McKay Orthopaedic Research Laboratory

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McKay Orthopaedic Research Laboratory > Soslowsky Lab > Louis J. Soslowsky

Louis J. Soslowsky, Ph.D.

Fairhill Professor of Orthopaedic Surgery
Professor of Bioengineering
Vice Chair for Research-Orthopaedic Surgery
Director of McKay Orthopaedic Research Laboratory
Graduate Group Member in Bioengineering and Mechanical Engineering in Applied Mechanics

HOMETOWN
East Brunswick, New Jersey

EDUCATION
Ph.D. Engineering Mechanics, 1991, Columbia University
B.S. Engineering Mechanics, 1986, Columbia University

AREAS OF EXPERTISE
Orthopaedic bioengineering and tissue engineering

AREAS OF SPECIAL INTEREST
Structure-function relationships of tendons and ligaments; models for tendon injury, healing, repair and regeneration; biomechanics of the shoulder and elbow

CURRENT POSITIONS HELD
  1. Research Editor, Journal of Shoulder and Elbow Surgery
  2. Editorial Advisory Board, Journal of Orthopaedic Research
  3. Editorial Consultant Panel, Journal of Biomechanics
  4. Ad Hoc Reviewer, National Institute of Health, several other agencies and foundations
  5. Chairman, Bioengineering Division of the American Society of Mechanical Engineers
  6. Member, United States National Committee on Biomechanics

PRESENT AND RECENT FUNDING
  1. National Institute of Health
  2. Orthopaedic Research and Educational Foundation
  3. Whitaker Foundation
  4. National Science Foundation
  5. Wyeth Research
  6. Biomet, Inc.

RECENT PUBLICATIONS
  1. Skalak, R., Soslowsky, L., Schmalzer, E., Impelluso, T., and Chien, S.: Theory of filtration of mixed blood suspensions. Biorheology, 24:35-52, 1987.
  2. Froimson, M.I., Ateshian, G.A., Soslowsky, L.J., and Mow, V.C.: Quantification of the surfaces and contact areas at the patellofemoral articulation. Proc Instit of Mech Engineers 5:73-78, 1989.
  3. Bigliani, L.U., Ticker, J.B., Flatow, E.L., Soslowsky, L.J., and Mow, V.C.: Die Beziehung von Akromialarchitektur zu Erkrankungen der Rotatorenmanschette. Orthopade 20:302-309, 1991.
  4. Ateshian, G.A., Soslowsky, L.J., and Mow, V.C.: Quantitation of articular surface topography and cartilage thickness in knee joints using stereophotogrammetry. J Biomechanics 24:761-776, 1991.
  5. Bigliani, L.U., Ticker, J.B., Flatow, E.L., Soslowsky, L.J., and Mow, V.C.: The relationship of acromial architecture to rotator cuff disease. Clin Sports Med 10:823-838, 1991.
  6. Bigliani, L.U., Pollock, R.G., Soslowsky, L.J., Flatow, E.L., Pawluk, R.J., and Mow, V.C.: Tensile properties of the inferior glenohumeral ligament. J Orthop Res 10:187-197, 1992.
  7. Soslowsky, L.J., Flatow, E.L., Bigliani, L.U., Pawluk, R.J., and Mow, V.C.: Quantitation of in situ contact areas in the glenohumeral joint: A biomechanical study. J Orthop Res 10: 524-534, 1992.
  8. Soslowsky, L.J., Flatow, E.L., Bigliani, L.U., and Mow, V.C.: Articular geometry of the glenohumeral joint. Clin Orthop Rel Res 185:181-190, 1992.
  9. Ateshian, G.A., Kwak, S.D., Soslowsky, L.J., and Mow, V.C.: A stereophotogrammetric method for determining in situ contact areas in diarthrodial joints, and a comparison with other methods. J Biomechanics 27:111-124, 1994.
  10. Soslowsky, L.J., An, C.H., Johnston, S.P., and Carpenter J.E.: Geometric and mechanical properties of the coracoacromial ligament and their relationship to rotator cuff disease. Clin Orthop Rel Res 304:10-17, 1994.
  11. Derwin, K.A., Soslowsky, L.J., Green, W.D.K., and Elder, S.H.: A new optical system for the determination of deformations and strains: Calibration characteristics and experimental results. J Biomechanics 27:1277-1285, 1994.
  12. Flatow, E.L., Ateshian, G.A., Soslowsky, L.J., Pawluk, R.J., Grelsamer, R.P., Mow, V.C., and Bigliani, L.U.: Computer simulation of glenohumeral and patellofemoral subluxation: Estimating pathological articular contact. Clin Orthop Rel Res 306:28-33, 1994.
  13. Flatow, E.L., Soslowsky, L.J., Ticker, J.B., Hepler, M.D., Ark, J.W., Pawluk, R.J., Bigliani, L.U., and Mow, V.C.: Excursion of the rotator cuff under the acromion: Patterns of subacromial contact. Am J Sports Med 22:779-788, 1994.
  14. Ateshian, G.A., Ark, J.W., Rosenwasser, M.P., Pawluk, R.J., Soslowsky, L.J., and Mow, V.C.: Contact areas in the thumb carpometacarpal joint. J Orthop Res 13:450-458, 1995.
  15. Malicky, D.M, Soslowsky, L.J., and Blasier, R.B.: Anterior glenohumeral stabilization factors: Progressive effects in a biomechanical model. J Orthop Res 14:282-288, 1996.
  16. Ticker, J.B., Bigliani, L.U., Soslowsky, L.J., Pawluk, R.J., Flatow, E.L., and Mow, V.C.: Inferior glenohumeral ligament: Geometric and strain-rate dependent properties. J Shoulder Elbow Surg 5:269-279, 1996.
  17. Soslowsky, L.J., An, C.H., DeBano, C.M., and Carpenter, J.E.: Coracoacromial ligament: In situ load and viscoelastic properties in rotator cuff disease. Clin Orthop Rel Res 330:40-44, 1996.
  18. Soslowsky, L.J., Carpenter, J.E., DeBano, C.M., Banerji, I., and Moalli, M.R.: Development and use of an animal model for investigations on rotator cuff disease. J Shoulder Elbow Surg 5:383-392, 1996.
  19. Blasier, R.B., Soslowsky, L.J., Malicky, D.M., and Palmer, M.L.: Posterior glenohumeral subluxation: Active and passive stabilization in a biomechanical model. J Bone Joint Surg 79-A:433-440, 1997.
  20. Soslowsky, L.J., Carpenter, J.E., Bucchieri, J., and Flatow, E.L.: Biomechanics of the Rotator Cuff. Orthop Clin North America 28:17-30, 1997.
  21. Soslowsky, L.J., Malicky, D.M., and Blasier R.B.: Active and passive factors in inferior glenohumeral stabilization: A biomechanical model. J Shoulder Elbow Surg 6:371-379, 1997.
  22. Bey, M.J. Elders, G.J., Huston, L.J., Kuhn, J.E., Blasier, R.B., and Soslowsky, L.J.: The mechanism of creation of superior labrum, anterior, and posterior lesions in a dynamic, biomechanical model of the shoulder: The role of inferior subluxation. J Shoulder Elbow Surg, 7:397-401, 1998.
  23. Carpenter, J.E., Flanagan, C.L., Thomopoulos, S., and Yian, E.H., Soslowsky, L.J.: The effects of overuse combined with intrinsic or extrinsic alterations in an animal model of rotator cuff tendinosis. Am J Sports Med, 26:801-807, 1998 (Hughston Award Winner).
  24. Carpenter, J.E., Thomopoulos, S., Flanagan, C.L., DeBano, C.M., Moalli, M.R., and Soslowsky, L.J.: Rotator cuff defect healing: A biomechanical and histologic analysis in an animal model. J Shoulder Elbow Surg, 7:599-605, 1998.
  25. Derwin, K.A. and Soslowsky L.J.: A quantitative investigation of structure-function relationships in a tendon fascicle model. J Biomech Eng, 121:598-604, 1999.
  26. Carpenter, L.J., Thompoulos, S., and Soslowsky, L.J.: Animal models of tendon and ligament injuries for tissue engineering applications. Clin Orthop Rel Res, 367:S296-311, 1999.
  27. Elder, S.H. Kimura, J.H., Soslowsky L.J., and Goldstein S.A.: Effect of compressive loading on chondrocyte differentiation in agarose cultures of chick limb-bud cells. J Orthop Res, 18:79-86, 2000.
  28. Kuhn, J.E., Bey, M.J., Huston, L.J., Blasier, R.B., and Soslowsky, L.J.: Ligamentous Restraints to External Rotation of the Humerus in the late-cocking phase of throwing: A cadaveric biomechanical investigation Am J Sports Med, 28:200-205, 2000.
  29. Soslowsky, L.J., Thomopoulos, S., Tun, S., Flanagan, C.L., Keefer, C.C., Mastaw, J., and Carpenter, J.E.: Overuse activity injuries the supraspinatus tendon in an animal model: A histologic and biomechanical study. J Shoulder Elbow Surgery, 9:79-84, 2000 (Neer Award Winner).
  30. Derwin, K.A., Soslowsky, L.J., Kimura, J.H., and Plaas, A.H.: Proteoglycans and glycosaminoglycan fine structure in the mouse tail tendon fascicle. J Orthop Res, 19:269-277, 2001.
  31. Elder, S.H. Goldstein, S.A., Kimura, J.H., Soslowsky L.J., and Spengler, D.M.: Chondrocyte differentiation is modulated by frequency and duration of cyclic compressive loading. Annals Biomed Eng, 29:476-482, 2001.
  32. Malicky, D.M., Soslowsky, L.J., Mouro, C.M., Frisancho, J.C., Lindholm, S.R., and Kuhn, J.E.: Total strain fields of the antero-inferior shoulder capsule. J Biomech Eng, 123:425-431, 2001.
  33. Abboud, J.A., Bozentka, D.J., Soslowsky, L.J., and Beredjiklian, P.K.: Effect of implant design on the cyclic loading properties of mini suture anchors in carpal bones, J Hand Surg [Am], 27:43-48, 2002.
  34. Bey M.J., Song, H.K., Wehrli, F.W., and Soslowsky, L.J.: A noncontact, nondestructive method for quantifying intratissue deformations and strains. J Biomech Eng, 124:253-258, 2002.
  35. Thomopoulos, S., Hattersley, G., Rosen, V., Mertens, M., Galatz, L., Williams, G.R., and Soslowsky, L.J.: The localized expression of extracellular matrix components in healing tendon insertion sites: An in situ hybridization study. J Orthop Res, 20:454-463, 2002.
  36. Thomopoulos, S., Soslowsky, L.J., Flanagan, C.L., Tun, S., Keefer, C.C., Mastaw, J., and Carpenter, J.E.: The effect of fibrin clot on healing rat supraspinatus tendon defects. J Shoulder Elbow Surg, 11:239-247. 2002.
  37. Abboud, J. and Soslowsky, L.J.: Interplay of the static and dynamic restraints in glenohumeral instability. Clin Orthop Rel Res, 400:48-57, 2002.
  38. Malicky, D.M., Kuhn, J.E., Frisancho, J.C., Lindholm, S.R., Raz, J.A., and Soslowsky, L.J.: Non-recoverable strain fields of the anteroinferior glenohumeral capsule under subluxation. J Shoulder Elbow Surg, 11:529-540, 2002 (2001 Neer Award Winner).
  39. Bey M.J., Song, H.K., Wehrli, F.W., and Soslowsky, L.J.: Intratendinous strain fields of the intact supraspinatus tendon: The effect of glenohumeral joint position and tendon region. J Orthop Res, 20:869-874, 2002.
  40. Soslowsky, L.J., Thomopoulos, S., Esmail, A., Flanagan, C.L., Iannotti, J.P., Williamson III, J.D., and Carpenter, J.E.: Rotator cuff tendinosis in an animal model: The role of extrinsic and overuse factors. Ann Biomed Eng, 30:1057-1063, 2002.
  41. Bey M.J., Ramsey, M.L., and Soslowsky, L.J.: Intratendinous strain fields of the supraspinatus tendon: Effect of a surgically created articular-surface rotator cuff tear. J Shoulder Elbow Surg, 11:562-569, 2002.
  42. Thomopoulos, S., Williams, G.R., and Soslowsky, L.J.: Tendon to bone healing: Differences in biomechanical, structural, and compositional properties due to a range of activity levels. J Biomech Eng, 125:106-113, 2003.
  43. Kuhn, J.E., Lindholm, S.R., Huston, L.J., Soslowsky, L.J., and Blasier, R.B.: Failure of the biceps superior labral complex: A cadaveric biomechanical investigation comparing the late cocking and early deceleration positions of throwing. Arthroscopy, 19:373-379, 2003.
  44. Elliott, D.M., Robinson, P.S., Gimbel, J.A., Sarver, J.J, Abboud, J.A., Iozzo, R.V., and Soslowsky, L.J.: Effect of altered matrix proteins on quasilinear viscoelastic properties in transgenic mouse tail tendons. Annals Biomed Eng, 31:599-605, 2003.
  45. Thomopoulos, S., Williams, G.R., Gimbel, J.A., Favata, M., and Soslowsky, L.J.: Variation of biomechanical, structural and compositional properties along the tendon to bone insertion site. J Orthop Res, 21:413-419, 2003.
  46. Mehta, S.M., Gimbel, J.A., and Soslowsky, L.J.: Etiologic and pathogenetic factors for rotator cuff tendinopathy. Clin Sports Med, 22:791-812, 2003.
  47. Beredjiklian, P.K., Favata, M., Cartmell, J.S., Flanagan, C.L., Crombleholme, T.M., and Soslowsky, L.J.: Regenerative vs. reparative healing in tendon: A study of biomechanical and histological properties in fetal sheep. Annals Biomed Eng, 31:1143-1152, 2003.
  48. Robinson, P.S., Placide, R., Soslowsky, L.J., and Born, C.T.: Mechanical strength of repairs of the hips short external rotators. J Arthroplasty, 19:204-210, 2004.
  49. Huang, T.F., Perry, S.M., and Soslowsky, L.J.: Achilles vs supraspinatus tendon changes due to treadmill running in an animal model. Annals Biomed Eng, 32:336-341, 2004.
  50. Gimbel, J.A., Van Kleunen, J.P., Mehta, S., Perry, S.M., Williams, G.R., and Soslowsky, L.J.: Supraspinatus tendon structural and mechanical properties in a chronic rotator cuff tear animal model. J Biomechanics, 37:739-749, 2004.
  51. Lin, T.W., Cardenas, L, and Soslowsky, L.J.: Biomechanics of tendon injury and repair. J Biomechanics, 37:865-877, 2004.
  52. Robinson, P.S., Lin, T.W., Reynolds, P., Derwin, K., Iozzo, R., and Soslowsky, L.J.: Strain rate sensitive mechanical properties of tendon fascicles from mice with genetically engineered alterations in collagen and decorin. J Biomech Eng, 126:252-257, 2004.
  53. Robinson, P.S., Lin, T.W., Reynolds, P., Jawad, A., Iozzo, R., and Soslowsky, L.J.: Investigating tendon fascicle structure-function relationships in a transgenic-age mouse model using multiple regression models. Annals Biomed Eng, 32:924-931, 2004.
  54. Gimbel, J.A., Mehta, S., Van Kleunen, J.P., Williams, G. R., and Soslowsky, L.J.: The tension required at repair to re-appose the supraspinatus tendon to bone rapidly increases following injury. Clin Orth Rel Res, 426:258-265, 2004.
  55. Gimbel, J.A., Sarver, J.J., and Soslowsky, L.J.: The effect of overshoot on estimating viscoelastic properties from stress relaxation experiments. J Biomech Eng, 126:844-848, 2004.
  56. Lin, T.W., Cardenas, L, and Soslowsky, L.J.: Tendon properties in interleukin-4 and interleukin-6 knockout mice. J Biomechanics, 38:99-105, 2005.
  57. Perry, S.M., Hoffman, M.C., and Soslowsky, L.J.: Inflammatory and angiogenic mRNA levels are altered in a supraspinatus tendon overuse animal model. J Shoulder Elbow Surg, 14:S79-83, 2005.
  58. Barton, E.R., Gimbel, J.A., Perry, S.M., Young, S.D. III, Williams, G.R., and Soslowsky, L.J.: Rat supraspinatus muscle atrophy after tendon detachment. J Orthop Res, 23:259-265, 2005.
  59. Yokota, A., Gimbel, J.A., Williams, G.R and Soslowsky, L.J.: Supraspinatus tendon composition remains altered long after tendon detachment. J Shoulder Elbow Surg, 14:S72-78, 2005.
  60. Kuhn, J.E., Huston, L.J., Soslowsky, L.J., Shyr, Y., and Blasier, R.B.: Ligament restraints and muscle effects in the neutral and abducted positions. J Shoulder Elbow Surg, 14:S39-48, 2005.
  61. Zhang, G., Young, B.B., Ezura, Y., Favata, M., Soslowsky, L.J., Chakravarti, S., and Birk, D.E.: Development of tendon structure and function: Regulation of collagen fibrillogenesis. J Musculoskeletal Neuronal Interactions, 5:5-21, 2005.
  62. Robinson, P.S., Huang, T.F., Kazam, E., Iozzo, R.V., Birk, D.E., and Soslowsky, L.J.: Influence of decorin and biglycan on mechanical properties of multiple tendons in knockout mice. J Biomech Eng, 127:181-185, 2005.
  63. Lin, T.W., Cardenas, L, Glaser, D.L., and Soslowsky, L.J.: Tendon healing in interleukin-4 and interleukin-6 knockout mice. J Biomechanics, 39:61-69, 2006.
  64. Ticker, J.B., Flatow, E.L., Pawluk, R.J., Soslowsky, L.J., Arnoczky, S.P., Hepler, M.D., Bigliani, L.U., and Mow, V.C.: The inferior glenohumeral ligament: A correlative biomechanical, biochemical, and histological investigation. J Shoulder Elbow Surg, in press, 2006.
  65. Christner, P.J., Gentiletii, J., Peters, J., Ball, S.T., Yamauchi, M., Atsawasuwan, P., Beason, D.P., Soslowsky, L.J., and Birk, D.E.: Collagen dysregulation in dermis of the SAGG/+ mouse: A loose skin model, J Invest Derm, in press, 2006.
  66. Zhang, G., Ezura, Y., Chervoneva, I., Robinson, P.S., Beason, D.P., Carine, E.T., Soslowsky, L.J., Iozzo, R.V., and Birk, D.E.: Decorin regulates assembly of collagen fibrils and acquisition of biomechanical properties during tendon development. J Cell Biochem, in press, 2006.
  67. Gimbel, J.A., Van Kleunen, J.P., Lake, S.P., Williams, G.R., and Soslowsky, L.J.: The role of repair tension on tendon to bone healing in an animal model of chronic rotator cuff tears. J Biomech, in press, 2006.

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