Perelman School of Medicine at the University of Pennsylvania

McKay Orthopaedic Research Laboratory

Smith Laboratory

Joseph Chiaro

Joseph Chiaro

Research Engineer
University of Pennsylvania

Hometown: Philadelphia, Pennsylvania

Education: B.S. Biology, 2010, Widener University                                         Candidate for MB, 2014, The University of Pennsylvania

Areas of Special Interest: Reducing the morbidity of children affected by the mucopolysaccharidoses.  The degeneration and regeneration of the intervertebral disc.

Publications:

Martin JT, Milby AH, Chiaro J, Kim DH, Hebela NM, Smith LJ, Elliott DM, Mauck RL. (2014). Translation of an engineered nanofibrous disc-like angle-ply structure for intervertebral disc replacement in a small animal model. Acta Biomater, [Epub ahead of print].

Smith LJ, Gorth DJ, Showalter BL, Chiaro JA, Beattie EE, Elliot D, Mauck RL, Chen W, Malhotra NR (2014).  In Vitro Characterization of a Stem Cell-Seeded Triple Interpenetrating Network Hydrogel for Functional Regeneration of the Nucleus Pulposus. Tissue Eng Part A., [Epub ahead of print].

Chiaro JA, Baron MD, Del Alcazar CM, O'Donnell P, Shore EM, Elliott DM, Ponder KP, Haskins ME, Smith LJ (2013). Postnatal progression of bone disease in the cervical spines of mucopolysaccharidosis I dogs. Bone, 55:78-83.

Gorth DG, Mauck RL, Chiaro JA, Mohanraj B, Hebela NM, Dodge GR, Elliott DM, Smith LJ (2012). IL-1ra Delivered from Poly(Lactic-co-Glycolic Acid) Microspheres Attenuates IL-1B Mediated Degradation of Nucleus Pulposus In Vitro, Arthritis Res Ther., 14(4):R179.

Smith LJ, Chiaro JA, Nerurkar NL, Cortes DH, Horava S, Dodge GR, Hebela N, Mauck RL, Elliott DM (2011). Effects of interleukin-1 beta and its receptor antagonist on the composition and mechanical function of engineered nucleus pulposus constructs. European Cells and Materials, 22:291-301

Schoenman ER, Chiaro JA, Jones A, Bastin LD, Coughlin DJ (2009). A comparative analysis of parvalbumin expression in pinfish (Lagodon rhomboides) and toadfish (Opsanus sp.). Comp Biochem Physiol A Mol Integr Physiol, 155(1):91-9.

Abstracts:
Farrell MJ, Chiaro JA, Henning EA, Pacifici M, Mauck RL. An Inverse Agonist for Retinoic Acid Receptors Boosts Mesenchymal Stem Cell Chondrogenesis and Functional Properties of Tissue Engineered Cartilage. Orthopedic Research Society Annual Conference, 2013 January 26-29; San Antonio, TX.

Gorth, DJ, Chiaro JA, Elliott DM, Mauck RL, Chen, W, Smith LJ, Malhotra NR. Mechanical Properties and Cyto-Compatibility of an Injectable Hydrogel Implant for Nucleus Pulposus Repair. Orthopedic Research Society Annual Conference, 2013 January 26-29; San Antonio, TX.

Gorth, DJ, Chiaro JA, Dodge GR, Hebela NM, Mauck RL, Elliott DM, Smith LJ. Effects of Low Oxygen Tension on the Biomechanical Properties, Composition and mRNA Expression of Engineered Nucleus Pulposus. Orthopedic Research Society Annual Conference, 2013 January 26-29; San Antonio, TX.

Chiaro JA, Baron MA, del Alcazar C, Shore EM, Elliott DM, Ponder KP, Haskins ME, Smith LJ. Pathogenesis of Cervical Vertebral Bone Disease in Mucopolysaccharidosis I During Postnatal Growth. The Philadelphia Spine Symposium, 2012 November 13; Philadelphia, PA.

Smith LJ, Gorth DJ, Chiaro JA, Martin JT, Dodge GR, Malhotra NR, Hebela NM, Mauck RL, Elliott DM. Targeting Inflammation in Intervertebral Disc Degeneration. 1st International Symposium on Nanomedicine in Drug Delivery and Cancer Diagnosis, 2012 August 16-17; The University of Delaware, Newark, DE.

Smith LJ, Gorth DJ, Martin JT, Chiaro JA, Dodge GR, Hebela NM, Mauck RL, Elliott DM. In Vivo Delivery of IL-1ra from PLGA Microspheres Attenuates IL-1beta Induced Nucleus Pulposus Glycosaminoglycan Loss in the Rat Caudal Intervertebral Disc. Gordon Research Conference on Musculoskeletal Science: Bedside to Bench to Bedside. Andover, NH (August 5-10, 2012).

Chiaro JA, Baron MA, Shore EM, Elliott DM, Ponder KP, Haskins ME, Smith LJ. Pathogenesis of vertebral bone disease in the cervical spines of mucopolysaccharidosis I dogs. 12th International symposium on MPS and related diseases, 2012 June 29; Noordwijkerhout, The Netherlands.

Chiaro JA, Dodge GR, Hebela NM, Mauck RL, Elliot DM, Smith LJ. Comparison of the Response of Nucleus Pulposus Cells and Articular Chondrocytes to Treatment with Hyaluronan Oligosaccharides. Orthopedic Research Society, 2012 February 4-7; San Francisco, CA.

Gorth DJ, Chiaro JA, Dodge GR, Hebela NM, Mauck RL, Elliot DM, Smith LJ. Sustained Delivery of IL-1ra from PLGA Microspheres Attenuates IL-1B Mediated Degredation of Engineered Nucleus Pulposus. Orthopedic Research Society, 2012 February 4-7; San Francisco, CA.

Gorth DJ, Chiaro JA, Dodge GR, Hebela NM, Mauck RL, Elliot DM, Smith LJ. IL-1ra Delivered from PLGA Microspheres Attenuates IL-1B Mediated Degredation of Engineered Nucleus Pulposus. To be presented at: Philadelphia Spine Research Symposium, 2011 Nov 16-18; Philadelphia, PA.