Welcome to Mauck Laboratory
The goals of our research program in soft tissue mechanobiology and tissue engineering are to understand the physiologic and patho-physiologic processes that regulate the formation, maturation, and adult function of soft connective tissues. We believe that such an understanding will better direct our efforts to generate functional tissue replacements with a particular focus on articular cartilage and the knee meniscus.
Our program utilizes various mechanical and biological testing modalities, scaffold fabrication techniques, and bioreactor culture conditions to explore these issues in both animal and human model systems. Specific information about current work in the Mauck Lab can be found by visiting the Ongoing Research Projects page.
- Congrats to Lachlan Smith and the translational spine research team for their paper entitled "Hypoxic Regulation of Functional Extracellular Matrix Elaboration by Nucleus Pulposus Cells in Long-Term Agarose Culture" accepted for publication in Journal of Orthopaedic Research!
- Congrats to Christain Pfeifer, Stu Kinsella, Dr. James Carey, and the OCD team on the publication of their paper entitled "Development of a Large Animal Model of Osteochondritis Dissecans of the Knee" accepted for publication in The Orthopaedic Journal of Sports Medicine!
- Congrats to Dr. Tristan Driscoll for successfully defending his thesis! Best of luck at Yale — we will miss you!
- Congrats to Rob Mauck for winning the 2015 Kappa Delta Young Investigator Award from the American Academy of Orthopaedic Surgeons!
- Congrats to Su Chin Heo for winning 1st place for his presentation at the International Biomedical Engineering Conference 2014 heald jointly with uHealthcare 2014!
- Congrats to Dr. Dodge for his groups research being featured in the Arthritis Foundation's "Spotlight on Research: Advances in OA Drug Discovery" winter newsletter!
- Congratulations to Sylvia Qu, Matt Fisher, and the meniscus translation team for their paper titled "Repair of Dense Connective Tissues via Biomaterial-Mediated Matrix Reprogramming of the Wound Interface" accepted for publication in Biomaterials!
- Congratulations to Tristan Driscoll for willing 1st place in the Histology category at the 2014 Penn Center for Musculoskeletal Disorders Annual Symposium poster competition!
- Congrats to DongHwa Kim for her paper titled "Phenotypic Stability, Matrix Elaboration, and Functional Maturation of Nucleus Pulposus Cells Encapsulated in Photocrosslinkable Hyaluronic Acid Hydrogels" accepted for publication in Acta Biomaterialia!
- Congrats to Su Chin Heo for successfully defending his thesis proposal!
- Welcome to rotating student Jon Beagan!
- Congratulations to Sylvia Qu for receiving a travel award for the 2014 TERMIS-AM Annual Conference!
- Congratulations John Martin and Harvey Smith for their paper titled "Population Average T2 MRI Maps Reveal Quantitative Regional Transformations in the Degenerating Rabbit Intervertebral Disc that Vary by Lumbar Level" accepted to the Journal of Orthopaedic Research!
- Congrats to Megan Farrell, John Shin, Lachlan Smith, and Rob Mauck for their paper titled "Functional Consequences of Glucose and Oxygen Deprivation on Engineered Mesenchymal Stem Cell-Based Cartilage Constructs" accepted for publication at Osteoarthritis and Cartilage!
- Congrats to Matt Fisher and the rest of the VA Cartilage Repair Team for their paper accepted at Tissue Engineering Part A entitled "Cartilage Repair and Subchondral Bone Remodeling in Response to Focal Lesions in a Mini-Pig Model: Impact of Injury Type and Treatment"!
- Congrats to Rob Mauck and Jason Burdick on the successful renewal of their NIH R01 entitled "Dynamic Fibrous Scaffolds for Repairing Dense Connective Tissues" for another five years!