Alice Huang, Ph.D.
Graduate Student in Bioengineering
NSF Graduate Research Fellow (2006-2009)
University of Pennsylvania
Hometown
Redondo Beach, California
Education
Ph.D. Bioengineering, 2010, University of Pennsylvania B.S. Biomedical Engineering 2003, Columbia University B.A. Asian and Middle Eastern Studies 2003, Barnard College
Clinical Interest
Adult reconstructive surgery
Areas of Special Interest
Alice has been working with Dr. Robert Mauck in McKay Orthopaedics since Fall 2005. Her current research is in the realm of cartilage tissue engineering; she is examining the role of mechanical stimulation in mesenchymal stem cell chondrogenesis and on cartilage tissue development. Specifically, she will use novel loading configurations to explore the evolution of structural anisotropy in MSC-laden engineered constructs. Alice hopes to graduate in a more or less reasonable amount of time. Alice is also deeply passionate about online grocery shopping and fly-fishing. One of these days, after she has acquired the appropriate equipment and dapper ensemble, she will actually go fly-fishing. In the meantime, she will buy her fish online.
Book Chapters
Huang AH, Hung, CT, Mauck RL: Functional Cartilage Tissue Engineering with Adult Stem Cells: Current Status and Future Directions. In: Stem Cells and Regenerative Medicine. Ed by Herman Cheung. Oak Park, IL, Bentham Science Publishers, in press.
Full-Length Manuscripts
Huang AH, Stein A, Mauck RL. "Evaluation of the Complex Molecular Topography of Mesenchymal Stem Cell Chondrogenesis for Cartilage Tissue Engineering," 2009, Tissue Engineering, Part A, in review.
Huang AH, Farrell MJ, Kim M, Mauck RL. "Long-term Dynamic Compressive Loading Improves the Mechanical Properties of Mesenchymal Stem Cell-Laden Hydrogels," 2010, European Cells and Materials, 19:72-85.
Nerurkar NL, Sen S,Huang AH, Elliott DM, Mauck RL. "Engineered Disc-Like Angle-Ply Structures for Intervertebral Disc Replacement," 2009, Spine, in press.
Huang AH, Farrell MJ, Mauck RL. "Mechanics and Mechanobiology of Mesenchymal Stem Cell-Based Engineered Cartilage," 2010, Journal of Biomechanics, 43(1):128-36.
Erickson IE, Huang AH, Sengupta S, Kestle S, Burdick JA, Mauck RL. "Macromer Density Influences Mesenchymal Stem Cell Chondrogenesis and Maturation in Photocrosslinked Hyaluronic Acid Hydrogels," 2009, Osteoarthritis and Cartilage, 17(12):1639-48.
Huang AH, Stein A, Tuan RS, Mauck RL. "Transient Exposure to TGF-B3 Improves the Mechanical Properties of Mesenchymal Stem Cell-Laden Constructs in a Density Dependent Manner," 2009, Tissue Engineering: Part A, 15(11): 3461-72.
Bargman R*, Huang A*, Boskey AL, Raggio C, Pleshko N. "RANKL Inhibition Improves Bone Properties in a Mouse Model of Osteogenesis Imperfecta," 2009, Connective Tissue Resesarch, in press. * authors contributed equally
Canuto HC, Fishbein KW, Huang A, Doty SB, Herbert RA, Peckham J, Pleshko N, Spencer RG. "Characterization of Skin Abnormalities in a Mouse Model of Osteogenesis Imperfecta Using High Resolution Magnetic Resonance Imaging and Fourier Transform Infrared Imaging Spectroscopy," 2008, in review.
Huang AH, Motlekar NA, Stein A, Diamond SL, Shore EM, Mauck RL. "High-Throughput Screening for Modulators of Mesenchymal Stem Cell Chondrogenesis," 2008, Annals of Biomedical Engineering, 36(11):1909-1921.
Erickson IE, Huang AH, Chung C, Li RT, Burdick JA, Mauck RL. "Differential Maturation and Structure-Function Relationships in MSC and Chondrocyte Seeded Hydrogels," 2008, Tissue Engineering: Part A, 15(5):1041-52.
Huang AH, Yeger-McKeever M, Stein A, Mauck RL. "Tensile Properties of Engineered Cartilage Formed from Chondrocyte- and MSC-Laden Hydrogels," 2008, Osteoarthritis and Cartilage, 16(9):1074-1082.
Lopez Franco GE, Huang A, Camacho NP, Stone DS, Blank RD. "Increased Young's Modulus and Hardness of Col1aoim Dentin," 2006, J Dent Res, 85(11):1032-1036.
Lopez Franco GE, Huang A, Camacho NP, Blank RD. "Dental phenotype of the col1a2oim mutation: DI is present in both homozygotes and heterozygotes," 2005, Bone, 36(6):1039-46.
Conference Abstracts
Huang AH, Baker BM, Ateshian GA, Mauck RL. "Sliding Contact Loading Improves the Tensile Properties of MSC-Based Engineered Cartilage," Proceedings of ASME 2010 Summer Bioengineering Conference, Naples, FL, June 16-19, 2010, submitted.
Huang AH, Mauck RL. "Extended Long-Term Culture of MSC-Laden Agarose Constructs Does Not Produce Functional Tissue Comparable to Primary Chondrocytes," Proceedings of ASME 2010 Summer Bioengineering Conference, Naples, FL, June 16-19, 2010, submitted.
Huang AH, Baker BM, Ateshian GA, Mauck RL. "Sliding Contact Enhances Mesenchymal Stem Cell Chondrogenesis in 3D Culture," Transactions of the 56th Annual Orthopaedic Research Society Meeting, New Orleans, LA, March 6-9, 2009, 35:315 (podium).
Huang AH, Farrell MJ, Mauck RL. "Dynamic Compression Initiated After Chondrogenesis Improves Mechanical Properties of Mesenchymal Stem Cell Seeded Hydrogel Constructs," Transactions of the 56th Annual Orthopaedic Research Society Meeting, New Orleans, LA, March 6-9, 2009, 35:1336.
Nerurkar NL, Sen S, Huang AH, Elliott DM, Mauck RL. "Functional Maturation of Engineered Composites that Mimic the Hierarchical Organization of the Intervertebral Disc," Transactions of the 56th Annual Orthopaedic Research Society Meeting, New Orleans, LA, March 6-9, 2009 (podium).
Huang AH, Farrell MJ, Mauck RL. "Delayed Dynamic Compression Improves the Mechanical Properties of MSC-Laden Constructs," Biomedical Engineering Society Meeting, Pittsburgh, PA, October 7-10, 2009.
Huang AH, Mauck RL. "Repeated Dynamic Loading Modulates Cartilage Gene Expression but Does Not Improve Mechanical Properties of MSC-Laden Hydrogels," Proceedings of ASME 2009 Summer Bioengineering Conference, Lake Tahoe, CA, June 17-21, 2009, paper 204339.
Huang AH, Stein A, Mauck RL. "Genome-Wide Analysis to Identify Functional Determinants of Mesenchymal Stem Cell Chondrogenesis," Transactions of the 55th Annual Orthopaedic Research Society Meeting, Las Vegas, NV, February 22-25, 2009, 34:279.
:Huang AH, Stein A, Yeger-McKeever M, Tuan RS, Mauck RL. "Transient Exposure to TGF-B3 Improves Mechanical Properties of MSC-Laden Constructs," Proceedings of ASME 2008 Summer Bioengineering Conference, Marco Island, FL, June 25-29, paper 193130.
Huang AH, Motlekar NA, Stein A, Shore EM, Diamond SL, Mauck RL. "High-Throughput Screening of Chemical Libraries for Moduluators of Mesenchymal Stem Cell Chondrogenesis," Proceedings of ASME 2008 Summer Bioengineering Conference, Marco Island, FL, June 25-29, paper 193118.
Huang AH, Stein A, Diamond SL, Shore EM, Mauck RL. "High-Throughput Screening of MSC Chondrogenesis: Assay Development and Application," Transactions of the 54th Annual Orthopaedic Research Society Meeting, San Francisco, CA, March 2-5, 2008 33:520.
Huang AH, Yeger-McKeever M, Stein A, Mauck RL. "Identification of Molecular Antecedents Limiting Functional Maturation of MSC-Laden Hydrogels," Transactions of the 54th Annual Orthopaedic Research Society Meeting, San Francisco, CA, March 2-5, 2008, 33:549.
Erickson IE, Chung C, Huang AH, Li R, Burdick JA, Mauck RL. "Hydrogel Effects on Long-Term Maturation of Chondrocyte and MSC Laden Hydrogels," Transactions of the 54th Annual Orthopaedic Research Society Meeting, San Francisco, CA, March 2-5, 2008, 33:557.
Yeger-McKeever M, Huang AH, Stein AF, Mauck RL. "Engineered MSC-Laden Cartilage Constructs are Sensitive to Infllammatory Cytokine-Mediated Degradation," Proceedings of ASME 2007 Summer Bioengineering Conference, Keystone, CO, June 20-24, paper 176186.
Huang AH, Mauck RL. "Sliding Contact Modulates ECM Expression in Chondrocyte-Laden Agarose Gels," Proceedings of ASME 2007 Summer Bioengineering Conference, Keystone, CO, June 20-24, paper 176427.
Huang AH, Yeger-McKeever M, Yuan X, Mauck RL. "Direct Measurement of Tensile Properties of Chondrocyte- and MSC-laden Hydrogels," 2007, Transactions of the 53rd Annual Orthopaedic Research Society Meeting, 32:345.
Huang AH, Mauck RL. "Sliding Contact Enhances Cartilage ECM Gene Expression in Chondrocyte-Laden Hydrogels," 2006, Gordon Research Conference on Musculoskeletal Biology and Bioengineering.
Zhu J, Huang AH, Bi X, Zhang H, Camacho NP. "Quantification of Osteoclastic Resorption on Bone Slices by Infrared Imaging," 2006, Journal of Bone and Mineral Research 21:S212-S213 Suppl.
King D, Camacho N, Huang A, Jarjoura D, McEwen H, Askew M, Majors A. "Growth hormone injections improve bone quality in OI mice," 2006, FASEB Journal, 20(4):A637-A638.
Huang AH, Raggio CL, Fritton JC, Camacho NP. "Comparison of radiographic and micro ct-determined parameters in mouse bone specimens," 2005, Transactions of the 51st Annual Orthopaedic Research Society Meeting, 30:713.
Lopez Franco GE, Stone D, Huang A, Camacho NP, Blank RD. "Mechanical consequences of the Col1a2(oim) mutation in mouse dentin," 2005, Journal of Bone and Mineral Research, 20(9):S417-S417 Suppl.
Li G, Huang A, Camacho NP. "Diagnosis of bone quality by near-IR (NIR) spectroscopy," 2005, NIAMS-ASBMR Scientific Meeting, Bone Quality: What Is It and Can We Measure It?
Lopez Franco GE, Huang A, Camacho NP, Blank RD. "Col1a2oim/oim and col1a2oim/+ mice express dentinogenesis imperfecta," 2004, 8th International Conference on the Chemistry and Biology of Mineralized Tissues.