Perelman School of Medicine at the University of Pennsylvania

McKay Orthopaedic Research Laboratory

Smith/Malhotra Laboratory


Peck SH, O’Donnell PJ, Kang J, Shore EM, Pacifici M, Dodge GR, Haskins ME, Malhotra NR, Smith LJ. (2015) Delayed Hypertrophic Differentiation of Epiphyseal Chondrocytes Contributes to Failed Bone Formation in Mucopolysaccharidosis VII Dogs. Molecular Genetics and Metabolism. (PubMed)

Gorth DG, Lothstein KE, Chiaro JA, Farrell MJ, Dodge GR, Elliott DM, Malhotra NR, Mauck RL, Smith LJ. (2015) Hypoxic Regulation of Functional Extracellular Matrix Elaboration by Nucleus Pulposus Cells in Long Term Agarose Culture. Journal of Orthopaedic Research.  33:747-54. (PubMed)

Showalter BL, Elliott DM, Chen W, Malhotra NR. (2015) Evaluation of an In Situ Gelable and Injectable Hydrogel Treatment to Preserve Human Disc Mechanical Function Undergoing Physiologic Cyclic Loading Followed by Hydrated Recovery. Journal of Biomechanical Engineering.137:081008. (PubMed)

Kim DH, Martin JT, Elliott DM, Smith LJ, Mauck RL. (2015) Phenotypic Stability, Matrix Elaboration, and Functional Maturation of Nucleus Pulposus Cells Encapsulated in Photocrosslinkable Hyaluronic Acid Hydrogels. Acta Biomaterialia. 12:21-9. (PubMed)

Farrell MJ, Shin JI, Smith LJ, Mauck RL. (2015) Functional consequences of glucose and oxygen deprivation on engineered mesenchymal stem cell-based cartilage constructs. Osteoarthritis and Cartilage. 23:134-42. (PubMed)

Chiaro JA, O’Donnell P, Shore EM, Ponder KP, Malhotra NR, Haskins ME, Smith LJ. (2014) Effects of Neonatal Enzyme Replacement Therapy and Simvastatin Treatment Cervical Spine Disease in Mucopolysaccharidosis I Dogs. Journal of Bone and Mineral Research. 29(12):2610-7. (PubMed)

Gorth DG, Martin JT, Dodge GR, Malhotra NR, Elliott DM, Mauck RL, Smith LJ. (2014) In Vivo Retention and Bioactivity of IL-1ra Microspheres in the Rat Caudal Intervertebral Disc: A Preliminary Investigation. Journal of Experimental Orthopaedics. 1:15. *Highly Accessed

Smith LJ, Gorth DJ, Showalter BL, Chiaro JA, Beattie EE, Chen W, Elliott DM, Mauck RL, Malhotra NR. (2014) In Vitro Characterization of a Stem Cell-Seeded Triple Interpenetrating Network Hydrogel for Functional Regeneration of the Nucleus Pulposus. Tissue Engineering: Part A. 20:1841-9. (PubMed)

Cortes DH, Han WN, Smith LJ, Elliott DM. (2013). Mechanical properties of the extra-fibrillar matrix of human annulus fibrosus are location and age dependent. J Orthop Res. 31(11):1725-32.  (PubMed)

Han WM, Heo SJ, Driscoll TP, Smith LJ, Mauck RL, Elliott DM. (2013). Macro- to microscale strain transfer in fibrous tissues is heterogeneous and tissue-specific. Biophys J. 105(3):807-17. (PubMed)

Moon SM, Yoder JH, Wright AC, Smith LJ, Vresilovic EJ, Elliott DM. (2013). Evaluation of intervertebral disc cartilaginous endplate structure using magnetic resonance imaging. Eur Spine J. 22(8):1820-8. (PubMed)

Martin JT, Gorth DJ, Beattie EE, Harfe BD, Smith LJ, Elliott DM. (2013). Needle puncture injury causes acute and long-term mechanical deficiency in a mouse model of intervertebral disc degeneration. J Orthop Res. 31(8):1276-82. (PubMed)

Chiaro JA, Baron MD, Del Alcazar CM, O'Donnell P, Shore EM, Elliott DM, Ponder KP, Haskins ME, Smith LJ. (2013). Postnatal progression of bone disease in the cervical spines of mucopolysaccharidosis I dogs. Bone. 55(1):78-83. (PubMed)

Smith LJ, Martin JT, O’Donnell P, Wang P, Elliott DM, Haskins ME, Ponder KP (2012). Effect of neonatal gene therapy on lumbar spine disease in mucopolysaccharidosis VII dogs. Molecular Genetics and Metabolism.107:145-152. (PubMed) IF:2.827

Smith LJ, Baldo G, Wu S, Liu Y, Whyte MP, Giugliani R, Elliott DM, Haskins ME, Ponder KP. (2012). Pathogenesis of lumbar spine disease in mucopolysaccharidosis VII. Mol Genet Metab. 107(1-2):153-60. (PubMed)

Malhotra NR, Han WN, Beckstein J, Cloyd J, Chen W, Elliott DM. (2012). An injectable nucleus pulposus implant restores compressive range of motion in the ovine disc. Spine (Phila Pa 1976). 37(18):E1099-105. (PubMed)

Gorth DJ, Mauck RL, Chiaro JA, Mohanraj B, Hebela NM, Dodge GR, Elliott DM, Smith LJ. (2012). IL-1ra delivered from poly(lactic-co-glycolic acid) microspheres attenuates IL-1B-mediated degradation of nucleus pulposus in vitro. Arthritis Res Ther. 14(4):R179. (PubMed)

Han WM, Nerurkar NL, Smith LJ, Jacobs NT, Mauck RL, Elliott DM. (2012). Multi-scale structural and tensile mechanical response of annulus fibrosus to osmotic loading. Ann Biomed Eng. 40(7):1610-21. (PubMed)

Smith LJ, Chiaro JA, Nerurkar NL, Cortes DH, Horava SD, Hebela NM, Mauck RL, Dodge GR, Elliott DM. (2011). Nucleus pulposus cells synthesize a functional extracellular matrix and respond to inflammatory cytokine challenge following long-term agarose culture. Eur Cell Mater. 22:291-301. (PubMed)

Jacobs NT, Smith LJ, Han WM, Morelli J, Yoder JH, Elliott DM. (2011). Effect of orientation and targeted extracellular matrix degradation on the shear mechanical properties of the annulus fibrosus. J Mech Behav Biomed Mater. 4(8):1611-9. (PubMed)

O'Connell GD, Malhotra NR, Vresilovic EJ, Elliott DM. (2011). The effect of nucleotomy and the dependence of degeneration of human intervertebral disc strain in axial compression. Spine (Phila Pa 1976). 36(21):1765-71. (PubMed)

Smith LJ, Elliott DM. (2011). Formation of lamellar cross bridges in the annulus fibrosus of the intervertebral disc is a consequence of vascular regression. Matrix Biol. 30(4):267-74. (PubMed)

Smith LJ, Kurmis AP, Slavotinek JP, Fazzalari NL. (2011). In vitro evaluation of a manganese chloride phantom-based MRI technique for quantitative determination of lumbar intervertebral disc composition and condition. Eur Spine J. 20(3):434-9. (PubMed)

Smith LJ, Nerurkar NL, Choi KS, Harfe BD, Elliott DM. (2011). Degeneration and regeneration of the intervertebral disc: lessons from development. Dis Model Mech. 4(1):31-41. (PubMed)

Smith LJ, Martin JT, Szczesny SE, Ponder KP, Haskins ME, Elliott DM. (2010). Altered lumbar spine structure, biochemistry, and biomechanical properties in a canine model of mucopolysaccharidosis type VII. Journal of Orthopaedic Research, 28:616-622. (PubMed)