Publications
Recent papers of interest from CBP faculty (2007-2008)
Wang Y, Litvinov RI, Chen X, Bach TL, Lian L, Petrich BG, Monkley SJ, Critchley DR, Sasaki T, Birnbaum MJ, Weisel JW, Hartwig J and Abrams CS (2008). Loss of PIP5KIgamma, unlike other PIP5KI isoforms, impairs the integrity of the membrane cytoskeleton in murine megakaryocytes. J. Clin. Invest. 118: 812-819.
Bach TL, Kerr WT, Wang Y, Bauman EM, Kine P, Whiteman EL, Morgan RS, Williamson EK, Ostap EM, Burkhardt JK, Koretzky GA, Birnbaum MJ and Abrams CS (2007). PI3K regulates pleckstrin-2 in T-cell cytoskeletal reorganization. Blood 109: 1147-1155.
Wanderling S, Simen BB, Ostrovsky O, Ahmed NT, Vogen SM, Gidalevitz T and Argon Y (2007). GRP94 is essential for mesoderm induction and muscle development because it regulates insulin-like growth factor secretion. Mol. Biol. Cell 18: 3764-3775.
Assoian RK and Klein EA (2008). Growth control by intracellular tension and extracellular stiffness. Trends Cell Biol. 18: 347-352.
Yung Y, Walker JL, Roberts JM and Assoian RK (2007). A Skp2 autoinduction loop and restriction point control. J. Cell Biol. 178: 741-747.
Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, Prabhu VV, Allard JS, Lopez-Lluch G, Lewis K, Pistell PJ, Poosala S, Becker KG, Boss O, Gwinn D, Wang M, Ramaswamy S, Fishbein KW, Spencer RG, Lakatta EG, Le Couteur D, Shaw RJ, Navas P, Puigserver P, Ingram DK, de Cabo R and Sinclair DA (2006).Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444: 337-342.
Pearson KJ, Baur JA, Lewis KN, Peshkin L, Price NL, Labinskyy N, Swindell WR, Kamara D, Minor RK, Perez E, Jamieson HA, Zhang Y, Dunn SR, Sharma K, Pleshko N, Woolett LA, Csiszar A, Ikeno Y, Le Couteur D, Elliott PJ, Becker KG, Navas P, Ingram DK, Wolf NS, Ungvari Z, Sinclair DA, and de Cabo R (2008). Resveratrol delays age-related deterioration and mimcis transcriptional aspects of dietary restriction without extending life span.Cell Metabolism 8: 157-168.
Bence KK, Delibegovic M, Xue B, Gorgun C, Hotamisligil G, Neel BG, and Kahn BB (2006). Neuronal PTP-1B regulates body mass/adiposity and leptin action. Nature Med. 12: 917-924.
Delibegovic M, Bence KK, Mody N, Hong EG, Ko HJ, Kim JK, Kahn BB and Neel BG (2007). Improved glucose homeostasis in mice with muscle-specific deletion of protein-tyrosine phosphatase 1B. Mol. Cell. Biol. 27: 7727-7734.
Li X, Monks B, Ge Q, and Birnbaum MJ (2007). Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1a. Nature 447: 1012-1016.
Schmitz KR, Liu J, Li S, Setty TG, Wood CS, Burd CG, and Ferguson KM (2008). Golgi localization of glycosyltransferases requires a Vps74p oligomer. Dev Cell 14: 523-534.
Strochlic TI, Setty TG, Sitaram A, and Burd CG (2007). Grd19/Snx3p functions as a cargo-specific adapter for retromer-dependent endocytic recycling. J Cell Biol. 177: 115-125.
Huang Y, Comiskey EO, Dupree RS, Li S, Koleske AJ, and Burkhardt JK (2008). The c-Abl tyrosine kinase regulates actin remodeling at the immune synapse. Blood 112: 111-119.
Burkhardt JK, Carrizosa E and Shaffer MH (2008). The actin cytoskeleton in T cell activation. Annu. Rev. Immunol. 26: 233-259.
Lu J and Deutsch C (2008). Electrostatics in the ribosomal tunnel modulate chain elongation rates. J. Mol. Biol., in press.
Tu L, Wang J, and Deutsch C (2007). Biogenesis of the T1-S1 linker of voltage-gated K+ channels. Biochemistry 46: 8075-8084.
Engler A, Sen S, Sweeney SL and Discher DE (2006). Matrix elasticity directs stem cell lineage specification. Cell 126: 677-689.
Johnson CP, Tang HY, Carag C, Speicher DW and Discher DE (2007). Forced unfolding of proteins within cells. Science 317: 663-666.
Tsai R and Discher DE (2008). Inhibition of ‘Self’ Engulfment through deactivation of myosin-II at the phagocytic synapse between human cells. J. Cell Biol. 180: 989-1003.
Honaramooz A, Megee S, Rathi R, and Dobrinski I (2007). Building a Testis - Formation of Functional Testis Tissue after Transplantation of Isolated Porcine (Sus scrofa) Testis Cells. Biol. Reprod. 76: 43-47.
Honaramooz A, Megee S, Zeng W, Destrempes MM, Overton SA, Luo J, Galantino-Homer H, Modelski M, Chen F, Blash S, Melican DT, Gavin WG, Ayres S, Yang F, Wang PJ, Echelard Y and Dobrinski I (2008). Adeno-associated virus (AAV)-mediated transduction of male germline stem cells results in transgene transmission after germ cell transplantation. FASEB J. 22: 374-382.
Cheung KH, Shineman D, Müller M, Cárdenas C, Mei L, Yang J, Tomita T, Iwatsubo T, Lee VM and Foskett JK (2008). Mechanism of Ca2+ disruption in Alzheimer's disease by presenilin regulation of InsP(3) receptor channel gating. Neuron 58: 871-883.
Dreses-Werringloer U, Lambert JC, Vingtdeux V, Zhao H, Vais H, Siebert A, Jain A, Koppel J, Rovelet-Lecrux A, Hannequin D, Pasquier F, Galimberti D, Scarpini E, Mann D, Lendon C, Campion D, Amouyel P, Davies P, Foskett JK, Campagne F, and Marambaud P (2008). A polymorphism in CALHM1 influences Ca2+ homeostasis, Abeta levels, and Alzheimer's disease risk. Cell 133: 1149-1161.
He B, Xi F, Zhang X, Zhang J, and Guo W (2007). Exo70 interacts with phospholipids and mediates the targeting of the exocyst to the plasma membrane. EMBO J. 26: 4053-4065
Zuo X, Zhang J, Zhang Y, Hsu S, Zhou D, and Guo W (2006). Exo70 interacts with the Arp2/3 complex and regulates cell migration. Nature Cell Biol. 8: 1383-1388.
Sun Y, Schroeder HW 3rd, Beausang JF, Homma K, Ikebe M, and Goldman YE (2007). Myosin VI walks "wiggly" on actin with large and variable tilting. Mol. Cell 28: 954-964.
Dixit R, Ross JL, Goldman YE, and Holzbaur EL (2008). Differential regulation of dynein and kinesin motor proteins by tau. Science 319: 1086-1089.
Caviston JP, Ross JL, Antony SM, Tokito M and Holzbaur EL (2007) Huntingtin facilitates dynein/dynactin-mediated vesicle transport. Proc. Natl. Acad. Sci. U.S.A. 104: 10045-10050.
Bucki R, Byfield FJ, Kulakowska A, McCormick ME, Drozdowski W, Namiot Z, Hartung T, and Janmey PA (2008). Extracellular gelsolin binds lipoteichoic acid and modulates cellular response to proinflammatory bacterial wall components. J. Immunol. 181: 4936-4944.
Janmey PA and McCulloch CA (2007). Cell mechanics: integrating cell responses to mechanical stimuli. Annu. Rev. Biomed. Eng. 9: 1-34.
Sebzda E, Zou Z, Lee JS, Wang T and Kahn ML (2008). Transcription factor KLF2 regulates the migration of naive T cells by restricting chemokine receptor expression patterns. Nat Immunol 9: 292-300.
Perkins KJ, Basu U, Budak MT, Ketterer C, Baby SM, Lozynska O, Lunde JA, Jasmin BJ, Rubinstein NA and Khurana TS (2007). ERF silences extra-synaptic utrophin by N-box mediated repression in skeletal muscle. Mol. Biol. Cell 18: 2864-2872.
Davies KE and Khurana TS (2007). A new way to regulate the NMJ. Nature Med. 13, 538-539.
Klein DE, Stayrook SE, Shi F, Narayan K and Lemmon MA (2008). Structural basis for EGFR ligand sequestration by Argos. Nature 453: 1271-1275.
Lemmon MA (2008). Membrane recognition by phospholipid-binding domains. Nature Rev. Mol. Cell. Biol. 9: 99-111.
Hellman NE, Spector J, Robinson J, Zuo X, Saunier S, Antignac C, Tobias JW and Lipschutz JH 2008. Matrix Metalloproteinase 13 (MMP13) and tissue inhibitor of matrix metalloproteinase 1 (TIMP1), regulated by the MAPK pathway, are both necessary for MDCK tubulogenesis. J. Biol. Chem. 283: 4272-4282.
Lu, B., Su, Y., Das, S., Liu, J., Xia, J. and Ren, D. (2008) Peptide neurotransmitters activate a cation channel complex of NALCN and UNC-80. Nature (in press).
Xu Y, Ramu Y and Lu Z (2008). Removal of phospho-head groups of membrane lipids immobilizes voltage sensors of K+ channels. Nature 451: 826-829.
Ramu Y, Xu Y. and Lu Z (2007). Inhibition of CFTR Cl- channel function caused by enzymatic hydrolysis of sphingomyelin. Proc. Natl. Acad. Sci. U.S.A. 104: 6448-6453.
Kurischko C, Kuravi VK, Wannisorn N, Nazarov PA, Husain M, Zhang C, Shokat KM, McCaffrey JM and Luca FC (2008). The yeast LATS/Ndr kinase Cbk1 regulates growth via Golgi-dependent glycosylation and secretion. Mol. Biol. Cell, in press.
Kubo J, Jaleel N, Kumarapeli A, Beretta R, Bratinov G, Shan X, Wang H, Houser SR and Margulies KB (2008). Increased Cardiac Myocyte Progenitors in Failing Human Hearts. Circulation 118: 649-657.
Setty SRG, Tenza D, Sviderskaya EV, Bennett DC, Raposo G and Marks MS (2008). ATP7A transport sustains copper-dependent tyrosinase activity in melanosomes. Nature 454: 1142-1146.
Raposo G and Marks MS (2007). Melanosomes - dark organelles enlighten endosomal membrane transport. Nature Rev. Mol. Cell Biol. 8: 786-797.
Banerjee PP, Pandey R, Zheng R, Suhoski ., Monaco-Shawver L and Orange JS (2007). Cdc42-interacting protein-4 functionally links actin and microtubule networks at the cytolytic NK cell immunological synapse. J. Exp. Med. 204: 2305-2320.
Orange JS (2008). Formation and function of the lytic NK cell immunological synapse. Nature Rev. Immunol. 8: 713-725
Laakso JM, Lewis JH, Shuman H and Ostap EM (2008). Myosin I can act as a molecular force sensor. Science 321: 133-136.
Hokanson DE and Ostap EM (2006). Myo1c binds tightly and specifically to phosphatidylinositol 4,5-bisphosphate and inositol 1,4,5-trisphosphate. Proc. Natl. Acad. Sci. U.S.A. 103: 3118-3123.
Payne AS, Siegel DL, Stanley JR (2007). Targeting pemphigus autoantibodies by their heavy chain variable region genes. J. Invest. Dermatol. 127: 1681-1691.
Mao X, Choi EJ, Payne AS (2008). Disruption of desmosome assembly by monovalent human pemphigus vulgaris monoclonal antibodies. J.Invest.Dermatol., in press.
Lu B, Su Y, Das S, Liu J, Xia J and Ren D (2007). The neuronal channel NALCN contributes resting sodium permeability and is required for normal respiratory rhythm. Cell 129: 371-383.
Kim GH, Kosterin P, Obaid AL and Salzberg BM (2007). A mechanical spike accompanies the action potential in mammalian nerve terminals. Biophys. J. 92: 3122-3129.
Fisher JAN, Barchi JR, Welle CG, Kim GH, Kosterin P, Obaid AL, Yodh A, Contreras D and Salzberg BM (2008). Two-photon excitation of potentiometric probes enables optical recording of action potentials from mammalian nerve terminals in situ. J. Neurophysiol. 99: 1545-1553.
Li, W., Marshall, C., Mei, L., Gelfand, J., Seykora, J. T. “Srcasm corrects Fyn-induced epidermal hyperplasia by kinase downregulation.” Published online October 16, 2006, Journal of Biological Chemistry. 282: 1161-69. 2007
Ayli, E., Li, W., Brown, T., Elenitsas, R., Seykora, J. “Activation of Src-family tyrosine kinases in epidermal hyperproliferative disorders.” J. Cutan. Path. 35: 273-7. 2008
Korobova F and Svitkina T (2008). Arp2/3 complex is important for filopodia formation, growth cone motility, and neuritogenesis in neuronal cells. Mol. Biol. Cell 19:1561-1574.
Yang C, Czech L, Gerboth S, Kojima S, Scita G, and Svitkina T (2007). Novel roles of formin mDia2 in lamellipodia and filopodia formation in motile cells. PLoS Biol. 5: e317.
Huang H, Feng J, Famulski J, Rattner JB, Liu ST, Kao GD, Muschel R, Chan GK and Yen TJ (2007). Tripin/hSgo2 recruits MCAK to the inner centromere to correct defective kinetochore attachments. J. Cell Biol. 177: 413-424.
Huang H, Yen TJ, Zappacosta F, Annan R, Hershko A and Yen TJ (2008). Phosphorylation sites in BubR1 that regulate kinetochore attachment, tension and mitotic exit. J. Cell Biol. (in press).
Cao W, Krishnaswamy S, Camire RM, Lenting PJ and Zheng XL (2008). Factor VIII accelerates proteolytic cleavage of von Willebrand factor by ADAMTS13. Proc. Natl. Acad. Sci. U.S.A. 105: 7416-7421.
Zheng XL and Sadler JE (2008). Pathogenesis of thrombotic microangiopathies. Annu. Rev. Pathol. 3: 249-277.