Perelman School of Medicine at the University of Pennsylvania

McKay Orthopaedic Research Laboratory

Soslowsky Laboratory

Julianne Huegel, Ph.D.

Julianne H. Potocek

Senior Researcher
University of Pennsylvania

Hometown: Gainesville, Florida

Education: B.S.E. Bioengineering, 2008, University of Pennsylvania
Ph.D. Cell and Developmental Biology, 2013, Thomas Jefferson University

Publications:

  1. Huegel J, Choi DS, Nuss CA, Minnig MCC, Tucker JJ, Kuntz AF, Waldorff EI, Zhang N, Ryaby JT, Soslowsky LJ Effects of pulsed electromagnetic field therapy at different frequencies and durations on rotator cuff tendon-to-bone healing in a rat model. J Shoulder Elbow Surg. 2017 Nov 22: @1058-2746(17)30603-1. doi: 10.1016/j.jse.2017.09.024. [Epub ahead of print]

  2. Nuss CA, Huegel J, Boorman-Padgett JF, Choi DS, Weiss SN, Vournakis J, Soslowsky LJ. Poly-N-Acetyl Glucosamine (sNAG) Enhances Early Rotator Cuff Tendon Healing in a Rat Model. Ann Biomed Eng. 2017 Dec;45(12):2826-2836. doi: 10.1007/s10439-017-1923-4. Epub 2017 Sep 13.

  3. Robinson KA, Sun M, Barnum CE, Weiss SN, Huegel J, Shetye SS, Lin L, Saez D, Adams SM, Iozzo RV, Soslowsky LJ, Birk DE. Decorin and biglycan are necessary for maintaining collagen fibril structure, fiber realignment, and mechanical properties of mature tendons. Matrix Biol. 2017 Dec;64:81-93. doi: 10.1016/j.matbio.2017.08.004. Epub 2017 Sep 5.

  4. Riggin CN, Qu F, Kim DH, Huegel J, Steinberg DR, Kuntz AF, Soslowsky LJ, Mauck RL, Bernstein J. Electrospun PLGA Nanofiber Scaffolds Release Ibuprofen Faster and Degrade Slower After In Vivo Implantation. Ann Biomed Eng. 2017 Oct;45(10):2348-2359. doi: 10.1007/s10439-017-1876-7.

  5. Johnston JM, Connizzo BK, Shetye SS, Robinson KA, Huegel J, Rodriguez AB, Sun M, Adams SM, Birk DE, Soslowsky LJ. Collagen V haploinsufficiency in a murine model of classic Ehlers-Danlos syndrome is associated with deficient structural and mechanical healing in tendons. J Orthrop Res. 2017 Apr 7. doi: 10.1002/jor.23571. [Epub ahead of print]

  6. Huegel J, Kim DH, Cirone JM, Pardes AM, Morris TR, Nuss CA, Mauck RL, Soslowsky LJ, Kuntz AF. Autologous tendon-derived cell-seeded nanofibrous scaffolds improve rotator cuff repair in an age-dependent fashion. J Orthop Res. 2017 Jun;35(6):1250-1257. doi: 10.1002/jor.23381. Epub 2016 Aug 19.

  7. Tucker JJ, Cirone JM, Morris TR, Nuss CA, Huegel J, Waldorff EI, Zhang N, Ryaby JT, Soslowsky LJ. Pulsed electromagnetic field therapy improves tendon-to-bone healing in a rat rotator cuff repair model. J Orthop Res. 2017 Apr;35(4):902-909. doi: 10.1002/jor.23333. Epub 2016 Jun 22.

  8. Huegel J, Enomoto-Iwamoto M, Sgariglia F, Koyama E, Pacifici M. Heparanase stimulates chondrogenesis and is up-regulated in human ectopic cartilage: a mechanism possibly involved in hereditary multiple exostoses. Am J Pathol. 2015 Jun;185(6):1676-85. doi: 10.1016/j.ajpath.2015.02.014. Epub 2015 Apr 8.

  9. Huegel J, Williams AA, Soslowsky LJ. Rotator cuff biology and biomechanics: a review of normal and pathological conditions. Curr Rheumatol Rep. 2015 Jan;17(1):476. doi: 10.1007/s11926-014-0476-x. Review.

  10. Sgariglia F, Candela ME, Huegel J, Jacenko O, Koyama E, Yamaguchi Y, Pacifici M, Enomoto-Iwamoto M. Epiphyseal abnormalities, trabecular bone loss and articular chondrocyte hypertrophy develop in the long bones of postnatal Ext1-deficient mice. Bone. 2013 Nov;57(1):220-31. doi: 10.1016/j.bone.2013.08.012.

  11. Huegel J, Sgariglia F, Enomoto-Iwamoto M, Koyama E, Dormans JP, Pacifici M. Heparan sulfate in skeletal development, growth, and pathology: the case of hereditary multiple exostoses. Dev Dyn. 2013 Sep;242(9):1021-32. doi: 10.1002/dvdy.24010. Epub 2013 Jul 29. Review.
  12. Huegel J, Mundy C, Sgariglia F, Nygren P, Billings PC, Yamaguchi Y, Koyama E, Pacifici M. Perichondrium phenotype and border function are regulated by Ext1 and heparan sulfate in developing long bones: a mechanism likely deranged in Hereditary Multiple Exostoses. Dev Biol. 2013 May 1;377(1):100-12. doi: 10.1016/j.ydbio.2013.02.008. Epub 2013 Mar 1.

Conference Abstracts:

  1. Huegel J, Choi DS, Nuss CA, Minnig MC, Tucker JJ, Hillin CD, Kuntz AF, Waldorff EI, Nianli Zhang N, Ryaby JT, Soslowsky LJ. Effects of Pulsed Electromagnetic Field Therapy at Different Frequencies and Durations on Rotator Cuff Tendon-to-Bone Healing in a Rat Model. Orthopaedic Research Society Annual Meeting 2017 (poster presentation).
  2. Shetye SS, Johnston JM, Connizzo BK, Robinson KA, Huegel J, Rodriguez AB, Sun M, Adams SM, Birk DE, Soslowsky LJ. Collagen V Haploinsufficiency Results in Deficient Mechanical and Structural Recovery of Injured Mouse Patellar Tendons. Orthopaedic Research Society Annual Meeting 2017 (poster presentation).
  3. Robinson, K., Barnum, C., Weiss, S., Huegel, J., Shetye, S., Sun, M., Adams, S., Birk, D., Soslowsky, L. (2016). Conditional deletion of decorin and biglycan in mature mouse tendons results in delayed collagen fiber realignment. Trans Orthop Res Soc, San Diego, CA, 2017.

  4. Huegel J, Kim DH, Cirone JM, Pardes AM, Morris TR, Nuss CA, Mauck RL, Soslowsky LJ, Kuntz AF. (2016). Effects of Autologous Tenocyte-Seeded Nanofibrous Scaffolds Rotator Cuff Repair are Age-Dependent. Orthopaedic Research Society Annual Meeting 2016 (podium presentation).
  5. Huegel, J. (2015, March). Differential Effects of Growth Factors on Neonatal and Adult Achilles Tenocytes. Abstract for poster presentation. Orthopaedic Research Society, Las Vegas, NV.
  6. Huegel, J., (2012, November). Homeostasis and Degradation of Heparan Sulfate: Involvement in Normal and Pathological Skeletogenesis. Abstract for poster presentation. American Society for Matrix Biology, San Diego, CA.
  7. Huegel, J., (2012, November). Homeostasis and Degradation of Heparan Sulfate: Involvement in Normal and Pathological Skeletogenesis. Abstract for podium presentation. Fourth International Research Conference on Multiple Hereditary Exostoses, Philadelphia, PA November 2012.
  8. Huegel, J., (2012, February). Heparan Sulfate Dependent Mechanisms of Pathological Skeletogenesis. Abstract for poster presentation. Orthopaedic Research Society, San Francisco, CA.
  9. Huegel, J., (2011, June). Mechanisms of Exostosis Formation in HME Syndrome. Abstract for podium presentation. Bones & Teeth Gordon Research Seminar, Les Diablerets, Switzerland.
  10. Huegel, J., (2011, January). Mechanisms of Exostosis Formation In a Mouse Model of Hereditary Multiple Exostoses. Abstract for podium presentation, Orthopaedic Research Society, Long Beach, CA.
  11. Huegel, J., (2010, October). Pathogenesis of Hereditary Multiple Exostoses: Modeling Exostosis Formation In Vivo and In Vitro. Abstract for poster presentation, American Society for Matrix Biology, Charleston, SC.
  12. Huegel, J., (2010, October). Mechanisms of Exostosis Formation in Hereditary Multiple Exostoses Syndrome. Abstract for podium presentation, American Society for Bone and Mineral Research, Toronto, ON.

Awards and Recognitions:

  1. Orthopaedic Research Society New Investigator Recognition Award, March 2016
  2. American Society for Matrix Biology Biennial Conference Travel Award: Poster Presentation October 2010
  3. American Society for Bone and Mineral Research Shun Harada Young Investigator Award October 2010

Julianne joined the McKay Orthopaedic Research Laboratory in 2014. She enjoys running, reading, traveling, and cooking/eating/writing about food.