Perelman School of Medicine at the University of Pennsylvania

McKay Orthopaedic Research Laboratory

Mauck Laboratory

Su Chin Heo

Su Chin Heo

Graduate Student in Bioengineering
University of Pennsylvania

Hometown: Busan, Korea

Education:
B.S. Biomedical Engineering, 2008, Rensselaer Polytechnic Institute
M.S. Biomedical Engineering, 2008, Inje University, Korea

Areas of Special Interest:
Su Chin Heo is from S. Korea. His areas of interest are the micro-environments of Cells and Tissues. For these, his research has focused on the fabrication methods of scaffolds, incorporation of MSCs, biomaterials and micro-bioreactors, especially related to cell/tissue engineering. Now, his research is focused on mechanical regulation of mesenchymal stem cells, mechanotransduction, and the tissue engineering of the knee meniscus. He also enjoys traveling and watching movies.

Awards:
2012, 3rd Place, award winning poster at the 2012 IRM/CECR Tissue Engineering Symposium
2011, 1st Place, award winning poster at the 2011 Penn Center for Musculoskeletal Disorders Annual symposium
2008, Korea Baek-Yup Graduate Scholarship
2007, ANSYS User's conference award for Best Student Paper
2007, 2006 INJE University Graduate Scholarship
2006, Korea Science and Engineering Foundation, S&T Graduate Scholarchip
2004, 2005 INJE University Undergraduate Scholarship
2004, INJE University Undergraduate award for excellent attitude

Patents:
JW Shin, SJ Heo, HP Yoon, CI Jung, “Method of preparation of bone chips for bone tissue regeneration,” Korea Patent Application, 10-2009-0105406, 03 Nov 2009.

JW Shin, SJ Heo, J Wei, “Manufacturing method for nanoparticles of hydroxyapatite and hydroxyapatite nanoparticles,” Korea Patent Application, 10-2008-0018129, 28 Feb 2008.

JW Shin, SJ Heo, J Wei, SE Kim, YT Hyun, HS Yun, “Manufacturing method for nanoparticles-biogradable polymer composites,” Korea Patent Application, 10-2008-0029914, 31 Mar 2008.

JW Shin, SJ Heo, J Wei, SE Kim, YT Hyun, HS Yun, “Manufacturing method for nanoparticles of calcium silicate,” Korea Patent Application, 10-2008-0029916, 31 Mar 2008.

Publications:
SJ Heo, TD Driscoll, NL Nerurkar, R L Mauck. "Differentiation and deformation modulate nuclear mechanics during mesenchymal stem cell fibrochondrogenesis," 2012, in preparation.

DH Kim, SJ Heo, JW Shin. "Differentiation of mesenchymal stem cells into vascular cells under mechanical stimulation for bioengineered blood vessels," 2012, in preparation.

SJ Heo, NL Nerurkar, BM Baker, JW Shin, DM. Elliott, R L Mauck. "Fiber Stretch and Reorientation Modulates Mesenchymal Stem Cell Morphology and Fibrous Gene Expression on Oriented Nanofibrous Microenvironments," 2011, Ann Biomed Eng, 39(11): 2780-2790 [**Cover article**].

DH Kim, SJ Heo, SH Kim, JW Shin, SH Park, JW Shin. "Shear Stress Magnitude is Critical in Regulating the Differentiation of Mesenchymal Stem Cells even with Endothelial Growth Medium," 2011, Biotechnology letters, 33: 2351-2359.

DH Kim, SJ Heo, JW Shin, CW Mun, KM Park, KS Jee. "Preparation of Thermosensitive Gelatin-Pluronic® Copolymer for Cartilage tissue engineering," 2010, Macromolecular Research, In press.

SW Lee, SJ Heo, JY Jang, JY Jeong, SH Kim, SA Park, ES Jeon, JW Shin. "Novel Perfusion Culture with 3-Dimensional Shape-controlled Scaffolds for Bone Tissue Engineering," 2010, Tissue Engineering and Regenerative Medicine, In press.

DH Kim, SJ Heo, JW Shin, SH Park, JW Shin. "Effects of Mechanical Stimulation on Chondrogenesis of Mesenchymal Stem Cells via 3D Co-culturing System," 2009, Tissue Engineering and Regenerative Medicine, 6(4): 739-745.

DH Kim, SH Kim, SJ Heo, JW Shin, SW Lee, SA Park, JW Shin. "Enhanced Differentiation of Mesenchymal Stem cells into NP-like cells via 3D Co-culturing with Mechanical Stimulation," 2009, J. of bioscience and bioengineering, 108(1): 63-67.

SJ Heo, SE Kim, J Wei, DH Kim, YT Hyun, HS Yun, HK Kim, TR Yoon, SA Park, JW Shin, JW Shin. "In-vitro and animal study of novel nano-HA/PCL composite scaffolds fabricated by layer manufacturing process," 2009, Tissue engineering: Part A, 15(5): 977-98.

SJ Heo, SE Kim, J Wei, YT Hyun, HS Yun, DH Kim, JW Shin, JW Shin. "Fabrication and characterization of novel nano- and micro-HA/PCL composite scaffolds using a modified rapid prototyping process," 2009, J. of Biomedical Materials Research: Part A, 89A: 108-116.

J Wei, SJ Heo, DH Kim, SE Kim, YT Hyun, JW Shin. "Comparison of physical, chemical and cellular responses to nano- and micro-sized calcium silicate/poly(e-caprolactone) bioactive composites, " 2008, J. of the Royal Society Interface, Jun 6;5(23):617-30.

J Wei, SJ Heo, DH Kim, SE Kim, YT Hyun, JW Shin. "Preparation and characterization of bioactive calcium silicate and PCL nanocomposite for bone tissue regeneration,"2009, J. of Biomedical Materials Research: Part A, 90(3): 702-712.

JW Shin, YJ Lee, SJ Heo, SA Park, SH Kim, YJ Kim, DW Kim, JW Shin. "Manufacture of the multi-layered anofibrous structures composed of polyurethane and poly(ethylene oxide) for the potential scaffolds of blood vessels," 2009, J. of Biomaterials Science: Polymer Edition, 20: 754-771.

J Wei, X Wu, C Liu, J Jia, SJ Heo, SE Kim, YT Hyun, JW Shin. "Fabrication of Bioactive Scaffold of Poly(e-Caprolactone) and Nanofiber Wollastonite Composite," 2009, J. of the American Ceramic Society. 92(5):1017-1023.

HS Yun, SE Kim, YT Hyun, SJ Heo, JW Shin. "Three-Dimensional Mesoporous-Giantporous Inorganic/Organic Composite Scaffolds for Tissue Engineering," 2008, Chemistry of Materials, 19(25): 6364-6366.

HS Yun, SE Kim, YT Hyun, SJ Heo, JW Shin. "Hierarchically Mesoporous-Macroporous Bioactive Glass Scaffolds for Bone Tissue Regeneration,"2008, J. of Biomedical Materials Research: Part B, 87B(2):374-380.

YJ Kim, S Park, YJ Lee, JW Shin, DH Kim, SJ Heo, KD Park, JW Shin. "The effects of intermittent hydroststic pressure on cell adhesive forces and other related parameters under various resting periods," 2008, J. of Biomedical Materials Research: Part B, 87(B): 374-380.

SJ Heo, SA Park, HJ Shin, YJ Lee, TR Yoon, HY Seo, KC Ahn, SE Kim, JW Shin. "Evaluation of Bonding Stress for the Newly Suggested Bone Cement: Comparison with Currently Used PMMA through Animal Studies," 2007, Key Engineering Materials, 342: 373-376.

SJ Heo, SE Kim, YT Hyun, DH Kim, HM Lee, YM Hwang, SA Park, JW Shin. "In Vitro Evaluation of Poly e-Caprolactone/Hydroxyapatite Composite as Scaffolds for Bone Tissue Engineering with Human Bone Marrow Stromal Cells," 2007, Key Engineering Materials, 342: 369-372.

SJ Heo, SE Kim, W Jie, YT Hyun, DH Kim, HS Yun, JW Shin, YM Hwang, JW Shin. "Effects of HA Particle Sizes on Proliferation of Osteoblasts in Novel 3-dimensional HA/PCL Scaffolds, " 2007, Biomaterials Research, 11:70-74.

YT Hyun, SE Kim, SJ Heo, J Shin. "Characterization of PCL/HA Composite Scaffolds for Bone Tissue Engineering," 2007, Key Engineering Materials, 342: 109-112.

SE Kim, YT. Hyun, DJ Chung, SJ Heo, JW Shin, JH Lee. "Biodegradable Porous PCL/HA Scaffolds for Bone Tissue Engineering, " 2007, Key Engineering Materials, 342: 77-80.

JW Shin, YJ Kim, JH Kim, YJ Lee, SJ Heo, YM Hwang, DH Kim, JW Shin. "The effects of cyclic strains on the hybrid aligned nanofibrous scaffold seeded with smooth muscle cells," 2006, Molecular & Cellular Biomechanics, 3(4), 223-224.

SJ Heo, SE Kim, YT Hyun, DH Kim, JH Kim, YJ Lee, YJ Kim, JW Shin, YM Hwang, JW Shin. "Fabrication of Porous Scaffolds for Bone Tissue Engineering Using a 3-D Robotic System: Comparison with Conventional Scaffolds Fabricated by Particulate, "2006, Molecular & Cellular Biomechanics, 3(4), 179-180.

JW Shin, HJ Shin, SJ Heo, JH Kim, YM Hwang, DH Kim, JW Shin, "Dual Electrospinning to Manufacture Hybrid Nanofibrous Scaffold using Polyurethane and PEO, " 2006, J. of Biomedical Engineering Research, 27(5), 224-228.

Abstracts:
SJ Heo, TP Driscoll, SK Hashmi, RL Mauck, "Nuclear Remodeling During Fibrochondrogenesis Sensitizes Mesenchymal Stem Cells to Mechanical Stretch," 59th Annual Meeting of the Orthopaedic Research Society, San Antonio, TX. 2013. (Podium)

SJ Heo, SD Thorpe, TP Driscoll, SK Hashmi, DA Lee, RL Mauck, "Dynamic Stretch Rapidly Alters Nuclear Structure and Increases Chromatin Condensation in Mesenchymal Stem Cells," 59th Annual Meeting of the Orthopaedic Research Society, San Antonio, TX. 2013. (Podium)

AM. Silverstein, SJ Heo, RL. Mauck, "Nanofiber Length Scale Differentially Impacts Meniscus and Mesenchymal Stem Cell Morphology and Nuclear Deformation," 59th Annual Meeting of the Orthopaedic Research Society, San Antonio, TX. 2013. (Poster)

TP Driscoll, Shurden ZE, SJ Heo, RL Mauck "Cytoskeletal Tension is Required for Dynamic Tensile Loading Induced Alterations in Mesenchymal Stem Cell Shape, Nuclear Connectivity, and Scleraxis Expression," 59th Annual Meeting of the Orthopaedic Research Society, San Antonio, TX. 2013.(Podium)

SJ Heo, TP Driscoll, RL Mauck, "Dynamic Tensile Loading Activates TGF and BMP Signaling Mesenchymal Stem Cells on Aligned Nanofibrous Scaffolds, " Proceedings of the ASME 2012 Summer Bioengineering Conference. Farjardo, Fajardo, Puerto Rico. 2012. (Podium)

TP Driscoll, SJ Heo, RL Mauck "Dynamic Tensile Loading and Altered Cell Contractility Modulate Nuclear Deformation and Cytoskeletal Connectivity," Proceedings of the ASME 2012 Summer Bioengineering Conference. Farjardo, Fajardo, Puerto Rico. 2012. (Podium)

WM Han, SJ Heo, TP Driscoll, RL Mauck, DM Elliott "Micro-Scale Strain Transfer in Fiber-Reinforced Native Tissue is Distinct from Cell-Seeded Nanofibrous Scaffolds," Proceedings of the ASME 2012 Summer Bioengineering Conference, Fajardo, Puerto Rico. 2012. (Podium)

SJ Heo, TP Driscoll, RL Mauck, " Effects of Dynamic Tensile Loading on TGF and BMP Signaling Pathways in Mesenchymal Stem Cells on Aligned Nanofibrous Scaffolds," 38th Annual North East Bioengineering Conference, Philadelphia, PA. 2012. (Podium)

TP Driscoll, SJ Heo, RL Mauck, "Dynamic Tensile Loading and Altered Cell Contractility Modulate Nuclear Deformation and Nesprin Espression," 38th Annual North East Bioengineering Conference, Philadelphia, PA. 2012. (Podium)

WM Han, SJ Heo, TP Driscoll, RL Mauck, DM Elliott "Micro-Scale Strain Transfer in Fiber-Reinforced Native Tissues and Cell-Seeded Nanofibrous Scaffolds," 38th Annual North East Bioengineering Conference, Philadelphia, PA. 2012. (Podium)

SJ Heo, TP Driscoll, Z Zhong, RL Mauck, "Altered Mechanosensitivity of Fibrochondrogenic Mesenchymal Stem Cells with Modulation of Nuclear Mechanics," 58th Annual Meeting of the Orthopaedic Research Society, San Francisco, CA [**Spotlight session**]. (Podium)

SJ Heo, TP Driscoll, NL Nerurkar, RL Mauck, "Dynamic Tensile Stretch Promotes Lamin A/C Reorganization and Chromatin Condensation in Adult Stem Cells," 58th Annual Meeting of the Orthopaedic Research Society, San Francisco, CA. (Podium)

TP Driscoll, MT Yang, SJ Heo, RH Nakasone, CS Chen, RL Mauck, "Differential Nesprin Expression with Mesenchymal Stem Cell Fibrochondrogenesis and Altered Contractility," 58th Annual Meeting of the Orthopaedic Research Society, San Francisco, CA. (Podium)

SJ Heo, TP Driscoll, RL Mauck, "Differentiation and Dynamic Tensile Loading Enduces Lamin A/C reorganization and Heterochromatin formation. Penn Center for Musculoskeletal Disorders 8th Annual Symposium, Philadelphia, PA. October 26, 2011. [**poster - 1st place biomechanics**]

SJ Heo, NL Nerurkar, TP Driscoll, RL Mauck. "Differentiation and Dynamic Tensile Loading Alter Nuclear Mechanics and Mechanoreception in Mesenchymal Stem Cells," Proceedings of the ASME 2011 Summer Bioengineering Conference. Nemacolin Woodlands Resort, Famington, PA, June 22-25, 2011. (Podium)

SJ Heo, NL Nerurkar, RL Mauck. "Differentiation and deformation modulate nuclear mechanichs during mesenchymal stem cell fibrochondrogenesis," The Society for Physical Regulation in Biology and Medicine 29th Scientific Conference, Miami, FL, January 4 - 8, 2011 [**Rising Stars session**]. (Podium)

SJ Heo, NL Nerurkar, BM Baker, RL Mauck. "Fibrochondrogenesis attenuates stretch-induced nuclear deformation on aligned nanofibrous electrospun scaffolds," 57th Annual Meeting of the Orthopaedic Research Society, Long Beach, CA, January 13 - 16, 2011. (Poster)

SJ Heo, NL Nerurkar, BM Baker, RL Mauck. "Microstructure dictates stretch-induced cell and nucleus reorganization on aligned nanofibrous scaffolds," 57th Annual Meeting of the Orthopaedic Research Society, Long Beach, CA, January 13 - 16, 2011. (Podium)

DH Kim, SJ Heo, YG Kang, SH Kim, JW Shin, SH Park, JY Han, JW Shin. " The effects of intermittent hydrostatic pressure of the differentiation of mesenchymal stem cells co-cultured with chondrocytes in alginate beads, " SPRBM, Tucson, USA, 2010. (Poster)

JW Shin, NR Kim, SH Park, JY Jang, DH Kim, SJ Heo, JY Han, YG Kang, SH Kim, JW Shin. "The effects of TGF-β1 and culture medium on differentiation of human mesenchymal stem cells into cardiomyocytes, " SPRBM, Tucson, USA, 2010. (Poster)

DH Kim, KS Jee, SJ Heo, GD Park, JW Shin. "Evaluations of the cellular responses of novel Gelatin-Pluronic thermo-sensitive hydrogel using chondrocyte," TERMIS 2nd World Congress 2009, Seoul, KOREA, 2009. [**Best Poster Presentation award**]

SJ Heo, SE Kim, DH Kim, SW Lee, TR Yun, JW Shin. "Cell and Tissue In-growth Behavior into n-HA/PCL Composite Scaffold Fabricated by LMS: Comparison with Conventional SGP Scaffolds through Animal Studies, " TERMIS NA 2008, San Diego, Cal., USA, 2008. (Podium)

DH Kim, SH Park, JW Jun, SW Lee, JY Jang, JY Jeong, SJ Heo, JW Shin. "Effects of Intermittent Hydrostatic Pressure on the Chondrogenesis of Mesenchymal stem cells through 3D Co-culture, " TERMIS NA 2008, San Diego, Cal., USA, 2008. (Poster)

YJ Kim, DH Kim, JW Shin, SJ Heo, SH Park, SW Lee, Ji Y Jang, JY Jeong, KS Jee, JW Shin. "The Effects of Intermittent Hydrostatic Pressure Patterns: The Changes in Cell Adhesive along with Intracellular CA2+ Concentration, " TERMIS AP 2008, Chinese Taipei, 2008. (Poster)

SJ Heo, SE Kim, DH Kim, YT Hyun, SH Kim, JW Shin, JW Shin. "A novel 3-D scaffold of nano-hydroxyapatite/poly e-caprolactone by layer manufacturing process for bone tissue engineering," 26th Society for Physical Regulation in Biology and Medicine, Miami, Florida, USA, 2008. (Podium)

SJ Heo, SA Park, HJ Shin, YJ Lee, TR Yoon, HY Seo, KC Ahn, SE Kim, JW Shin. "Evaluation of bonding stress for the novel bone cement : comparison with currently used PMMA through animal studies, " 53th Annual Meeting of the Orthopaedic Research Society, Chicago, IL, USA, 2007. (Poster)

SA Park, JW Shin, SJ Heo, DH Kim, YM Hwang, WD Kim, JW Shin. "The effects of mechanical stretching on ligament fibroblats to the micropatterned silicone surface," 53th Annual Meeting of the Orthopaedic Research Society, Chicago, IL, USA, 2007. (Poster)

SJ Heo, SE Kim, YT Hyun, DH Kim, JH Kim, YJ Lee, YJ Kim, JW Shin, YM Hwang, JW Shin. "Fabrication of Porous Scaffolds for Bone Tissue Engineering Using a 3-D Robotic System: Comparison with Conventional Scaffolds Fabricated by Particulate Leaching, " 25th Society for Physical Regulation in Biology and Medicine, Honolulu, Hawaii, USA, 2007. (Podium)

SE Kim, YT Hyun, HS Yun, DJ Chung, SJ Heo, JW Shin. "Characterization of 3D scaffolds fabricated by a modified layer manufacturing process," 21st European Conference on Biomaterials, Birmingham, UK, 2007. (Podium)

SJ Heo, SE Kim, YT Hyun, DH Kim, HM Lee, JW Shin, YM Hwang, JH Kim, JW Shin. "Bone tissue engineering using poly e-caprolactone/hydroxyapatite 3-D scaffolds with human bone marrow stromal cells," 5th Asian International Symposium on Biomaterials, Xiamen, China, 2006. (Poster)