Numerous laboratories at Penn are actively engaged in investigations regarding thetranslocation of ions and other solutes across cell membranes. Ion channels, transporters, and pumps are studied using a range of technical approaches, including crystallography, single molecule real-time electrical recording and high-resolution real-time optical imaging, biochemistry and molecular biology. Ongoing projects address ion channel and pump structure, single channel kinetics and their regulation, ion channel biogenesis and trafficking, and pharmacological discovery, using normal as well as disease models. In addition to many collaborations and informal interactions, the membrane transport community sponsor seminars and lectures, and an ion channel journal club. Penn offers an opportunity to conduct high quality, high impact research related to membrane transport, as well as education and training for students and postdoctoral fellows.