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McKay Orthopaedic Research Laboratory > Mauck Lab > Lachlan J. Smith, Ph.D.

Lachlan J. Smith, Ph.D.

Research Associate
University of Pennsylvania

HOMETOWN
Adelaide, South Australia

EDUCATION
B.E. (Hons) Mechatronic Engineering, 2001, University of Adelaide
Ph.D. Medical Science, 2008, University of Adelaide

AREAS OF SPECIAL INTERESTS
Structure, function and pathology of the intervertebral disc

COLLABORATORS
Robert L. Mauck, Ph.D., Department of Orthopaedic Surgery, University of Pennsylvania
Dawn M. Elliott, Ph.D., Department of Biomedical Engineering, University of Delaware
Neil R. Malhotra, M.D., Department of Neurosurgery, University of Pennsylvania
George R. Dodge, Ph.D.,Department of Orthopaedic Surgery, University of Pennsylvania
Katherine P. Ponder, M.D., Department of Medicine, Washington University in St Louis
Mark E. Haskins, V.M.D., Ph.D., School of Veterinary Medicine, University of Pennsylvania
Brian D. Harfe, Ph.D., Department of Molecular Genetics and Microbiology, University of Florida
Nader M. Hebela, M.D., Department of Orthopaedic Surgery, Philadelphia VA Medical Center
Eileen M. Shore, Ph.D., Department of Orthopaedic Surgery, University of Pennsylvania


PUBLICATIONS
  1. Martin JT, Beattie E, Gorth DJ, Harfe BD, Smith LJ, Elliott DM. Mechanical consequences of needle puncture injury in the mouse caudal disc. (in review)
  2. Gorth DG, Mauck RL, Chiaro JA, Mohanraj B, Hebela NM, Dodge GR, Elliott DM, Smith LJ. IL-1ra Delivered from Poly(Lactic-co-Glycolic Acid) Microspheres Attenuates IL-1B Mediated Degradation of Nucleus Pulposus In Vitro. (in review)
  3. Moon SM, Yoder JH, Wright AC, Smith LJ, Vresilovic EJ, Elliott DM. Evaluation of intervertebral disc cartilaginous endplate structure using magnetic resonance imaging. (In review).
  4. Smith LJ, Martin JT, O'Donnell P, Wang P, Elliott DM, Haskins ME, Ponder KP (2012). Effect of neonatal gene therapy on lumbar spine disease in mucopolysaccharidosis VII dogs. Molecular Genetics and Metabolism. In press. PMID:22510705
  5. Smith LJ, Baldo G, Wu S, Whyte MP, Elliott DM, Haskins ME, Ponder KP (2012). Pathogenesis of lumbar spine disease in mucopolysaccharidosis VII. Molecular Genetics and Metabolism. In press. PMID:22513347
  6. Han W, Nerurkar NL, Jacobs NT, Smith LJ, Mauck RL, Elliott DM (2012). Multi-scale structural and tensile mechanical response of the annulus fibrosus to osmotic loading. Annals of Biomedical Engineering. In press. PMID:22314837
  7. Smith LJ, Nerurkar NL, Cortes DH, Chiaro JA, Horava SD, Hebela NM, Mauck RL, Dodge GR, Elliott DM (2011) Nucleus pulposus cells synthesize a functional extracellular matrix and respond to inflammatory cytokine treatment following long term agarose culture. European Cells and Materials, 22:291-301. PMID:22102324.
  8. Smith LJ, Elliott DM (2011) Formation of lamellar cross bridges in the annulus fibrosus of the intervertebral disc is a consequence of vascular regression. Matrix Biology, 30:267-274. PMID:21504791
  9. Jacobs NT, Smith LJ, Han W, Morelli J, Yoder JH, Elliott DM (2011) Effects of testing orientation and targeted extracellular matrix degradation on the shear mechanical properties of the annulus fibrosus. Journal of the Mechanical Behavior of Biomedical Materials, 4:1611-1619. PMID:22098863
  10. Smith LJ, Nerurkar NL, Choi KS, Harfe BD, Elliott DM (2011) Degeneration and regeneration of the intervertebral disc: lessons from development. Disease Models and Mechanisms, 4:31-41. PMID:21123625
  11. Smith LJ, Kurmis AP, Slavotinek JP, Fazzalari NL (2011) In-vitro evaluation of a manganese chloride phantom-based MRI technique for quantitative determination of lumbar intervertebral disc composition and condition. European Spine Journal, 20:434-439. PMID:21181479
  12. Smith LJ, Schirer JP, Fazzalari NL (2010) The role of mineral content in determining the micromechanical properties of discrete trabecular bone remodeling packets. Journal of Biomechanics, 43:3144-3149. PMID:20723898
  13. Smith LJ, Martin JT, Szczesny SE, Ponder KP, Haskins ME, Elliott DM (2010) Altered lumbar spine structure, biochemistry, and biomechanical properties in a canine model of mucopolysaccharidosis type VII. Journal of Orthopaedic Research, 28:616-622. PMID:19918911.
  14. Smith LJ, Fazzalari NL (2009) The elastic fibre network of the human lumbar anulus fibrosus: architecture, mechanical function and potential role in the progression of intervertebral disc degeneration. European Spine Journal, 18:439-448. PMID:19263091
  15. Kurmis AP, Slavotinek J, Barber C, Smith LJ and Fazzalari NL (2009) An unusual MR signal reduction artefact in an incompletely thawed cadaver spine specimen, Radiography, 15:86-90
  16. Smith LJ, Byers S, Costi JJ, Fazzalari NL (2008) Elastic fibres enhance the mechanical integrity of the human lumbar anulus fibrosus in the radial direction. Annals of Biomedical Engineering, 36:214-223. PMID:18066662
  17. Norman J, Shapter JG, Short K, Smith LJ, Fazzalari NL (2008) Micromechanical properties of human trabecular bone: A hierarchical investigation using nanoindentation, Journal of Biomedical Materials Research Part A, 87A:196-202. PMID:18085652
  18. Smith LJ, Fazzalari NL (2006) Regional variations in the density and arrangement of elastic fibres in the anulus fibrosus of the human lumbar disc, Journal of Anatomy, 209:359-367. PMID:16928204
CONFERENCE PROCEEDINGS
  1. Martin JT, Smith LJ, Gorth DJ, Hebela N, Elliott DM, Mauck RL (2012). Nanofibrous disc-like angle ply structures maintain rat caudal intervertebral disc height. Military Health System Research Symposium, Fort Lauderdale, USA. (in review)
  2. Chiaro JA, Baron MA, Shore EM, Elliott DM, Ponder KP, Haskins ME, Smith LJ (2012). Pathogenesis of vertebral bone disease in the cervical spines of mucopolysaccharidosis I dogs. 12th International symposium on MPS and related diseases, Noordwijkerhout, The Netherlands.
  3. Smith LJ, Martin JT, Baldo G, Wu S, O'Donnell P, Wang P, Giuliani R, Elliott DM, Haskins ME, Ponder KP (2012). Pathogenesis of lumbar spine disease in mucopolysaccharidosis and response to neonatal gene therapy. 12th International symposium on MPS and related diseases, Noordwijkerhout, The Netherlands.
  4. Han W, Nerurkar NL, Jacobs NT, Smith LJ, Mauck RL, Elliott DM (2012). Multi-scale structural and tensile mechanical response of the annulus fibrosus to osmotic loading. ASME Summer Bioengineering Conference, Fajardo, Puerto Rico.
  5. Cortes DH, Han WM, Smith LJ, Elliott DM (2012). Extrafibrillar matrix properties of the annulus fibrosus are location and age dependent. ASME Summer Bioengineering Conference, Fajardo, Puerto Rico.
  6. Martin JT, Beattie E, Gorth DJ, Smith LJ, Elliott DM (2012). Mechanical consequences of needle puncture injury in the mouse caudal disc. ASME Summer Bioengineering Conference, Fajardo, Puerto Rico.
  7. Smith LJ, Martin JT, Baldo G, Wu S, Elliott DM, Haskins ME, Ponder KP (2012). Pathogenesis of lumbar spine disease in mucopolysaccharidosis and response to neonatal gene therapy. Annual Meeting of the American Society for Gene and Cell Therapy. Philadelphia, USA.
  8. Gorth DG, Strutz W, Mohanraj B, Mauck RL, Smith LJ, Dodge GR (2012) Sustained Delivery of IL-1ra from PLGA Microspheres Attenuates Detrimental Effects of IL-1B on a Cartilage Tissue Analog. World Congress on Osteoarthritis, Barcelona, Spain.
  9. Gorth DG, Chiaro JA, Dodge GR, Hebela NM, Mauck RL, Elliott DM, Smith LJ (2012) Sustained Delivery of IL-1ra from PLGA Microspheres Attenuates IL-1B Mediated Degradation of Engineered Nucleus Pulposus, 58th Annual Meeting, Orthopaedic Research Society, San Francisco, USA
  10. Chiaro JA, Dodge GR, Hebela NM, Mauck RL, Elliott DM, Smith LJ (2012) Nucleus Pulposus Cells and Articular Chondrocytes Respond Differently to Hyaluronan Oligosaccharides, 58th Annual Meeting, Orthopaedic Research Society, San Francisco, USA
  11. Martin JT, Beattie E, Gorth DJ, Smith LJ, Elliott DM (2012) Mechanical and Biochemical Consequences of Needle Puncture Injury in the Mouse Caudal Disc, 58th Annual Meeting, Orthopaedic Research Society, San Francisco, USA
  12. Cortes DH, Smith LJ, Moon SM, Magland JF, Wright AC, Elliott DM (2011) Magnetic Resonance Elastography for the Measurement of Annulus Fibrosus Material Properties, New Horizons in Intervertebral Disc Research, Philadelphia, USA
  13. Gorth DG, Chiaro JA, Dodge GR, Hebela NM, Mauck RL, Elliott DM, Smith LJ (2011) IL-1ra released from PLGA microspheres inhibits IL-1B mediated degradation of engineered nucleus pulposus constructs in-vitro, New Horizons in Intervertebral Disc Research, Philadelphia, USA
  14. Cortes DH, Smith LJ, Moon SM, Magland JF, Wright AC, Elliott DM (2011) Magnetic Resonance Elastography for the Measurement of Annulus Fibrosus Material Properties, ASME Summer Bioengineering Conference, Farmington, USA
  15. Smith LJ, Elliott DM (2011) Formation of Lamellar Cross Bridges in the Annulus Fibrosus of the Intervertebral Disc is a Consequence of Vascular Regression, International Society for the Study of the Lumbar Spine Annual Meeting, Stockholm, Sweden
  16. Han W, Nerurkar NL, Jacobs NT, Smith LJ, Mauck RL, Elliott DM (2011) Differential structure-function mechanisms of the inner and outer annulus fibrosus in tension, International Society for the Study of the Lumbar Spine Annual Meeting, Stockholm, Sweden
  17. Smith LJ, Nerurkar NL, Cortes DH, Horava SD, Dodge GR, Hebela NM, Mauck RL, Elliott DM (2011) Inhibition of Functional Matrix Degradation in a Cytokine-Mediated In-Vitro Model of Nucleus Pulposus Degeneration, 57th Annual Meeting, Orthopaedic Research Society, Long Beach, USA
  18. Cortes DH, Gerasimowicz KM, Smith LJ, Elliott DM (2011) Material Properties of the Extrafibrillar Matrix of the Annulus Fibrosus in Tension and Compression, 57th Annual Meeting, Orthopaedic Research Society, Long Beach, USA
  19. Han W, Jacobs NT, Nerurkar NL, Smith LJ, Mauck RL, Elliott DM (2011) Differential tensile mechanical behavior of the inner and outer annulus fibrosus following treatment with chondroitinase ABC and buffer solutions, 57th Annual Meeting, Orthopaedic Research Society, Long Beach, USA
  20. Smith LJ, Elliott DM (2010) Formation of Lamellar Cross Bridges in the Annulus Fibrosus of the Intervertebral Disc is a Consequence of Vascular Regression, Philadelphia Spine Symposium, Drexel University, Philadelphia, USA
  21. Elliott DM, Nerurkar NL, Huang AH, Kluge JA, Smith LJ, Martin JT, Hebela N, Mauck RL (2010) Disc Tissue Engineering - Can We Make it Stick?, World Congress on Biomechanics, Singapore.
  22. Ponder KP, Smith LJ, Elliott DM, Martin JT, Haskins ME (2010) Molecular mechanisms for skeletal/soft tissue pathology, 11th International Symposium on Mucopolysaccharide and Related Diseases, Adelaide, Australia.
  23. Ponder KP, Smith LJ, Martin JT, Gerasimovic KM, Haskins ME, Elliott DM (2010) Altered cervical spine biomechanical properties and gene expression in mucopolysaccharidosis VII dogs, 11th International Symposium on Mucopolysaccharide and Related Diseases, Adelaide, Australia.
  24. Smith LJ, Schaer TP, Liechty KW, Elliott DM (2010) Developmental Origins of the Annulus Fibrosus Lamellar Cross Bridge Network, 56th Annual Meeting, Orthopaedic Research Society, New Orleans, USA
  25. Smith LJ, Ponder KP, Martin JT, Haskins ME, Elliott DM (2010) Lumbar Spine Segment Mechanical Properties, Composition and Gene Expression in Mucopolysaccharidosis VII Dogs Following Neonatal Gene Therapy, 56th Annual Meeting, Orthopaedic Research Society, New Orleans, USA
  26. Martin JT, Balderston JR, Gerasimowicz KM, Smith LJ, Hebela N, Elliott DM (2010) Direct effects of intervertebral disc needle puncture injury on mouse lumbar and caudal motion segment mechanical function, 56th Annual Meeting of the Orthopaedic Research Society, New Orleans, USA
  27. Jacobs NT, Morelli J, Smith LJ, Yoder JH, Elliott DM (2010) Annulus Fibrosus Shear Mechanical Properties and the Contributions of Glycosaminoglycans and Elastic Fibers to Shear are Anisotropic, 56th Annual Meeting of the Orthopaedic Research Society, New Orleans, USA
  28. Smith LJ, Martin JT, Szczesny SE, Ponder KP, Haskins ME, Elliott DM (2009) Mucopolysaccharidosis VII and the developing lumbar spine: consequences for annulus fibrosus and vertebral end plate mechanical properties, ASME Summer Bioengineering Conference, Lake Tahoe, USA
  29. Smith LJ, Martin JT, Ponder KP, Haskins ME, Elliott DM (2009) Structural and mechanical consequences of mucopolysaccharidosis VII for the developing lumbar spine, International Society for the Study of the Lumbar Spine Annual Meeting, Miami, USA
  30. Smith LJ, Schirer JP, Dickinson ME, Fazzalari NL (2009) The influence of degree of mineralisation on the micromechanical properties of discrete remodelling packets in non-diseased human trabecular bone spicules, 55th Annual Meeting, Orthopaedic Research Society, Las Vegas, USA
  31. Smith LJ, Kurmis AP, Slavotinek JP, Fazzalari NL (2009) Evaluation of a manganese chloride phantom-based magnetic resonance imaging technique as a quantitative tool for predicting human lumbar intervertebral disc condition, 55th Annual Meeting, Orthopaedic Research Society, Las Vegas, USA.
  32. Smith LJ, Fazzalari NL (2008) Structural changes to the human lumbar anulus fibrosus elastic fibre network following radial tensile deformation, 54th Annual Meeting, Orthopaedic Research Society, San Francisco, USA.
  33. Smith LJ, Schirer JP, Dickinson ME, Fazzalari NL (2008) Relationships between mineralisation and micromechanical properties within the individual remodelling packets of human femoral trabecular bone spicules, Annual Scientific Meeting, Australian Society for Medical Research SA Branch, Adelaide, Australia.
  34. Costi JJ, Stanley RM, Smith LJ, Tettis H, Tsangari H, Hearn TC, Fazzalari NL (2008) The effect of intervertebral disc degeneration on vertebral cortical strains and disc mechanical properties, 54th Annual Meeting, Orthopaedic Research Society, San Francisco, USA.
  35. Smith LJ, Schirer JP, Dickinson ME, Fazzalari NL (2008) Relationships between mineralisation and micromechanical properties within the individual remodelling packets of human femoral trabecular bone spicules, 5th Clare Valley Bone Meeting, Clare, Australia.
  36. Smith LJ, Byers S, Costi JJ, Fazzalari NL (2007) The roles of elastic fibres and glycosaminoglycans in the radial tensile mechanical properties of the human lumbar anulus fibrosus, ASME Summer Bioengineering Conference, Keystone, USA.
  37. Smith LJ, Fazzalari NL (2007) Variations in the density and arrangement of elastic fibres in the anulus fibrosus of the human lumbar disc suggest functional significance, 53rd Annual Meeting, Orthopaedic Research Society, San Diego, USA.
  38. Smith LJ, Byers S, Costi JJ, Fazzalari NL (2007) Elastic fibres enhance the mechanical integrity of the anulus fibrosus transverse to the collagen fibre direction, 13th Annual Scientific Meeting, Australian and New Zealand Orthopaedic Research Society, Auckland, New Zealand.
  39. Kurmis AP, Slavotinek JP, Barber C, Smith LJ, Fazzalari NL (2007) An unusual MR core signal reduction artefact in an incompletely thawed cadaveric spine specimen, 13th Annual Scientific Meeting, Australian and New Zealand Orthopaedic Research Society, Auckland, New Zealand.
  40. Smith LJ, Byers S, Costi JJ, Fazzalari NL (2007) The roles of elastic fibres in the radial tensile mechanical properties of the human lumbar anulus fibrosus, Annual Scientific Meeting, Australian Society for Medical Research SA Branch, Adelaide, Australia.
  41. Smith LJ, Fazzalari NL (2006) Variations in elastic fibre density and arrangement in the anulus fibrosus of the human lumbar disc. Annual Scientific Meeting, Australian Orthopaedic Association SA Branch, Adelaide, Australia.
  42. Smith LJ, Fazzalari NL (2006) Regional variations in elastic fibre density and arrangement in the anulus fibrosus of the human lumbar disc, 12th Annual Scientific Meeting, Australian and New Zealand Orthopaedic Research Society, Canberra, Australia.
  43. Smith LJ, Fazzalari NL (2005) Elastic fibre architecture in the human lumbar anulus fibrosus, 29th Annual Meeting, Matrix Biology Society of Australia and New Zealand, Victor Harbor, Australia.

PATENTS
  1. Glasson JH, Smith LJ (2005) Microbial streaking device. United States Patent 20070202564.



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