Perelman School of Medicine at the University of Pennsylvania

McKay Orthopaedic Research Laboratory

Qin Laboratory

Dr. Ji Zhu, Ph.D 

  • group picture

Research Specialist

Hometown: Hubei, China                          

Contact Information                                   Department of Orthopaedic Surgery
School of Medicine, University of Pennsylvania
510 Stemmler Hall, 36th Street and Hamilton Walk
Philadelphia, PA 19104
215-898-3261 (tel) 215-5732133 (fax)
zhuji@mail.med.upenn.edu

 

 

Education:
• Ph.D., Fermentation Engineering and Molecular Biology (2002), South China University of Technology; Institute of Genetic Engineering, Southern Medical University, Guangzhou, China
• M.S., Plant Genetics (1996) South China Institute of Botany, Chinese Academy of Sciences, Guangzhou, China
• B.S., Biology (1990) Department of Biology, Huazhong Normal University, Wuhan, China

Areas of Special Interest                                                                                                                                  Bone and fat metabolism, mesenchymal stem cell differentiation, blood vessel regeneration, cancer bone metastasis. I enjoy running, Taijiquan and travel.

PUBLICATIONS:
Chandra A., Lan S., Zhu J., Siclari VA., Qin L. (2013) Epidermal growth factor receptor (EGFR) signaling promotes proliferation and survival in osteoprogenitors by increasing early growth response 2 (EGR2) expression.     J Biol Chem., 288(28):20488-98.

Zhang X., Zhu J., Li Y., Lin T., Siclari VA., Chandra A., Candela EM., Koyama E., Enomoto-Iwamoto M., Qin L. (2013) Epidermal Growth Factor Receptor (EGFR) Signaling Regulates Epiphyseal Cartilage Development through β-Catenin-dependent and -independent Pathways. J Biol Chem., 288(45):32229-40.

Chandra,A., Lan, S., Zhu, J., Lin, L., Zhang, X., Siclari, V., Altman,A., Cengel, K., Liu, X., Qin, L. (2013) PTH prevents the adverse effects of focal radiation on bone architecture in young rats. Bone, Available online 4 March 2013.

Zhu, J., Siclari, V., Liu, F., Spatz, J., Chandra, A., Pajevic, P.D. and Qin, L. (2012) Amphiregulin-EGFR Signaling Mediates the Migration of Bone Marow Mesenchymal Progenitors toward PTH-Stimulated Osteoblasts and Osteocytes. Plos One,7 (12):e50099.

Siclari, V. *, Zhu, J. *, Akiyama, K., Liu, F., Zhang, X., Chandra, A., Nah-Cederquist, HD., Shi, S., and Qin, L. (2012) Mesenchymal progenitors residing close to the bone surface are functionally distinct from those in the central bone marrow. Bone, 12:01431-7 ( * These authors contribute equally to this paper).

Zhu, J., Shimizu, E., Prtridge, N.C. and Qin, L. (2011) Epidermal Growth Factor (EGF) -like Ligands Derived from Breast Cancer Cells Suppress Osteoblast Differentiation and Bone Formation. Journal of Cell Biochemisrty, 112: 1749-1760.

Zhang, X., Siclari, VA., Lan, S., Zhu, J., Koyama, E., Dupuis, HL., Enomoto-Iwamoto, M., Beier, F., Qin, L. (2011) The critical role of the epidermal growth factor receptor in endochondral ossification. Journal of Bone and Mineral Research. 26(11): 2622-2633.

Zhang, X., Tamasi, J., Lu, X., Zhu, J., Chen, H., Tian, X., Threadgill, D.W., Kream, B.E., Kang, Y., Partridge, N.C., Qin, L. (2011) Epidermal Growth Factor Receptor Plays an Anabolic Role in Bone Metabolism In vivo. Journal of Bone and Mineral Research. 26(5):1022-1034.

Zhu, J., Jia, X., Xiao, G., Kang, Y., Partridge, N.C. and Qin, L. (2007) EGF-like Ligands Stimulate Osteoclastogenesis by Regulating Expression of Osteoclast Regulatory Factors by Osteoblasts: Implications for Osteolytic Bone Metastases. Journal of Biological Chemistry, 14; 282(37): 26656-64.

Zhang, J.*, Zhu, J. *, Valverde, P., Li, L., Pageau, S., Tu, Q.,. Nishimura, R., Yoneda, T. Yang, P., Zheng, W., Ma, W. and Chen, J. (2008) Phenotypic Analysis of Dlx5 Overexpression in Post-natal Bone. Journal of Dental Research, 87(1): 45-50 ( * These authors contribute equally to this paper).

Valverde P., Zhang J., Fix, A., Zhu J., Ma W., Tu Q. and Chen J. (2008) Overexpression of Bone Sialoprotein Leads to an Uncoupling of Bone Formation and Bone Resorption in Mice. Journal of Bone and Mineral Research, 23(11): 1775-1788.

Li, L., Zhu, J., Tu, Q., Yamauch, M., Sodek, J., Karsenty, G., Tang, J. and Chen, J. (2005) An In Vivo Model to Study Osteogenic Gene Regulation: Targeting an avian Retroviral Receptor (TVA) to Bone With the Bone Sialoprotein (BSP) promotor. Journal of Bone and Mineral Research, 20(8): 1403-1413.

Li, L., Ma, W., Zhu J., Shi, R., Liu, C., Chen, J. and Zheng, W. (2003). A modified restriction display PCR method in sample-labelling of DNA microarray. Journal of Virological Methods, 114(1): 71-75.

Fang, Zh., Zhu, J., Mao, X., Yue, L. and Xiong, J. (2007) Primary Culture and Differentiation of Human Preadipocyte (In Chinese). Shangdong Medical Journal, 47(/ 21): 11-13.

Zhu, J., Ma, W., Mao, X., Li, L., Wu, Q. and Zheng, W. (2005) Application of green fluorescent protein gene in study of adipocyte differentiation (In Chinese). Journal of First Military Medical University, 25(9): 1119-1124.

Zhu, J., Ma, W., Mao, X., Li, L., Song, Y. and Zheng, W. (2005) Cloning of human obesity gene and its expression in E. coli(In Chinese). Journal of First Military Medical University, 25(4):395-398.

Zhu, J., Ma, W., Li, L., Mao, X., Wu, Q. and Zheng, W. (2004) Studies of effect factors on the hybridization of gene expression microarray(In Chinese). Life Science Research, 8(2): 133-139.

Zhu, J., Ma, W., Li, L. and Yao R. (2002) A Method for Construction of Restriction cDNA Library. Hereditas (In Chinese). 24(2): 174-176.

Zhu, J., Ma, W., Li, L., Zheng, W. and Yao R. (2002) Effects of Glass Slide Surface Treatment on DNA Attachment Rate in the Fabrication of Genechip(In Chinese). Journal of South China University of Technology (Natural Science Edition In Chinese). 30(3): 94-97.

Zhu, J., Ma, W., Yao R. and Zheng, W. (2002) Study of Probe-Preparation of the Expression Genes for K562 Cell Line (In Chinese). Acta Anatomica Sinica, 33(1): 59-62.

Zhu, J., Ma, W., Li L., Song, Y., Wu, Q., Yao, R. and Zheng, W. (2002) Fabrication of cDNA Microarray for the Gene Expression in Leukemia K562 Cell Line(In Chinese). Academic Journal of Guangdong College of Pharmacy, 18(1): 7-10.

Zhu, J., Ma, W., Li L., Song, Y., Yao, R. and Zheng, W. (2002) Influence of Gene Expression in Leukemia K562 Cells Treated with Kudingcha Glycoside by cDNA Microarray(In Chinese). Journal of South China University of Technology (Natural Science Edition), 30(7):83-86.

Zhu, J., Ma, W., Yao, R., Li L., Song, Y., Wu, Q. and Zheng, W. (2002) Probes-Preparation of cDNA Microarray for the Gene Expression in Leukemia K562 Cell using Restriction cDNA Library(In Chinese). Life Science Research, 6(2): 142-146.

Zhu, J., Ma, W. and Yao, R. (2000) DNA Chip Technology and the Studies of Gene Expression (Review) (In Chinese). Life Science Research, 4(2):106-111.

Zhu, J., Ma, W. and Yao, R. (2000) DNA Chip Technology and its Application in the Pharmaceutics Research (Review) (In Chinese). Foreign Medicine, 27(4):193-197.

Feng, Ch., Ma, W., Li, L., Song, Y., Shi, R., Wu, Q., Guo, Q., Zhu, J. and Zheng W. (2002) Analysis with DNA chips of the changes of gene expressions in K562 cells in response to As2O3 treatment (In Chinese). Journal of First Military Medical University, 22(9): 772-775.

Li, L., Ma, W., Mao, X., Zhu, J. and Zheng, W. (2002) Preliminary Study of Development of Gene Chips for HIV Diagnosis (In Chinese). Journal of First Military Medical University, 22(8):724-727.

Li, L., Ma, W., Zhu, J., Zhu L., Song, Y., Wu, Q., Guo, Q. and Zheng, W. (2002) Preparation of HIV genechip probes by RD-PCR technology (In Chinese). Chin J Biochem Mol Biol, 18(1):105-109.

Li, L., Ma, W., Zhu, J., Shi, R. and Zheng, W. (2002) Screening of HIV-1 F subtype gene probes amplified by restriction display with genechip technology (In Chinese). Chin J Biochem Mol Biol, 18(5):564-567.

Feng, Ch., Ma, W., Song, Y., Wu, Q., Guo, Q., Zhu, J., Zhang, B. and Zheng, W.(2002) Differential Expressed Gene-Mac30 identification by Restriction Display Method (In Chinese). Chin J Hematol, 23(12): 654-656.

Zhu, J., Yao, R. and Liang, Ch. (2000) Callus Induction and Browning Inhibtion in Ilex Kuding- cha C.J. Tseng(In Chinese). Journal of Tropical and Subtropical Botany, 8(4):319-323.

Zhu, J., Huang, Y. and Liang, Ch. (1998) Improvement of plant regeneration from cyclic somatic embryos in Cassava (Manihot esculenta Crantz) (In Chinese). Journal of Tropical and Subtropical Botany, 6(2):144-151