Perelman School of Medicine at the University of Pennsylvania

McKay Orthopaedic Research Laboratory

Mauck Laboratory

Claire McLeod

Claire McLeod

Graduate Student in Bioengineering
University of Pennsylvania

Hometown: Lake Tahoe, Nevada

Education: B.S. Engineering with a concentration in Bioengineering, 2011, Franklin W. Olin College of Engineering, Needham, MA

Areas of Special Interests: Stem cell differentiation, cell-matrix interactions, mechanical regulation of cell behavior, tissue engineering.

Awards:

2015, Scholarship and travel award, Summer Institute for Statistics in Big Data, University of Washington

2015, Second Place Talk Award, University of Pennsylvania Bioengineering Graduate Student Symposium

2014, Top Poster Award, University of Pennsylvania Orthopaedic Research Day

2011, NSF Graduate Research Fellowship

Publications:
C. McLeod, J. Higgins, Y.A. Miroshnikova, R. Liu, A.L. Sarang-Sieminski, "Microscopic matrix remodeling precedes endothelial morphological changes during capillary morphogenesis," J Biomech Eng 2013; 135(7): 071002

BM.D. Stevenson, A.L. Sieminski, C.M. McLeod, F.J. Byfield, V.H. Barocas, K.J. Gooch. "Pericellular conditions regulate extent of cell-mediated compaction of collagen gels," Biophysical Journal 2010; 99(1): 19-28.

Abstracts:
A.J. Cote*, C.M. McLeod*, A. Raj**, R.L. Mauck**. "Single-cell RNA FISH analysis of mesenchymal stem cell chondrogenesis and chondrocyte dedifferentiation challenges traditional definitions of phenotype," Keystone Symposium on Transcriptional and Epigenetic Influences on Stem Cell States, March 2015, Keystone CO (poster by AJC). * co-first authors, **co-senior authors.

J. Haupt, B. Cosgrove, C. McLeod, A. Culbert, R. Mauck, E. Shore. "Altered force sensing and cell-cell adhesion by mutant ACVR1/ALK2 FOP progenitor cells- implications for heterotopic ossification," ASBMR, September 2014, Houston TX (talk by JH). 2014 ASBMR Young Investigator Award.

B.D. Cosgrove, M.J. Farrell, M. Dunagin, C.M. McLeod, A.J. Cote, A. Raj, R.L. Mauck. "Inherent and Emergent Heterogeneity in Clonal Stem Cell Populations," Orthopaedic Research Society Annual Meeting, March 2014, New Orleans LA (talk by BDC).

C.M. McLeod, R.L. Mauck. "Mechanobiologic Heterogeneity in Clonal Mesenchymal Stromal Cell Populations," Cellular and Molecular Bioengineering Conference, January 2014, San Diego CA (poster by CMM).

B.D. Cosgrove, M.J. Farrell, M. Dunagin, C.M. McLeod, A.J. Cote, A. Raj, R.L. Mauck. "Inherent and Emergent Heterogeneity in Clonal Stem Cell Populations," Cellular and Molecular Bioengineering Conference, January 2014, San Diego CA (poster by BDC).

C.M. McLeod, T.P. Driscoll, B.D. Cosgrove, S. Heo, R.L. Mauck, "Mesenchymal Stem Cell Mechanobiology is Clone Dependent," Biomedical Engineering Society Annual Meeting, September 2013, Seattle, WA (talk by CMM).

B.D. Cosgrove, C.M. McLeod, R.L. Mauck, "Heterogeneous Traction Force Distributions in MSC Clonal Populations," Biomedical Engineering Society Annual Meeting, September 2013, Seattle, WA (poster by BDC).

C.M. McLeod, J. Higgins, Y.A. Miroshnikova, R. Liu, A.L. Sarang-Sieminski, "Local Matrix Alignment During Microvascular Network Formation," Biomedical Engineering Society Annual Meeting, October 2011, Hartford, CT (talk by ALSS)

M.D. Stevenson, A.L. Sieminski, C.M. McLeod, F.J. Byfield, V.H. Barocas, K.J. Gooch, "Pericellular Conditions Regulate Extent of Cell-mediated Compaction of Collagen Gels," Biomedical Engineering Society Annual Meeting, Austin Texas, October 2010 (poster by MDS)

C.M. McLeod, Y.A. Miroshnikova, A.L. Sieminski, "Microscopic Matrix Remodeling During Capillary Morphogenesis," Biomedical Engineering Society Annual Meeting, 2009, Pittsburgh, PA (poster by CMM)

M.D. Stevenson, A.L. Sieminski, C.M. McLeod, F.J. Byfield, V.H. Barocas, K.J. Gooch, "Pericellular Conditions Regulate Extent of Cell-mediated Compaction of Collagen Gels," Biomedical Engineering Society Annual Meeting, 2009, Pittsburgh, PA (poster by MDS)