Perelman School of Medicine at the University of Pennsylvania

McKay Orthopaedic Research Laboratory

Soslowsky Laboratory

Brianne Connizzo

Brianne Connizzo

Graduate Student in Bioengineering
University of Pennsylvania

Hometown: Demarest, New Jersey

Education: B.S. Highest Honors in Engineering Science, 2010, Smith College

Areas of Special Interest: Tendon Structure Function-Relationships, Development and Healing, Tissue Engineering

CONFERENCE ABSTRACTS

  1. Mikic B, Connizzo B, McGrath M, Shea J, Bierwert L. The Effect of Myostatin Deficiency on Murine Tendon Material Behavior. Trans Orthop Res Soc 36:916, 2011.(Poster Presentation)
  2. Miller KS, Connizzo BK, Tucker JJ, Soslowsky LJ. Collagen Fiber Re-Alignment in a Neonatal Developmental Mouse Supraspinatus Tendon Model. Trans Orthop Res Soc 37:1289, 2012.(Poster Presentation)
  3. Miller KS, Connizzo BK, Tucker JJ, Feeney E, Trasolini NR, Soslowsky LJ. Local Differences in Collagen Fiber Crimp Throughout Mechanical Testing in a Mouse Supraspinatus Tendon Model. Trans Orthop Res Soc 37:1290, 2012.* (Poster Presentation)
  4. Beason DP, Connizzo BK, Dourte LM, Edelstein L, Tucker JJ, Liu SS, Mauck RL, Soslowsky LJ, Steinberg DR, Bernstein J. Fiber-Aligned Polymer Scaffolds for Rotator Cuff Repair in a Rat Model. Trans Orthop Res Soc 37:1664, 2012. (Poster Presentation)
  5. Connizzo BK, Liechty KW, Soslowsky LJ. Altered Mechanical Properties and Fiber Re-Alignment in Diabetic Mouse Supraspinatus and Achilles Tendons. Proceedings of ASME 2012 Summer Bioengineering Conference, SBC2012-80129.** (Poster Presentation)
  6. Connizzo BK, Birk DE, Iozzo RV, Soslowsky LJ. Effects of Decorin and Biglycan on Re-Alignment and Mechanical Properties of Aging Supraspinatus Tendons. Trans Orthop Res Soc 38:613, 2013. (Poster Presentation)
  7. Connizzo BK, Freedman BR, Sun M, Birk DE, Soslowsky LJ. Collagen V Null Mice Have Decreased ACL Mechanical Properties and Altered Fibril Morphology. Trans Orthop Res Soc 39:110, 2014. (Poster Presentation)
  8. Connizzo BK, Feeney E, Iozzo RV, Birk DE, Soslowsky LJ. In Situ Collagen Crimp is Altered with Age and Proteoglycan Deficiency in Mouse Supraspinatus Tendons. Trans Orthop Res Soc 39:1346, 2014. (Podium Presentation)
  9. Connizzo BK, Sarver JJ, Han L, Soslowsky LJ. In Situ Fibril Stretch In Mouse Supraspinatus Tendons is Location-Dependent. Proceedings of World Congress of Biomechanics 2014, Boston, MA
  10. Sun M, Connizzo BK, Adams SM, Freedman BR, Johnson R, Schweitzer R, Soslowsky LJ, Birk DE. A Tendon Specific Collagen V-Null Mouse Model Demonstrates A Joint Phenotype Characteristc of Classic Ehlers-Danlos Syndrome. (Poster Presentation, American Society of Matrix Biology Biennial Meeting 2014).
  11. Tucker JJ, Connizzo BK, Riggin CN, Mauck RL, Steinberg DR, Kuntz AF, Soslowsky LJ, Benstein J. Tendon Healing in a Supraspinatus Tear and Repair Rat Model is not Altered by Overuse-Induced Tendinopathy. (Accepted Poster Presentation, Othopaedic Research Society Annual Meeting 2015)
  12. Connizzo BK, Fried JH, Sun M, Birk DE, Soslowsky LJ. Critical Regulatory Role for Colllagen V in Establishing the Unique Mechanical Properties of Joint Stabilizing Tendons. (Accepted Podium Presentation, Orthopaedic Research Society Annual Meeting 2015)
  13. Connizo BK, Birk DE, Soslowsky LJ. The Dynamic Mechanical Response is Severly Altered in Collagen V Deficient Mouse Supraspinatus Tendons. (Accepted Podium Presentaiton ASME SB3C, PhD Competition Finalist)

PUBLICATIONS

  1. Miller KS, Connizzo BK, Soslowsky LJ: Collagen Fiber Re-Alignment in a Neonatal Developmental Mouse Supraspinatus Tendon Model. Ann Biomed Eng. 2012 May;40(5):1102-10.
  2. Beason DP, Connizzo BK, Dourte LM, Edelstein L, Tucker JJ, Liu SS, Mauck RL, Soslowsky LJ, Steinberg DR, Bernstein J. Fiber-Aligned Polymer Scaffolds for Rotator Cuff Repair in a Rat Model. Journal of Shoulder and Elbow Surgery. 2012 Feb;21(2):245-50.
  3. Miller KS, Edelstein L, Connizzo BK, Soslowsky LJ: Effect of Preconditioning and Stress Relaxation on Local Collagen Fiber Re-Alignment: Inhomogeneous Properties of Rat Supraspinatus Tendon. J Biomech Eng. 2012 Mar;134(3):031007
  4. Miller KS, Connizzo BK, Feeney E, Tucker JJ, Soslowsky LJ: Examining differences in local Collagen Fiber Crimp Frequency Throughout Mechanical Testing in a Developmental Mouse Supraspinatus Tendon Model. J Biomech Eng. 2012 Apr;134(4):041004.
  5. Miller KS, Connizzo BK, Feeney E, Soslowsky LJ: Characterizing Local Collagen Fiber Re-Alignment and Crimp Behavior Throughout Mechanical Testing in a Mature Mouse Supraspinatus Tendon Model. J Biomech. 2012 Aug 9;45(12):2061-5.
  6. Connizzo BK, Sarver JJ, Birk DE, Soslowsky LJ: Effect of Age and Proteoglycan Deficiency on Collagen Fiber Re-Alignment and Mechanical Properties in Mouse Supraspinatus Tendon. J Biomech Eng. 135(2): 021019.
  7. Connizzo BK, Yannascoli SM, Soslowsky LJ: Structure-function relationships of postnatal tendon development: A parallel to healing. Matrix Biology. 32(2): 106-116
  8. Ahmadzadeh H, Connizzo BK, Freedman BR, Soslowsky LK, Shenoy V. Determing the Contribution of Glycosaminoglycans to Tendon Mechanical Properties with a Modified Shear-Lag Model. J Biomech. 46(14): 2497-2503.
  9. Connizzo BK, Yannascoli SM, Tucker JJ, Caro AC, Riggin CN, Mauck RL, Soslowsky LJ, Steinberg DR, Bernstein J. The Detrimental Effects of Systemic Ibuprofen Delivery on Tendon Healing Are Time-Dependent. Clin Orthop Relat Res. 2013
  10. Connizzo BK, Bhatt PR, Liechty KW, Soslowsky LJ. Diabetes Alters Mechanical Properties and Collagen Fiber Re-Alignment in Multiple Mouse Tendons. Ann Biomed Eng 2014;42(9):1880-8.
  11. Connizzo BK, Sarver JJ, Han L, Soslosky LJ. In Situ Fibril Stretch and Sliding is Location-Dependent in Mouse Supraspinatus Tendons. J Biomech 2014;57(16):3794-8.
  12. Sun M, Connizo BK, Adams SM, Freedman BR, Schweitzer R, Wenstrup RJ, Soslowsky LJ, Birk DE. Targeted Deletion of Collagen V in Tendons and Ligaments Results in a Classic Ehlers-Danlos Syndrome Joint Phenotype. J Am Pathol. 2015:185(5):1436-47.
  13. Connizzo BK, Freedman BR, Fried JH, Sun M, Birk DE, Soslowsky LJ. Regulatory Role for Collagen V in Establishing the Unique Mechanical Properties of Tendons and Ligaments is Tissue-Specific. J Orthop Res. 2015: 33(6):882-8
  14. Ahmadzadeh H, Freedamn BR, Connizzo BK, Soslowsky LJ, Shenoy VB. Micromechanical poroelastic finite element and shear-lag models of tendon predict large strain dependent Poisson's ratios and fluid expulsion under tensile loading. Acta Biomater. 2015 Apr 28

AWARDS

  1. 2nd Place in Poster Competition at Penn Bioengineering Annual Symposium, 01/2012
  2. Best Paper in Solids, Imaging and Orthopaedics Category of MS Competition at ASME Summer Bioengineering Conference, 06/2012
  3. Best Poster in University of Pennsylvannia Orthopaedic Annual Research Day Symposium, 06/2013
  4. 2nd Place in Biomechanics Category at Penn Center for Muscoloskeletal Disorders Annual Symposium, 11/2013
  5. Best Poster in University of Pennsylvannia Orthopaedic Annual Research Day Symposium, 06/2014
  6. 2nd Place in Biomechanics Categroy at Penn Center for Muscoloskeletal Disorders Annual Symposium,

 

Bri joined the McKay Orthopaedic Research Laboratory in the fall of 2010 and is currently working toward completion of her graduate studies in the Department of Bioengineering. In her spare time, she likes to watch movies, play volleyball and travel.