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McKay ORL > Liu Lab > X. Sherry Liu

X. Sherry Liu, Ph.D.

Assistant Professor of Orthopaedic Surgery
Assistant Professor of Bioengineering

HOMETOWN
Beijing, China

EDUCATION
Ph.D. Biomedical Engineering, 2007, Columbia University, New York, NY
M.S. Biomedical Engineering, 2004, Columbia University, New York, NY
B.E. Electrical Engineering and Applied Science, 2002, Tsinghua University, Beijing, P. R. China

RESEARCH POSITIONS
2009-2011: Associate Research Scientist, Division of Endocrinology, College of Physicians and Surgeons, Columbia University, New York, NY
2007-2009: Post-Doctoral Research Scientist, Department of Biomedical Engineering and Medicine, Columbia University, New York, NY

AREAS OF EXPERTISE
Imaging and Image Analysis of Biological Tissues
Bone Biomechanics
Metabolic Bone Diseases

MANUSCRIPTS
  1. Lan S, Luo S, Huh BK, Chandra A, Altman AR, Qin L, and Liu XS, 3D Image registration is critical to ensure accurate detection of longitudinal changes in trabecular bone density, microstructure, and stiffness measurements in rat tibiae by in vivo micro computed tomography (µCT), Bone (in press)
  2. Wang H, Ji B, Liu XS, Guo XE, Huang Y, Hwang K-C, Osteocyte-viability-based simulations of bone loss and recovery in disuse and reloading, Biomechanics and Modeling in Mechanobiology (in press)
  3. Nickolas TL, Stein EM, Dworakowski E, Nishiyama K, Komandah-Kosseh M, Zhang CA, McMahon DJ, Liu XS, Boutroy S, Cremers S, and Shane E, Rapid cortical bone loss in patients with chronic kidney disease, Journal of Bone and Mineral Research (in press)
  4. Cohen A, Dempster DW, Recker RR, Lappe JM, Zhou H, Wirth AJ, van Lenthe GH, Zwahlen A, Muller R, Zhao B, Guo X, Lang T, Saeed I, Liu XS, Guo XE, Cremers S, Rosen CJ, Stein EM, Nickolas TL, McMahon DJ, Young P, Shane E, Abdominal fat is associated with lower bone formation and lower trabecular bone volume in healthy premenopausal women: a transiliac bone biopsy study, Journal of Clinical Endocrinology and Metabolism (in press)
  5. Chandra A, Lan S, Zhu J, Siclari V, Altman A, Cengel K, Liu XS, and Qin L, PTH prevents the adverse effects of focal radiation on bone architecture in young rats, Bone (in press)
  6. Liu XS, Wang J, Zhou B, Stein E, Shi X, Adams M, Shane E, Guo XE, Fast trabecular bone strength predictions of HR-pQCT and individual trabeculae segmentation (ITS)-based plate and rod finite element model discriminate postmenopausal vertebral fractures, Journal of Bone and Mineral Research (in press)
  7. Wang H, Liu XS, Zhou B, Wang J, Ji B, Huang Y, Hwang K-C, Guo XE, Accuracy of plate-rod microstructural finite element models of trabecular bone based on individual trabecula segmentation, Journal of Biomechanical Engineering (in press)
  8. Walker MD, Liu XS, Zhou B, Agarwal S, Liu G, McMahon DJ, Bilezikian JP, and Guo XE, Pre- and post-menopausal differences in bone microstructure and mechanical competence in Chinese-American and White women, Journal of Bone and Mineral Research,(Epub ahead of print, doi:10.1002/jbmr.1860)
  9. Cohen A, Lang TF, McMahon DJ, Liu XS, Guo XE, Zhang C, Stein EM, Dempster DW, Young P, Saeed I, Lappe JM, Recker RR, Shane E, Central QCT reveals lower volumetric BMD and stiffness in premenopausal women with idiopathic osteoporosis, regardless of fracture history, Journal of Clinical Endocrinology and Metabolism,97(11): 4244-52, 2012
  10. Wang H, Ji B, Liu XS, Guo, XE, Huang Y, Hwang K-C, Analysis of microstructural and mechanical alterations of trabecular bone in a simulated three-dimensional remodeling process, Journal of Biomechanics, 45(14): 2417-25, 2012
  11. Stein EM, Liu XS, Nickolas TL, Cohen A, McMahon DJ, Zhou B, Zhang C, Kamanda-Kosseh M, Cosman F, Nieves J, Guo XE, Shane E, Microarchitectural Abnormalities are More Severe in Postmenopausal Women with Vertebral Compared to Non-vertebral Fractures, Journal of Clinical Endocrinology and Metabolism, 97(10): E1918-26, 2012
  12. Liu XS, Ardeshirpour L, VanHouten JN, Shane E, and Wysolmerski JJ, Site-Specific Changes in Bone Microarchitecture, Mineralization, and Stiffness during Lactation and After Weaning in Mice, Journal of Bone and Mineral Research, 27 (4): 865-75, 2012. (Featured on the journal's cover)
  13. Liu XS, Stein EM, Zhou B, Zhang CA, Nickolas TL, Cohen A, Thomas V, McMahon DJ, Cosman F, Nieves J, Shane E, and Guo XE, Individual Trabecula Segmentation (ITS)-Based Morphological Analyses and Micro Finite Element Analysis of HR-pQCT Images Discriminate Postmenopausal Fragility Fractures Independent of DXA Measurements, Journal of Bone and Mineral Research, 27 (2):263-72, 2012.
  14. Peng S, Liu XS, Huang S, Li Z, Pan H, Zhen W, Luk KD, Guo XE, Lu WW, The Cross-talk between Osteoclasts and Osteoblasts in Response to Strontium Treatment: Involvement of Osteoprotegerin, Bone, 49 (6): 1290-8, 2011.
  15. Liu XS, Shane E, McMahon DJ, and Guo XE, Individual Trabeculae Segmentation (ITS)-Based Morphological Analysis of Micro-Scale Images of Human Tibial Trabecular Bone at Limited Spatial Resolution, Journal of Bone and Mineral Research, 26 (9): 2184-93, 2011. (Featured on the journal's cover)
  16. Liu XS*, Walker MD*, McMahon DJ, Udesky J, Liu G, Bilezikian JP, and Guo XE, Better Skeletal Microstructure Helps to Explain Lower Fracture Risk among Chinese-American Women versus Caucasian Women, Journal of Bone and Mineral Research, 26 (8): 1783-92, 2011. *authors contributed equally
  17. Walker MD*, Liu XS*, Stein E, Zhou B, Bezati E, McMahon DJ, Udesky J, Liu G, Guo XE, and Bilezikian JP, Differences in Bone Microarchitecture between Postmenopausal Chinese-American and White Women, Journal of Bone and Mineral Research, 26(7): 1392-8, 2011. *authors contributed equally
  18. Nickolas TL, Cremers S, Zhang C, Thomas V, Stein EM, Cohen A, Chauncey R, Nikkel L, Yin MT, Liu XS, Boutroy S, Staron RB, Leonard MB, McMahon DJ, Dworakowski E, and Shane E, Discriminants of Prevalent Fractures in Chronic Kidney Disease, Journal of the American Society of Nephrology, 22 (8): 1560-72, 2011.
  19. Stein EM, Liu XS, Nickolas TL, Cohen A, Thomas V, McMahon DJ, Zhang C, Cosman F, Nieves J, Greisberg J, Guo XE, and Shane E, Abnormal Microarchitecture and Stiffness in Postmenopausal Women with Ankle Fractures, Journal of Clinical Endocrinology and Metabolism, 96 (7): 2041-8, 2011.
  20. Peng SL, Liu XS, Zhou GQ, Li ZY, Keith DKL, Guo XE, and Lu WW, Osteoprogeterin Deficiency Attenuates Strontium-Mediated Inhibition of Osteoclastogenesis and Bone Resorption, Journal of Bone and Mineral Research, 26(6): 1272-82, 2011.
  21. Fields AJ, Lee GL, Liu XS, Jekir MG, Guo XE, and Keaveny TM, Influence of Vertical Trabeculae on the Compressive Strength of the Human Vertebra, Journal of Bone and Mineral Research, 26(2): 263-9, 2011.
  22. Stein EM, Liu XS, Nickolas TL, Cohen A, Thomas V, McMahon DJ, Zhang C, Cosman F, Nieves J, Guo XE, and Shane E, Abnormal Microarchitecture and Reduced Stiffness at the Radius and Tibia in Postmenopausal Women with Fractures, Journal of Bone Mineral Research, 25(12): 2296-305, 2010.
  23. Oury F, Yadav VK, Wang Y, Zhou B, Liu XS, Guo XE, Tecott LH, Schutz G, Means AR, and Karsenty G, CREB mediates brain serotonin regulation of bone mass through its expression in ventromedial hypothalamic neurons, Genes & Development, 24(20): 2330-42, 2010.
  24. Liu XS, Cohen A, Shane E, Yin PT, Stein EM, Roger H, Kokolus SL, McMahon DJ, Lappe JM, Recker RR, Lang T, and Guo XE, Bone Density, Geometry, Microstructure and Stiffness: Relationships Between Peripheral and Central Skeletal Sites Assessed by DXA, HR-pQCT, and cQCT in Premenopausal Women, Journal of Bone Mineral Research, 25(10): 2229-38, 2010.
  25. Liu XS, Zhang XH, Rajapakse CS, Wald MJ, Magland J, Sekhon KK, Adam MF, Sajda P, Wehrli FW, and Guo XE, Accuracy of High-Resolution In Vivo Micro Magnetic Resonance Imaging for Measurements of Microstructural and Mechanical Properties of Human Distal Tibial Bone, Journal of Bone Mineral Research,25(9): 2039-50, 2010.
  26. Shi X, Liu XS, Wang X, Guo XE, and Niebur GL, Type and Orientation of Yielded Trabeculae During Overloading of Trabecular Bone Along Orthogonal Directions, Journal of Biomechanics, 43(13): 2460-6, 2010.
  27. Fang G, Ji B, Liu XS, and Guo XE, Quantification of Trabecular Bone Microdamage Using the Virtual Internal Bond Model and the Individual Trabeculae Segmentation Technique, Computer Methods in Biomechanics and Biomedical Engineering, 13(5): 605-15, 2010.
  28. Liu XS, Cohen A, Shane E, Stein E, Roger H, Kokolus SL, Yin PT, McMahon DJ, Lappe JM, Recker RR, and Guo XE, Individual Trabeculae Segmentation (ITS)-Based Morphological Analyses of High Resolution Peripheral Quantitative Computed Tomography Images Detect Abnormal Trabecular Plate and Rod Microarchitecture in Premenopausal Women with Idiopathic Osteoporosis, Journal of Bone and Mineral Research, 25(7): 1496-505, 2010. (Featured on the journal's cover)
  29. Rajapakse CS, Wald MJ, Magland J, Liu XS, Zhang XH, Wehrli FW, and Guo XE, Computational Biomechanics and Structure of the Distal Tibia from High-Resolution MRI and Micro-CT, Bone, 47 (3): 556-63, 2010.
  30. Kulak CAM, Borba VC, Jorgetti V, Reis L, Liu XS, Recker RR, Kimmel DB, Kulak Jr J, Rabelo LM, Zhou H, Guo XE, Bilezikian JP, Boguszewski CL, and Dempster DW, Skeletal Microstructural Abnormalities in Postmenopausal Women with Chronic Obstructive Pulmonary Disease, Journal of Bone Mineral Research, 25(9): 1931-40, 2010.
  31. Peng S*, Liu XS*, Wang T, Li Z, Zhou G, Luk KDK, Guo XE, and Lu WW, In Vivo Anabolic Effect of Strontium on Trabecular Bone Was Associated with Increased Osteoblastogenesis of Bone Marrow Stromal Cells, Journal of Orthopaedic Research, 28(9): 1208-14, 2010. *authors contributed equally
  32. Shi X, Liu XS, Wang X, Guo XE, and Niebur GL, Effects of trabecular type and orientation on microdamage susceptibility in trabecular bone, Bone 46(5): 1260-6, 2010. (Featured on the journal's cover)
  33. Liu XS, Zhang XH, Sekhon KK, Adam MF, McMahon DJ, Shane E, Bilezikian JP, and Guo XE, High-Resolution Peripheral Quantitative Computed Tomography Can Assess Microstructural and Mechanical Properties of Human Distal Tibial Bone, Journal of Bone and Mineral Research 25 (4): 746-56, 2010.
  34. Yadav VK, Balaji S, Suresh PS, Liu XS, Lu X, Li Z, Guo XE, Mann JJ, Balapure AK, Gershon MD, Medhamurthy R, Vidal M, Karsenty G, and Ducy P, Inhibition of gut-derived serotonin synthesis: a potential bone anabolic treatment, Nature Medicine 16(3): 308-12, 2010).
  35. Shi Y, Oury F, Yadav VK, Wess J, Liu XS, Guo XE, Murshed M, and Karsenty G, Signaling through the M(3) Muscarinic Receptor Favors Bone Mass Accrual by Decreasing Sympathetic Activity, cell metabolism 11(3): 231-8, 2010.
  36. Grayson WL, Fr鰄lich M, Yeager K, Bhumiratana S, Chan ME, Cannizzaro C, Wan LQ, Liu XS, Guo XE, and Vunjak-Novakovic G, Regenerative Medicine Special Feature: Engineering Anatomically Shaped Human Bone Grafts, Proceedings of the National Academy of Science of USA 107(8): 3299-304, 2010.
  37. Cohen A, Dempster DW, M黮ler R, Guo XE, Nickolas TL, Liu XS, Zhang XH, Wirth AJ, van Lenthe GH, Kohler T, McMahon DJ, Zhou H, Rubin MR, Bilezikian JP, Lappe JM, Recker RR, and Shane E, Assessment of Trabecular and Cortical Architecture and Mechanical Competence of Bone by High-Resolution Peripheral Computed Tomography: Comparison with Transilial Bone Biopsy, Osteoporosis International 21(2): 263-73, 2010.
  38. Cohen A, Liu XS, McMahon DJ, Rogers HF, LeMaster J, Recker RR, Lappe JM, Guo XE, and Shane E, Bone Microarchitecture and Stiffness in Premenopausal Women With Idiopathic Osteoporosis, Journal of Clinical Endocrinology and Metabolism 94(11): 4351-60, 2009.
  39. Rajapakse CS, Magland J, Zhang XH, Liu XS, Wehrli SL, Guo XE, and Wehrli FW, Implications of Noise and Resolution on Mechanical Properties of Trabecular Bone Estimated by Image-based Finite-Element Analysis, Journal of Orthopaedic Research 27(10): 1263-71, 2009.
  40. Liu XS, Zhang XH, and Guo XE, Contributions of Trabecular Rods of Various Orientations in Determining the Elastic Properties of Human Vertebral Trabecular Bone, Bone 45(2): 158-63, 2009. (Featured on the journal's cover)
  41. Liu XS, Bevill G, Keaveny TM, Sajda P, and Guo XE, Micromechanical Analyses of Vertebral Trabecular Bone Based on Individual Trabeculae Segmentation of Plates and Rods, Journal of Biomechanics, 42(3): 249-56, 2009.
  42. Shi Y, Yadav VK, Suda N, Liu XS, Guo XE, Myers Jr. MG, and Karsenty G, Dissociation of the Neuronal Regulation of Bone Mass and Energy Metabolism by Leptin in vivo, Proceedings of the National Academy of Sciences of USA, 105(51):20529-33, 2008.
  43. Liu XS, Huang AH, Zhang XH, Sajda P, and Guo XE, Dynamic Simulation of Three Dimensional Architectural and Mechanical Alterations in Human Trabecular Bone during Menopause, Bone, 43(2): 292-301, 2008.
  44. Zhang XH, Liu XS, Vasilic B, Wehrli FW, Benito M, Snyder PJ, and Guo XE, In Vivo 礛RI Based Finite Element and Morphological Analyses of Tibial Trabecular Bone in Eugonadal and Hypogonadal Men before and after Testosterone Treatment, Journal of Bone and Mineral Research, 23(10): 1426-34, 2008.
  45. Liu XS, Sajda P, Saha, PK, Wehrli FW, Bevill G, Keaveny TM, and Guo XE, Complete Volumetric Decomposition of Individual Trabecular Plates and Rods and Its Morphological Correlations with Anisotropic Elastic Moduli in Human Trabecular Bone, Journal of Bone and Mineral Research, 23(2): 223-35, 2008.
  46. Liu XS, Sajda P, Saha, PK, Wehrli FW, and Guo XE, Quantification of the Roles of Trabecular Microarchitecture and Trabecular Type in Determining the Elastic Modulus of Human Trabecular Bone, Journal of Bone and Mineral Research, 21(10): 1608-17, 2006.
BOOK CHAPTER
  1. Guo XE, Liu XS, and Wehrli FW, Advanced Structural Assessment of Bone Using CT and MRI, In: Orwoll E, Bilezikian JP, and Vanderschueren D (ed.) Osteoporosis in Men, ISBN-13: 978-0-12-374602-3, Academic Press, 2009.
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