McKay Orthopaedic Research Laboratory

 Search | Contact

McKay Orthopaedic Research Laboratory > Mauck Lab > Robert L. Mauck

Robert L. Mauck, Ph.D.

Assistant Professor of Orthopaedic Surgery
Assistant Professor of Bioengineering

HOMETOWN
York, Pennsylvania

EDUCATION
Post-Doctoral Fellow, Cartilage Biology and Orthopaedics Branch, NIAMS, NIH, Bethesda, MD
Ph.D., Biomedical Engineering, 2003, Columbia University, New York, NY
M.S., Biomedical Engineering, 2000, Columbia University, New York, NY
B.S., Biomedical Engineering, 1998, Columbia University, New York, NY
B.A., Biochemistry, 1998, Columbia University, New York, NY

AREAS OF EXPERTISE
Orthopaedic Tissue Engineering
Orthopaedic Biomechanics
Stem Cell Biology

AREAS OF SPECIAL INTEREST
Rob Mauck joined the faculty in the Departments of Orthopaedic Surgery and Bioengineering at the University of Pennsylvania in the Summer of 2005. Before coming to Penn, Rob received his Ph.D. from Columbia University under the direction of Dr. Clark Hung and Dr. Gerard Ateshian. Rob went on to do a postdoctoral stint in the Cartilage Biology and Orthopaedics Branch of NIAMS, headed by Dr. Rocky Tuan. While Rob's interests are many and varied, those pertaining to work that are of special interest include: MANUSCRIPTS
  1. Hung CT, Henshaw DR, Wang CC, Mauck RL, Raia F, Palmer G, Chao PH, Mow VC, Ratcliffe A, Valhmu WB. "Mitogen-Activated Protein Kinase Signaling in Bovine Articular Chondrocytes in Response to Fluid Flow Does Not Require Calcium Mobilization," 2000, Journal of Biomechanics, 33(1): 73-80.
  2. Mauck RL, Soltz MA, Wang CCB, Wong DD, Chao PH, Valhmu WB, Hung CT, Ateshian GA. "Functional Tissue Engineering of Articular Cartilage Through Dynamic Loading of Chondrocyte-Seeded Agarose Gels," 2000, Journal of Biomechanical Engineering, 122: 252-60.
  3. Chao PH, Roy R, Mauck RL, Liu W, Valhmu WB, Hung CT. "Chondrocyte Translocation Response to Direct Current Electric Fields," 2000, Journal of Biomechanical Engineering, 122: 261-267.
  4. Palmer GD, Chao PH, Raia F, Mauck RL, Valhmu, WB, Hung CT. "Time-Dependent Aggrecan Gene Expression of Articular Chondrocytes in Response to Hyperosmotic Loading," 2001, Osteoarthritis and Cartilage, 9: 761-70.
  5. Mauck RL, Seyhan SL, Ateshian GA, Hung CT, "The Influence of Seeding Density and Dynamic Deformational Loading in the Development of Structure/Function Relationships of Chondrocyte-Seeded Agarose Hydrogels," 2002, Annals of Biomedical Engineering, 30(8): 1046-56.
  6. Ateshian GA, Soltz MA, Mauck RL, Basalo IB, Hung CT, Lai MW. "The Role of Osmotic Pressure and Tension-Compression Nonlinearity in the Frictional response of Articular Cartilage," 2003, Transport in Porous Media, 50: 5-33.
  7. Mauck RL, Nicoll SB, Seyhan SL, Ateshian GA, Hung CT, "Synergistic Action of Growth Factors and Dynamic Loading for Articular Cartilage Tissue Engineering," 2003, Tissue Engineering, 9(4): 597-611.
  8. Mauck RL, Hung CT, Ateshian GA "Modeling Neutrally Charged Solute Diffusion in Dynamically Loaded Porous Permeable Gels: Applications for Cartilage Biosynthesis and Tissue Engineering," 2003, Journal of Biomechanical Engineering, 125(5): 602-14.
  9. Hung CT, Lima EG, Mauck RL, LeRoux MA, Lu HH, Stark RG, Guo XE, Ateshian GA. "Anatomically Shaped Osteochondral Constructs for Articular Cartilage Repair," 2003, Journal of Biomechanics, 36(12): 1853-64.
  10. Mauck RL, Wang CCB, Oswald ES, Ateshian GA, Hung CT, "The Role of Seeding Density and Nutrient Supply for Articular Cartilage Tissue Engineering with Dynamic Deformational Loading," 2003, Osteoarthritis and Cartilage, 11(12): 879-90.
  11. Hung CT, Mauck RL, Wang CCB, Lima EG, Ateshian GA, "A Paradigm for Functional Tissue Engineering of Articular Cartilage via Applied Physiologic Deformational Loading," 2004, Annals of Biomedical Engineering, 32(1): 35-49.
  12. Kelly TN, Wang CCB, Mauck RL, Ateshian GA, Hung CT, "The Influence of the Native Pericellular Matrix on Matrix Development of Chondrocyte-Seeded Agarose Hydrogels," 2004, Biorheology, 41(3-4): 223-37.
  13. Ng KW, Wang CCB, Mauck RL, Ateshian GA, Hung CT, "Characterization of Inhomogeneity in Bi-Layered Chondrocyte-Seeded Constructs of Differing Agarose Concentrations," 2004, Journal of Orthopaedic Research, 12(12): 947-55.
  14. Lima EG, Mauck RL, Han SH, Park SY, Ng KW, Ateshian GA, Hung CT, "Functional Tissue Engineering of Chondral and Osteochondral Constructs" 2004, Biorheology, 41(3-4): 577-90.
  15. Takai E, Mauck RL, Hung CT, Guo XE, "Osteocyte Viability and Regulation of Osteoblast Function in a 3D Trabecular Bone Explant Under Dynamic Hydrostatic Pressure," 2004, Journal of Bone and Mineral Research, 19(9): 1403-10.
  16. Basalo IM, Mauck RL, Kelly TN, Nicoll SB, Chen FH, Hung CT, Ateshian GA, "Cartilage Interstitial Fluid Load Support In Unconfined Compression Following Enzymatic Digestion," 2004, Journal of Biomechanical Engineering, 126(6): 779-786.
  17. Krishnan R, Caligaris M, Mauck RL, Hung CT, Costa KD, Ateshian GA, "Removal of the Superficial Zone of Bovine Articular Cartilage Does Not Increase its Frictional Coefficient," 2004, Osteoarthritis and Cartilage, 12(12): 947-55.
  18. Li W-J, Mauck RL, Tuan RS, "Electrospun Nanofibrous Scaffolds: Production, Characterization, and Applications for Tissue Engineering and Drug Delivery," 2005, Journal of Biomedical Nanotechnology, 1(3):259-275.
  19. Mauck RL, Yuan X, Tuan RS, "Chondrogenic Differentiation and Functional Maturation of Bovine Mesenchymal Stem Cells in Long-Term Agarose Culture," 2006, Osteoarthritis and Cartilage, 14(2):179-89.
  20. Kuo CK*, Li W-J*, Mauck RL*, Tuan RS, "Tissue Engineering: Its Potential and Uses," Current Opinion in Rheumatology, 2006, 18(1):64-73. *contributed equally.
  21. Li W-J, Cooper JA, Mauck RL, Tuan RS, "Fabrication and Characterization of Six Electrospun Poly(alpha-hydroxy ester)-Based Fibrous Scaffolds for Tissue Engineering Applications," 2006, Acta Biomaterialia, 2(4):377-85.
  22. Sheth NP, Baker BM, Huffman GR, Mauck RL, "Emerging Strategies for Meniscus Repair," 2006, University of Pennsylvania Orthopaedic Journal, 18:59-72.
  23. Mauck RL, Byers BA, Yuan X, Tuan RS, "Regulation of Cartilaginous ECM Gene Transcription by Chondrocytes and MSCs in 3D Culture in Response to Dynamic Loading," 2007, Biomechanics and Modeling in Mechanobiology, 6(1-2):113-125.
  24. Ng KW, Mauck RL, Statman LY, Lin EY, Ateshian GA, Hung CT, "Dynamic Deformational Loading Results in Selective Application of Mechanical Stimulation in a Layered, Tissue-Engineered Cartilage Construct," Biorheology, 2006, 43(3-4):497-507.
  25. Li W-J*, Mauck RL*, Cooper J, Yuan X, Tuan RS, "Engineering Controllable Anisotropy in Electrospun Biodegradable Nanofibrous Scaffolds for Musculoskeletal Tissue Engineering," Journal of Biomechanics, 2007, 40(8):1686-93. *contributed equally.
  26. Mauck RL, Martinez-Diaz GJ, Yuan X, Tuan RS, "Regional Multi-Lineage Differentiation Potential of Meniscal Fibrochondrocytes: Implications for Meniscal Repair," 2007, Anatomical Record, 290:48-58.
  27. Nerurkar NL, Elliott DM, Mauck RL, "Mechanics of Oriented Electrospun Nanofibrous Scaffolds for Annulus Fibrosus Tissue Engineering," 2007, Journal of Orthopaedic Research, 25(8):1018-28.
  28. Baker BM and Mauck RL, "The Effect of Nanofiber Alignment on the Maturation of Engineered Meniscus Constructs," 2007, Biomaterials, 28(11):1967-77.
  29. Cloyd JM, Malhotra NR, Weng L, Chen W, Mauck RL, Elliott DM, "Material Properties in Unconfined Compression of Human Nucleus Pulposus, Injectable Hyaluronic Acid Based Hydrogels and Tissue Engineering Scaffolds," 2007, European Spine Journal, 16(11):1892-8.
  30. Lima EG, Bian L, Mauck RL, Byers BA, Tuan RS, Ateshian GA, Hung CT, "The Beneficial Effect of Delayed Compressive Loading on Tissue-Engineered Cartilage Constructs Cultured with TGF- 3," 2007, Osteoarthritis and Cartilage, 15(9):1025-33.
  31. Tan AR, Ifkovits JL, Baker BM, Brey DM, Mauck RL, Burdick JA, "Electrospinning of Photocrosslinked and Degradable Fibrous Scaffolds," 2008, Journal of Biomedical Materials Research - Part A, 87A:1034-1043.
  32. Byers BA*, Mauck RL*, Chang I, Tuan RS, "Temporal Exposure of TGF- 3 Under Serum-Free Conditions Enhances Biomechanical and Biochemical Maturation of Tissue-Engineered Cartilage," 2008, Tissue Engineering, 14(11):1821-34. *contributed equally.
  33. Park S, Nicoll SB, Mauck RL, Ateshian GA, "Cartilage Mechanical Response Under Dynamic Compression at Physiological Stress Levels following Enzymatic Digestion," 2008, Annals of Biomedical Engineering, 36(3):425-34.
  34. Nerurkar NL, Mauck RL, Elliott DM, "Integrating Theoretical and Experimental Methods for Functional Tissue Engineering of the Annulus Fibrosus" 2008, Spine, 33(25):2691-2701 [**Winner of the 2008 ISSLS Prize in Biomechanics, International Society for the Study of the Lumbar Spine].
  35. Chung C, Erickson IE, Mauck RL, Burdick JA, "Differential Behavior of Auricular and Articular Chondrocytes in Hyaluronic Acid Hydrogels," 2008, Tissue Engineering, 14(7):1121-31.
  36. Huang AH, Yeger-McKeever M, Stein A, Mauck RL, "Tensile Properties of Engineered Cartilage Formed from Chondrocyte and MSC-Laden Hydrogels," 2008, Osteoarthritis and Cartilage, 16(9):1074-1082.
  37. Baker BM, Gee AO, Metter R, Nathan AS, Marklein RA, Burdick JA, Mauck RL, "Selective Removal of Sacrificial Fibers Improves Cell Infiltration in Composite Fiber-Aligned Nanofibrous Scaffolds," 2008, Biomaterials, 29:2348-2358.
  38. Kelly TN, Fisher MB, Oswald ES, Tai T, Mauck RL, Ateshian GA, Hung CT, "Low-Serum Media and Dynamic Deformational Loading in Tissue Engineering of Articular Cartilage," 2008, Annals of Biomedical Engineering, 36(5):769-79.
  39. Baker BM, Nathan AS, Huffman GR, Mauck RL "Tissue Engineering with Meniscus Cells Derived from Surgical Debris," 2009, Osteoarthritis and Cartilage, 17(3): 336-345. *Functional Tissue Engineering Conference Group, "Evaluation Criteria for Musculoskeletal and Craniofacial Tissue Engineering: A Conference Report," 2008, Tissue Engineering: Part A, 14(12):2089-2104. *Mauck RL, Conference Participant and Author on White Paper.
  40. Erickson IE, Huang AH, Chung C, Li R, Burdick JA, Mauck RL, "Differential Maturation and Structure-Function Relationships in MSC and Chondrocyte Seeded Hydrogels," 2008, Tissue Engineering: Part A, 15(5):1041-52.
  41. Huang AH, Moliktar N, Stein A, Shore EM, Diamond SL, Mauck RL, "High-Throughput Screening for Small Molecule Modulators of Mesenchymal Stem Cell Chondrogenesis," 2008, Annals of Biomedical Engineering, 36(11):1909-21.
  42. Baker BM, Gee AO, Sheth NP, Huffman GR, Sennett BJ, Schaer TP, Mauck RL, Meniscus Tissue Engineering on the Nanoscale: From Basic Principles to Clinical Application, 2009, Journal of Knee Surgery, 22(1):45-59.
  43. Mauck RL*, Baker BM, Nerurkar NL, Burdick JA, Li WJ, Tuan RS, Elliott DM, "Engineering on the Straight and Narrow: the Mechanics of Nanofibrous Assemblies for Fiber-Reinforced Tissue Regeneration", Tissue Engineering, Part B: Reviews, 15(2):171-93. *Corresponding Author
  44. Chung CC, Beecham M, Mauck RL, Burdick JA, "The Influence of Degradation Characteristics of Hyaluronic Acid Hydrogels on In Vitro Neocartilage Formation by Mesenchymal Stem Cells," 2009, Biomaterials, 30: 4287-4296.
  45. Huang AH, Stein A, Tuan RS, Mauck RL, "Transient Exposure to TGF- 3 Improves Mechanical Properties of MSC-Laden Constructs in a Density Dependent Manner," 2009, Tissue Engineering, Part A, in press.
  46. Baker BM, Nerurkar NL, Burdick JA, Elliott DM, Mauck RL, "Fabrication and Modeling of Dynamic Multi-Polymer Nanofibrous Scaffolds," 2009, Journal of Biomechanical Engineering, in press.
  47. Maher SA, Mauck RL, Rackwitz L, Tuan RS, "A Nano-Fibrous Cell Seeded Hydrogel Promotes Integration in a Cartilage Gap Model," 2009, Journal of Tissue Engineering and Regenerative Medicine, in press.
  48. Huang AH, Farrell MJ, and Mauck RL, "Mechanics and Mechanobiology of Mesenchymal Stem Cell-Based Engineered Cartilage" 2010, Journal of Biomechanics, in press.
  49. Erickson IE, Huang AH, Sengupa S, Kestle S, Burdick JA, Mauck RL, "Macromer Density Influences Mesenchymal Stem Cell Chondrogenesis and Maturation in Photocrosslinked Hyaluronic Acid Hydrogels, 2009, Osteoarthritis and Cartilage, in press.
  50. Ng KW*, Mauck RL*, Wang CC-B*, Kelly TN, How MM-Y, Chen FH, Ateshian GA, Hung CT, "Duty Cycle of Deformational Loading Influences the Growth of Engineered Articular Cartilage," 2009, Journal of Cellular and Molecular Bioengineering, in press. *contributed equally.
  51. Baker BM, Handorf AM, Ionsescu LC, Li WJ, Mauck RL, "New Directions in Nanofibrous Scaffolds for Soft Tissue Engineering and Regeneration," 2009, Expert Opinion on Medical Devices, in press.
  52. Nerurkar NL, Baker BM, Sen S, Wible EE, Elliott DM, Mauck RL, "Stem Cell-Seeded Nanofibrous Laminates Replicate the Form and Function of the Annulus Fibrosus," 2009, Nature Materials doi:10.1038/nmat2558.
BOOK CHAPTERS
  1. Hung CT and Mauck RL, "Biological Assays: Cellular Level," In: Moore J, Zouridakis G, eds. Biomedical Technology and Devices Handbook. Boca Raton, FL: CRC Press; 2004, pp. 15.1-15.39.
  2. Chen FH, Song L, Mauck RL, Li WJ, Tuan RS, "Mesenchymal Stem Cells in Tissue Engineering," In: Lanza R, Langer R, Vacanti JP, eds. Principles of Tissue Engineering. 3rd Edition. Elsevier/Academic Press, 2007, Chapter 57.
  3. Mauck RL, Li W-J, Tuan RS, "Microenvironmental Determinants of Stem Cell Fate: Implications for Musculoskeletal Tissue Engineering," In: Meyer et al, eds. Tissue Engineering and Regenerative Medicine. Springer, 2009, Chapter 45, pgs. 647-663.
  4. Mauck RL and Burdick JA, "Engineering Cartilage Tissue," In: The Tissue Engineering Book: State of the Art, Visions, and Limitations. Springer, 2009, in press.
  5. Huang AH, Hung CT, Mauck RL, "Functional Cartilage Tissue Engineering with Adult Stem Cells: Current Status and Future Directions," In: Stem Cells and Regenerative Medicine. Bentham Scientific Publishers, 2009, in press.

© Copyright The Trustees of the University of Pennsylvania. Site best viewed with Firefox, IE, Safari, or Chrome.