Claire McLeod, Ph.D.
Graduate Student in Bioengineering
University of Pennsylvania
Hometown
Lake Tahoe, Nevada
Education
B.S. Engineering with a concentration in Bioengineering, 2011, Franklin W. Olin College of Engineering, Needham, MA
Areas of Special Interests
single-cell measurements, stem cell heterogeneity, health informatics
Awards:
2015, Scholarship and travel award, Summer Institute for Statistics in Big Data, University of Washington
2015, Second Place Talk Award, University of Pennsylvania Bioengineering Graduate Student Symposium
2014, Top Poster Award, University of Pennsylvania Orthopaedic Research Day
2011, NSF Graduate Research Fellowship
Publications
C.M. McLeod, R.L. Mauck. "High fidelity visualization of cell-to-cell variation and temporal dynamics in nascent extracellular matrix formation."Scientific Reports, 2016.
A.J. Cote*, C.M. McLeod*, M.J. Farrell, P.D. McClanahan, M.C. Dunagin, A. Raj**, R.L. Mauck**, "Single cell differences in matrix gene expression do not predict matrix deposition," Nature Communications 2016 (in press). *, ** These authors contributed equally to this work, order determined randomly.
W.M. Han*, S. Heo*, T.P. Driscoll, J.F. Delucca, C.M. McLeod , L.J. Smith, R.L. Duncan, R.L. Mauck & D.M. Elliott, "Microstructural heterogeneity directs micromechanics and mechanobiology in native and engineered fibrocartilage," Nature Materials 2016, doi:10.1038/nmat4520. *These authors contributed equally to this work. "C. McLeod, J. Higgins, Y.A. Miroshnikova, R. Liu, A.L. Sarang-Sieminski, "Microscopic matrix remodeling precedes endothelial morphological changes during capillary morphogenesis," J Biomech Eng 2013; 135(7): 071002
BM.D. Stevenson, A.L. Sieminski, C.M. McLeod, F.J. Byfield, V.H. Barocas, K.J. Gooch. "Pericellular conditions regulate extent of cell-mediated compaction of collagen gels," Biophysical Journal 2010; 99(1): 19-28.
Abstracts:C.M. McLeod, R.L. Mauck. "Single-cell Molecular and Microenvironmental Heterogeneity in Differentiating Stem Cells," Musculoskeletal Biology & Bioengineering Gordon Research Seminar, August 2016, Andover NH (talk by CMM).
C.M. McLeod, A.J. Cote, A. Raj, R.L. Mauck. "Differentiating Stem Cells Exhibit Molecular and Microenvironmental Heterogeneity at the Single Cell Level," SB3C, June 2016, National Harbor MD (talk by CMM). C.M. McLeod, R.L. Mauck. "Temporal Dynamics of Nascent ECM Production by Chondrocytes and MSCs via Multi-Color Protein Labeling," Orthopaedic Research Society, March 2016, Orlando FL (talk by CMM).
C.M. McLeod*, A.J. Cote*, A. Raj**, R.L. Mauck**. "Single-cell RNA FISH Analysis Of Chondrocyte Dedifferentiation Challenges Traditional Definitions Of Phenotype," Orthopaedic Research Society, March 2016, Orlando FL (poster by CMM). *These authors contributed equally to this work., **co-corresponding authors.
S. Heo*, W.M. Han*, C.M. McLeod , R.L. Duncan, D.M. Elliott, R.L Mauck. "Heterogeneous Tissue Engineered Constructs (hetTECs) Recapitulate the Micromechanical and Mechanobiologic Complexity of Native Dense Connective Tissue," Orthopaedic Research Society, March 2016, Orlando FL (poster by SH). *These authors contributed equally to this work. "A.J. Cote*, C.M. McLeod*, A. Raj**, R.L. Mauck**. "Single-cell RNA FISH analysis of mesenchymal stem cell chondrogenesis and chondrocyte dedifferentiation challenges traditional definitions of phenotype," Keystone Symposium on Transcriptional and Epigenetic Influences on Stem Cell States, March 2015, Keystone CO (poster by AJC). * co-first authors, **co-senior authors.
J. Haupt, B. Cosgrove, C. McLeod, A. Culbert, R. Mauck, E. Shore. "Altered force sensing and cell-cell adhesion by mutant ACVR1/ALK2 FOP progenitor cells- implications for heterotopic ossification," ASBMR, September 2014, Houston TX (talk by JH). 2014 ASBMR Young Investigator Award.
B.D. Cosgrove, M.J. Farrell, M. Dunagin, C.M. McLeod, A.J. Cote, A. Raj, R.L. Mauck. "Inherent and Emergent Heterogeneity in Clonal Stem Cell Populations," Orthopaedic Research Society Annual Meeting, March 2014, New Orleans LA (talk by BDC).
C.M. McLeod, R.L. Mauck. "Mechanobiologic Heterogeneity in Clonal Mesenchymal Stromal Cell Populations," Cellular and Molecular Bioengineering Conference, January 2014, San Diego CA (poster by CMM).
B.D. Cosgrove, M.J. Farrell, M. Dunagin, C.M. McLeod, A.J. Cote, A. Raj, R.L. Mauck. "Inherent and Emergent Heterogeneity in Clonal Stem Cell Populations," Cellular and Molecular Bioengineering Conference, January 2014, San Diego CA (poster by BDC).
C.M. McLeod, T.P. Driscoll, B.D. Cosgrove, S. Heo, R.L. Mauck, "Mesenchymal Stem Cell Mechanobiology is Clone Dependent," Biomedical Engineering Society Annual Meeting, September 2013, Seattle, WA (talk by CMM).
B.D. Cosgrove, C.M. McLeod, R.L. Mauck, "Heterogeneous Traction Force Distributions in MSC Clonal Populations," Biomedical Engineering Society Annual Meeting, September 2013, Seattle, WA (poster by BDC).
C.M. McLeod, J. Higgins, Y.A. Miroshnikova, R. Liu, A.L. Sarang-Sieminski, "Local Matrix Alignment During Microvascular Network Formation," Biomedical Engineering Society Annual Meeting, October 2011, Hartford, CT (talk by ALSS)
M.D. Stevenson, A.L. Sieminski, C.M. McLeod, F.J. Byfield, V.H. Barocas, K.J. Gooch, "Pericellular Conditions Regulate Extent of Cell-mediated Compaction of Collagen Gels," Biomedical Engineering Society Annual Meeting, Austin Texas, October 2010 (poster by MDS)
C.M. McLeod, Y.A. Miroshnikova, A.L. Sieminski, "Microscopic Matrix Remodeling During Capillary Morphogenesis," Biomedical Engineering Society Annual Meeting, 2009, Pittsburgh, PA (poster by CMM)
M.D. Stevenson, A.L. Sieminski, C.M. McLeod, F.J. Byfield, V.H. Barocas, K.J. Gooch, "Pericellular Conditions Regulate Extent of Cell-mediated Compaction of Collagen Gels," Biomedical Engineering Society Annual Meeting, 2009, Pittsburgh, PA (poster by MDS)