Perelman School of Medicine at the University of Pennsylvania

McKay Orthopaedic Research Laboratory

Qin Laboratory

Dr. Abhishek Chandra, Ph.D

  • Abhishek Chandra

Post-doctoral Researcher

Country- India

Contact Information:

Department of Orthopaedic Surgery
School of Medicine, University of Pennsylvania
510 Stemmler Hall, 36th Street and Hamilton Walk
Philadelphia, PA 19104
732-354-6848 (tel) 215-5732133 (fax)
abhic@mail.med.upenn.edu

 

 

 

Education:
1998-2001: Bachelor of Science (Botany, Zoology, Chemistry) University of Allahabad, U.P (India)
2001-2003: Masters of Science (Biochemistry) School of Biochemistry, DAVV, Indore, M.P (India)
2004-2008: Ph.D. in Medical Science. Mentor: Dr. Naoyuki Miura, Department of Biochemistry, Hamamatsu Univ. School of Medicine, JAPAN

PUBLICATIONS

Chandra A, Lin T, Zhu J, Wei T, Huo Y, Jia H, Zhang Y, Liu XS, Cengel K, Xia B, Qin L.:PTH1-34 Blocks Radiation-Induced Osteoblast Apoptosis by Enhancing DNA Repair through Canonical Wnt Pathway.J Biol Chem. 2014 Oct 21. pii: jbc.M114.608158. [Epub ahead of print]

Zhang X, Zhu J, Liu F, Li Y, Chandra A, Levin L.S, Beier F, Enomoto-Iwamoto M,Qin L.:Reduced EGFR signaling enhances cartilage destruction in a mouse osteoarthritis model. Bone Research 2, Article number: 14015 (2014) ​doi:10.1038/boneres.2014.15

Altman A, de Bakker CM, Tseng WJ, Chandra A, Qin L, Liu X. :Enhanced Individual Trabecular Repair and Its Mechanical Implications in PTH and Alendronate Treated Rat Tibial Bone.J Biomech Eng. 2014 Oct 1. doi: 10.1115/1.4028823. [Epub ahead of print]

Zhu J, Siclari VA, Qin L. :Isolating endosteal mesenchymal progenitors from rodent long bones. Methods Mol Biol. 2015;1226:19-29.

Chandra A, Lin T, Tribble MB, Zhu J, Altman AR, Tseng WJ, Zhang Y, Akintoye SO, Cengel K, Liu XS, Qin L. :PTH1-34 alleviates radiotherapy-induced local bone loss by improving osteoblast and osteocyte survival.Bone. 2014 Oct;67:33-40.

Altman AR, Tseng WJ, de Bakker CM, Huh BK, Chandra A,Qin, L., Liu, X.S.: A closer look at the immediate trabecula response to combined parathyroid hormone and alendronate treatment.Bone. 2014 Jan 24;61:149-157.

Zhang X, Zhu J, Li Y, Lin T, Siclari VA, Chandra A, Elena CM, Koyama E, Enomoto-Iwamoto M, Qin L (2013)- Epidermal growth factor receptor (EGFR) signaling regulates epiphyseal cartilage development through beta-catenin-dependent and -independent pathways- J Biol Chem. 2013 Sep 18.

Chandra A, Lan S, Zhu J, Zhang X, Siclari VA, Altman AR, Cengel K, Liu X.S., Qin L (2013) - PTH prevents the deterioration of trabecular bone architecture induced by localized radiation- Bone.

Chandra A*, Lan S*, Siclari VA, Zhu J, Qin L (2013)- EGFR signaling promotes proliferation and survival in osteoprogenitors by increasing Egr2 expression- J Biol Chem.

Lan S*, Luo S*, Huh BK*, Chandra A, Altman AR, Qin L, Liu XS (2012)- 3D Image registration is critical to ensure accurate detection of longitudinal changes in trabecular bone density, microstructure and stiffness measurements in rat tibiae by in vivo micro computed tomography (µCT)- Bone.

Siclari VA, Zhu J, Akiyama K, Liu F, Zhang X, Chandra A, Nah H, Shi S, Qin L (2012) Mesenchymal stem cells residing close to the bone surface are functionally distinct from those in the central bone marrow- Bone.

Zhu J, Siclari VA, Liu F, Spatz JM, Chandra A, Pajevic PD, Qin L (2012)-Amphiregulin-EGFR signaling mediates the migration of bone marrow mesenchymal progenitors toward PTH-stimulated osteoblasts and osteocytes. PLoS One.

Chandra A, Chen L, Madura K. (2010) - Synthetic lethality of rpn11-1 rpn10Δ is linked to altered proteasome assembly and activity. Curr Genet. 2010 Dec;56 (6):543-57.

Chandra A, Chen L, Liang H, Madura K. (2010) –Proteasome assembly influences interaction with ubiquitinated proteins and shuttle factors. J Biol Chem. March 12th 2010,Vol. 285, No.11 pp 8330-8339.

Yang Z, Hikosaka K, Sharkar M.T.K , Tamakoshi T, Chandra A, Wang B, Itakura T, Xue X, Uezato T, Kimura W, Miura N (2010)- The mouse forkhead gene Foxp2 modulates expression of the lung genes. Life Science 2010 Jul 3;87 (1-2):17-25. Epub 2010 May 27.

Itakura T, Chandra A, Yang Z, Xue X, Wang B, Kimura W, Hikosaka K, Inohaya K, Kudo A, Uezato T, Miura N.(2008) –The medaka FoxP2,a homologue of human gene FOXP2, has a diverged structure and function. J Biochem. Mar; 143(3):407-16.

Chandra A, Itakura T, Yang Z, Tamakoshi T, Xue X, Wang B, Ueki T, Sato K, Uezato T, Miura N(2006) Neurogenesin-1 differentially inhibits the osteoblastic differentiation by bone morphogenetic proteins in C2C12 cells. Biochem Biophys Res Commun. Jun 9; 344(3):786-91.

Tamakoshi T, Itakura T, Chandra A, Uezato T, Yang Z, Xue XD, Wang B, Hackett BP, Yokoyama T, Miura N. (2006) Roles of the Foxj1 and Inv genes in the left-right determination of internal organs in mice. Biochem. Biophys. Res. Commun. Jan 20; 339(3):932-8.

Kanzaki-Kato N, Tamakoshi T, Fu Y, Chandra A, Itakura T, Uezato T, Tanaka T, Clouthier DE, Sugiyama T, Yanagisawa M, Miura N. (2005) Roles of forkhead transcription factor Foxc2 (MFH-1) and endothelin receptor A in cardiovascular morphogenesis. Cardiovasc Res. Feb 15; 65(3):711-8.


pubmed