Cell Biology @ Penn

Recent Publications

Abrams, CS. Kindlin ignites a new flame. Blood. 2013 Oct 2; 122(14):2297-8

Addis RC, Epstein JA. Induced regeneration-the progress and promise of direct reprogramming for heart repair. Nat Med. 2013 Jul;19(7):829-36

Ahima, RS, Lazar MA. Physiology. The health risk of obesity -- better metrics imperative. Science. 2013 Aug 23; 341(6148):856-8

Arsenault PR, Pei F, Lee R, Kerestes H, Percy MJ, Keith B, Simon MC, Lappin TR, Khurana TS, Lee FS. A knock-in mouse model of human PHD2 gene-associated erythrocytosis establishes a haploinsufficinecy mechanism. J Biol Chem. 2013 Nov 22;288(47):33571-84. doi: 10.1074/jbc.M113.482364. Epub 2013 Oct 11.

Babich A, Burkhardt JK. Immunol Rev. 2013 Nov;256(1):80-94

Bailis W, Yashiro-Ohtani Y, Fang TC, Hatton RD, Weaver CT, Artis D, Pear WS. Notch simultaneously orchestrates multiple helper T cell programs independently of cytokine signals. Immunity. 2013 Jul 25;39(1):148-59

Baker BM, Trappmann B, Stapleton SC, Toro E, Chen CS. Microfluidics embedded within extracellular matrix to define vascular architectures and pattern diffusive gradients. Lab Chip. 2013 Aug 21;13(16):3246-52

Carbone CJ, Fuchs SY. Eliminative signaling by Janus kinases: role in the down-regulation of associated receptors. J Cell Biochem. 2013 Aug 19

Chatterjee S, Fisher AB. Mechanotransduction in the endothelium: Role of membrane proteins and reactive oxygen species in sensing, transduction and transmission of the signal with altered blood flow. Antioxid Redox Signal. 2013 Dec 13

Chitnis N, Pytel D, Diehl JA. UPR-inducible miRNAs contribute to stressful situations. Trends Biochem Sci. 2013 Jul 29

Choi SY, Chacon-Heszele MF, Huang L, McKenna S, Wilson FP, Zuo X, Lipschutz JH. Cdc42 deficiency causes ciliary abnormalities and cystic kidneys. J Am Soc Nephrol. 2013 Sep;24(9):1435-50

Choi YS, Zhang Y, Xu M, Yang Y, Ito M, Peng T, Cui Z, Nagy A, Hadjantonakis AK, Lang RA, Cotsarelis G, Andl T, Morrisey EE, Millar SE. Distinct functions for Wnt/B-Catenin in hair follicle stem cell proliferation and survival and interfollicular epidermal homeostasis. Cell Stem Cell. 2013 Dec 5;13(6):720-33. doi: 10.1016/j.stem.2013.10.003.

Chopra A, Murray ME, Byfield FJ, Mendez MG, Halleluyan R, Restle DJ, Raz-Ben Aroush D, Galie PA, Pogoda K, Bucki R, Marcinkiewicz C, Prestwich GD, Zarembinski TI, Chen CS, Puré E, Kresh JY, Janmey PA. Augmentation of integrin-mediated mechanotransduction by hyaluronic acid. Biomaterials. 2014 Jan;35(1):71-82. doi: 10.1016

Cines DB, Lebedeva T, Nagaswami C, Hayes V, Massefski W, Litvinov RI, Rauova L, Lowery TJ, Weisel JW . Clot contraction: compression of eryhtrocytes into tightly packed polyhedra and redistribution of platelets and fibrin

Cohen DM, Yang MT, Chen CS. Measuring cell-cell tugging forces using bowtie-patterned mPADs (microarray post detectors). Methods Mol Biol. 2013;1066:157-68

Combs DJ, Shin HG, Xu Y, Ramu Y, Lu Z. Tuning voltage-gated channel activity and cellular excitability with a sphingomyelinase. J Gen Physiol. 2013 Oct;142(4):367-80

Costa J, Fu C, Syrovatkina V, Tran PT . Imaging individual spindle microtubule dynamics in fission yeast. Methods Cell Biol. 2013;115:385-94

Cushman-Nick M, Bonini NM, Shorter J. Hsp104 suppresses polyglutamine-induced degeneration post onset in a drosophila MJD/SCA3 model. PLoS Genet. 2013 Sep;9(9):e1003781

Dennery PA. Signaling function of heme oxygenase proteins. Antioxid Redox Signal. 2013 Nov 1. [Epub ahead of print]

Desantis ME, Sweeny EA, Snead D, Leung EH, Go MS, Gupta K, Wendler P, Shorter J. Conserved distal loop residues in the Hsp104 and ClpB middle domain contact nucleotide-binding domain 2 and enable Hsp70-dependent protein disaggregation. J Biol Chem. 2013 Nov 27. [Epub ahead of print]

Dinardo CD, Propert KJ, Loren AW, Paietta E, Sun Z, Levine RL, Straley KS, Yen K, Patel JP, Agresta S, Abdel-Wahab O, Perl AE, Litzow MR, Rowe JM, Lazarus HM, Fernandez HF, Margolis DJ, Tallman MS, Luger SM, Carroll M. Serum 2-hydroxyglutarate levels predict isocitrate dehydrogenase mutations and clinical outcome in acute myeloid leukemia. Blood. 2013 Jun 13;121(24):4917-24

Dishowitz MI, Mutyaba PL, Takacs JD, Barr AM, Engiles JB, Ahn J, Hankenson KD. Systemic inhibition of canonical notch signaling results in sustained callus inflammation and alters multiple phases of fracture healing. PLoS One. 2013 Jul 3;8(7):e68726

Du W, Jiang P, Mancuso A, Stonestrom A, Brewer MD, Minn AJ, Mak TW, Wu M, Yang X. TAp73 enhances the pentose phosphate pathway and supports cell proliferation. Nat Cell Biol. 2013 Aug;15(8):991-1000

Foley AR, Quijano-Roy S, Collins J, Straub V, McCallum M, Deconinck N, Mercuri E, Pane M, D'Amico A, Bertini E, North K, Ryan MM, Richard P, Allamand V, Hicks D, Lamandé S, Hu Y, Gualandi F, Auh S, Muntoni F, Bönnemann CG. Natural history of pulmonary function in collagen VI-related myopathies. Brain. 2013 Dec;136(Pt 12):3625-33. doi: 10.1093

Fu MM, Holzbaur EL. JIP1 regulates the directionality of APP axonal transport by coordinating kinesin and dynein motors. J Cell Biol. 2013 Jul 29

Gay D, Kwon O, Zhang Z, Spata M, Plikus MV, Holler PD, Ito M, Yang Z, Treffeisen E, Kim CD, Nace A, Zhang X, Baratono S, Wang F, Ornitz DM, Millar SE, Cotsarelis G. Fgf9 from dermal γδ T cells induces hair follicle neogenesis after wounding. Nat Med. 2013 Jul;19(7):916-23

G Nayak, S Lee, R Yousaf, S Edelmann, C Trincot, C Van Itallie, G Sinha, M Rafeeq, S Jones, I Belyantseva, J Anderson, A Forge, G Frolenkov, S Riazuddin (2013). Tricellulin is essential for associating bicellular and tricellular tight junctions and for survival of cochlear hair cells. Journ of Clin Invest. 2013.

Guha S, Baltazar GC, Coffey EE, Tu LA, Lim JC, Beckel JM, Patel S, Eysteinsson T, Lu W, O'Brien-Jenkins A, Laties AM, Mitchell CH. Lysosomal alkalinization, lipid oxidation, and reuced phagosome clearance triggered by activation of the P2X7 receptor. FASEB J. 2013 Aug 20

Guo JL, Covell DJ, Daniels JP, Iba M, Stieber A, Zhang B, Riddle DM, Kwong LK, Xu Y, Trojanowski JQ, Lee VM. Distinct α-Synuclein Strains Differentially Promote Tau Inclusions in Neurons. Cell. 2013 Jul 3;154(1):103-17

Gurung B, Hua X. Menin/PRMT5/hedgehog signaling: a potential target for the treatment of multiple endocrine neoplasia type 1 tumors. Epigenomics. 2013 Oct;5(5):469-7

Hess PR, Rawnsley DR, Jakus Z, Yang Y, Sweet DT, Fu J, Herzog B, Lu M, Nieswandt B, Oliver G, Makinen T, Xia L, Kahn ML. Platelets mediate lymphovenous hemostasis to maintain blood-lymphatic esparation throughout life. J Clin Invest. 2013 Dec 2. pii: 70422. doi: 10.1172/JCI70422. 

Janmey PA, Wells RG, Assoian RK, McCulloch CA. From tissue mechanics to transcription factors. Differentiation. 2013 Oct;86(3):112-20

Jiang P, Du W, Yang X. A critical role of glucose-6-phosphate dehydrogenase in TAp73-mediated cell proliferation. Cell Cycle. 2013 Dec 15;12(24):3720-6. doi: 10.4161/cc.27267. Epub 2013 Nov 21.

Joshi RP, Schmidt AM, Das J, Pytel D, Riese MJ, Lester M, Diehl JA, Behrens EM, Kambayashi T, Koretzky GA. The ζ Isoform of Diacylglycerol Kinase Plays a Predominant Role in Regulatory T Cell Development and TCR-Mediated Ras Signaling. Sci Signal. 2013 Nov 26;6(303):ra102. doi: 10.1126/scisignal.2004373.

Kim C, Bergelson JM. Echovirus 7 entry into polarized Caco-2 intestinal epithelila cels involves core components of the autophagy machinery. J Virol. 2013 Oct 23

Kim JS, Sklarz T, Banks LB, Gohil M, Waickman AT, Skuli N, Krock BL, Luo CT, Hu W, Pollizzi KN, Li MO, Rathmell JC, Birnbaum MJ, Powell JD, Jordan MS, Koretzky GA. Natural and inducible TH17 cells are regulated differently by Akt and mTOR pathways. Nat Immunol. 2013 Jun;14(6):611

Lazarus JE, Moughamian AJ, Tokito MK, Holzbaur EL. Dynactin Subunit p150(Glued) Is a Neuron-Specific Anti-Catastrophe Factor. PLoS Biol. 2013 Jul;11(7):e1001611

Lian L, Suzuki A, Hayes V, Saha S, Han X, Xu T, Yates JR, Poncz M, Kashina A, Abrams CS. Loss of ATE1-mediated arginylation leads to impaired platelet myosin phosphorylation, clot retraction, and in vivo thrombosis formation. Haematologica. 2013 Nov 29. [Epub ahead of print]

Litvinov RI, Yarovoi SV, Rauova L, Barsegov V, Sachais BS, Rux AH, Hinds JL, Arepally GM, Cines DB, Weisel JW. Distinct specificity and single-molecule kinetics of the interaction of pathogenic and non-pathogenic anti-platelet factor 4/heparin antibodies with platelet factor 4. J Biol Chem. 2013 Oct 4

Lu H, Liu J, Liu S, Zeng J, Ding D, Carstens RP, Cong Y, Xu X, Guo W. Exo70 isoform switching upon epithelial-mesenchymal transition mediates cancer cell invasion. Dev Cell. 2013 Dec 9;27(5):560-73. doi: 10.1016

Lu J, Qu Y, Liu Y, Jambusaria R, Han Z, Ruthel G, Freedman BD, Harty RN. Host IQGAP1 and Ebola virus VP40 interactions facilitate virus-like particle egress. J Virol. 2013 Jul;87(13):7777-80

Luo G, Zhang J, Luca FC, Guo W. Mitotic phosphorylation of Exo84 disrupts exocyst assembly and arrests cell growth. J Cell Biol. 2013 Jul 8;202(1):97-111

Majkut S, Idema T, Swift J, Krieger C, Liu A, Discher DE. Heart-specific stiffening in early embryos parallels matrix and myosin expression to optimize beating. Curr Biol. 2013 Dec 2;23(23):2434-9. doi: 10.1016/j.cub.2013.10.057. Epub 2013 Nov 21.

Mak DO, Vais H, Cheung KH, Foskett JK. Nuclear patch-clamp electrophysiology of Ca2+ channels. Cold Spring Harb Protoc. 2013 Sep 1;2013(9):885-91

Marks MS, Heijnen HF, Raposo G. Lysosome-related organelles: unusual compartments become mainstream. Curr Opin Cell Biol. 2013 Aug;25(4):495-505

Mendrola JM, Shi F, Park JH, Lemmon MA. Receptor tyrosine kinases with intracellular pseudokinase domains. Biochem Soc Trans. 2013 Aug 1;41(4):1029-36

Min SH, Abrams CS. Regulation of platelet plug formation by phosphoinositide metabolism. Blood. 2013 (in press)

Mosqueira M, Baby SM, Lahiri S, Khurana TS. Ventilatory chemosensory drive is blunted in the mdx mouse model of Duchenne Muscular Dystrophy (DMD). PLoS One. 2013 Jul 29;8(7):e69567

Moughamian AJ, Osborn GE, Lazarus JE, Maday S, Holzbaur EL. Ordered recruitment or dynactin to the microtubule plus-end is required for eiffcient initiation of retrograde axonal transport. J Neurosci. 2013 Aug 7;33(32):13190-203

Murray JM. HIV treatment as prevention in a developed country setting the current situation and future scenarios of Australia. J Acquir Immune Defic Syndr. 2013 Dec 1;64(4):409-16. doi: 10.1097/QAI.0b013e3182a6b20c.

Naidoo N, Davis JG, Zhu J, Yabumoto M, Singletary K, Brown M, Galante R, Agarwal B, Baur JA. Aging Cell. 2013 Sep 18

Noel J, Wang H, Hong N, Tao JQ, Yu K, Sorokina EM, Debolt K, Heayn M, Rizzo V, Delisser H, Fisher AB, Chatterjee S. PECAM-1 and caveolae form the mechanosensing complex necessary for NOX2 activation and angiogenic signaling with stopped flow in pulmonary endothelium. Am J Physiol Lung Cell Mol Physiol. 2013 Dec;305(11):L805-18. doi: 10.1152/ajplung.00123.2013. Epub 2013 Sep 27.

Panda D, Rose PP, Hanna SL, Gold B, Hopkins KC, Lyde RB, Marks MS, Cherry S. Genome-wide RNAi screen identifies SEC61A and VCP as conserved regulators of Sindbis virus entry. Cell Rep. 2013 Dec 11. pii: S2211-1247(13)00695-5. doi: 10.1016/j.celrep.2013.11.028

Parker ZF, Iyer SS, Wilen CB, Parrish NF, Chikere KC, Lee FH, Didigu CA, Berro R, Klasse PJ, Lee B, Moore JP, Shaw GM, Hahn BH, Doms RW. Transmitted/founder and chronic HIV-q envelope proteins are distinguished by differential utilization of CCR5. J Virol. 2013 Mar;87(5):2401-11

Rawnsley DR, Xiao J, Lee JS, Liu X, Mericko-Ishizuka P, Kumar V, He J, Basu A, Lu M, Lynn FC, Pack M, Gasa R, Kahn ML. The transcription factor Atonal homolog 8 regulates Gata4 and Friend of Gata-2 during vertebrate development. J Biol Chem. 2013 Aug 23;288(34):24429-40

Riese MJ, Wang LC, Moon EK, Joshi RP, Ranganathan A, June CH, Koretzky GA, Albelda SM. Enhanced Effector Responses in Activated CD8+ T Cells Deficient in Diacylglycerol Kinases. Cancer Res. 2013 Jun 15;73(12):3566-77

Rosenblum G, Chen C, Kaur J, Cui X, Zhang H, Asahara H, Chong S, Smilansky Z, Goldman YE, Cooperman BS. Quantifying Elongation Rhythm during Full-Length Protein Synthesis. J Am Chem Soc. 2013 Jul 31;135(30):11322-9

Rubin AI, Seykora JT. Is more hair always better? A single biopsy specimen is preferred for the evaluation of alopecia. J Cutan Pathol. 2013 Oct 7

Shin JW, Buxboim A, Spinler KR, Swift J, Christian DA, Hunter CA, Léon C, Gachet C, Dingal PC, Ivanovska IL, Rehfeldt F, Chasis JA, Discher DE. Contractile forces sustain and polarize hematopoiesis from stem and progenitor cells. Cell Stem Cell. 2013 Nov 19. pii: S1934-5909(13)00455-4. doi: 10.1016

Shin JW, Spinler KR, Swift J, Chasis JA, Mohandas N, Discher DE. Lamins regulate cell trafficking and lineage maturation of adult human hematopoietic cells. Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):18892-7. doi: 10.1073/pnas.1304996110. Epub 2013 Nov 4

Slochower DR, Huwe PJ, Radhakrishnan R, Janmey PA. Quantum and all-atom molecular dynamics simulations of protonation and divalent ion binding to phosphatidylinosital 4,5-bisphosphate (PIP2). J Phys Chem B. 2013 Jul 18;117(28):8322-

Smith JR, Syre PP, Oake SA, Nicholson KJ, Weisshaar CL, Cruz K, Bucki R, Baumann BC, Janmey PA, Winkelstein BA. Salmon and Human Thrombin Differentially Regulate Radicular Pain, Glial-Induced Inflammation and Spinal Neuronal Excitability through Protease-Activated Receptor-1. PLoS One. 2013 Nov 20;8(11):e80006. doi: 10.1371/journal.pone.0080006.

Srinivasan S, Spear J, Chandran K, Joseph J, Kalyanaraman B, Avadhani NG. Oxidative stress induced mitochondrial protein kinase A mediates cytochrome C oxidase dysfunction. PLoS One. 2013 Oct 10;8(10):e77129. doi: 10.1371

Stanger BZ, Kahn ML. Platelets and tumor cells: a new form of border control. Cancer Cell. 2013 Jul 8;24(1):9-11

Stettler N, Murphy MM, Barraj LM, Smith KM, Ahima RS. Systematic review of clinical studies related to pork intake and metabolic syndrome or its components. Diabetes Metab Syndr Obes. 2013 Sep 25;6:347-357

Syrovatkina V, Fu C, Tran PT. Antagonistic spindle motors and MAPs regulate metaphase spindle length and chromosome segregation. Curr Biol. 2013 Dec 2;23(23):2423-9. doi: 10.1016/j.cub.2013.10.023. Epub 2013 Nov 14.

Sun Z, Feng D, Fang B, Mullican SE, You SH, Lim HW, Everett LJ, Nabel CS, Li Y, Selvakumaran V, Won KJ, Lazar MA. Deacetylase-independnt function of HDAC3 in transcription and metabolism requires nuclear receptor corepressor. Mol Cell. 2013 Nov 19. pii: S1097-2765(13)00788-0. doi: 10.1016/j.molcel.2013.10.022

Swift J, Ivanovska IL, Buxboim A, Harada T, Dingal PC, Pinter J, Pajerowski JD, Spinler KR, Shin JW, Tewari M, Rehfeldt F, Speicher DW, Discher DE. Nuclear lamin-A scales with tissue stiffness and enhances matrix-directed differentiation. Science. 2013 Aug 30;341(6149):1240104

Tanis JE, Ma Z, Krajacic P, He L, Foskett JK, Lamitina T. CLHM-1 is a Functionally Conserved and Conditionally Toxic Ca2+-Permeable Ion Channel in Caenorhabditis elegans. J Neurosci. 2013 Jul 24;33(30):12275-86

Tripepi M, Esquivel R, Wirth R, Pohlschröder M. Haloferax volcanii cells lacking the flagella subunit, FlgA2, are hypermotile. Microbiology. 2013 Aug 29

Tsygankova OM, Wang H, Meinkoth J. Tumor cell migration and invasion are enhanced by depletion of Rap1GAP. J Biol Chem. 2013 Jul 17

Tu L, Khanna P, Deutsch C. Transmembrane segments form tertiary hairpins in the folding vestibule of the ribosome. J Mol Biol. 2013 Sep 17

Valvezan AJ, Huang J, Lengner CJ, Pack M, Klein PS. Oncongenic mutations in adenomatous polyposis coli (Apc) activate mechanistic target of rapmycin complex 1 (mTORC1) in mice and zebrafish. Dis Model Mech. 2013 Nov 7. [Epub ahead of print]

Wang H, Svoronos AA, Boudou T, Sakar MS, Schell JY, Morgan JR, Chen CS, Shenoy VB. Necking and failure of constrained 3D microtissues induced by cellular tension. Proc Natl Acad Sci U S A. 2013 Dec 9. [Epub ahead of print]

Wannemacher KM, Jiang H, Hess PR, Shin Y, Suzuki-Inoue K, Brass LF. An expanded role for Semaphorin 4D in platelets includes contact-dependent amplifcation of Clec-2 signaling. J Thromb Haemost. 2013 Oct 17. doi: 10.1111/jth.12428

Weisel JW, Litvinov RI. Adaptation of fibrous biopolymers to recurring increasing strains. Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):12164-5

Wickramasinghe SR, Patel VV. Local innervation and atrial fibrillation. Circulation. 2013 Oct 1;128(14):1566-75

Xu J, Hopkins K, Sabin L, Yasunaga A, Subramanian H, Lamborn I, Gordesky-Gold B, Cherry S. ERK signaling couples nutrient status to antiviral defense in the insect gut. Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):15025-30

Zajac AL, Goldman YE, Holzbaur EL, Ostap EM. Local cytoskeletal and organelle interactions impact molecular-motor- driven early endosomal trafficking. Curr Biol. 2013 Jul 8;23(13):1173-80

Zhao Y, Liu J, Yang C, Capraro BR, Baumgart T, Bradley RP, Ramakrishnan N, Xu X, Radhakrishnan R, Svitkina TGuo W. Exo70 generates membrane curvature for morphogenesis and cell migration. Dev Cell. 2013 Aug 12;26(3):266-78

Zhang XH, Feng R, Lv M, Jiang Q, Zhu HH, Qing YZ, Bao JL, Huang XJ, Zheng XL. Arsenic trioxide induces apoptosis in B-cell chronic lymphocytic leukemic cells through down-regulation of survivin via the p53-dependent signaling pathway. Leuk Res. 2013 Dec;37(12):1719-25. doi: 10.1016/j.leukres.2013.09.019. Epub 2013 Sep 29

Zhang Y, Morris JP 4th, Yan W, Schofield HK, Gurney A, Simeone DM, Millar SE, Hoey T, Hebrok M, Pasca di Magliano M. Canonical Wnt Signaling Is Required for Pancreatic Carcinogenesis. Cancer Res. 2013 Aug 1;73(15):4909-4922

Zhang Z, Pinto AM, Wan L, Wang W, Berg MG, Oliva I, Singh LN, Dengler C, Wei Z, Dreyfuss G. Dysregulation of synaptogenesis genes antecedes motor neuron pathology in spinral muscular atrophy. Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19348-53. doi: 10.1073/pnas.1319280110. Epub 2013 Nov 4

Zou Y, Zwolanek D, Izu Y, Gandhy S, Schreiber G, Brockmann K, Devoto M, Tian Z, Hu Y, Veit G, Meier M, Stetefeld J, Hicks D, Straub V, Voermans NC, Birk DE, Barton ER, Koch M, Bönnemann CG. Recessive and dominant mutations in COL12A1 cause a novel EDS/myopathy overlap syndrome in human and mice. Hum Mol Genet. 2013 Dec 11. [Epub ahead of print]

Zwolak A, Yang C, Feeser EA, Michael Ostap E, Svitkina T, Dominguez R. CARMIL leading edge localization depends on a non-canonical PH domain and dimerization. Nat Commun. 2013;4:2523