Nandan L. Nerurkar, Ph.D.
Post-doctoral Fellow
University of Pennsylvania
Hometown
Edmond, OK
Education
Ph.D. in Mechanical Engineering and Applied Mechanics 2010, University of Pennsylvania, Philadelphia
M.S. in Biomedical Engineering 2005, Washington University, St. Louis
B.S. in Biological Engineering 2003, University of Maryland, College Park
Areas of Special Interest
Nandan has been working with Dr. Robert Mauck and Dr. Dawn Elliott in the McKay Orthopaedic Research Lab since the Fall of 2005. His research is focused on the application of stem cells for tissue engineering of the intervertebral disc, with particular emphasis on the annulus fibrosus. In his spare time, Nandan enjoys cheering on the Phillies while drinking well-hopped ales. Between baseball seasons, Nandan enjoys re-watching Big Trouble in Little China and drinking doppelbocks.
Publications
Heo SC, Nerurkar NL, Driscoll TD, Mauck RL. Differentiation and deformation modulate nuclear mechanics during mesenchymal stem cell fibrochondrogenesis (in preparation).
Driscoll TD, Nerurkar NL, Jacobs NT, Elliott DM, Mauck RL. Shear mechanics of electrospun scaffold for annulus fibrosus tissue engineering Journal of the Mechanical Behavior of Biomedical Materials (in press).
Heo SC, Nerurkar NL, Baker BM, Mauck RL. Microstructure dictates stretch-induced cell and nucleus reorganization on aligned nanofibrous scaffolds (submitted).
Smith LJ, Nerurkar NL, Harfe BD, Elliott DM. Pathogenesis and treatment of intervertebral disc degeneration: lessons from development Disease Models and Mechanisms, 4(1), 2011.
Nerurkar NL, Mauck RL, Elliott DM. Modeling inter-lamellar interactions in angle-ply biologic laminates for annulus fibrosus tissue engineering Biomechanics and Modeling in Mechanobiology (in press).
Nerurkar NL, Mauck RL, Elliott DM. Selective removal of extracellular matrix components reveals homologous structure-function relationships between engineered and native fibrocartilage Biomaterials, 32(2), 2011.
Nathan AS, Baker BM, Nerurkar NL, Mauck RL. Nuclear deformations on nanofibrous scaffolds. Acta Biomaterialia, 7(1), 2011.
Nerurkar NL, Sen S, Baker BM, Elliott DM, Mauck RL. Dynamic culture enhances stem cell ingress and extracellular matrix deposition on electrospun nanofibrous scaffolds Acta Biomaterialia (in press).
Nerurkar NL, Elliott DM, Mauck RL. Functional metrics for intervertebral disc tissue engineering: challenges and opportunities. Journal of Biomechanics, 43(6), 2010.
Nerurkar NL, Sen S, Huang AH, Elliott DM, Mauck RL. Engineered disc-like angle-ply structures for intervertebral disc replacement. Spine, 35(8), 2010 [**Invited for Special Issue**].
Nerurkar NL, Baker BM, Sen S, Wible EE, Elliott DM, Mauck RL. Nanofibrous biologic laminates replicate the form and function of the annulus fibrosus. Nature Materials, 8 (12), 2009 [**Cover article**].
Mauck RL, Baker BM, Nerurkar NL, Burdick JA, Li WJ, Tuan RS, Elliott DM. Engineering on the straight and narrow: the mechanics of nanofibrous assemblies for fiber-reinforced tissue regeneration. Tissue Engineering B: Reviews, 15(2), 2009.
Baker BM, Nerurkar NL, Burdick JA, Elliott DM, Mauck RL. Fabrication and modeling of multi-polymer nanofibrous scaffolds. Journal of Biomechanical Engineering, 131 (10), 2009.
Nerurkar NL, Mauck RL, Elliott DM. ISSLS prize winner: Integrating theoretical and experimental methods for functional tissue engineering of the annulus fibrosus. Spine, 33 (25), 2008.
Ramasubramanian A, Nerurkar NL, Achtien KH, Filas BA, Voronov DA, Taber LA. On modeling morphogenesis of the looping heart following mechanical perturbation. Journal of Biomechanical Engineering, 130 (6), 2008.
Nerurkar NL, Elliott DM, Mauck RL. Mechanics of oriented electrospun nanofibrous scaffolds for annulus fibrosus tissue engineering. Journal of Orthopaedic Research, 25(8), 2007.
Nerurkar NL, Ramasubramanian A, Taber LA. Morphogenetic adaptation of the looping embryonic heart to altered mechanical loads. Developmental Dynamics, 235(7), 2006.
Wagenseil JE, Nerurkar NL, Knutsen RH, Okamoto RJ, Li DY, Mecham RP. Effects of elastin haploinsufficiency on the mechanical behavior of mouse arteries. Am J Physiol Heart Circ Physiol, 289 (3), 2005.
Anderson GP, Nerurkar NL. Improved fluoroimmunoassays using the dye Alexa Fluor 647 with the RAPTOR, a fiber optic biosensor. Journal of Immuunological Methods, 271 (1-2), 2002.
Conference Papers
Han WJ, Jacobs NT, Nerurkar NL, Smith LJ, Mauck RL, Elliott DM. Differential tensile mechanical behavior of the inner and outer annulus fibrosus following treatment with chondroitinase ABC and buffer solutions. 6th Annual Philadelphia Spine Symposium, Philadelphia, PA, December 14, 2010.
Driscoll TD, Nerurkar NL, Jacobs NT, Mauck RL, Elliott DM. Shear mechanics of electrospun scaffolds for annulus fibrosus tissue engineering. 6th Annual Philadelphia Spine Symposium, Philadelphia, PA, December 14, 2010.
Kluge JA, Nerurkar NL, Martin JT, Amaniera FA, Pampati RA, Elliott DM, Mauck RL. Functional enhancement of disc-like angle-ply structures via dynamic culture. 6th Annual Philadelphia Spine Symposium, Philadelphia, PA, December 14, 2010.
Heo SC, Nerurkar NL, Mauck RL. Differentiation and deformation modulate nuclear mechanichs during mesenchymal stem cell fibrochondrogenesis. The Society for Physical Regulation in Biology and Medicine 29th Scientific Conference, Miami, FL, January 4 – 8, 2011.
Han WJ, Nerurkar NL, Jacobs NT, Smith LJ, Mauck RL, Elliott DM. Differential structure–function mechanisms of the inner and outer annulus fibrosus in tension. International Society for the Study of Lumbar Spine Annual Meeting, Gothenburg, Sweden, June 14 – 18, 2011.
Driscoll TD, Nerurkar NL, Jacobs NT, Mauck RL, Elliott DM. Shear mechanics of electrospun scaffold for annulus fibrosus tissue engineering. 57th Annual Meeting of the Orthopaedic Research Society, Long Beach, CA, January 13 – 16, 2011.
Heo SC, Nerurkar NL, Baker BM, Mauck RL. Microstructure dictates stretch-induced cell and nucleus reorganization on aligned nanofibrous scaffolds. 57th Annual Meeting of the Orthopaedic Research Society, Long Beach, CA, January 13 – 16, 2011 (podium).
Heo SC, Nerurkar NL, Baker BM, Mauck RL. Fibrochondrogenesis attenuates stretch–induced nuclear deformation on aligned nanofibrous electrospun scaffolds. 57th Annual Meeting of the Orthopaedic Research Society, Long Beach, CA, January 13 – 16, 2011.
Smith LJ, Nerurkar NL, Cortes DH, Horava SD, Dodge GR, Hebela NM, Mauck RL, Elliott DM. Functional matrix degradation and inhibition in a cytokine–mediated in–vitro model of nucleus pulposus degeneration. 57th Annual Meeting of the Orthopaedic Research Society, Long Beach, CA, January 13 – 16, 2011.
Kluge JA, Martin JT, Nerurkar NL, Amaniera FA, Pampati RA, Elliott DM, Mauck RL. Functional enhancement of disc–like angle–ply structures via dynamic culture. 57th Annual Meeting of the Orthopaedic Research Society, Long Beach, CA, January 13 – 16, 2011.
Farrell MJ, Comeau ES, Nerurkar NL, Mauck RL. Depth–dependent mechanical properties of MSC–laden engineered cartilage constructs. 57th Annual Meeting of the Orthopaedic Research Society, Long Beach, CA, January 13 – 16, 2011 (podium).
Han WJ, Jacobs NT, Nerurkar NL, Smith LJ, Mauck RL, Elliott DM. Differential tensile mechanical behavior of the inner and outer annulus fibrosus following treatment with chondroitinase ABC and buffer solutions. 57th Annual Meeting of the Orthopaedic Research Society, Long Beach, CA, January 13 – 16, 2011.
Elliott DM, Nerurkar NL, O'Connell GD, Vresilovic EJ, Mauck RL. Tissue engineering from the ground up: building an annulus fibrosus that has mechanical function at each scale. The 25th Annual Research Meeting of the Japanese Orthopaedic Association, Kyoto, Japan, October 14 – 15, 2010 (podium).
Elliott DM, Nerurkar NL, Huang AH, Kluge JA, Smith LJ, Martin JT, Hebela N, Mauck RL. Disc Tissue Engineering – Can We Make it Stick? 6th World Congress on Biomechanics, Singapore, August 1 – 6, 2010 (podium).
Nerurkar NL, Mauck RL, Elliott DM. Modeling inter–lamellar interactions in engineered nanofibrous biologic laminates for annulus fibrosus tissue engineering. Proceedings of the ASME 2010 Summer Bioengineering Conference, Naples, FL, June 16 – 19, 2010 (podium).
Nerurkar NL, Sen S, Baker BM, Zachry TL, Elliott DM, Mauck RL. Dynamic culture enhances stem cell ingress and extracellular matrix deposition on electrospun nanofibrous scaffolds. 56th Annual Meeting of the Orthopaedic Research Society, New Orleans, March 6 – 9, 2010.
Nerurkar NL, Sen S, Huang AH, Elliott DM, Mauck RL. Functional maturation of composites that mimic the hierarchical organization of the intervertebral disc. 56th Annual Meeting of the Orthopaedic Research Society, New Orleans, March 6 – 9, 2010 (podium, selected for Spotlight Session: Tissue Engineering).
Nerurkar NL, Sen S, Mauck RL, Elliott DM. Selective removal of extracellular matrix components reveals homologous structure–function relationships between engineered and native fibrocartilage. 56th Annual Meeting of the Orthopaedic Research Society, New Orleans, March 6 – 9, 2010 (podium).
Nathan AS, Baker BM, Nerurkar NL, Mauck RL. Time–dependent and anisotropic nuclear deformations on aligned nanofibrous scaffolds. 56th Annual Meeting of the Orthopaedic Research Society, New Orleans, March 6 – 9, 2010 (podium).
Nerurkar NL, Mauck RL, Elliott DM. Alternating Fiber Orientation Enhances the Functional Growth of Nanofibrous Laminates for Annulus Fibrosus Tissue Engineering. BMES 2009 Fall Scientific Meeting, Pittsburgh PA, October 7–10, 2009.
Nerurkar NL, Elliott DM, Mauck RL. Functional maturation of engineered composites that mimic the hierarchical organization of the intervertebral disc. 5th Annual Philadelphia Spine Symposium, Philadelphia, PA, December 9, 2009.
Mauck RL, Baker BM, Ionescu LC, Nerurkar NL, Burdick JA. Multi–functional and dynamic fibrous scaffolds for tissue engineering and controlled release. Materials Research Society Conference, Boston, MA, November 30 –December 4, 2009 (podium).
Nerurkar NL, Sen S, Wible EE, Stambough JB, Elliott DM, Mauck RL. Mesenchymal Stem Cell Seeded Nanofibrous Laminates Mimic the Multi–scale Form and Function of the Annulus Fibrosus. Proceedings of the ASME 2009 Summer Bioengineering Conference, Lake Tahoe, CA, June 17 – 21, 2009 (podium).
Nerurkar NL, Sen S, Mauck RL, Elliott DM. Bilamellar Engineered Constructs Mimic Form and Function of the Native Annulus Fibrosus. Annual Meeting of the International Society for the Study of Lumbar Spine, Miami, FL, May 4–9, 2009 (podium).
Nerurkar NL, Sen S, Wible EE, Stambough JB, Elliott DM, Mauck RL. MSC–Seeded Nanofibrous Laminates Mimic Multi–Scale Form and Function of the Annulus Fibrosus. 55th Annual Meeting of the Orthopaedic Research Society, Las Vegas, NV, 0209; February 22–25, 2009 (podium).
Baker BM, Nerurkar NL, Burdick JA, Elliott DM, Mauck RL. Instilling Time–Dependent Behavior in Electrospun, Multi–Polymer Nanofibrous Composites. 55th Annual Meeting of the Orthopaedic Research Society, Las Vegas, NV, 0473; February 22–25, 2009.
Baker BM, Nerurkar NL, Burdick JA, Mauck RL. The Temporal Behavior of Electrospun, Multi–Polymer Nanofibrous Composites. Proceedings of TERMIS–NA 2008 Conference, San Diego, CA, December 7–11, 2008 (podium).
Nerurkar NL, Sen S, Wible EE, Stambough JB, Elliott DM, Mauck RL. "MSC–Seeded Nanofibrous Laminates Mimic Multi–Scale Form and Function of the Annulus Fibrosus." Philadelphia Spine Research Symposium, Philadelphia, PA, November 13, 2008.
Baker BM, Nerurkar NL, Burdick JA, Elliott DM, Mauck RL. "Fabrication and Modeling of an Electrospun Tri–Polymer Composite for the Engineering of Fibrous Tissues," Proceedings of ASME 2008 Summer Bioengineering Conference, Marco Island, FL, June 25–29, 2008 (podium).
Nerurkar NL, Nguyen AM, Mauck RL, Elliott DM. Functional evolution of engineered annulus fibrosus using constitutive modeling. 54th Annual Meeting of the Orthopaedic Research Society, San Francisco, CA, 0292; March 2–5, 2008 (podium).
Nerurkar NL, Orlansky AS, Sen S, Elliott DM, Mauck RL. Multi–scale tissue engineering of the intervertebral disc. 54th Annual Meeting of the Orthopaedic Research Society, San Francisco, CA, 0340; March 2–5, 2008 (podium).
Lake SP, Nerurkar NL, Mauck RL, Kaldowec JA, Elliott DM, Soslowsky LJ. Development of a Nonlinear Anisotropic Fiber Dispersion Model to Quantify and Predict Mechanics of Normal and Injured Tendon. 54th Annual Meeting of the Orthopaedic Research Society, San Francisco, CA, p. 0824; March 2–5, 2008.
Nerurkar NL, Elliott DM, Mauck RL. Architecture of nanofibrous scaffolds influences fibrocartilagenous gene expression of annulus fibrosus and mesenchymal stem cells. 6th Combined meeting of the Orthopaedic Research Society, Honolulu, Hawaii, p. 0388; October 20–24, 2007.
Nerurkar NL, Nguyen AM, Tsing P, Mauck RL, Elliott DM. A hyperelastic fiber–reinforced continuum model to assay functional evolution of tissue engineered annulus fibrosus. 6th Combined meeting of the Orthopaedic Research Society, Honolulu, Hawaii, p. 0389; October 20–24, 2007.
Taber LA, Nerurkar NL, Ramasubramanian A. Finite element modeling of the looping embryonic heart including mechanical feedback. 9th US National Congress on Computational Mechanics, San Francisco, CA, July 22–26, 2007 (podium).
Ramasubramanian A, Nerurkar NL, Taber LA. Role of mechanical feedback in restoration of normal cardiac c–looping following perturbed loading. 2007 Summer Bioengineering Conference, Keystone, CO, June 20–24, 2007 (podium).
Nerurkar NL, Nguyen AM, Elliott DM, Mauck RL. Annulus Fibrosus tissue engineering with aligned electrospun nanofibrous scaffolds. 53rd Annual Meeting of the Orthopaedic Research Society, San Diego, CA, p. 0249; February 11–14, 2007 (podium).
Nerurkar NL, Baker BM, Elliott DM, Mauck RL. Engineering of fiber–reinforced tissues with anisotropic biodegradable nanofibrous scaffolds. 2006 IEEE–EMBS Meeting, New York, NY, Aug 30–Sept 3, 2006 (podium).
Nerurkar NL, Ramasubramanian A, Taber LA. Morphogenetic adaptation of the embryonic heart to perturbed loading. 2006 ASME Summer Bioengineering Conference, Amelia Island, FL, June 21–25, 2006 (podium).