Perelman School of Medicine at the University of Pennsylvania

McKay Orthopaedic Research Laboratory

Soslowsky Laboratory

Ongoing Research Projects

Scarless Regenerative Tendon Healing

Tendon injuries are a frequent cause of disability as they often fail to heal or else do so by scar formation. Scar is less organized than normal tendon and exhibits inferior properties long after initial injury. Scarring is also responsible for the formation of adhesions, which disrupt the normal gliding mechanism that is critical for function. Previous studies have shown that fetal skin and cartilage heal regeneratively, without scar. Developing methods and understanding the underlying mechanisms of scarless healing in tendon would have a truly significant benefit to the treatment of tendon injuries.

  1. Fetal Tissue Engineering for Tendon Regeneration
  2. Investigating the Role of HAS-1 Overexpression and Increased HA Production on Tendon Healing Properties