Perelman School of Medicine at the University of Pennsylvania

McKay Orthopaedic Research Laboratory

Mauck Laboratory

Minwook Kim

Minwook Kim

Research Engineer
Graduate Student in Bioengineering
University of Pennsylvania

Hometown: Seoul, Korea

 


Education:

M.S. Biomedical Engineering, 2004, City College of New York (CUNY), New York, NY
B.S. Mechanical Engineering, 2000, Myong-Ji University, Korea

Areas of Special Interest: Minwook joined Dr. Mauck's lab in August 2009. His research has focused on cartilage tissue engineering using mesenchymal stem cells and integrative cartilage repair. Before joining the lab, Minwook worked at the Hospital for Special Surgery under direction of Drs. Nancy Pleshko and Adele Boskey and Nemours/Alfred I. DuPont Hospital for Children under direction of Dr. George Dodge. Personal interests include fishing, playing soccer, basketball and drums with his three children.

Awards:
Force and Motion Foundation Scholarship (AMTI) (2012-2013)

Young Investigator Award: The 9th International Conference on the Chemistry and Biology of Mineralized Tissues (ICCBMT), Austin, TX, Nov. 2007

Publications:
Kim M, Burdick JA, Mauck RL, “Mechanism of Enhanced Functional Properties with Co-culture of Adult MSCs and Juvenile Chondrocytes in Hyaluronic Acid Hydrogels” (In preparation)

Kim M, Farrell MJ, Burdick JA, Mauck RL, “Enhanced Nutrient Transport Improves Depth-dependent Properties of a Tri-layered HA Construct with Zonal Co-culture of Chondrocytes and MSCs” (In preparation)

Kim M, Garrity ST, Burdick JA, Dodge GR, Mauck RL, “Media Components Regulate Functional Properties of MSC-laden Hyaluronic Acid Hydrogel in Long-term Culture” (In preparation)

Kim M, Erickson IE, Huang AH, Garrity ST, Burdick JA, Mauck RL, “Functional Chondrogenesis of Human Mesenchymal Stem Cells in Hyaluronic Acid Hydrogels: Effect of Donor Variability, Gel Mechanics, and Contractility” (In preparation)

Erickson IE, Kestle SR, Zellars KH, Farrell MJ, Kim M, Burdick JA, and Mauck RL, “High Stem Cell Seeding Densities in Hyaluronic Acid Hydrogels Produce Engineered Cartilage with Native Tissue Properties,” Acta Biomater. 2012 Aug; 8(8):3027-34. Epub 2012 Apr 27.

Kim M, Erickson IE, Choudhury M, Pleshko N, and Mauck RL, “Transient exposure of TGF-ß3 improves the functional chondrogenesis of MSC-laden hyaluronic acid hydrogels,” J Mech Behav Biomed Mater. 2012 Jul; 11: 92-101. Epub 2012 Mar 24.

Kim M, Pugarelli J, Miller TL, Wolfson MR, Dodge GR, and Shaffer TH, “Brief Mechanical Ventilation Impacts Airway Cartilage Properties in Neonatal Lambs,” Pediatr Pulmonol. 2012 Aug; 47(8):763-70.doi: 10.1002/ppul.21616. Epub 2011 Dec 13.

Kim M, Volk AC, Kraft JJ, Pugarelli J, Pleshko N, and Dodge GR, “Characterizaton of a tissue engineered porcine cartilage using a self aggregating suspension culture (SASC) model: a long-term (4 year) study,” J Orthop Res. 2011 Dec; 29(12):1881-7. Doi:10.1002/jor.21467. Epub 2011 May 31.

Arteaga E, Arteaga SL, Kim M, Jepsen K, Schaffler M, Pleshko N, Ramirez F, “Material and Mechanical properties of bones deficient for fibrillin-1 or fibrillin-2 microfibrils,” Matrix Biol. 2011 Apr;30(3):188-94.doi:10.1016/j.matbio.2011.03.004. Epub 2011 Mar 29.

Huang AH, Farrell MJ, Kim M, Mauck RL, "Long-term Dynamic Loading improves the mechanical properties of chondrogenic mesenchymal stem cell-laden hydrogels," Eur Cell Mater. 2010 Feb 26; 19:72-85

Kim M, Foo LF, Lyman E, Ryaby JT, Grande DA, Potter HG, Pleshko N, “Evaluation of f early osteochondral defect in a rabbit model utilizing Fourier transform-infrared imaging spectroscopy (FT-IRIS), Magnetic resonance imaging (MRI) and quantitative T2 mapping,” Tissue Eng Part C Methods. 2010 Jun:16(3):355-64

Kim M, Bi X, Horton WE, Spencer RG, Camacho NP, “Fourier transform infrared imaging spectroscopic analysis of tissue engineered cartilage: histologic and biochemical correlations,” J Biomed Opt. 2005, May-Jun; (10)3:031105

Abstracts:
Kim M, Burdick JA, Mauck RL, “Enhanced Nutrient Transport Improves Depth-dependent Properties of a Tri-layered HA Construct with Zonal Co-culture of Chondrocytes and MSCs” 2014, Transactions of the 60th Annual Orthopaedic Research Society Meeting, New Orleans, LA

Kim M, Garrity ST, Burdick JA, Dodge GR, Mauck RL, “Media Components Regulate Functional Properties of MSC-laden Hyaluronic Acid Hydrogel in Long-term Culture” 2014, Transactions of the 60th Annual Orthopaedic Research Society Meeting, New Orleans, LA

Kim M, Burdick JA, Mauck RL, “Mechanism of Enhanced Functional Properties with Co-culture of Adult MSCs and Juvenile Chondrocytes in Hyaluronic Acid Hydrogels” 2014, Transactions of the 60th Annual Orthopaedic Research Society Meeting, New Orleans, LA

Pfeifer CG, Kim M, Farrell MJ, Pacifici M, Mueller MB, Mauck RL, “Attenuation of MSC Hypertrophy in 3D Culture via Treatment with a Retinoic Acid Receptor Inverse Agonist” 2014, Transactions of the 60th Annual Orthopaedic Research Society Meeting, New Orleans, LA

Kim D, Smith LJ, Kim M, Elliott DM, Mauck RL, “Functional Maturation of a Cell-seeded Hyaluronic Acid Hydrogel-Based Engineered Nucleus Pulpous” Biomedical Engineering Society Annual Meeting, 2013, Seattle, WA

Kim M, Burdick JA, Mauck RL, “Age-dependent Impact on Co-cultures with MSCs and Zonal Chondrocytes in HA Hydrogels for Cartilage Tissue Engineering” Osteoarthritis Research Society International 2013 World Congress, Philadelphia, PA

Kim M, Farrell MJ, Burdick JA, Mauck RL, “Depth-Dependent Properties of a Tri-layered Hyaluronic acid Hydrogel Construct with Zonal Co-culture of chondrocytes and MSCs” 2013, Transactions of the 59th Annual Orthopaedic Research Society Meeting, San Antonio, TX

Kim M, Burdick JA, Mauck RL, “Influence of Chondrocyte Zone on Co-cultures with Mesenchymal Stem Cells in HA Hydrogels for Cartilage Tissue Engineering” Proceedings of the ASME 2012 Summer Bioengineering Conference, Farjardo, Puerto Rico, USA

Kim M, Garrity ST, Erickson IE, Huang AH, Burdick JA, Mauck RL, “Optimization of Macromer Density in Human MSC-laden Hyaluronic Acid (HA) Hydrogels” 2012, North Eastern Bioengineering Conference, Philadelphia, PA

Kim M, Garrity ST, Erickson IE, Choudhury M, Mauck RL, “Removal from Defined Media Reduces Properties of MSC-Laden HA Hydrogels after Transient TGF-ß3 Exposure” 2012, Transactions of the 58th Annual Orthopaedic Research Society Meeting, San Francisco, CA

Kim M, Erickson IE, Burdick JA, Mauck RL, “Transient Exposure to TGF-ß3 Improves the Functional Properties of MSC-Seeded Photocrosslinked Hyaluronic Acid Hydrogels,” Proceedings of the ASME 2011 Summer Bioengineering Conference, Farmington, PA

Kim M, Erickson IE, Huang AH, Dodge GR, Burdick JA, Mauck RL, “Variability in Human MSC Functional Chondrogenesis in Photocrosslinked Hyaluronic Acid Hydrogels,” 2011, Transactions of the 57th Annual Orthopaedic Research Society Meeting, Long Beach, CA

Kim M, Erickson IE, Huang, AH, Schenker M, Dodge GR, Burdick JA, Mauck RL, “Functional Maturation of Porcine MSC- and Chondrocyte-Seeded Hydrogels for Cartilage Repair,” 2011, Transactions of the 57th Annual Orthopaedic Research Society Meeting, Long Beach, CA

Erickson IE, Kestle SR, Kim M, Zellars KH, Burdick JA, Dodge GR, Mauck RL, “uCT and Mechanical Analysis of Maturation and Integrative Cartilage Repair in MSC-Seeded HA Hydrogels,” 2010, Tissue Engineering and Regenerative Medicine International Society-North America Annual Conference, Orlando, FL

Kim M, Erickson, IE, Burdick JA, Dodge GR, Mauck RL, “Differential Chondrogenic Potential of Human and Bovine Mesenchymal Stem Cells in Agarose and Photocrosslinked Hyaluronic Acid Hydrogels,” Proceedings of the ASME 2010 Summer Bioengineering Conference, Naples, FL

Kim M, Dodge GR, Pugarelli J, Miller TL, Wolfson MR, Shaffer TH, "Mechanical Ventilation (MV) of the neonatal airway: Effect on mechanical and macromolecular properties of cartilage,” 2010, Pediatric Academy Society, Vancouver, BC, Canada

Kim M, Erickson IE, Yoder J, Mauck RL, Witschey W, Fenty M, Reddy R, Dodge GR, "Evaluation of Integrative Cartilage Repair with Scaffold-free Constructs," 2010, Transactions of the 56th Annual Orthopaedic Research Society Meeting, New Orleans, LA

Volk A, Kim M, Dodge GR, “Biocellulose: A Novel Bioscaffold that supports chondrocyte growth and phenotype,”2010, Transactions of the 56th Annual Orthopaedic Research Society Meeting, New Orleans, LA

Kim M, Mauck R.L, Dodge GR, “Evaluation of cartilage Integration using Tissue Engineered Cartilage in an in vitro model of Cartilage Repair,” 2009, World Congress on Osteoarthritis Research Society International, Montreal, Quebec, Canada

Volk A, Kim M, Dodge GR, “Demonstration of a Novel Bioscaffold Suitable for Use in Cartilage Tissue Engineering that Supports Chondrocytes Phenotype,” 2009, World Congress on Osteoarthritis, Montreal, Quebec, Canada

Kim M, Volk A, Kraft J A, Pugarelli J, Pleshko N, Dodge GR. “FT-IRIS and phenotypic characterization of a tissue engineered porcine cartilage using a self aggregating suspension culture (SASC) medel: a long-term (4 year) study,” 2009, Transactions of the 55th Annual Orthopaedic Research Society Meeting, Las Vegas, NV

Kundi R, Liu B, Doty S, Pleshko Camacho N, Zohlman A, Kim M, Kent KC, “Adaptive Remodeling after Injury is Associated with Quantitative and Qualitative Changes in Adventitial Collagen,” 2008, Academic Surgical Congress, Fort Myers, FL

Kim M, Hidaka C, Cheng C, Deguchi Y, Yamauchi M, Spencer RG, Pleshko Camacho N. “Analysis of Tissue Engineered Mammalian Cartilage Grown in a Hollow Fiber Bioreactor (HFBR),” 2008, Transactions of the 54th Annual Orthopaedic Research Society Meeting, San Francisco, CA

Raggio CL, Fishbein KW, Carter EM, Kim M, Pleshko N, Spencer RG. “Indentification of Skin Abnormalities in Osteogenesis Imperfecta Patients by Magnetic Resonance Imaging - A Pilot Study,” 2008, The American Society for Bone and Mineral Research, Montreal, Quebec, Canada

Raggio CL, Fishbein KW, Carter EM, Kim M, Pleshko N, Spencer RG. “Indentification of Skin Abnormalities in Osteogenesis Imperfecta Patients by Magnetic Resonance Imaging - A Pilot Study,” 2008, The American Society of Human Genetics, Philadelphia, PA

Kim M, Lee-Arteaga S, Ramirez F, Pleshko Camacho N, “Defective Mineralization in Fibrillin 1 Knockout Mice,” 2007, The 9th International Conference on the Chemistry and Biology of Mineralized Tissues, Austin, TX

Kim M, Richardson JB, Evans EH, Roberts S, Pleshko Camacho N. “Fourier transform infrared Imaging spectroscopic (FT-IRIS) and histological assessment of cartilage repair following autologous chondrocyte implantation,” 2007, Transactions of the 53rd Annual Orthopaedic Research Society Meeting, San Diego, CA

Devon C, Kim M, Attia E, Torzilli PA, Peterson M, Pleshko Camacho N, Maher SA. “Incorporation of FN into PVA scaffolds enhances chondrocyte adhesion,” 2007, Transactions of the 53rd Annual Orthopaedic Research Society Meeting, San Diego, CA

Conte EJ, Kim M, Cheng C, Pleshko Camacho N, Hidaka C. “Formation of engineered cartilage-like tissue with superficial or deep zone chondrocytes,” 2007, Transactions of the 53rd Annual Orthopaedic Research Society Meeting, San Diego, CA

Uggen C, Foo L, Kim M, Moynihan D, Ryaby J, Potter H, Pleshko Camacho N, Grande D. “Repair of osteochondral d efects in the rabbit with the synthetic peptide TP-508,” 2007, Transactions of the 53rd Annual Orthopaedic Research Society Meeting, San Diego, CA

Kundi R, Liu B, Doty S, Pleshko Camacho N, Kim M, Zohlman A, Wang C, Tsai S, Kent C. “Adaptive Remodeling After Injury Is Associated With Quantitative and Qualitative Changes In Adventital Collagen,” 2007, American Heart Association Scientific Sessions, Orlando, FL

Kim M, Hidaka C, Cheng C, Ramaswamy S, Spencer RG, Camacho NP. “Development and analysis of tissue-engineered mammalian cartilage in a hollow-fiber bioreactor: FTIR spectroscopic and gene expression studies,” 2006, International Cartilage Repair Society Meeting, San Diego, CA

Kim M, Devon C, Doty S, Maher Z, Camacho NP. “Distribution of PLGA and PVA in hydrogels as determined by Fourier transform infrared imaging spectroscopy (FT-IRIS),” 2006, International Cartilage Repair Society Meeting, San Diego, CA

Potter HG, Foo LF, Tamaroff E, Lyman S, Kim M, Ryaby JT, Moyniham D, Grande DA. “MRI, quantitative T2 mapping and FT-IRIS of cartilage repair using a synthetic thrombin receptor based peptide (TP-508) in a rabbit model,” 2006, International Cartilage Repair Society Meeting, San Diego, CA

Kim M, Bi X, Horton WE, Spencer RG, Camacho NP. “Fourier Transform Infrared Imaging Spectroscopy (FT-IRIS) of Tissue Engineered Cartilage correlated with biochemical S-GAG determination,” 2005, Transactions of the 51st Annual Orthopaedic Research Society Meeting, Washington, DC

Thesis:
Kim M, “Fourier Transform infrared imaging spectroscopic (FT-IRIS) analysis of cartilage degradation,” 2004, viii, 79 leaves: ill. ; 28cm, Department of Biomedical Engineering, City College of New York (CUNY) and Hospital for Special Surgery, New York, NY, USA