Cell Biology @ Penn

Microtubule motors drive robust nuclear dynamics.

Golgi around nucleus in myotube.

Image: Confocal micrograph of a C2C12 mouse myotube immunostained to label microtubules (red) and golgi (green). Nuclei are labeled with Hoechst dye (blue).

Meredith Wilson, a Ph.D. student in the lab of Dr. Erika Holzbaur and member of The Pennsylvania Muscle Institute, studies how the microtubule-based motors kinesin-1 and dynein work to drive nuclear motility in myotubes. Meredith recently published that myonuclei move in three dimensions through their intracellular environment. Using biochemical and advanced microscopy techniques, she found that kinesin-1 and dynein are found on the myonucleo-envelope, dynamically interact with the bipolar microtubule cytoskeleton, and use their opposing forces to facilitate myonuclei movement.

Related Links of Interest:

Recent review on tools used by the Holzbaur lab to study multi-motor intracellular transport

Erika Holzbaur faculty page