in an annual societal cost exceeding $50 billion in the United States alone. Definitive surgical interventions exist, but increasing age is associated with increasing risk as comorbidities accumulate. My research aims to develop a comprehensive therapy for intervertebral disc degeneration that is less invasive than open surgery, and more effective than current non-surgical options. This therapy will combine anti-inflammatory treatment, mechanical stabilization, and tissue regeneration into a single percutaneous injection to treat intervertebral disc degeneration.

Publications:
Gorth DJ, Mauck RL, Chiaro JA, Mohanraj B, Hebela NM, Dodge GR, Elliott DM, Smith LJ.(2012) IL-1ra delivered from poly(lactic-co-glycolic acid) microspheres attenuates IL-1B-mediated degradation of nucleus pulposus in vitro. Arthritis Res Ther. 2012 Aug 3;14(4):R179.

Gorth DJ, Puckett S, Ercan B, Webster TJ, Rahaman M, Bal BS. (2012) Decreased bacteria activity on Si(3)N(4) surfaces compared with PEEK or titanium.Int J Nanomedicine. 2012;7:4829-40.

Gorth, DJ, Rand DM and Webster TJ, (2011) Silver nanoparticle toxicity in Drosophila: size does matter. International Journal of Nanomedicine, 6: 343-350. Gorth, DJ., and Webster, TJ. (2010) Matrices for Tissue Engineering and Regenerative Medicine. In Lysaght M. and Webster, T. (Eds.), Biomaterials for artificial organs, Cambridge: Woodhead Publishing Ltd.

Gorth, D., and Webster, T. (2010) Nanotechnology for Regenerative Medicine. AzONano.

Abstracts:
Gorth, D J; Martin, J T; Dodge G R; Hebela N M; Mauck R L; Elliott, D M; Smith L J. In Vivo Delivery of IL-1ra from PLGA Microspheres Prevents IL-1B Induced Glycosaminoglycan Loss in the Rat Caudal Intervertebral Disc. To be presented at: Orthopedic Research Society, 2013 January 26-29; San Antonio, TX.

Gorth, D J; Elliott, D M; Mauck R L; Chen, W; Smith, L J; Malhotra, N R. Mechanical Properties and Cyto-Compatibility of an Injectable Hydrogel Implant for Nucleus Pulposus Repair. To be presented at: Orthopedic Research Society, 2013 January 26-29; San Antonio, TX.

Gorth, D J; Elliott, D M; Mauck R L; Chen, W; Smith, L J; Malhotra, N R. Mechanical Properties and Cyto-Compatibility of an Injectable Hydrogel Implant for Nucleus Pulposus Repair. To be presented at: Orthopedic Research Society, 2013 January 26-29; San Antonio, TX.

Kim, DH; Gorth, DJ; Elliott, DM; Smith, LJ; Mauck, RL. Functional Maturation of an Engineered Nucleus Pulposus in Photocrosslinked Hyaluronic Acid Hydrogels. To be presented at: Orthopedic Research Society, 2013 January 26-29; San Antonio, TX.

Martin, JT; Smith, LJ; Gorth, DJ; Adan, A; Hebela, NM; Elliott, DM; Mauck, RL. Nanofibrous disc-like angle ply structures maintain disc height in the rat caudal spine. To be presented at: Orthopedic Research Society, 2013 January 26-29; San Antonio, TX.

Smith LJ; Gorth, DJ; Martin, JT; Chiaro JA; Dodge GR; Hebela NM; Mauck RL; Elliott, DM. In Vivo Delivery of IL-1ra from PLGA Microspheres Prevents IL-1B Induced Glycosaminoglycan Loss in the Rat Caudal Intervertebral Disc. Presented at: Gordon Research Conference: Musculoskeletal Biology & Bioengineering, August 5-10; Andover, NH.

Gorth DJ, Strutz W, Mohanraj B, Mauck RL, Smith LJ, Dodge GR. Sustained Delivery of IL-1ra from PLGA Microspheres Attenuates IL-1B Mediated Inflammaion in a Cartilage Tissue Analog. To be presented at: Osteoarthritis Research Society International, 2012 April 26-29; Barcelona ES.

Gorth DJ., Chiaro JA., Dodge GR., Hebela NM., Mauck RL., Elliot DM., Smith LJ. Sustained Delivery of IL-1ra from PLGA Microspheres Attenuates IL-1B Mediated Degredation of Engineered Nucleus Pulposus. Presented at: Orthopedic Research Society, 2012 February 4-7; San Francisco, CA.

Martin JT, Beattie EE, Gorth DJ, Smith LJ, Elliot DM Mechanical and Biochemical Consequences of Needle Puncture Injury in the Mouse Caudal Disc. Presented at: Orthopedic Research Society, 2012 February 4-7; San Francisco, CA.

Gorth DJ., Chiaro JA., Dodge GR., Hebela NM., Mauck RL., Elliot DM., Smith LJ. IL-1ra Delivered from PLGA Microspheres Attenuates IL-1B Mediated Degredation of Engineered Nucleus Pulposus. Presented at: Philadelphia Spine Research Symposium, 2011 Nov 16-18; Philadelphia, PA.

Gorth DJ, Rand DM, and Webster TJ, Silver nanoparticle toxicity in vivo, Poster session presented at: Materials Research Society Fall Meeting; 2010 Nov 29-Dec 3; Boston, MA.