Perelman School of Medicine at the University of Pennsylvania

McKay Orthopaedic Research Laboratory

Shore Laboratory

Girish Ramaswamy

Girish Ramaswamy

Postdoctoral Fellow
University of Pennsylvania

Hometown: Tamil Nadu, India

Education:Ph.D., Biomedical Engineering, 2012, University of Alabama at Birmingham, Birmingham, AL
M.S., Biomedical Engineering, 2007, University of Alabama at Birmingham, Birmingham, AL
B.E., Mechanical Engineering, 2005, Birla Institute of Technology and Science, Rajasthan, India

Areas of Special Interest: My research interests are growth factor signaling in skeletal development and disease, signaling pathways regulating stem cell differentiation and orthopedic biomechanics. Currently, I am working on understanding the mechanisms underlying heterotopic bone formation in Progressive Osseous Heteroplasia (POH), a rare genetic bone disorder affecting G-protein signaling. My focus is to delineate the factors which regulate differentiation of stem cells into adipogenic and osteogenic lineages.

Peer-Reviewed Publications:
Ramaswamy G, Sohn P, Eberhardt A, Serra R. Altered Responsiveness to TGF-? Results in Reduced Papss2 Expressions & Alterations in the Biomechanical Properties of Mouse Articular Cartilage. Arthritis Research & Therapy, 2012, 14:R49.

Chang CF, Ramaswamy G, Serra R. Deletion of primary cilia in articular chondrocytes results in reduced Gli3 repressor to activator ratio, increased hedgehog signaling and symptoms of early osteoarthritis. Osteoarthritis & Cartilage, 2012, 20:152-161.

Kumar S, Wan C, Ramaswamy G, Clemens TL, Ponnazhagan S. Mesenchymal Stem Cells Expressing Osteogenic and Angiogenic Factors Synergistically Enhance Bone Formation in a Mouse Model of Segmental Bone Defect. Molecular Therapy, 2010, 18:1026-1034.

Chanda D, Isayeva T, Kumar S, Hensel JA, Sawant A, Ramaswamy G, Seigal GP, Beatty MS, Ponnazhagan S. Therapeutic Potential of Adult Bone Marrow-derived Mesenchymal Stem Cells in Prostate Cancer Bone Metastasis. Clinical Cancer Research, 2009, 15:7175-7185.

Shen X, Wan C, Ramaswamy G, Mavalli M, Wang Y, Duvall CL, Deng LF, Guldberg RE, Eberhart A, Clemens TL, Gilbert SR. Prolyl Hydroxylase Inhibitors Increase Neoangiogenesis and Callus Formation Following Femur Fracture in Mice. J Orthopedic Research, 2009, 27:1298-1305.

Wan C, Gilbert SR, Wang Y, Cao XM, Shen X, Ramaswamy G, Jacobsen KA, Alaql ZS, Gerstenfeld LC, Einhorn TA, Eberhardt AW, Deng L, Guldberg RE, Clemens TL. Role of Hypoxia Inducible Factor-1alpha Pathway in Bone Regeneration. Journal of Musculoskeletal and Neuronal Interactions, 2008, 8: 323-324.

Wan C, Gilbert SR, Wang Y, Cao X, Shen X, Ramaswamy G, Jacobsen KA, Alaq ZS, Eberhardt AW, Gerstenfeld LC, Einhorn TA, Deng L, Clemens TL. Activation of the Hypoxia Inducible Factor-1? Pathway Accelerates Bone Regeneration. Proceedings of the National Academy of Sciences, 2008, 15: 686-692.

Conference Papers and Abstracts:
Ramaswamy G, Serra R, Regulation of PAPS Synthetase 2 by Transforming Growth Factor-beta and its Role in the Maintenance of Mouse Articular Cartilage, UAB Department of Cell Biology Retreat, Alabama 2012.

Ramaswamy G, Sohn P, Eberhardt AE, Serra R, Characterization of Mechanical Properties in Mouse Articular Cartilage with Alterations in TGF-? Signaling, Gordon Research Conference on Cartilage Biology and Pathology, Ventura, California, 2011.

Ramaswamy G, Serra R, Characterization of Mechanical Properties in Mouse Articular Cartilage with Alterations in TGF-? Signaling, Gordon Research Conference on Musculoskeletal Biology and Bioengineering, Andover, New Hampshire, 2010.

Gilbert S, Shen X, Ramaswamy G, Mavalli M, Wang Y, Wan C, Duvall C, Deng L, Guldberg R, Clemens T, Prolyl Hydroxylase Inhibitors Induce Angiogenesis and Improve Callus Formation Following Femur Fracture in Mice, 55th Annual Meeting of the Orthopedic Research Society, Las Vegas, 2009.

Ramaswamy G, Cao X, Wan C, Chowdhury S, McGwin G, Clemens TL, Eberhardt, AE, Geometric alterations in cortical bone in mice lacking IGF1 receptor in osteoblasts, Southeastern Meeting of the American Society of Biomechanics, Birmingham, 2008.

Ramaswamy G, Cao X, Chowdhury S, Wan C, McGwin G, Lemons JE, Clemens TL, Eberhardt AE, Osteoblast-specific Knockout of IGF Receptor Gene in Mice Alters Mechanical Properties of Cortical Bone, 29th Annual Meeting of The American Society for Bone and Mineral Research, Hawaii, 2007.

Wan C, Gilbert SR, Cao XM, Ramaswamy G, Gerstenfeld LC, Einhorn TA, Guldberg RE, Clemens T, Genetic Activation of the Hypoxia Inducible Factor Pathway Accelerates Bone Repair, 53rd Annual Meeting of the Orthopedic Research Society, 2007.

Ramaswamy G, Wan C, Cao XM, Chowdhury SA, Clemens TL, Eberhardt AW, Mechanical Characterization of Cortical Bone in Mice with Osteoblast-specific Knockout of the Insulin-Like Growth Factor Receptor 1 Gene, Biomedical Engineering Society Annual Fall Meeting, Chicago, 2006.

Ramaswamy G, Study of Motor Protein Models and Related Issues, Nanosphere, National Conference on Nanoscience and Technology, India, 2004

Book Chapters:
Ramaswamy G, Bidez MW, Misch CE. Bone Response to Mechanical Loads. In: Misch CE. Contemporary Implant Dentistry. Misch CE (Editor), 3rd Ed., Mosby Elsevier 2007, pp 317-328.