McKay Orthopaedic Research Laboratory > Soslowsky Lab > David Beason

David P. Beason

Research Engineer
Laboratory Manager
University of Pennsylvania

HOMETOWN
Knoxville, Tennessee

EDUCATION
M.S. Biomedical Engineering, 2000, University of Alabama at Birmingham
B.S. Engineering Science, 1999, University of Tennessee

AREAS OF SPECIAL INTEREST
Biomechanics of Tendon Healing
          Effect of Hypercholesterolemia
          Roles of Decorin and Biglycan
          Effect of Aging
Regenerative Tendon Healing
Orthopaedic Biomechanics
Injury Biomechanics

PEER-REVIEWED PUBLICATIONS

1. Beason DP, Tucker JJ, Abboud JA, Soslowsky LJ: Rat Rotator Cuff Tendon-to-Bone Healing Properties are Adversely Affected by Hypercholesterolemia, J Orthop Res, in preparation.
2. Beason DP, Hsu JE, Marshall SM, McDaniel AL, Temel RE, Abboud JA, Soslowsky LJ: High Cholesterol Increases Supraspinatus Tendon Mechanical Properties Across Multiple Species, J Shoulder Elbow Surg, in review.
3. Beason DP, Kuntz AF, Hsu JE, Miller KS, Soslowsky LJ: Development and Evaluation of Multiple Tendon Injury Models in the Mouse, J Biomech, in press.
4. Beason DP, Connizzo BK, Dourte LM, Mauck RL, Soslowsky LJ, Steinberg DR, Bernstein J: Fiber-Aligned Polymer Scaffolds for Rotator Cuff Repair in a Rat Model, J Shoulder Elbow Surg 21(2):245-50, 2012.
5. Abboud JA, Beason DP, Soslowsky LJ: Emerging Ideas: The Effect of Hypercholesterolemia on Tendons, Clin Orthop Rel Res 470(1):317-20, 2012.
6. Castello-Cros R, Whitaker-Menezes D, Molchansky A, Purkins G, Soslowsky LJ, Beason DP, Sotgia F, Iozzo RV, Lisanti MP: Scleroderma-like properties of skin from caveolin-1 deficient mice: Implications for new treatment strategies in patients with fibrosis and systemic sclerosis, Cell Cycle 10(13):2140-50, 2011.
7. Bermudez DM, Herdrich BJ, Xu J, Lind R, Beason DP, Mitchell ME, Soslowsky LJ, Liechty KW: Impaired biomechanical properties of diabetic skin: Implications in the pathogenesis of diabetic wound complications, Am J Pathol 178(5):2215-23, 2011.
8. Wenstrup RJ, Smith SM, Florer JB, Zhang G, Beason DP, Seegmiller RE, Soslowsky LJ, Birk DE: Regulation Of Collagen Fibril Nucleation And Initial Fibril Assembly Involves Coordinate Interactions With Collagens V And XI In Developing Tendon, J Biol Chem 286(23):20455-65, 2011.
9. Beason DP, Abboud JA, Kuntz AF, Bassora R, Soslowsky LJ: Cumulative Effects of Hypercholesterolemia on Tendon Biomechanics in a Mouse Model, J Orthop Res 29(3):380-3, 2011.
10. Gilley RS, Beason DP, Snyder DM, Boston RC, Radin A, Kapatkin AS, Smith GK, Soslowsky LJ: External Fixator Clamp Reuse Degrades Clamp Mechanical Performance, Vet Surg 38(4):530-6, 2009.
11. Ansorge HL, Meng X, Zhang G, Veit G, Klement JF, Beason DP, Soslowsky LJ, Koch M, Birk DE: Type XIV Collagen Regulates Fibrillogenesis: Premature Collagen Fibril Growth and Tissue Dysfunction in Null Mice, J Biol Chem 284(13):8427-38, 2009.
12. Favata M, Beredjiklian PK, Zgonis MH, Beason DP, Crombleholme TM, Soslowsky LJ: Regenerative properties of fetal sheep tendon are not adversely affected by transplantation into an adult environment, J Orthop Res 24(11):2124-32, 2006.
13. Zhang G, Ezura Y, Chervoneva I, Robinson PS, Beason DP, Carine ET, Soslowsky LJ, Iozzo RV, Birk DE: Decorin Regulates Assembly of Collagen Fibrils and Acquisition of Biomechnical Properties during Tendon Development, J Cell Biochem 98:1436-49, 2006.
14. Christner PJ, Gentiletti J, Peters J, Ball ST, Yamauchi M, Beason DP, Soslowsky LJ, Birk DE: Collagen Dysregulation in Dermis of the Sagg/+ Mouse: A Loose Skin Model, J Invest Dermatol 126(3):595-602, 2006.
15. Sparks DR, Beason DP, Etheridge BS, Alonso JE, Eberhardt AW: Contact Pressures in the Flexed Hip Joint Under Lateral Trochanteric Loading, J Orthop Res 23(2):359-66, 2005.
16. Etheridge BS, Beason DP, Lopez RR, Alonso JE, McGwin G, Eberhardt AW: Effects of Trochanteric Soft Tissues and Bone Density on Fracture of the Female Pelvis in Experimental Side Impacts, Ann Biomed Eng 33(2):248-54, 2005.
17. Beason DP, Dakin GJ, Lopez RR, Alonso JE, Bandak FA, Eberhardt AW: Bone Mineral Density Correlates with Fracture Load in Experimental Side Impacts of the Pelvis, J Biomech 36(2):219-27, 2003.

THESIS

1. Beason DP: The Effects of Impact Parameters and Bone Mineral Density on Pelvic Fracture in Lateral Impact, Master's Thesis, University of Alabama at Birmingham, 2000.

BOOK CHAPTERS

1. Beason DP, Soslowsky LJ, Karthikeyan T, Huard J: Muscle, Tendon, and Ligament. In Fischgrund JS, ed: Orthopaedic Knowledge Update 9, ed 9, Rosemont, IL, American Academy of Orthopaedic Surgeons; pp 35-48, 2008.
2. Pedowitz DI, Beason DP, Soslowsky LJ: Biomechanics of the Shoulder and Elbow Complex. In Nordin M, Andersson GBJ, Pope MH, eds: Musculoskeletal Disorders in the Workplace, ed 2, St. Louis, Mosby-Year Book; pp 155-166, 2006.

CONFERENCE PAPERS AND ABSTRACTS

1. Morris MW, Urencio M, Beason DP, Caskey RC, Dorsett-Martin W, Mitchell ME, Soslowsky LJ, Liechty KW: The Effect of Diabetes on the Biomechanical Properties of the Skin, Proceedings of the 7th Annual Academic Surgical Congress, Las Vegas, NV, 2012.
2. Beason DP, Connizzo BK, Dourte LM, Edelstein L, Tucker JJ, Liu SS, Mauck RL, Soslowsky LJ, Steinberg DR, Bernstein J: Fiber-Aligned Polymer Scaffolds for Rotator Cuff Repair in a Rat Model, Trans Orthop Res Soc 37:1664, 2012.
3. Buckley MR, Pathmanathan L, Mienaltowski MJ, Dunkman AA, Kumar A, Beason DP, Iozzo RV, Birk DE, Soslowsky LJ: Age-Related Changes in Tendon Mechanical Properties are Not Enhanced by the Absence of Biglycan and Decorin, Trans Orthop Res Soc 37:1308, 2012.
4. Beason DP, Hsu JE, Edelstein L, Lee CS, Lee BC, Marshall SM, McDaniel AL, Temel RE, Abboud JA, Soslowsky LJ: High Cholesterol Increases Supraspinatus Tendon Mechanical Properties Across Multiple Species, Trans Orthop Res Soc 37:1225, 2012.
5. Kumar A, Dunkman AA, Buckley MR, Pathmanathan L, Mienaltowski MJ, Beason DP, Iozzo RV, Birk, DE, Soslowsky LJ: Tendon Repair Response to Injury is Affected by the Absence of Biglycan and Decorin, Trans Orthop Res Soc 37:158, 2012.
6. Beason DP, Tucker JJ, Edelstein L, Lee CS, Abboud JA, Soslowsky LJ: Rat Rotator Cuff Tendon-to-Bone Healing Properties are Adversely Affected by Hypercholesterolemia, Trans Orthop Res Soc 37:42, 2012. Podium Presentation
7. Urencio M, Bermudez DM, Beason D, Caskey RC, Zhang L, Xu J, Dorsett-Martin WA, Soslowsky LJ, Mitchell ME, Liechty KW: Improved Biomechanical Properties of Diabetic Skin Following Mesenchymal Stem Cell (MSC) Treatment, Americal College of Surgeons Clinical Congress, San Francisco, CA, 2011.
8. Beason DP, Kuntz AF, Hsu JE, Miller KS, Soslowsky LJ: Development and Evaluation of Multiple Tendon Injury Models in the Mouse, Trans Orthop Res Soc 36:919, 2011.
9. Beason DP, Hsu JE, Edelstein L, Lee CS, Tucker JJ, Abboud JA, Soslowsky LJ: Effect of Diet-Induced Hypercholesterolemia on Rotator Cuff Tendon Mechanics in a Rat Model, Trans Orthop Res Soc 36:223, 2011. Short Talk Podium Presentation
10. Bermudez DM, Beason DP, Soslowsky LJ, Liechty KW: Diabetic skin has less tensile strength than normal skin at baseline, Symposium on Advanced Wound Care and Wound Healing Society Meeting 20:GP12, 2010.
11. Herdrich BJ, Bermudez DM, Beason DP, Soslowsky LJ, Liechty KW: Lentiviral Mediated IL-10 Overexpression Promotes Scarless Wound Healing Without Affecting Wound Biomechanics, Symposium on Advanced Wound Care and Wound Healing Society Meeting 19:68, 2009.
12. Beason DP, Abboud JA, Bassora R, Kuntz AF, Soslowsky LJ: Hypercholesterolemia is Detrimental to Tendon Properties and Healing in a Mouse Injury Model, Trans Orthop Res Soc 34:1418, 2009.
13. Beason DP, Kuntz AF, Hamamdzic D, Wilensky RL, Mohler ER III, Abboud JA, Soslowsky LJ: High Cholesterol Adversely Affects Biceps Tendon Mechanical Properties in a Porcine Model, Trans Orthop Res Soc 34:184, 2009. Podium Presentation.
14. Gilley RS, Beason DP, Boston RC, Snyder DM, Radin A, Kapatkin AS, Smith GK, Soslowsky LJ: External Fixator Clamp Reuse Degrades Clamp Mechanical Performance, Proceedings of the American College of Veterinary Surgeons Veterinary Symposium, San Diego, CA, 2008.
15. Lind RC, Herdrich BJ, Beason DP, Soslowsky LJ, Liechty KW: The Biomechanical Properties of Diabetic Skin Are Inferior at Baseline Compared to Non-Diabetic Controls, Wound Rep Reg 16:A53, 2008.
16. Kuntz AF, Van Kleunen JP, Beason DP, Soslowsky LJ: Effect of Protein Malnutrition on Tendon Healing in a Mouse Patellar Tendon Injury Model, Trans Orthop Res Soc 33:816, 2008.
17. Beason DP, Abboud JA, Bassora R, Soslowsky LJ: Tendon Healing in a Mouse Injury Model: The Role of Hypercholesterolemia, Trans Orthop Res Soc 33:814, 2008.
18. Ansorge HL, Beason DP, Xianmin M, Birk DE, Soslowsky LJ: The Temporal Expression of Collagen XIV Alters the Mechanics of Developing Mouse Flexor Digitorum Longus Tendons, Trans Orthop Res Soc 33:200, 2008.
19. Beason DP, Zgonis MH, Ansorge HL, Birk DE, Soslowsky LJ: Tendon Healing in a Mouse Patellar Tendon Injury Model: Effect of Age, Trans Orthop Res Soc 32:885, 2007.
20. Ansorge HL, Beason DP, Meng X, Birk DE, Soslowsky LJ: Functional Characterization of Connective Tissues in a Collagen XIV Knockout Mouse, Trans Orthop Res Soc 32:26, 2007.
21. Favata M, Zgonis MH, Beredjiklian PK, Beason DP, Savani RC, Soslowsky LJ: Hyaluronic Acid Levels Rise and Then Return to Normal Following Injury: An Immunohistochemical Investigation in Mouse Patellar Tendon, Trans Orthop Res Soc 31:1068, 2006.
22. Favata M, Beredjiklian PK, Beason DP, Burdick J, Pedowitz DI, Soslowsky LJ: Loss of Viscoelasticity After Injury and Increased TGF-ß1 in Adult But Not Fetal Tendons, Trans Orthop Res Soc 30:765, 2005.
23. Favata M, Beredjiklian PK, Beason DP, Pedowitz DI, Andarawis NA, Boxberger JI, Soslowsky LJ: The Effect of Environment on Adult and Fetal Tendon Healing, Biomedical Engineering Society Annual Fall Meeting, Philadelphia, PA, 2004.
24. Etheridge BS, Beason DP, Alonso JE, Lopez RR, Eberhardt AW: Further Evidence that Bone Mineral Density and Soft Tissues Influence Pelvic Fracture in Older Women During Lateral Impact, Proceedings of the American Society of Biomechanics, Portland, OR, 2004.
25. Etheridge BS, Beason DP, Lopez RR, Alonso JE, Eberhardt AW: The Influence of Bone Mineral Density on Pelvic Fracture Load and Compression in Lateral Impact, Proceedings of the 2003 ASME International Mechanical Engineering Congress and Exposition, Washington, DC, 2003.
26. Hornbuckle HF, Beason DP, Volgas DA, Eberhardt AW: Contact Area and Pressure Measurements in the Isolated Tibiotalar Joint at Motion Extremes, Biomedical Engineering Society Annual Fall Meeting, Nashville, TN, 2003.
27. Sparks DR, Beason DP, Alonso JE, Eberhardt AW: Femoral Orientation Alters Contact Mechanics in the Hip Joint Under Lateral Trochanteric Loading, Proceedings of the 2003 ASME Summer Bioengineering Conference, Key Biscayne, FL: 545-6, 2003.
28. Schifano TL, Beason DP, Eberhardt AW, Bandak FA: Coupled Rotations of the Talar Joint at Extremes of Ankle Motion, Biomedical Engineering Society Annual Fall Meeting, Houston, TX, 2002.
29. Sparks DR, Beason DP, Eberhardt AW, Bandak FA: Contact Pressure Measurements in the Hip Joint: Effects of Femoral Angle in Greater Trochanter Loading, Biomedical Engineering Society Annual Fall Meeting, Houston, TX, 2002.
30. Eberhardt AW, Beason DP, Dakin GJ, Lopez RR, Alonso JE: The Role of Bone Mineral Density in Pelvic Fractures Resulting from Lateral Impact, Orthopaedic Trauma Association 17th Annual Meeting, San Diego, CA, 2001.
31. Beason DP, Dakin GJ, Lopez RR, Alonso JE, Eberhardt AW: Effect of Bone Mineral Density on Pelvic Fracture in Lateral Impact, 20th Southern Biomedical Engineering Conference, Birmingham, AL 2001. Podium Presentation

David joined the McKay Lab in September of 2003 after spending over two years as the engineer/lab manager in the Musculoskeletal Mechanics Laboratory at the University of Alabama at Birmingham. Since joining McKay, he has participated in various research projects pertaining to the biomechanics of tendon healing in a mouse injury model as well as other orthopaedic biomechanical studies.

David's enjoys spending time with his wife, Hilary, and daughter, Harper, as well as playing guitar; writing, producing, and listening to music; watching college football; and playing tennis and racquetball.