Ekaterina Grishchuk, PhD

Assistant Professor of Physiology

Lab Web Site

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675 Clinical Research Building

415 Curie Boulevard

Philadelphia, PA 19104

215-746-8178

Lab: 215-746-8177

Fax: 215-573-2273

gekate@mail.med.upenn.edu

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Grishchuk Lab Makes Biophysical Journal Cover


January 9, 2016

Cover picture: Molecular-dynamics simulations of microtubules reveal subtle changes in the conformation of elongating tubulin protofilaments—changes that lead to microtubule instability. Assembling tubulin subunits are associated with GTP molecules (orange), which subsequently hydrolyze to GDP (green), forming the ram’s horn geometry that promotes microtubule instability. For more information, see the article by Zakharov et al. on pages 2574–2591.

It’s a catastrophe! Highlighted on the cover, Ekaterina Grishchuk explains why in her article Molecular and Mechanical Causes of Microtubule Catastrophe and Aging, published in the Dec 15, 2015 issue of the Biophysical Journal (Biophys J. 109(12):2574-91)).

Access the article online here!



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