Soslowsky Laboratory

Stephanie Weiss

Pronouns: She/Her

Research Specialist
University of Pennsylvania

Hometown

Oley, Pennsylvania

Education

BS, Small Animal Science, 2011, Delaware Valley College

Bio

Steph joined the McKay Orthopaedic Research Lab in September 2015. She loves all animals, but especially dogs. She enjoys reading romance novels, watching the Phillies, and listening to Taylor Swift. Check out her very cute pets, Jolene and Joon, on the Soslowsky pet page!

Publications

  1. Beach ZM, Nuss CA, Weiss SN, Soslowsky LJ. Neonatal Achilles Tendon Microstructure is Negatively Impacted by Decorin and Biglycan Knockdown After Injury and During Development. Ann Biomed Eng. 2023 Dec 11.
  2. Carlson JA, Shetye SS, Sun M, Weiss SN, Birk DE, Soslowsky LJ. Collagen V haploinsufficiency in female murine patellar tendons results in altered matrix engagement and cellular density, demonstrating decreased healing. J Orthop Res. 2023 Nov 17. doi: 10.1002/jor.25740. Epub ahead of print. PMID: 37975633.
  3. Newton JB, Nuss CA, Weiss SN, Betts RL, Soslowsky LJ. Novel Application of In Vivo Microdialysis in a Rat Achilles Tendon Acute Injury Model. J Appl Physiol 2023 Nov 16. 
  4. Leahy TP, Fung AK, Weiss SN, Dyment NA, Soslowsky LJ. Investigating the temporal roles of decorin and biglycan in tendon healing. J Orthop Res. 2023 May 3. 
  5. Darrieutort-Laffite C, Beach ZM, Weiss SN, Eekhoff JD, Soslowsky LJ. Knockdown of biglycan reveals an important role in maintenance of structural and mechanical properties during tendon aging. J Orthop Res. 2023 Feb 23.
  6. Leiphart RJ, Weiss SN, DiStefano MS, Mavridis AA, Adams SA, Dyment NA, Soslowsky LJ. Collagen V deficiency during murine tendon healing results in distinct healing outcomes based on knockdown severity. J Biomech. 2022 Sep 30.
  7. Beach ZM, Fung AK, Weiss SN, Soslowsky LJ. Post-injury tendon mechanics are not affected by tamoxifen treatment. Connect Tissue Res. 2022 Jul 11.
  8. Beach ZM, Dekhne MS, Rodriguez AB, Weiss SN, Adams TH, Adams SM, Sun M, Birk DE, Soslowsky LJ. Decorin knockdown is beneficial for aged tendons in the presence of biglycan expression. Matrix Biol Plus. 2022 Jun 24.
  9. Riggin CN, Weiss SN, Rodriguez AB, Raja H, Chen M, Schultz SM, Sehgal CM, Soslowsky LJ. Increasing Vascular Response to Injury Improves Tendon Early Healing Outcome in Aged Rats. Ann Biomed Eng. 2022 May.
  10. Beach ZM, Bonilla KA, Dekhne MS, Sun M, Adams TH, Adams SM, Weiss SN, Rodriguez AB, Shetye SS, Birk DE, Soslowsky LJ. Biglycan has a major role in maintenance of mature tendon mechanics. J Orthop Res. 2022 Feb 16.
  11. Leiphart RJ, Pham H, Harvey T, Komori T, Kilts TM, Shetye SS, Weiss SN, Adams SM, Birk DE, Soslowsky LJ, Young MF. Coordinate roles for collagen VI and biglycan in regulating tendon collagen fibril structure and function. Matrix Biol Plus. 2021 Dec 28.
  12. Huegel J, Chan PYW, Weiss SN, Nuss CA, Raja H, Waldorff EI, Zhang N, Ryaby JT, Soslowsky LJ, Kuntz AF. Pulsed electromagnetic field therapy alters early healing in a rat model of rotator cuff injury and repair: Potential mechanisms. J Orthop Res. 2021 Oct 17.
  13. Riggin CN, Rodriguez AB, Weiss SN, Raja HA, Chen M, Schultz SM, Sehgal CM, Soslowsky LJ. Modulation of vascular response after injury in the rat Achilles tendon alters healing capacity. J Orthop Res. 2020 Sep 16. 
  14. Leiphart R, Shetye S, Weiss S, Dyment N, Soslowsky LJ. Induced Knockdown of Decorin, Alone and in Tandem with Biglycan Knockdown, Directly Increases Aged Tendon Viscoelasticity. J Biomech Eng. 2020 Aug 7.
  15. Kim DH, Huegel J, Taylor BL, Nuss CA, Weiss SN, Soslowsky LJ, Mauck RL, Kuntz AF. "Biocompatibility and bioactivity of an FGF-loaded microsphere-based bilayer delivery system." Acta Biomater. 2020 Jul 15.
  16. Taylor BL, Kim DH, Huegel J, Raja HA, Burkholder SJ, Weiss SN, Nuss CA, Soslowsky LJ, Mauck RL, Kuntz AF, Bernstein J. "Localized delivery of ibuprofen via a bilayer delivery system (BiLDS) for supraspinatus tendon healing in a rat model." J Orthop Res. 2020 Mar 25.
  17. Chen M, Shetye SS, Huegel J, Riggin CN, Gittings DJ, Nuss CA, Weiss SN, Kuntz AF, Soslowsky LJ. "Biceps Detachment Preserves Joint Function in a Chronic Massive Rotator Cuff Tear Rat Model: Response." Am J Sports Med. 2019 Apr.
  18. Hillin CD, Fryhofer GW, Freedman BR, Choi DS, Weiss SN, Huegel J, Soslowsky LJ. "Effects of immobilization angle on tendon healing after achilles rupture in a rat model." J Orthop Res. 2019 Mar.
  19. Chen M, Shetye SS, Huegel J, Riggin CN, Gittings DJ, Nuss CA, Weiss SN, Kuntz AF, Soslowsky LJ. "Biceps Detachment Preserves Joint Function in a Chronic Massive Rotator Cuff Tear Rat Model." Am J Sports Med. 2018 Dec.
  20. Cheema AN, Newton JB, Boorman-Padgett JF, Weiss SN, Nuss CA, Gittings DJ, Farber DC, Soslowsky LJ. "Nicotine Impairs Intra‐Substance Tendon Healing After Full Thickness Injury in a Rat Model." J Orthop Res. 2018 Oct.
  21. Freedman BR, Rodriguez AB, Hillin CD, Weiss SN, Han B, Han L, Soslowsky LJ. “Tendon healing affects the multiscale mechanical, structural and compositional response of tendon to quasi-static tensile loading.” Journal of the Royal Society Interface. 2018 Feb
  22. Nuss CA, Huegel J, Boorman-Padgett JF, Choi DS, Weiss SN, Vournakis J, Soslowsky LJ. “Poly-N-Acetyl Glucosamine (sNAG) Enhances Early Rotator Cuff Tendon Healing in a Rat Model.” Annals of Biomedical Engineering. 2017 Dec
  23. Robinson KA, Sun M, Barnum CE, Weiss SN, Huegel J, Shetye SS, Lin L, Saez D, Adams SM, Iozzo RV, Soslowsky LJ, Birk DE. “Decorin and biglycan are necessary for maintaining collagen fibril structure, fiber realignment, and mechanical properties of mature tendons.” Matrix Biology. 2017 Dec
  24. Barnum CE, Fey JL, Weiss SN, Barila G, Brown AG, Connizzo BK, Shetye SS, Elovitz MA, Soslowsky LJ. “Tensile Mechanical Properties and Dynamic Collagen Fiber Re-Alignment of the Murine Cervix are Dramatically Altered Throughout Pregnancy.” Journal of Biomechanical Engineering. 2017 Jun
  25. Fryhofer GW, Freedman BR, Hillin CH, Salka NS, Pardes AM, Weiss SN, Farber DC, Soslowsky LJ. Post-Injury Biomechanics of Achilles Tendon Vary By Sex and Hormone Status. J Applied Physiology, October 2016.

Conference Abstracts

  1. Stein MK, Shetye SS, Nuss CA, Fung AK, Carlson JA, Weiss SN, Cohen JS, Dyment NA, Soslowsky LJ. Scleraxis Targeted Deletion of Collagen XI Disrupts Mouse Patellar Tendon Structure During Postnatal Development. Orthopaedic Research Society Annual Meeting 2022.
  2. Newton JB, Weiss SN, Darrieutort-Laffite C, Nuss CA, Birk DE, Sowslowsky LJ. Knockdown of Decorin and Biglycan Immediately Following Tendon Injury Significantly Alters Gene Expression and Fibril Morphology, with Minimal Effects on Mechanical Properties.  Orthopaedic Research Society Annual Meeting 2022.
  3. Leiphart RJ, Weiss SN, Dyment NA, Soslowsky LJ. Regional FDL Tendon Development Involves Differential Pericellular Matrix Expression and Presence. Orthopaedic Research Society Annual Meeting 2022.
  4. Leiphart RJ, Weiss SN, Carlson JA, Paglia PL, Soslowsky LJ. Collagen V Knockdown Alters Collagen Fibril Size, but Not Mechanics, in Mature Female Murine Tendons. Orthopaedic Research Society Annual Meeting 2022.
  5. Leahy TP, Fung AK, Weiss SN, Adams SM, Dyment NA, Birk DE, Sosolwosky LJ. Knockdown of Decorin and Biglycan During the Early Proliferative and Remodeling Phases of Tendon Healing Alters Gene Expression and Fibril Morphology. Orthopaedic Research Society Annual Meeting 2022.
  6. Fung AK, Leahy TP, Weiss SN, Adams SM, Dyment NA, Birk DE, Sosolwosky LJ. Knockdown of Decorin and Biglycan at Time of Tendon Injury Alters Gene Expression and Fibril Morphology. Orthopaedic Research Society Annual Meeting 2022.
  7. DiStefano MS, Han B, Paglia PL, Weiss SN, Kuntz AF, Soslwosky LJ. Determining Region-Specific Mechanical and Structural Differences in Aging Mouse Supraspinatus Tendons. Orthopaedic Research Society Annual Meeting 2022.
  8. Carlson JA, Weiss SN, Volk SW, Soslowsky LJ. Collagen III Deficiency Alters Mechanical Properties and Decreases Regulation of Fibrillogenesis Following Injury in Female Murine Tendons. Orthopaedic Research Society Annual Meeting 2022.
  9. Darrieutort-Laffite C, Fung AK, Weiss SN, Nuss CA, Birk DE, Soslowsky LJ. The injury response of aged tendons after induced knockdown of decorin and biglycan during the proliferative and remodeling phases of healing. Orthopaedic Research Society Annual Meeting 2022.
  10. Carlson JA , Sun M , Adams SM , Weiss SN , Birk DE , Soslowsky LJ. Collagen V Haploinsufficiency Results in Delayed Healing and Altered Wound Matrix Post-Injury in Murine Tendons. Orthopaedic Research Society Annual Meeting 2021.
  11. Leiphart RJ, Taylor BL, Weiss SN, Dyment NA, Soslowsky LJ. Collagen V Knockdown during Phases of Tendon Healing Differentially Impacts Gene Expression. Orthopaedic Research Society Annual Meeting 2021
  12. Leiphart RJ, Taylor BL, Weiss SN, Soslowsky LJ, Dyment NA. Collagen V Knockdown in Mature Murine Tendons Causes Sex-Dependent Expression Changes. Orthopaedic Research Society Annual Meeting 2021
  13. Carlson JA, Beach ZM, Weiss SN, Birk DE, Soslowsky LJ. Injury and Healing Effect on Fatigue Properties of Collagen V Haploinsufficient Female Murine Tendons. Orthopaedic Research Society Annual Meeting 2020
  14. Fung AK, Weiss SN, Birk DE, Soslowsky LJ. Determining the Roles of Decorin and Biglycan in Tendon Healing Using Conditional Deletion at Time of Injury. Orthopaedic Research Society Annual Meeting 2020
  15. Huegel J, Weiss SN, Nuss CA, Raja H, Waldorff EI, Zhang N, Ryaby JT, Soslowsky LJ, Kuntz AF. Mechanisms of Action of Pulsed Electromagnetic Field Therapy on a Rat Model of Rotator Cuff Injury and Repair. Orthopaedic Research Society Annual Meeting 2020
  16. Leahy TP, Fung AK, Weiss SN, Birk DE, Soslowsky LJ. The Differential Roles of Decorin and Biglycan in the Early Proliferative and Remodeling Phases of Tendon Healing. Orthopaedic Research Society Annual Meeting 2020
  17. Leiphart RJ, Weiss SN, Birk DE, Soslowsky LJ. Collagen V Deficiency during Healing Mitigates the Quasi-Static Mechanical Deficits of Injured Tendons. Orthopaedic Research Society Annual Meeting 2020
  18. Leiphart RJ, Weiss SN, Birk DE, Soslowsky LJ. Acute Reduction in Collagen V Expression Increases Viscoelasticity in Mature Tendons. Orthopaedic Research Society Annual Meeting 2020
  19. Beach ZM, Dekhne M, Rodriguez AB, Weiss SN, Shetye SS, Adams TH, Adams SM, Sun M, Birk DE, Soslowsky LJ. Differential Roles for Decorin and Biglycan in Tendon Aging. Trans Orthop Res Soc, Austin, TX, 2019 (podium presentation).
  20. Beach ZM, Robinson KA, Rodriguez AB, Shetye, SS, Weiss SN, Adams TH, Adams SM, Sun M, Birk DE, Soslowsky LJ. “Induced Deletion of Biglycan in Mature Tendon Reveals a Surprising Role during Adulthood.” Orthopaedic Research Society Annual Meeting, New Orleans, LA, 2018
  21. Chen M, Shetye SS, Huegel J, Gittings DJ, Nuss CA, Weiss SN, Kuntz AF, Soslowsky LJ. “Biceps detachment alters joint function and tendon mechanical properties in a chronic massive rotator cuff tear rat model.” Orthopaedic Research Society Annual Meeting, New Orleans, LA, 2018
  22. Kim DH, Huegel J, Nuss CA, Weiss SN, Soslowsky LJ. “Biocompatibility and Bioactivity of an FGF-Loaded Microsphere-Based Bilayer Delivery System.” Orthopaedic Research Society Annual Meeting, New Orleans, LA, 2018
  23. Riggin CN, Rodriguez AB, Weiss SN, Raja HA, Chen M, Schultz SM, Sehgal CM, Soslowsky LJ. “Modulation of Vascular Response after Injury in the Rat Achilles Tendon Alters Healing Capacity.” Orthopaedic Research Society Annual Meeting, New Orleans, LA, 2018
  24. Riggin CN, Weiss SN, Rodriguez AB, Schultz SM, Sehgal CM, Soslowsky LJ. “Increasing Vascular Response to Injury improves Tendon Healing Outcome in Aged Rats.” Orthopaedic Research Society Annual Meeting, New Orleans, LA, 2018
  25. Freedman BR, Rodriguez AB, Hillin CD, Weiss SN, Sarver JJ, Soslowsky LJ. Tendon Strain Stiffening is Reduced During Healing and High Magnitude Long Duration Dynamic Loading. Trans Orthop Res Soc, San Diego, CA, 2017.
  26. Hillin CD, Fryhofer GW, Freedman BR, Choi DS, Weiss SN, Soslowsky LJ. Immobilization Angle Effect on Tendon Healing in Achilles Tendon Rupture. Trans Orthop Res Soc, San Diego, CA, 2017.
  27. Nuss CA, Choi D, Huegel J, Weiss SN, Vournakis J, Soslowsky LJ. Poly-N-Acetyl Glucosamine (sNAG) Enhances Rotator Cuff Tendon Healing in a Rat Model. Trans Orthop Res Soc, San Diego, CA, 2017.
  28. Robinson, K., Barnum, C., Weiss, SN., Huegel, J., Shetye, S., Sun, M., Adams, S., Birk, D., Soslowsky, L. (2016). Conditional deletion of decorin and biglycan in mature mouse tendons results in delayed collagen fiber realignment. Trans Orthop Res Soc, San Diego, CA, 2017.
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