Perelman School of Medicine at the University of Pennsylvania

McKay Orthopaedic Research Laboratory

Shore Laboratory

Haitao Wang, Ph.D.

Haitao Wang Ph.D.

Senior Research Investigator
University of Pennsylvania

Hometown: Hebei, China

Education:Ph.D. Cell Biology, 2002, Peking Union Medical College
M.S. Pathology, 1999, Peking Union Medical College

Areas of Special Interest: Effect of the tissue microenvironment on initiation and progression of heterotopic ossification.

Peer-Reviewed Publications:
H Wang, Brennan TA, Russell E, Kim JH, Egan KP, Chen Q, Israelite C, Schultz DC, Johnson FB, Pignolo RJ. R-Spondin 1 promotes vibration-induced bone formation in mouse models of osteoporosis. J Mol Med (Berl). 2013 Dec;91(12):1421-9.

H Wang, Chen, Q., Lee, S.-H., Choi, Y., Johnson, B and Pignolo, R. J. (2012), Impairment of osteoblast differentiation due to proliferation-independent telomere dysfunction in mouse models of accelerated aging. Aging Cell, 11: 704-713.

Kaplan FS, Lounev VY, Wang H, Pignolo RJ, Shore EM. Fibrodysplasia ossificans progressiva: a blueprint for metamorphosis. Ann N Y Acad Sci. 2011 Nov;1237(1):5-10.

H Wang, T. Harshani Peiris, Mowery A, Le Lay J, Gao Y, Greenbaum LE. C/EBP is a transcriptional regulator of pgc-1 in the regenerating liver. Molecular endocrinology, 2008 Jul; 22(7):1596-605.

He X, Park K, H Wang, He X, Zhang Y, Hua X, Li Y, Kappes DJ CD4-CD8 lineage commitment is regulated by a silencer element at the ThPOK transcription-factor locus. Immunity, 2008 Mar; 28(3):346-358.

H Wang, B Larris, T.H. Peiris, L Zhang, Y Gao and L.E. Greenbaum. C/EBPβ activates E2F-regulated genes in vivo via recruitment of the coactivator CBP/P300 J Biol Chem., 2007, 282: 24679-24688.

X Li, S Wang, H Wang, D Gupta. Differential expression of peptidoglycan recognition protein 2 in the skin and liver requires different transcription factors J Biol Chem., 3; 281(9): 5895-9073, 2006 Mar.

Lu X, Wang M, Qi J, Wang H, Li X, Gupta D, Dziarski R. Peptidoglycan recognition proteins are a new class of human bactericidal proteins. J Biol Chem., 2005 Dec 14.

H Wang, D Gupta, X Li, R Dziarski. Human Peptidoglycan Recognition Protein 2 (N-Acetylmuramoyl-L-Alanine Amidase) Is Induced in Keratinocytes by Bacteria Through a p38 Kinase-Dependent Pathway. Infection and Immunity, 73(11): 7216-7225, 2005 Nov.

Zhang Y, van der Fits L, Voerman JS, Melief MJ, Laman JD, Wang M, Wang H, Wang M, Li X, Walls CD, Gupta D, Dziarski R. Identification of serum N-acetylmuramoyl-l-alanine amidase as liver peptidoglycan recognition protein 2. Biochim Biophys Acta., 1752(1): 34-46. 2005 Aug.

H Wang, Kong JP, Ding F, Wang XQ, Wang MR, Liu LX, Wu M, Liu ZH. Analysis of gene expression profile induced by EMP-1 in esophageal cancer cells using cDNA Microarray. World J Gastroenterol, 9(3): 392-98, 2003.

Liu YH, Tang PZ, Xu ZG, Qi YF, Ding F, Zhang LY, Wang HT, Liu ZH Differential expression of the epithelial membrane protein 1 of laryngeal carcinoma. Zhongguo Yi Xue Ke Xue Yuan Xue Bao, 25(1): 47-51, 2003.

H Wang, Liu ZH, Wang XQ, Wu M. Effect of EMP-1 gene on human esophageal cancer cell line. Chinese Cancer Journal, 21(3): 229-32. 2002.

H Wang, M Wu, The principle and application of radiation hybridization map. The Foreign Medical Sciences, 24(5): 233-36, 2001.

H Wang, J Ma, X Luo, H Wei. The fumonisin B1 content in corn from North China, a high-risk area of esophageal cancer. J Environ Pathol Toxicol Oncol, 19(1-2): 139-41, 2000.

H Wang, H Wei, J Ma, X Luo. The determination of FumonisinB1 in corn from high-risk area of esophageal cancer. Cancer Research on Prevention and Treatment, 26 (3): 168-70, 1999.

Conference Papers and Abstracts:
H Wang, E.M. Shore, F.S. Kaplan, J. Groppe, R.J. Pignolo. Hypoxia Promotes Ligand-independent Activation of the ACVR1 (R206H) Mutant Receptor in C2C12 Cells, ASBMR Annual Meeting; Montreal, Canada, 2008.

H Wang, M Xu, J Groppe, T Katagiri, E Shore, F Kaplan, R Pignolo. BMP-independent Activation of the ACVR1 (R206H) Mutant Receptor by Hypoxia in Fibrodysplasia Ossificans Progressiva (FOP). ASBMR Annual Meeting; Denver, Colorado, 2009.

H Wang, Q Chen, SH Lee, Y Choi, B Johnson, R Pignolo. Telomere Dysfunction Mediates Age-Related Impairment of Osteoblast Differentiation, ASBMR Annual Meeting; Denver, Colorado, 2009.