Perelman School of Medicine at the University of Pennsylvania

McKay Orthopaedic Research Laboratory

Qin Laboratory


  1. Jia, H., Ma, X., Wei, Y., Tong, W.J., Tower, R.J., Chandra, A., Wang, L., Sun, Z., Yang, Z., Badar, F., Zhang, K., Tseng, W., Kramer, I., Kneissel, M., Xia, Y., Liu, X.S., Wang, J., Han, L.,  Enomoto-Iwamoto, M., and Qin, L. Subchondral bone plate sclerosis during late osteoarthritis is caused by loading-induced reduction in Sclerostin. Arthritis Rheum. In press.
  2. Chandra, A., Wang, L., Young, T., Zhong, L., Tseng, W.J., Levine, M.A., Cengel, K., Liu, X.S., Zhang, Y., Pignolo, R.J., and Qin, L. Proteasome inhibitor Bortezomib is a novel therapeutic agent for focal radiation-induced osteoporosis. FASEB J. In press.
  3. Tian, Z., Ma, X., Yasen, M., Mauck, R.L., Qin, L., Shofer, F.S., Smith, L.J., Pacifici, M., Enomoto-Iwamoto, M., and Zhang, Y. Intervertebral disc degeneration in a percutaneous mouse tail injury model. Am. J. Phys. Med. Rehabil. In press.
  4. Marcucio, R.S., Qin, L., Alsberg, E., and Boerckel, J.D. Reverse engineering development: crosstalk opportunities between developmental biology and tissue engineering. (2017) J Orthop Res. In press.
  5. Tong, W., Lu, Z., Qin, L., Mauck, R.L., Smith, H.E., Smith, L.J., Malhotra, N.R., Heyworth, M.F., Caldera, F., Enomoto-Iwamoto, M., and Zhang, Y. Cell therapy for the degenerating intervertebral disc. (2017) Transl. Res. 181:49-58.
  6. Xu, H., Dahiya, S., Wang, L., Akimova, T., Han, R., Zhang, T., Zhang, Y., Qin, L., Levine, M.H., Hancock, W.W., and Levin, S.L. Utility of IL-2 complexes in promoting the survival of murine orthotopic forelimb vascularized composite allografts. (2017) Transplantation. In press.
  7. Altman-Singles, A.R., Jeong, Y., Tseng, W.J., de Bakker, C.M.J., Zhao, H., Lott, C., Robberts, J., Qin, L., Han, L., Kim, D.G., Liu, X.S. Intermittent Parathyroid Hormone after Prolonged Alendronate Treatment Induces Substantial New Bone Formation and Increases Bone Tissue Heterogeneity in Ovariectomized Rats. J. Bone Miner. Res. In press.
  8. Tong, W., Lu, Z., Qin, L., Mauck, R.L., Smith, H.E., Smith, L.J., Malhotra, N.R., Heyworth, M.F., Caldera, F., Enomoto-Iwamoto, M., and Zhang, Y. Cell therapy for the degenerating intervertebral disc. Translational Research. In press.
  9. Jia, H.*, Ma, X.*, Tong, W.*, Doyan, B., Sun, Z., Wang, L., Zhang, X., Zhou, Y., Badar, F., Chandra, A., Lu, X.L., Xia, Y., Han, L., Enomoto-Iwamoto, M., and Qin, L. EGFR signaling is critical for maintaining the superficial layer of articular cartilage and preventing osteoarthritis initiation. * these authors contributed equally to this paper. (2016) Proc. Natl. Acad. Sci. USA 113: 14360-14365.
  10. Bugueño, J., Li, W., Salat, P., Qin, L., and Akintoye, S.O. The bone regenerative capacity of canine mesenchymal stem cells is regulated by site-specific multilineage differentiation. (2017) Oral Surg Oral Med Oral Pathol Oral Radiol. 123: 163-172.  
  11. Chandra, A., Lin, T., Young, T., Tong, W., Ma, X., Tseng, W.J., Kramer, I., Kneissel, M., Levine, M.A., Zhang, Y., Cengel, K., Liu, X.S., and Qin, L. Suppression of Sclerostin alleviates radiation-induced bone loss by protecting bone forming cells and their progenitors through distinct mechanisms. (2017) J. Bone Miner. Res. 32: 360-372. .
  12. Doyran, B.#, Tong, W.#, Li, Q., Jia, H., Zhang, X., Chen, C., Enomoto-Iwamoto, M., Lu, X.L., Qin, L.*, and Han, L*. Nanoindentation modulus of murine cartilage: a sensitive indicator of the initiation and progression of post-traumatic osteoarthritis. #: these authors contributed equally to this work. *: both authors are corresponding authors. (2017) Osteoarthritis Cartilage. 25: 108-117.
  13. Candela, M.E., Wang, C., Gunawardena, A.T., Zhang, K., Cantley, L., Yasuhara, R., Usami, Y., Francois, N., Iwamoto, M., van der Flier, A., Zhang, Y., Qin, L., Han, L., and Enomoto-Iwamoto, M. Alpha 5 Integrin mediates osteoarthritic changes in mouse knee joints. (2016) PLoS One. 11:e0156783
  14. Wang, Y., Dellatore, P., Douard, V., Qin, L., Watford, M., Ferraris, R.P., Lin, T., and Shapses, S.A. High fat diet enriched with saturated, but not monounsaturated fatty acids adversely affects femur, and both diets increase calcium absorption in older female mice. (2016) Nutr Res. 36:742-50.
  15. Shi, P., Chen E.Y., Cs-Szabo, G., Chee, A., Tanoury, C., Qin, L., Lin, H., An, S., An, H.S., and Zhang, Y. Biglycan Inhibits Capsaicin-Induced Substance P Release by Cultured Dorsal Root Ganglion Neurons. (2016) Am. J. Phys. Med. Rehabil. 95: 656-662.
  16. Zhu, H., Xie, F., Luo, X., Qin, L., Liu, X.S., Levin, L.S., and Li, Q. Orthotopic forelimb allotransplantation in the rat model. (2016) Microsurgery. 36: 672-675.
  17. Lin, T., Tong, W., Chandra, A., Hsu, S.Y., Jia, H., Zhu, J., Tseng, W.J., Levine, M.A., Zhang, Y., Yan, S.G., Liu, X.S., Sun, D., Young, W., and Qin, L. A comprehensive study of long-term skeletal changes after spinal cord injury in adult rats. (2015) Bone Res. 3: 15028.
  18. Altman, A.R., de Bakker, C.M.J., Chandra, A., Huh, B.K., Luo, S., Leonard, M.B., Qin, L., and Liu, X.S. Quantification of skeletal growth, modeling, and remodeling by in vivo micro computed tomography. (2015) Bone 81: 370-379.
  19. de Bakker, C.M.J., Altman, A.R., Tseng, W., Tribble, M.B., Li, C., Chandra, A., Qin, L., and Liu, X.S. µCT-Based, in vivo dynamic bone histomorphometry allows 3D evaluation of the early responses of bone resorption and formation to PTH and Alendronate combination therapy. (2015) Bone 73: 198-207.
  20. Li, Q., Doyran, B., Gamer, L.W., Lu, X.L., Qin, L., Ortiz, C., Grodzinsky, A.J., Rosen, V., and Han, L. Biomechanical properties of murine meniscus surfaces via AFM-based nanoindentation. (2015) J. Biomech. 48: 1364-1370.
  21. Scanzello, C.R., Markova, D.Z., Chee, A., Xiu, Y., Adams, S.L., Anderson, G., Zgonis, M., Qin, L., An, H.S., and Zhang, Y. Fibronectin splice variation in human knee cartilage, meniscus and synovial membrane:  observations in osteoarthritic knee. (2015) J. Orthop. Res. 33: 556-562.
  22. Chandra, A., Lin, T., Zhu, J., Tong, W., Huo, Y., Jia, H., Zhang, Y., Liu, X.S., Cengel, K., Xia, B., and Qin, L. PTH1-34 blocks radiation-induced osteoblast apoptosis by enhancing DNA repair through canonical Wnt pathway. (2015) J. Biol. Chem. 290: 157-167.
  23. Altman A.R., de Bakker C.M.J., Tseng, W., Chandra, A., Qin, L., and Liu, X.S. Enhanced individual trabecular repair and its mechanical implications in PTH and alendronate treated rat tibial bone. (2015) J. Biomech. Eng. 137.
  24. Chandra, A., Lin, T., Tribble, M., Zhu, J., Altman, A.R., Tseng, W., Zhang, Y., Akintoye, S.O., Cengel, K., Liu, X.S., and Qin, L. PTH1-34 alleviates radiotherapy-induced local bone loss by improving osteoblast and osteocyte survival. (2014) Bone 67: 33-40.
  25. Zhang, X., Zhu, J., Liu, F., Li, Y., Chandra, A., Levin, L.S., Beier, F., Enomoto-Iwamoto, M., and Qin, L. Reduced EGFR signaling enhances cartilage destruction in a mouse osteoarthritis model. (2014) Bone Research. 2: 14015.
  26. Altman, A.R., de Bakker, C.M.J., Tseng, W., Huh, B.K., Chandra, A., Qin, L., and Liu, X.S. A closer look at the immediate trabecular response to combined parathyroid hormone and alendronate treatment. (2014) Bone 61: 149-157.
  27. Zhang, X., Zhu, J., Li, Y., Lin, T., Siclari, V.A., Chandra, A., Candela, E.M., Koyama, E., Enomoto-Iwamoto, M., and Qin, L. Epidermal growth factor receptor (EGFR) signaling regulates epiphyseal cartilage development through beta-catenin-dependent and -independent pathways. (2013) J. Biol. Chem. 288: 32229-32240.
  28. Chandra, A., Lan, S., Zhu, J., Siclari, V., and Qin. L. Epidermal growth factor receptor (EGFR) signaling promotes proliferation and survival in osteoprogenitors by increasing early growth response protein (Egr2) expression. (2013) J. Biol. Chem. 288: 20488-20498.
  29. Lan, S., Luo, S., Huh, B., Chandra, A., Altman, A.R., Qin, L., and Liu, X.S. 3D image registration is critical to ensure accurate detection of longitudinal changes in trabecular bone density, microstructure, and stiffness measurements in rat tibiae by in vivo micro computed tomography (µCT). (2013) Bone 56: 83-90.
  30. Chandra, A., Lan, S., Zhu, J., Lin, T., Zhang, X., Siclari, V.A., Altman, A.R., Cengel, K.A., Liu, X.S., and Qin, L. PTH prevents the adverse effects of focal radiation on bone architecture in young rats. (2013) Bone 55: 449-457.
  31. Barnes, V.M., Xu, T., Shimizu, E., Nakatani, T., Jefcoat, S., Vasilov, A, Qin, L., and Partridge, N.C. Triclosan blocks Mmp 13 expression in hormone-stimulated osteoblasts. (2013) J Periodontol. 84: 1683-1689.
  32. Siclari, V.A., Zhu, J., Akiyama, K., Liu, F., Zhang, X., Chandra, A., Nah, H., Shi, S., and Qin, L. Mesenchymal progenitors residing close to the bone surface are functionally distinct from those in the central bone marrow. (2013) Bone 53: 575-586.
  33. Cantley, L., Saunders, C., Guttenberg, M., Candela, M.E., Ohta, Y., Yasuhara, R., Kondo, N., Sgariglia, F., Asai, S., Hugel, J., Zhang, X., Qin, L., Hecht, J.T., Chen, D., Yamatomto, M., Toyosawa, S., Dormans, J.P., Esko, J.D., Yamaguchi, Y., Iwamoto, M., Pacifici, M., and Enomoto-Iwamoto. Loss of β-Catenin induces multifocal periosteal chondroma-like masses in mice. (2013) Am. J. Pathol. 182: 917-927.
  34. Zhu, J., Siclari, V.A., Liu, F., Spatz, J.M., Chandra, A., Divieti Pajevic, P., and Qin, L. Amphiregulin-EGFR signaling mediates the migration of bone marrow mesenchymal progenitors toward PTH-stimulated osteoblasts and osteocytes. (2012) PLoS ONE 7: e50099.
  35. Usmani, S.E., Pest, M.A., Kim, G., Ohora, S.N., Qin, L., and Beier, F. Transforming growth factor alpha controls the transition from hypertrophic cartilage to bone during endochondral bone growth. (2012) Bone 51: 131-141.
  36. Moorthi, A., Saravanan, S., Srinivasan, N., Partridge, N.C., Zhu, J., Qin, L., and Selvamurugan, N. Synthesis, characterization and biological action of nano-bioglass ceramic particles for bone formation. (2012) J. Biomaterials and Tissue Engineering 2: 197-205.
  37. Zhang, X., Siclari, V.A., Lan, S., Zhu, J., Koyama, E., Dupuis, H.L., Enomoto-Iwamoto, M., Beier, F., and Qin, L. The critical role of the epidermal growth factor receptor in endochondral ossification. (2011) J. Bone Miner. Res. 26: 2622-2633.
  38. Zhu, J., Shimizu, E., Zhang, X., Partridge, N.C., and Qin, L. EGFR signaling suppresses osteoblast differentiation and inhibits expression of master osteoblastic transcription factors Runx2 and Osterix. (2011) J. Cell. Biochem. 112: 1749-1760.
  39. Zhang, X., Tamasi, J., Lu, X., Zhu, J., Chen, H., Tian, X., Lee, T., Threadgill, D.W., Kream, B.E., Kang, Y., Partridge, N.C. and Qin, L. Epidermal growth factor receptor plays an anabolic role in bone metabolism in vivo. (2011) J. Bone Miner. Res. 26: 1022-1034.

Research Publications, Peer-reviewed Reviews

1. Siclari, V.A. and Qin, L. (2010) Targeting the osteosarcoma cancer stem cells. J. Orthop. Surg. Res.; 5: 78.

Book chapters

1. Zhu, J., Siclari, V.A. and Qin, L. (2014) Isolating endosteal mesenchymal progenitors from rodent long bones. Invited chapter in “Osteoporosis and Osteoarthritis, Methods in Molecular Biology”, Vol. 1226, Edited by Westendorf and van Wijnen, Springer, 19-29.

2. Qin, L. & Partridge, N.C. (2012) Parathyroid hormone and parathyroid hormone-related protein: normal function, diseases, and emerging therapeutics. Invited chapter in “Bone-Metabolic Functions and Modulators (Topics in Bone Biology)” Vol. 7, Edited by Bronner, Farach-Carson, and Roach. Springer, 1-20.