Perelman School of Medicine at the University of Pennsylvania

McKay Orthopaedic Research Laboratory

Shore Laboratory

Haitao Wang, Ph.D.

Haitao Wang Ph.D.

Senior Research Investigator
University of Pennsylvania

Hometown: Hebei, China

Education:Ph.D. Cell Biology, 2002, Peking Union Medical College
M.S. Pathology, 1999, Peking Union Medical College

Areas of Special Interest: Effect of the tissue microenvironment on initiation and progression of heterotopic ossification.

Peer-Reviewed Publications:

H Wang, C Lindborg, V Lounev, JH Kim, R McCarrick-Walmsley, M Xu, L Mangiavini, JC Groppe, EM Shore, E Schipani, FS Kaplan and RJ Pignolo. Cellular hypoxia promotes heterotopic ossification by amplifying BMP signaling. J Bone Miner Res. 2016; 31(9):1652-65.

CS Rajapakse, C Lindborg, H Wang, BT Newman, EA Kobe, G Chang, EM Shore, FS Kaplan, RJ Pignolo. Analogue method for radiographic assessment of heterotopic bone in Fibrodysplasia Ossificans Progressiva. Acad Radiol. 2016; 12(16):30386-5.

J Farr, D Fraser, H Wang, K Jaehn, M Ogrodnik, M Weivoda, M Drake, T Tchkonia, N LeBrasseur, J Kirkland, L Bonewald, R Pignolo, D Monroe, S Khosla. Identification of senescent cells in the bone microenvironment. J Bone Miner Res, 2016; 31(11):1920-9.

MR Convente, H Wang, RJ Pignolo, FS Kaplan, EM Shore. The immunological contribution to heterotopic ossification disorders. Curr Osteoporos Rep. 2015; 13(2):116-24.

H Wang, Brennan TA, Russell E, Kim JH, Egan KP, Chen Q, Israelite C, Schultz DC, Johnson FB, Pignolo RJ. R-Spondin 1 promotes vibration-induced bone formation in mouse models of osteoporosis. J Mol Med (Berl). 2013 Dec;91(12):1421-9.

H Wang, Chen, Q., Lee, S.-H., Choi, Y., Johnson, B and Pignolo, R. J. (2012), Impairment of osteoblast differentiation due to proliferation-independent telomere dysfunction in mouse models of accelerated aging. Aging Cell, 11: 704-713.

Kaplan FS, Lounev VY, Wang H, Pignolo RJ, Shore EM. Fibrodysplasia ossificans progressiva: a blueprint for metamorphosis. Ann N Y Acad Sci. 2011 Nov;1237(1):5-10.

H Wang, T. Harshani Peiris, Mowery A, Le Lay J, Gao Y, Greenbaum LE. C/EBP is a transcriptional regulator of pgc-1 in the regenerating liver. Molecular endocrinology, 2008 Jul; 22(7):1596-605.

H Wang, B Larris, T.H. Peiris, L Zhang, Y Gao and L.E. Greenbaum. C/EBPβ activates E2F-regulated genes in vivo via recruitment of the coactivator CBP/P300 J Biol Chem., 2007, 282: 24679-24688.

Lu X, Wang M, Qi J, Wang H, Li X, Gupta D, Dziarski R. Peptidoglycan recognition proteins are a new class of human bactericidal proteins. J Biol Chem., 2005 Dec 14.

H Wang, D Gupta, X Li, R Dziarski. Human Peptidoglycan Recognition Protein 2 (N-Acetylmuramoyl-L-Alanine Amidase) Is Induced in Keratinocytes by Bacteria Through a p38 Kinase-Dependent Pathway. Infection and Immunity, 73(11): 7216-7225, 2005 Nov.

H Wang, Kong JP, Ding F, Wang XQ, Wang MR, Liu LX, Wu M, Liu ZH. Analysis of gene expression profile induced by EMP-1 in esophageal cancer cells using cDNA Microarray. World J Gastroenterol, 9(3): 392-98, 2003.

H Wang, J Ma, X Luo, H Wei. The fumonisin B1 content in corn from North China, a high-risk area of esophageal cancer. J Environ Pathol Toxicol Oncol, 19(1-2): 139-41, 2000.

Conference Papers and Abstracts:
H Wang, E.M. Shore, F.S. Kaplan, J. Groppe, R.J. Pignolo. Hypoxia Promotes Ligand-independent Activation of the ACVR1 (R206H) Mutant Receptor in C2C12 Cells, ASBMR Annual Meeting; Montreal, Canada, 2008.

H Wang, M Xu, J Groppe, T Katagiri, E Shore, F Kaplan, R Pignolo. BMP-independent Activation of the ACVR1 (R206H) Mutant Receptor by Hypoxia in Fibrodysplasia Ossificans Progressiva (FOP). ASBMR Annual Meeting; Denver, Colorado, 2009.

H Wang, Q Chen, SH Lee, Y Choi, B Johnson, R Pignolo. Telomere Dysfunction Mediates Age-Related Impairment of Osteoblast Differentiation, ASBMR Annual Meeting; Denver, Colorado, 2009.

Awards 2014-present:

2017 Ashley Martucci Fellowship for outstanding contributions in FOP Research

2016 “Compelling breakthrough" designation for H Wang, et al. Cellular hypoxia promotes heterotopic ossification by amplifying BMP signaling, J Bone Miner Res. 2016; 31(9):1652-65 (Source: Hess, E. J. Bone Miner. Res. 2016; 31(9): 1647–1651)

2016 “Most talked about articles” in Muscle and Bone for H Wang, et al. Cellular hypoxia promotes heterotopic ossification by amplifying BMP signaling, J Bone Miner Res. 2016;31(9):1652-65

2016 Cover page selection, JBMR 30 th anniversary celebration, J Bone Miner Res on Volume 31, Issue 9

2016 Ashley Martucci Fellowship for outstanding contributions in FOP Research

2015 Roemex Fellowship for outstanding contributions in FOP Research

2014 The Helen Bates Law Book Award for outstanding contributions in Basic Gerontology Research, Perelman School of Medicine, University of Pennsylvania

2014 Roemex Fellowship for outstanding contributions in FOP Research