Penn Genome Integrity Group

  • DNA Strand
  • University of Pennsylvania Communications
  • Melina Chromosomes

    Chromosomes in metaphase, stained in DAPI and telomere PNA probe (red). Image courtesy of Melina Gyparaki (Greenberg Lab

  • Veena Composite

    Replication dynamics as monitored by the DNA fiber assay; red-Green DNA fibers represent an ongoing replication fork. Image courtesy of Veena Jagannathan (Brown Lab)

Why Genome Integrity?

Genome integrity is essential for organism survival and for the inheritance of traits to offspring. The maintenance of genome integrity plays a critical role in the prevention of cancer and other age-associated diseases. Genomic instability is caused by DNA damage, aberrant DNA replication or uncoordinated cell division, which can lead to chromosomal aberrations and gene mutations. The Penn Genome Integrity Group brings together laboratories from Penn, the Children's Hospital of Philadelphia, and The Wistar Institute interested in the mechanisms that safeguard the genome, and how failures in these processes impact tissue homeostasis and cancer risk.

Tracings of telomere mobility during DNA double-strand break induced alternative telomere lengthening (Greenberg Lab)

 

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