Perelman School of Medicine at the University of Pennsylvania

McKay Orthopaedic Research Laboratory

Mauck Laboratory

John Martin

John Martin

Graduate Student in Mechanical Engineering
University of Pennsylvania

Hometown: Delran, NJ

Education:
B.S. Mechanical Engineering, 2006, The College of New Jersey
M.S. Mechanical Engineering/Bioengineering, 2008, University of Colorado at Boulder

Areas of Special Interest:
Intervertebral disc tissue engineering
Animal models of intervertebral disc degeneration

Publications:

  1. Martin JT, Kim DH, Ikuta K, Pfeifer CG, Smith LJ, Smith HE, Elliott DM, Mauck RL (2015). In vitro growth trajectory and in vivo implantation of cell-seeded disc-like angle ply structures for total disc replacement. (in preparation)
  2. Martin JT, Milby AH, Poudel S, Pfeifer CG, Smith HE, Elliott DM, Mauck RL (2015). A radiopaque electrospun scaffold for engineering fibrous tissues: Scaffold characterization and in vivo applications. Acta Biomaterialia (in review)
  3. Smith HE, Martin JT, Rihn J, Mauck RL, Anderson DG, Weiner BK, Vaccaro AR, Albert TH (2015). Mechanisms of lidocaine toxicity in bovine nucleus pulposus cells cultured in vitro. Spine J (in review)
  4. Gorth DJ, Martin JT, Dodge GR, Elliott DM, Malhotra NR, Mauck RL, Smith LJ (2015). In vivo retention and bioactivity of IL-1ra delivered from poly(lactic-co-glycolic acid) microspheres in the rat caudal intervertebral disc. J Exp Ortho (in press)
  5. Kim DH, Martin JT, Smith LJ, Elliott DM, Mauck RL (2015). Phenotypic stability, matrix elaboration, and functional maturation of nucleus pulposus cells encapsulated in photocrosslinkable hyaluronic acid hydrogels. Acta Biomaterialia (in press)
  6. Martin JT, Collins CM, Ikuta K, Mauck RL, Elliott DM, Zhang Y, Vaccaro AR, Albert TJ, Anderson DG, Collins CM, Smith HE (2015). Population average T2 MRI Maps reveal quantitative regional transformations in the degenerating rabbit intervertebral disc that vary by lumbar level. J Orthop Res; 33(1):140-148
  7. Martin JT, Milby AH, Chiaro JA, Kim DH, Smith LJ, Elliott DM, Mauck RL (2014). Translation of an engineered nanofibrous disc-like angle ply structure for intervertebral disc replacement in a small animal model. Acta Biomaterialia; 10(6):2473-2481
  8. Martin JT, Gorth DJ, Beattie EE, Smith LJ, Harfe BD, Elliott DM (2013). Needle puncture injury causes acute and long-term mechanical deficiency in a mouse model of intervertebral disc degeneration. J Orthop Res; 31:1276–1282
  9. Dodson RB, Martin JT, Hunter KS, Ferguson VL (2013). Determination of hyperelastic properties for umbilical artery in preeclampsia from uniaxial extension tests. Eur J Obstet Gynecol Reprod Biol; 169(2):207-212
  10. Holguin N, Martin JT, Elliott DM, Judex S (2012). Low-intensity vibrations partially maintain intervertebral disc mechanics and spinal muscle area during deconditioning. Spine J; 13(4):428-436
  11. Smith LJ, Martin JT, Elliott DM, Haskins ME, Ponder KP (2012). Effect of neonatal gene therapy on lumbar spine disease in mucopolysaccharidosis VII dogs. Mol Genet Metab; 107(1-2):145-15
  12. Showalter BL, Beckstein JC, Martin JT, Beattie EE, Espinoza Orias AA, Schaer TP, Vresilovic EJ, Elliott DM (2012). Comparison of animal discs used in disc research to human lumbar disc: torsion mechanics and collagen content. Spine; 37(15):E900-E907
  13. Smith LJ, Martin JT, Szczesny SE, Ponder KP, Haskins ME, Elliott DM (2009) Structural and biomechanical foundations of lumbar spine deformity in mucopolysaccharidosis type VII. J Orthop Res; 28(5):616-622

Conference Proceedings:

  1. Martin JT, Kim DH, Ikuta K, Pfeifer CG, Smith LJ, Elliott DM, Smith HE, Mauck RL (2015). In vitro growth trajectory and in vivo implantation of a cell-seeded disc-like angle ply structure for total disc replacement. 2015 Summer Biomechanics, Bioengineering and Biotransport Conference (Podium Presentation, PhD Competition Finalist)
  2. Martin JT, Ikuta K, Kim DH, Pfeifer CG, Smith LJ, Elliott DM, Smith HE, Mauck RL (2015). In vitro growth trajectory and in vivo implantation of a cell-based disc-like angle ply structure for total disc replacement. 61st Annual Meeting of the Orthopaedic Research Society (Podium Presentation)
  3. Martin JT, Collins CM, Ikuta K, Mauck RL, Elliott DM, Zhang Y, Anderson DG, Vaccaro AR, Albert TJ, Arlet V, Harvey HE (2015). Population average T2 MRI maps reveal quantitative regional transformations in the degenerating rabbit intervertebral disc that vary by lumbar level. 61st Annual Meeting of the Orthopaedic Research Society
  4. Martin JT, Ikuta K, Kim DH, Pfeifer CG, Smith LJ, Elliott DM, Smith HE, Mauck RL (2015). In vitro growth trajectory and in vivo implantation of a cell-based disc-like angle ply structure for total disc replacement. Philadelphia Spine Research Symposium (Podium Presentation, Best Paper – Diagnostics and Therapeutics)
  5. Martin JT, Mauck RL, Zhang Y, Elliott DM, Smith HE (2014). Population average T2 MRI maps reveal quantitative transformations of the degenerating disc in a rabbit puncture model. 7th World Congress of Biomechanics, Boston, MA
  6. Farrell MJ, Cosgrove BD, Martin JT, Mauck RL (2014). Micromechanical Assessment of Chondrogenic Stem Cell Heterogeneity. 60th Annual Meeting of the Orthopaedic Research Society, New Orleans, LA
  7. Martin JT, Milby AH, Chiaro JA, Kim DH, Smith LJ, Smith HE, Elliott DM, Mauck RL (2014). Engineered nanofibrous disc-like angle ply structures with sacrificial layers for intervertebral disc replacement in a small animal model. 60th Annual Meeting of the Orthopaedic Research Society, New Orleans, LA
  8. Martin JT, Poudel S, Milby AH, Pfeifer C, Smith HE, Elliott DM, Mauck RL (2014). A radiopaque electrospun scaffold for engineering fibrous tissues: characterization and in vivo application. 60th Annual Meeting of the Orthopaedic Research Society, New Orleans, LA (Podium Presentation)
  9. Milby AH, Martin JT, Smith LJ, Chiaro JA, Smith HE, Elliot DM, Mauck RL (2014). Nanofibrous disc-like angle structures for intervertebral disc tissue engineering in a small animal model. 7th Annual Lumbar Spine Research Society Meeting, Chicago, IL (Podium Presentation)
  10. Martin JT, Milby AH, Chiaro JA, Hebela NM, Elliott DM, Mauck RL (2013). Translation of a nanofibrous disc-like angle ply structure for intervertebral disc replacement in a small animal model. Philadelphia Spine Research Society, Second International Spine Research Symposium, Philadelphia, PA (Podium Presentation)
  11. Gorth DJ, Martin JT, Elliott DM, Dodge GR, Malhotra NR, Mauck RL, Smith LJ (2013). In vivo retention and bioactivity of IL-1ra microspheres in the rat caudal intervertebral disc. International Society for Studying the Lumbar Spine Annual Meeting 2013, Scottsdale, Arizona
  12. Martin JT, Smith LJ, Milby AH, Gorth DJ, Adan A, Hebela NM, Elliott DM, Mauck RL (2013). Nanofibrous disc-like angle ply structures maintain disc height in the rat caudal spine. 59th Annual Meeting of the Orthopaedic Research Society, San Antonio, TX
  13. Gorth DJ, Martin JT, Hebela NM, Mauck RL, Elliott DM, Smith LJ (2013). In vivo delivery of IL-1ra from PLGA microspheres prevents IL-1β induced extracellular matrix loss in the rat caudal intervertebral disc. 59th Annual Meeting of the Orthopaedic Research Society, San Antonio, TX (Podium Presentation, Spotlight Session)
  14. Smith LJ, Gorth DJ, Martin JT, Chiaro JA, Dodge GR, Hebela N, Mauck RL, Elliott DM (2012). In Vivo Delivery of IL-1ra from PLGA microspheres attenuates IL-1β induced nucleus pulposus glycosaminoglycan loss in the rat caudal intervertebral disc. 2012 Gordon Research Conference: Musculoskeletal Biology and Bioengineering, Andover, NH
  15. Smith LJ, Gorth DJ, Chiaro JA, Martin JT, Dodge GR, Malhotra NR, Hebela NM, Mauck RL, Elliott DM. Targeting inflammation in intervertebral disc degeneration. 2012. International Symposium on Nanomedicine in Drug Delivery and Cancer Diagnosis, Newark, DE
  16. Martin JT, Smith LJ, Gorth DJ, Hebela N, Elliott DM, Mauck RL (2012). Nanofibrous disc-like angle ply structures maintain rat caudal intervertebral disc height. 2012 Military Health System Research Symposium, Fort Lauderdale, FL
  17. Martin JT, Beattie EE, Gorth DJ, Smith LJ, Elliott DM (2012). Mechanical consequences of needle puncture injury in the mouse caudal disc. American Society of Mechanical Engineers Summer Bioengineering Conference, Fajardo, Puerto Rico, USA (Podium Presentation, PhD Competition Finalist)
  18. Martin JT, Beattie EE, Gorth DJ, Smith LJ, Elliott DM (2012). Mechanical and biochemical consequences of needle puncture injury in the mouse caudal disc. 58th Annual Meeting of the Orthopaedic Research Society, San Francisco, CA (Podium Presentation, Spotlight Session)
  19. Martin JT, Beattie EE, Smith LJ, Elliott DM (2011). Mechanical consequences of needle puncture injury in the mouse caudal disc. Spine Research Symposium: New Horizons in Intervertebral Disc Research, Philadelphia, PA
  20. Showalter BL, Beckstein JC, Martin JT, Beattie EE, Espinoza Orías AA, Schaer TP, Vresilovic EJ, and Elliott DM (2011). Disc torsion mechanics: Comparison of animal models to human, American Society of Mechanical Engineers Summer Bioengineering Conference, Farmington, PA
  21. Kluge JA, Martin JT, Nerurkar NL, Amaniera FA, Pampati RA, Elliott DM, Mauck RL (2010). Functional enhancement of disc-like angle-ply structures via dynamic culture, 57th Annual Meeting of the Orthopaedic Research Society, Long Beach, USA
  22. Elliott DM, Nerurkar NL, Huang AH, Kluge JA, Smith LJ, Martin JT, Hebela N, Mauck RL (2010). Disc Tissue Engineering – Can We Make it Stick? 6th World Congress on Biomechanics, Suntec City, Singapore (Keynote Presentation)
  23. Ponder KP, Smith LJ, Martin JT, Gerasimowicz KM, Haskins ME, Elliott DM (2010) Altered cervical spine biomechanical properties and gene expression in Mucopolysaccharidosis VII dogs, 11th International Symposium on Mucopolysaccharide and Related Diseases, Adelaide, Australia
  24. Ponder KP, Smith LJ, Elliott DM, Martin JT, Wu S, Liu Y, Haskins ME (2010) Molecular mechanisms for skeletal/soft tissue pathology, 11th International Symposium on Mucopolysaccharide and Related Diseases, Adelaide, Australia
  25. Martin JT, Balderston JR, Gerasimowicz KM, Smith LJ, Hebela N, Elliott DM (2010) Direct effects of intervertebral disc needle puncture injury on mouse lumbar and caudal motion segment mechanical function, 56th Annual Meeting of the Orthopaedic Research Society, New Orleans, USA
  26. Smith LJ, Ponder KP, Martin JT, Haskins ME, Eliott DM (2010) Lumbar spine segment mechanical properties, composition and gene expression in Mucopolysaccharidosis VII dogs following neonatal gene therapy, 56th Annual Meeting of the Orthopaedic Research Society, New Orleans, USA
  27. Martin JT, Ferguson VL (2009) Regional similarities in the mechanical properties of the human umbilical artery, American Society of Mechanical Engineers Summer Bioengineering Conference, Lake Tahoe, USA
  28. Smith LJ, Martin JT, Szczesny SE, Ponder KP, Haskins ME, Elliott DM (2009) Mucopolysaccharidosis VII and the developing lumbar spine: consequences for annulus fibrosus and vertebral end plate mechanical properties, American Society of Mechanical Engineers Summer Bioengineering Conference, Lake Tahoe, USA
  29. Smith LJ, Martin JT, Ponder KP, Haskins ME, Elliott DM (2009) Structural and mechanical consequences of mucopolysaccharidosis VII for the developing lumbar spine, International Society for the Study of the Lumbar Spine Annual Meeting, Miami, USA
  30. Martin JT, Ferguson VL (2008) Biomechanics of Umbilical Cord Tissues, Reproductive Bioengineering 2008, Wenns/Pitzal, Austria