Perelman School of Medicine at the University of Pennsylvania

McKay Orthopaedic Research Laboratory

Mourkioti Laboratory

Welcome to Mourkioti Lab

  • cardiac
  • skeletal muscle

Our lab has a long-term interest in understanding the fundamental aspects of skeletal muscle and cardiac function in normal or diseased conditions and in the practical aspects of manipulating these functions by using animal models and tissue engineering approaches for treatment intervention.

We believe that combining bioengineering approaches with stem cell biology, testing cell-based therapies and modulating the signaling pathways of adult stem cells we can enhance the replacement of skeletal muscle and cardiac tissue upon injury. We are presently combining genetic knockout mice and gene recombination with cellular engineering techniques to investigate the temporal and spatial communication of cells and signaling pathways during muscle regeneration.