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Department of Pharmacology
Teresa Reyes, Ph.D.

Education:

1992	B.S. (Psychology)	University of Wisconsin-Madison
1991	M.S. (Psychology)	University of Wisconsin-Madison
1999	Ph.D. (Biological Psychology)	University of Wisconsin-Madison
2000-2004	(Postdoc Fellow) Laboratory of Neuronal Structure and Function, Salk Institute for Biological Studies

Research Summary:
My research focuses on the central nervous system (CNS) control of appetite and metabolism. Two primary research projects are underway. In one, we are using a mouse model of in utero programming of obesity (nutrient restriction in utero). We are characterizing the development of obesity; evaluating CNS neuropeptide changes, fat distribution, proinflammatory markers, metabolic changes and gene expression profiles. A second line of research is designed to characterize the CNS pathways that underlie the loss of appetite and shift in metabolism in a model of illness-associated anorexia and cachexia. The lab uses a range of techniques including standard functional neuroanatomical techniques (immunohistochemistry and in situ hybridization), gene expression analyses (genome arrays, TaqMan assays) and genetic animal models.

Selected Key Publications:
Reyes TM, Walker JR, DeCino C, Hogenesch JB & Sawchenko PE: Categorically distinct acute stressors elicit dissimilar transcriptional profiles in the paraventricular nucleus of the hypothalamus. J Neurosci 23: 5607-5616, 2003.

Inoue K, Valdez GR, Reyes TM, Reinhardt LE, Tabarin A, Rivier J, Vale WW, Sawchenko PE, Koob GF & Zorrilla EP: Human Urocortin II, A Selective Agonist for the Type 2 Corticotropin-Releasing Factor Receptor, Decreases Feeding and Drinking in the Rat. J Pharmacol Exp Ther 305: 385-393, 2003.

Reyes TM & Sawchenko PE: Involvement of the arcuate nucleus of the hypothalamus in interleukin-1-induced anorexia. J Neurosci 22: 5091-5099, 2002.

Reyes TM, Lewis K, Perrin MH, Kunitake KS, Vaughn J, C. Aria CA, Hogenesch JB, Gulyas J, Rivier J, Vale WW & Sawchenko PE: Urocortin II: A member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors. Proc Natl Acad Sci 98: 2843-2848, 2001.

Lewis K, Li C, Perrin MH, Blount A., Kunitake K., Donaldson C, Vaughan J, Reyes TM, Gulyas J, Fischer W, Bilezikjian L, Rivier J, Sawchenko PE & Vale WW: Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor. Proc Natl Acad Sci 98: 2843-2848, 2001.

Awards, Honors, Membership in Honorary Societies:

•	Mentored Research Scientist Development Award, National Institutes of Health
•	National Research Service Award-Postdoctoral Fellowship, National Institutes of Health
•	National Research Service Award-Predoctoral Fellowship, National Institutes of Health

Lab Address:
833 Biomedical Research Building II/III
University of Pennsylvania School of Medicine
421 Curie Blvd.
Philadelphia, PA 19104-6160

Lab Telephone:   215-573-6595   Lab Fax:   215-573-9004