Perelman School of Medicine at the University of Pennsylvania

McKay Orthopaedic Research Laboratory

Shore Laboratory

Dr. rer. nat. Julia Haupt

Julia Haupt

Postdoctoral Fellow
University of Pennsylvania

Hometown: Freiberg, Germany

Education: Dr. rer. nat., 2012, Free University of Berlin, Germany
Diploma Biology, 2006, Friedrich-Schiller University Jena, Germany

Areas of Special Interest: Fibrodysplasia ossificans progressive (FOP): impact of BMP signaling on myofibroblast differentiation and inflammation

Peer-Reviewed Publications:
Stricker S, Mathia S, Haupt J, Seemann P, Meier J, Mundlos S. (2011). Odd-skipped related genes regulate differentiation of embryonic limb mesenchyme and bone marrow mesenchymal stromal cells. Stem Cells Dev.; 21(4):623-33.

Kaplan FS, Seemann P, Haupt J, Xu M, Lounev VY, Mullins M, Shore EM. (2010). Investigations of activated ACVR1/ALK2, a bone morphogenetic protein type I receptor, that causes fibrodysplasia ossificans progressiva. Methods Enzymol.;484:357-73.

Villavicencio-Lorini P, Kuss P, Friedrich J, Haupt J, Farooq M, Türkmen S, Duboule D, Hecht J, Mundlos S. (2010). Homeobox genes d11-d13 and a13 control mouse autopod cortical bone and joint formation. J Clin Invest.;120(6):1994-2004.

Seemann P, Brehm A, Konig J, Reissner C, Stricker S, Kuss P, Haupt J, Renninger S, Nickel J, Sebald W, Groppe JC, Ploger F, Pohl J, Schmidt-von Kegler M, Walther M, Gassner I, Rusu C, Janecke AR, Dathe K, Mundlos S. (2010). Mutations in GDF5 reveal a key residue mediating BMP inhibition by NOGGIN. PLoS Genet.;5(11):e1000747.

Shen Q, Little SC, Xu M, Haupt J, Ast C, Katagiri T, Mundlos S, Seemann P, Kaplan FS, Mullins MC, Shore EM. (2009). The fibrodysplasia ossificans progressiva R206H ACVR1 mutation activates BMP-independent chondrogenesis and zebrafish embryo ventralization. J Clin Invest.;119(11):3462-72.

Stricker S, Brieske N, Haupt J, Mundlos S. (2006). Comparative expression pattern of Odd-skipped related genes Osr1 and Osr2 in chick embryonic development. Gene Expr Patterns.;6(8):826-34.

Conference Papers and Abstracts:
Haupt J, Deichsel A, Stange K, Kajikhina K, Ast C, Souidi N, Kaplan FS, Shore EM, Seemann P. Functional consequences of FOP-associated mutations ACVR1R206H and ACVR1Q207E in comparison to constitutive active ACVR1Q207D. ASBMR 2012 Annual Meeting, October 2012, Minneapolis, Minnesota, USA (poster presentation).

Haupt J, Souidi N, Ast C, Shore EM, Kaplan FS, Mews P, Walther M, Mundlos S, Seemann P. Functional analysis of FOP-associated point mutations of the BMP type I receptor ACVR1. 1st International BMP Workshop - Modern Trends in BMP Signaling, September 2009, Berlin, Germany (podium talk and poster presentation).

Haupt J, Ast C, Shore EM, Kaplan FS, Mundlos S, Seemann P. Functional analysis of FOP-associated point mutations in the BMP type I receptor Alk2. 4th International PhD Symposium Horizons in Molecular Biology, September 2007, Goettingen, Germany (poster presentation).

Julia joined our lab in the spring of 2012 as a post-doctoral fellow. In her doctoral work she focused on the functional characterization of different FOP mutations. Currently she investigates the role of fibroblasts in the formation of ectopic bone in FOP.