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McKay Orthopaedic Research Laboratory > Mauck Lab > DongHwa Kim

DongHwa Kim

Post-Doctoral Fellow
University of Pennsylvania

HOMETOWN
Busan, Korea

EDUCATION
Ph.D. Biomedical Engineering, 2011, Inje University, Korea M.S. Biomedical Engineering, 2008, Inje University, Korea B.S. Biomedical Engineering, 2006, Inje University, Korea

AREAS OF SPECIAL INTERESTS
DongHwa Kim is from S. Korea. Her research is focused on mechanical stimulation of cells and related tissues, mesenchymal stem cell differentiation, development of bioreactors for blood vessel regeneration, and micro-physical environments on cells. Now, she is working on intervertebral disc regeneration using mesenchymal stem cells. In her spare time, she enjoys listening to music, cooking food, and traveling.

AWARDS

  1. 2011, Post-Doctoral Fellow by National Research Foundation of Korea (NRF) [Fostering next-generation researchers program]
  2. 2010, Travel Support Award in Society for Physical Regulation in Biology and Medicine (SPRBM)
  3. 2009, Best Poster Presentation award in 2nd World Congress of Tissue Engineering and Regenerative Medicine International Society (TERMIS)
  4. 2009, Korea Science and Engineering Foundation, S&T Graduate Scholarship
  5. 2009, Excellence award, Women in Science Engineering and Technology in Korea
  6. 2009, Certificate of commendation, Inje University (Four times)
  7. 2008, Korea, Busan Future Scientist Award
  8. 2007, Korea Baek-Yup Graduate Scholarship
  9. 2007, First place win in the annual contest of thesis proposal (Inje University)
  10. 2006 - 2009 INJE University Graduate Scholarship
PATENTS
  1. JW Shin, DH Kim "A Double-Layered Tube-type Porous Scaffold Comprising Biodegradable Polymer And Manufacturing Method Thereof, " Korea Patent Application, 10-2011-0029816, 31 Mar 2011.
PUBLICATIONS
  1. DH Kim, SJ Heo, JW Shin. "Differentiation of mesenchymal stem cells into vascular cells under mechanical stimulation for bioengineered blood vessels," 2012, in preparation.
  2. DH Kim, SJ Heo, SH Kim, JW Shin, SH Park, JW Shin. "Shear stress magnitude is critical in regulating the differentiation of mesenchymal stem cells, even with endothelial growth medium," 2011, Biotechnology letters, 33: 2351-2359
  3. SH Park, JW Shin, DH Kim, SH Kim, OC Jeong, JK Kim, JW Shin. "Quantitative analyses of changes in intracellular calcium ion concentrations under flow-induced mechanical stimuli utilizing a microchip," 2011, Micro& Nano letters, 6(5): 296-300
  4. JY Jang, SW Lee, SH Park, JW Shin, CW Mun, SH Kim, DH Kim, JW Shin. "Combinational Effects of Surface Morphology and Mechanical Straining Magnitudes on the Differentiation of Mesenchymal Stem Cells Without Using Biochemical Reagents," 2011, J. of Biomedicine and Biotechnology, Article ID 860652: 1-9
  5. JY Han, JW Shin, SH Park, DH Kim, SH Kim, YG Kang, JW Shin. "Differentiation of Stem Cells based on Cocktail medium and Scaffold Characteristics for Osteochondral Tissue," 2011, Tissue Engineering and Regenerative Medicine, 8(2); 59-65
  6. SH Kim, SH Park, JW Jun, DH Kim, JW Shin, JY Han, YG Kang, JW Shin. "Hydrostatic pressure can control osteogenesis and osteoclastogenesis when Stromal Cells and Osteoclast Precursor Cells are Cocultured," 2010, Tissue Engineering and Regenerative Medicine, 7(4); 383-394
  7. JY Jeong, DH Kim, SH Park, JW Shin, JY Han, YG Kang, JW Shin. "Effects of PDMS Surface Patterns on Differentiation and Proliferation of MSCs under Intermittent Hydrostatic Pressure," 2010, Tissue Engineering and Regenerative Medicine, 7(3); 283-290
  8. SW Lee, JY Jang, SH Park, DH Kim, JW Shin, SH Kim, JW Shin. "Study of Mesenchymal Stem Cells Co-Cultured with Endothelial Cells under Vascular Fluidic Environments," 2010, Tissue Engineering and Regenerative Medicine, 7(2); 255-261
  9. DH Kim, SJ Heo, JW Shin, KM Park, KD Park, KS Jee. "Preparation of Thermosensitive Gelatin-Pluronic® Copolymer for Cartilage tissue engineering," 2010, Macromolecular Research, 18(4): 387-391
  10. DH Kim, SH Kim, SJ Heo, JW Shin, SW Lee, SA Park, JW Shin. "Enhanced Differentiation of Mesenchymal Stem Cells into NP-like cells via 3D Co-culturing with Mechanical Stimulation," 2009, J. of bioscience and bioengineering, 108(1): 63-67
  11. DH Kim, SJ Heo, JW Shin, SH Park, JW Shin. "Effects of Mechanical Stimulation on Chondrogenesis of Mesenchymal Stem Cells via 3D Co-culturing System," 2009, Tissue Engineering and Regenerative Medicine, 6(4-11); 739-745
  12. J Wei, SJ Heo, C Liu, DH Kim, SE Kim, YT Hyun, JW Shin, JW Shin. "Preparation and characterization of bioactive calcium silicate and poly(epsilon-caprolactone) nanocomposite for bone tissue regeneration," 2009, J. of Biomedical Materials Research: Part A, 90(3): 702-712
  13. SJ Heo, SE Kim, J Wei, DH Kim, YT Hyun, HS Yun, HK Kim, TR Yoon, SH Kim, SA Park, JW Shin, JW Shin. "Preparation and characterization of bioactive calcium silicate and PCL nanocomposite for bone tissue regeneration," 2009, Tissue Engineering, 15(5): 977-989
  14. SJ Heo, SE Kim, J Wei, YT Hyun, HS Yun, DH Kim, JW Shin, JW Shin. " Fabrication and characterization of novel nano- and micro-HA/PCL composite scaffolds using a modified rapid prototyping process," 2009, J. of Biomedical Materials Research: Part A, 89(1): 108-116
  15. JW Shin, YJ Lee, SJ Heo, SA Park, SH Kim, YJ Kim, DH Kim, JW Shin. "Manufacture of the multi-layered nanofibrous structures composed of polyurethane and poly(ethylene oxide) for the potential scaffolds of blood vessels," 2009, J. of Biomaterials Science: Polymer Edition, 20: 757-771
  16. SH Ha, DH Kim, JW Shin, HC Gwak, JS Choi. "Effects of Mechanical Stimulation and Scaffolds for Nucleus Pulposus Replacement of Intervertebral Disc," 2009, J. of Korean Orthopaedic Research Society, 12(2)
  17. J wei, SJ Heo, DH Kim, SE Kim, YT Hyun, JW Shin. "Comparison of physical, chemical and cellular responses to nano- and micro-sized calcium silicate/ poly(-caprolactone) bioactive composites," 2008, J. of the Royal Society Interface, 6;5(23): 617-630
  18. YJ Kim, SA Park, YJ Lee, JW Shin, DH Kim, SJ Heo, KD Park, JW Shin. "The Effects of Intermittent Hydrostatic Pressure on Cell Adhesive Forces and Other Related Parameters under Various Resting Periods," 2008, J. of Biomedical Materials Research: Part B, 85(2): 353-360
  19. DH Kim, SH Kim, SJ Heo, JW Shin, YJ Kim, SH Park, JW Jun, JW Shin. "The Differentiation of bone Marrow Stromal Cells into NP-like Cells through 3-Dimensional Co-culture System," 2008, Journal of Biomedical Engineering Research, 29(2): 159-163
  20. KM Park, DH Kim, JW Bae, YK Joung, JW Shin, KD Park. "Injectable Chitosan-Pluronic Hydrogel Releasing Osteogenic Protein-1 for the Regeneration of Intervetebral Disc," 2008, Biomaterials research, 12(1): 24-27
  21. JW Shin, DH Kim, SJ Heo, SH Kim, YJ Kim, JW Shin. "Effects of the Mechanical Stretch on Aligned Multi-Layered Nanofibrous Scaffolds Seeded with Smooth Muscle Cells," 2008, Journal of Biomedical Engineering Research, 29(1):52-58
  22. SJ Heo, SE Kim, YT Hyun, DH Kim, HM Lee, YM Hwang, SA Park, JW Shin. "In Vitro Evaluation of Poly ?-Caprolactone/Hydroxyapatite Composite as Scaffolds for Bone Tissue Engineering with Human Bone Marrow Stromal Cells," 2007, Key Engineering Materials, 342-343; 369-372
  23. SA Park, IA Kim, CR Kim, JW Shin, SJ Heo, YM Hwang, DH Kim, JW Shin. "Effects of mechanical stimuli on the cell proliferation and collagen production on the micropatterned substrate." 2006, J. Exp & Biomed. Sci, 12;224-228
ABSTRACTS
  1. S.I. Chun, D.H. Kim, J.H. Cho, K.S. Hong, J.W. Shin, C.W. Mun. "Preliminary study on MR spectroscopy measurements for metabolomic change during adipogenic differentiation of human mesenchymal stem cell," International Society for Magnetic resonance in Medicine," Montreal/Canada, 2011
  2. DH Kim, JY Han, SH Park, JW Shin, SH Kim, YG Kang, JW Shin. "The Effects of Flow-induced Shear Stress on the Differentiation of MSCs into Vascular Endothelial Cells," Termis_NA, Orlando, USA, 2010
  3. JY Han, DH Kim, SH Park, JW Shin, SH Kim, YG Kang, JW Shin. "Preparation and Preliminary Evaluations of 3-Dimensional Hybrid Scaffolds for Osteohondral Defects utilizing Rapid Prototype Processing," Termis_NA, Orlando, USA, 2010
  4. SH Park, JW Shin, SH Kim, DH Kim, JY Han, YG Kang, JW Shin. "Combinational effects of stimuli and co-culture on differentiation of MSCs into vascular lineages," Termis_NA, Orlando, USA, 2010
  5. JW Shin, SH Park, SH Kim, DH Kim, JY Han, YG Kang, JW Shin. "Early Effects of Flow-induced Shear Stress on the Differentiation of Mesenchymal Stem Cells (MSCs) when Co-cultured with Smooth Muscle Cells Aligned Perpendicular to Shear stress," Termis_NA, Orlando, USA, 2010
  6. YG Kang, JY Jeong, JY Han, DH Kim, JW Shin, SH Park, SH Kim, JW Shin. "The Effects of Intermittent Hydrostatic Pressure on the Differentiation of MSCs When Cocultured with Chondrocytes," Termis_NA, Orlando, USA, 2010
  7. YG Kang, JW Shin, SH Park, JW Shin, DH Kim, JY Han, SH Kim. "Flow-induced Shear Stress Contributes to Long Term Maintenance of Limbal Stem Cells," Termis_NA, Orlando, USA, 2010
  8. DH Kim, JY Han, SH Park, JW Shin, SH Kim, YG Kang, JW Shin. "The effects of shear stress on MSC differentiation into vascular endothelial cell using a Fluid flow bioreactor," ISNIT, Seoul, Korea, 2010
  9. YG Kang, JW Shin, SH Park, JW Shin, DH Kim, JY Han, SH Kim. "Long term maintenance of Limbal Stem Cells under shear stress," ISNIT, Seoul, Korea, 2010
  10. SI Chun, MY Jang, SY Lee, DH Kim, JH Cho, JW Shin, YI Yang, CW Mun. "Proton MR Spectroscopy Measurements for Metabolomic Changes during Adipogenic Differentiation of Muscle Derived Stem Cells," International Society for Magnetic Resonance in Medicine, Sweden, Europe, 2010
  11. DH Kim, SJ Heo, YG Kang, SH Kim, JW Shin, SH Park, JY Han, JW Shin. "The effects of intermittent hydrostatic pressure on the differentiation of mesenchymal stem cells co-cultured with chondrocytes in alginate beads," SPRBM, Arizona, USA, 2010
  12. JY Jeong, SW Lee, JY Jang, DH Kim, SH Park, JW Shin, JY Han, JW Shin. "The effects of PDMS surface pattern on differentiation and proliferation of MSCs under intermittent hydrostatic pressure," SPRBM, Arizona, USA, 2010
  13. JW Shin, NR Kim, SH Park, JY Jang, DH Kim, SJ Heo, JY Han, YG Kang, SH Kim, JW Shin. "The effects of TGF-?1 and culture mediumon differentiation of human mesenchymal stem cells into cardiomyocytes," SPRBM, Arizona, USA, 2010
  14. JY Jang, SW Lee, SH Park, JW Shin, JY Jeong, DH Kim, JY Han, JW Shin. "The effects of mechanical straining and substrate surface morphologies on differentiation of mesenchymal stem cells without biochemical reagents," SPRBM, Arizona, USA, 2010
  15. SH Park, SH Kim, JW Shin, DH Kim, SW Lee , JY Jang , JY Jeong, JY Han, JW Shin. "The effects of fluid flow on the expressions of intracellular calcium in MG-63," SPRBM, Arizona, USA, 2010
  16. DH Kim, KS Jee, SJ Heo, KD Park, JW Shin. "Evaluationsof the cellular responses of novel Gelatin-Pluronic thermo-sensitive hydrogel using chondrocyte," Termis 2nd World Congress, Seoul, Korea, 2009
  17. DH Kim, SH Kim, SJ Heo, JW Shin, JW Shin. "The effect of three dimensional co-culturing system on the differentiation of BMSCs into NP-like cells," SPRBM, Miami, USA, 2008
  18. SJ Heo, SE Kim, DH Kim, YT Hyun, SH Kim. JW Shin, JW Shin. "A novel 3-D scaffold of nano-hydroxyapatite/poly ?-caprolactone by layer manufacturing process for bone tissue engineering," SPRBM, Miami, USA, 2008
  19. SH Kim, JW Jun, SH Park, SJ Heo, DH Kim, JW Shin, SW Lee, JY Jang, JW Shin. "Promotion of osteogenesis using a co-culture with osteoclast precursors and the loading of hydrostatic pressure," SPRBM, Miami, USA, 2008
  20. D.H. Kim, S.H. Park, J.W. Jun, S.W. Lee, J.Y. Jang, J.Y. Jeong, S.J. Heo, J.W. Shin. "Effects of Intermittent Hydrostatic Pressure on the Chondrogenesis of Mesenchymal stem cells through 3D Co-culture," Termis_NA, San Diego, USA, 2008
  21. S.J. Heo, S.E. Kim, D.H. Kim, S.W. Lee, T.R. Yun, J.W. Shin. "Cell and Tissue In-growth Behavior into n-HA/PCL Composite Scaffold Fabricated by LMS: Comparison with Conventional SGP Scaffolds through Animal Studies," Termis_NA, San Diego, USA, 2008
  22. JW Jun, JW Shin, SH Park, DH Kim, SW Lee, JY Jang, JY Jung, SH Kim. "The effects of Intermittent Hydrostatic Pressure on M2-10B4 Cells in Co-Culturing System," Termis_NA, San Diego, USA, 2008
  23. YJ Kim, DH Kim, JW Shin, SJ Heo, SH Park, SW Lee, JY Jang, JY Jeong, KS Jee, JW Shin. "The effects of intermittent hydrostatic pressure patterns: the changes in cell adhesiveness along with intracellular ca2+ concentration," Termis_AP, Taiwan, 2008
  24. JW Shin, SJ Heo, DH Kim, YJ Kim, SH Park, SW Lee, JY Jang, JY Jeong, KS Jee, JW Shin. "Biomimetic approaches for Vascular environments with multi-layered scaffolds under mechanical stimulation," Termis_AP, Taiwan, 2008
  25. SH Park, OC Jeong, SH Shin, DH Kim, JY Jang, SW Lee, JY Jung, KS Jee, JW Shin. "Time response of calcium (Ca2+) ion flow of MG-63 cells induced by constant shear stress in micro chip," Termis_AP, Taiwan, 2008
  26. SA Park, JW Shin, SJ Heo, DH Kim, YM Hwang, WD Kim, JW Shin. "The effects of mechanical stretching on ligament fibroblats to the micropatterned silicone surface," Orthopeadic Research Society, Sandiego, USA, 2007
  27. DH Go, KM Park, JW Bae, DH Kim, JW Shin, KD Park. "BMP-7 delivery using injectable chitosan hydrogel for regeneration of intervertebral disc," International symposium on recent advances in drug delivery systems, Utah, USA 2007
  28. SJ Heo, SE Kim, YT Hyun, DH Kim, HM Lee, JW Shin, YM Hwang, JH Kim, JW Shin. "Bone tissue engineering using poly e-caprolactone/hydroxyapatite 3-D scaffolds with human bone marrow stromal cells," Asian Internationl Symposium on Biomaterials, Xiamen, CHINA, 2006
  29. JW Shin, SA Park, JH Kim, YJ Lee, SJ Heo, YM Hwang, DH Kim, JW Shin. "Effects of multi-layered nanofibrous scaffold for smooth muscle cells," Asian Internationl Symposium on Biomaterials, Xiamen, CHINA, 2006
  30. DH Kim, SJ Heo, JW Shin, YM Hwang, JH Kim, JW shin. "The effects of Intermittent hydrostatic pressure on MG-63 cells in three dimensional scaffolds obtained from porcine," Asian Internationl Symposium on Biomaterials, Xiamen, CHINA, 2006
  31. YM Hwang, YJ Kim, JW Shin, DH Kim, SJ Heo, JH Kim, JW Shin. "Effects of Ca2+ on adhesive forces of CPAE cells to substrates using a quantitative force measurement system," Asian Internationl Symposium on Biomaterials, Xiamen, CHINA, 2006
  32. SJ Heo, YT Hyun, HM Lee, DH Kim, JW Shin, YM Hwang, HS Yun, JW Shin, SE Kim. "In Vitro Evaluation of Poly(e-caprolactone)/Hydroxyapatite Composites Scaffolds By Human Bone Marrow Stromal Cells For Bone Tissue Engineering," Asian Internationl Symposium on Biomaterials, Xiamen, CHINA, 2006


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