Perelman School of Medicine at the University of Pennsylvania

McKay Orthopaedic Research Laboratory

Soslowsky Laboratory

Ongoing Research Projects

Tendon Structure-Function Relationships and Injury-Repair

The overall objective of this area of research is to investigate the relationship between structural organization, composition, and mechanical function of tendon/ligament for functional tissue engineering, development, and healing, in addition to evaluating the roles of small leucine-rich proteoglycans (SLRPs) through maturation and aging and in the repair response to tendon injury. These multidisciplinary studies utilize organizational, compositional, and biomechanical assays to provide a comprehensive study. These studies are critical for identifying mechanisms driving tissue injury and repair as well as data to guide functional tissue engineering strategies. Specific, ongoing research in this area includes the following:

  1. Inhomogeneous, Anisotropic and Nonlinear Structure-Function of Human Supraspinatus Tendon
  2. Comparison of the Structure-Function Relationships in Tendon during Development and Healing
  3. Mature & Aging Tendons: Extracellular Matrix Interactions in the Injury Response
  4. Relationships Between Decorin and Biglycan, Structure and Tendon Mechanics Using Transgenic Mouse Models
  5. Effects of Hypercholesterolemia