PennPORT

• Current Fellows
• Brian Estevez, PhD

Brian Estevez, PhD

Department of Pediatrics,
University of Pennsylvania

Education

• Research mentor: Mortimer Poncz, PhD; The Children's Hospital of Philadelphia

Research Topic: Megakaryocyte biology

My research interests focus primarily on megakaryocyte development. In adults mammals megakaryocytes reside in the bone marrow where they mature and release small anucleate platelets into the bloodstream. Platelets are essential for preventing blood loss (i.e., promoting blood clotting) upon blood vessel damage. Familial platelet disorder (FPD) with propensity to acute myeloid leukemia (AML) is an inherited disease that manifests in patients as thrombocytopenia, which causes excessive bleeding.

 
Publications

Journal Publications 

• Michael Keegan Delaney, Brian Estevez, Kyungho Kim, Aleksandra Stojanovic-Terpo, Bo Shen, Karl-Heinz Krause,Masuko Ushio-Fukai, Jaehyung Cho, and Xiaoping Du Differential roles of the NADPH-oxidase 1 and 2 in platelet activation and thrombosis (ATVB, Arteriosclerosis, Thrombosis, and Vascular Biology. 2016;ATVBAHA.116.307308 )
   
• B Estevez, M K Delaney, A Stojanovic-Terpo, C Ruan, and X Du. Signaling-Mediated Cooperativity between Platelet Glycoprotein Ib-IX and Protease-Activated Receptors in Thrombin-Induced Platelet Activation (Blood. 2016 Feb 4;127(5):626-36. doi: 10.1182/blood-2015-04-638387).
   
• B Shen, B Estevez, Z Xu, B Kreutz, A Karginov, Y Bai, F Qian, U Norifumi, D Mosher, X Du. The interaction of Gα13 with integrin β1 mediates cell migration by dynamic regulation of RhoA, Mol. Biol. Cell  mbc.E15-05-0274 (August 26, 2015 )
   
• B. Estevez, B. Shen and X. Du. Targeting Integrin and Integrin Signaling in Treating Thrombosis, ATVB in focus review article, 2014 doi:10.1161/ATVBAHA.114.303411 (September 2014).
   
• Penaloza, C. G. Estevez, B., Han, D. M.Norouzi, M.Lockshin, R. A.Zakeri, Z. Sex- dependent regulation of cytochrome P450 family members Cyp1a1, Cyp2e1, and Cyp7b1 by methylation of DNA. .  The FASEB journal 28(2):966-77. (Feb 2014).
   
• B. Estevez, A. Stojanovic-Terpo, M. K. Delaney, K. A. O’Brien, M. C. Berndt, C. Ruan, and X. Du. LIM kinase-1 selectively promotes glycoprotein Ib-IX-mediated TXA2 synthesis, platelet activation, and thrombosis. Blood 121(22): 4586-4594 (May 2013).
   
• C. Penaloza, B. Estevez, S. Orlanski, M. Sikorska, R. Walker, C. Smith, B. Smith, R. A. Lockshin Z. Zakeri. Sex of the cell dictates its response: Differential gene expression and sensitivity to cell death inducing stress in male and female cells. The FASEB journal 23(6): 1869-1879 (June 2009).

Contact info:

Brian Estevez, Ph.D.
Postdoctoral Fellow
Department of Pediatrics
The Children’s Hospital of Philadelphia
University of Pennsylvania
Abramson Research Bdg. Rm. 317
3615 Civic Center Blvd.
Philadelphia, PA 19104  

E-mail: estevezb@email.chop.edu