Nathaniel Dyment, PhD
Assistant Professor of Orthopaedic Surgery
Department: Orthopaedic Surgery
Contact information
McKay Orthopaedic Research Laboratory
330A Stemmler Hall
3450 Hamilton Walk
Philadelphia, PA 19104-6081
330A Stemmler Hall
3450 Hamilton Walk
Philadelphia, PA 19104-6081
Office: 215-746-8138
Fax: 215-573-2133
Lab: 215-746-8167
Fax: 215-573-2133
Lab: 215-746-8167
Education:
B.S. (Materials Science and Engineering)
University of Illinois at Urbana-Champaign , 2005.
Ph.D. (Biomedical Engineering)
University of Cincinnati, 2011.
Permanent linkB.S. (Materials Science and Engineering)
University of Illinois at Urbana-Champaign , 2005.
Ph.D. (Biomedical Engineering)
University of Cincinnati, 2011.
Description of Research Expertise
My primary research goals are directed towards understanding the genetic, cellular, and mechanical mechanisms that regulate normal development, disease (e.g., chronic tendon pathologies, osteoarthritis, psoriatic arthritis, ankylosing spondylitis), and repair of tissues in the joint. My current research focuses on 1) identifying the resident progenitor populations that contribute to normal growth, healing and repair, 2) characterizing the mechanisms that control the expansion and differentiation of these cells, and 3) ascertaining the phenotypical markers that define the stages of differentiation from early stem/progenitors to mature tendon/ligament fibroblasts and chondrocytes. These goals in combination will guide future therapeutic strategies and provide success criteria to assess efficacy moving forward.Selected Publications
J. Marcelin, R. Madi, T. Kamalitdinov, X. Jiang, D-H. Kim, R. L. Mauck, A. Kuntz, N. Dyment: Tailored delivery of a small molecule agonist for hedgehog signaling activation in tendon-to-bone integration Summer Biomechanics, Bioengineering and Biotransport Conference June 2024.Meghan E. Kupratis, Yuqi Zhang, Jiaqi Xiang, Bryan Kwok, Elisabeth A. Lemmon, Nathaniel A. Dyment, Lin Han, Eiki Koyama, Robert L. Mauck: Micromechanics and mechanoresponsivity of the developing porcine meniscus. Summer Biomechanics, Bioengineering and Biotransport Conference June 2024.
J. Xiang, B. Kwok, M. Fan, M. E. Kupratis, S. Tufa, D. R. Keene, R. L. Mauck, N.A. Dyment, E. Koyama, L. Han: Distinct molecular and structural traits of permanent versus transient cartilage in early development. Summer Biomechanics, Bioengineering, and Biotransport Conference June 2024.
Mary Kate Evans, Ellie Bernstein, Tonia K. Tsinman, Ellie J. Ferguson, Xi Jiang, Joel D. Boerckel, Lin Han, Eiki Koyama, Robert L. Mauck, Nathaniel A. Dyment: Scleraxis-targeted deletion of non-muscle myosin leads to tendon degeneration Summer Biomechanics, Bioengineering and Biotransport Conference June 2024.
Talayah A. Johnson, Natalie Fogarty, Alisia Lin, Tonia K. Tsinman, Xi Jiang, Eiki Koyama, Lin Han, Josh R. Baxter, Joel D. Boerckel, Robert L. Mauck, Nathaniel A. Dyment: Reduced loading after sciatic nerve resection impairs hindlimb growth and maturation. Summer Biomechanics, Bioengineering and Biotransport Conference June 2024.
Tyler Blanch, Yujia Zhang, Xi Jiang, Zizhao Li, Nathaniel A. Dyment, Su-Jin Heo: Age-Dependent Inflammatory Responsiveness and Chromatin Dynamics in Mouse Tenocytes. Orthopaedic Research Society Annual Meeting February 2024.
Harrison Cottingham, Camila Reyes, Nathan WC. Campbell, Talayah Johnson, Johnny M. Vanos, Zain A. Loges, Nathaniel Dyment, and Chad C. Carroll: Impact Of Serum Advanced Glycation End-products And Rage Inhibitor Administration On Patellar Tendon Healing In A Mouse Model. Orthopaedic Research Society Annual Meeting February 2024.
Rashad Madi, Jonathan Marcelin, Timur B. Kamalitdinov, Xi Jiang, Sereen Assi, Dong-Hwa Kim, Robert L Mauck, Andrew F. Kuntz, Nathaniel A. Dyment: Localized Delivery Of A Hedgehog Agonist From Electrospun Scaffolds Enhances Tendon-to-bone Integration. Orthopaedic Research Society Annual Meeting February 2024.
Thomas P. Leahy, Srish S. Chenna, Louis J. Soslowsky, Nathaniel A. Dyment: Focal Adhesion Kinase Regulates Physiological Tendon Development and Growth. Orthopaedic Research Society Annual Meeting February 2024.
Bryan Kwok, Mingyue Fan, Jiaqi Xiang, Aanya Mohan, Michael Newton, Yuchen Liu, David E. Birk, Eiki Koyama, Nathaniel A. Dyment, Robert L. Mauck, Tristan Maerz, Lin Han: Type V Collagen Is Essential For The Initial Matrix Templating Of Articular Cartilage And The Meniscus. Orthopaedic Research Society Annual Meeting February 2024.