Perelman School of Medicine at the University of Pennsylvania

McKay Orthopaedic Research Laboratory

Shore Laboratory

Haitao Wang Ph.D.

Haitao Wang Ph.D.

Research Associate
University of Pennsylvania

Hometown: Hebei, China

Education:Ph.D. Cell Biology, 2002, Peking Union Medical College
M.S. Pathology, 1999, Peking Union Medical College

Areas of Special Interest: Effect of the tissue microenvironment on initiation and progression of heterotopic ossification.

Peer-Reviewed Publications:
Haitao Wang, M. Xu, J. Groppe,T. Katagiri,E. M. Shore,F. S. Kaplan, Pignolo, R. J. MP-independent Activation of the ACVR1 (R206H) Mutant Receptor by Hypoxia in Fibrodysplasia Ossificans Progressiva (FOP). Manuscript.

Haitao Wang, Chen, Q., Lee, S.-H., Choi, Y., Brad Johnson, F. and Pignolo, R. J. (2012), Impairment of osteoblast differentiation due to proliferation-independent telomere dysfunction in mouse models of accelerated aging. Aging Cell, 11: 704-713.

Kaplan FS, Lounev VY, Wang H, Pignolo RJ, Shore EM. Fibrodysplasia ossificans progressiva: a blueprint for metamorphosis. Ann N Y Acad Sci. 2011 Nov;1237(1):5-10. doi: 10.1111/j.1749-6632.2011.06195.x.

Haitao Wang, T. Harshani Peiris, Mowery A, Le Lay J, Gao Y, Greenbaum LE. C/EBP is a transcriptional regulator of pgc-1? in the regenerating liver. Molecular endocrinology, 2008 Jul; 22(7):1596-605.

He X, Park K, Haitao Wang, He X, Zhang Y, Hua X, Li Y, Kappes DJ CD4-CD8 lineage commitment is regulated by a silencer element at the ThPOK transcription-factor locus. Immunity, 2008 Mar; 28(3):346-358.

Haitao Wang, Brian Larris, T. Harshani Peiris, Liping Zhang, Yan Gao and Linda E. Greenbaum. C/EBP? activates E2F-regulated genes in vivo via recruitment of the coactivator CBP/P300 J Biol Chem., 2007, 282: 24679-24688

Xinna Li, Shiyong Wang, Haitao Wang, Dipika Gupta. Differential expression of peptidoglycan recognition protein 2 in the skin and liver requires different transcription factors J Biol Chem., 3; 281(9): 5895-9073, 2006 Mar.

Lu X, Wang M, Qi J, Wang Haitao, Li X, Gupta D, Dziarski R. Peptidoglycan recognition proteins are a new class of human bactericidal proteins. J Biol Chem., 2005 Dec 14.

Haitao Wang, Dipika Gupta, Xinna Li, Roman Dziarski. Human Peptidoglycan Recognition Protein 2 (N-Acetylmuramoyl-L-Alanine Amidase) Is Induced in Keratinocytes by Bacteria Through a p38 Kinase-Dependent Pathway. Infection and Immunity, 73(11): 7216-7225, 2005 Nov.

Zhang Y, van der Fits L, Voerman JS, Melief MJ, Laman JD, Wang M, Wang H, Wang M, Li X, Walls CD, Gupta D, Dziarski R. Identification of serum N-acetylmuramoyl-l-alanine amidase as liver peptidoglycan recognition protein 2. Biochim Biophys Acta., 1752(1): 34-46. 2005 Aug.

Haitao Wang, Kong JP, Ding F, Wang XQ, Wang MR, Liu LX, Wu M, Liu ZH. Analysis of gene expression profile induced by EMP-1 in esophageal cancer cells using cDNA Microarray. World J Gastroenterol, 9(3): 392-98, 2003.

Liu YH, Tang PZ, Xu ZG, Qi YF, Ding F, Zhang LY, Wang HT, Liu ZH Differential expression of the epithelial membrane protein 1 of laryngeal carcinoma. Zhongguo Yi Xue Ke Xue Yuan Xue Bao, 25(1): 47-51, 2003.

Haitao Wang, Liu ZH, Wang XQ, Wu M. Effect of EMP-1 gene on human esophageal cancer cell line. Chinese Cancer Journal, 21(3): 229-32. 2002.

Haitao Wang, Min Wu, The principle and application of radiation hybridization map. The Foreign Medical Sciences, 24(5): 233-36, 2001.

Haitao Wang, Jilin Ma, Xianmao Luo, huijuan Wei. The fumonisin B1 content in corn from North China, a high-risk area of esophageal cancer. J Environ Pathol Toxicol Oncol, 19(1-2): 139-41, 2000.

Haitao Wang, Huijuan Wei, Jilin Ma, Xianmao Luo, The determination of FumonisinB1 in corn from high-risk area of esophageal cancer. Cancer Research on Prevention and Treatment, 26 (3): 168-70, 1999.

Conference Papers and Abstracts:
Haitao Wang, E. M. Shore, F. S. Kaplan, J. Groppe, R. J. Pignolo. Hypoxia Promotes Ligand-independent Activation of the ACVR1 (R206H) Mutant Receptor in C2C12 Cells ASBMR annual meeting , Montreal, Quebec , 2008

Haitao Wang, Meiqi Xu, Jay Groppe, Takenobu Katagiri, Eileen Shore, Frederick Kaplan, Robert Pignolo. BMP-independent Activation of the ACVR1 (R206H) Mutant Receptor by Hypoxia in Fibrodysplasia Ossificans Progressiva (FOP). ASBMR annual meeting , Denver, Colorado, 2009

Haitao Wang, Qijun Chen, Seoung-Hoon Lee, Youngwon Choi, Brad Johnson, Robert Pignolo. Telomere Dysfunction Mediates Age-Related Impairment of Osteoblast Differentiation, ASBMR annual meeting, Denver, Colorado, 2009