Ekaterina Grishchuk, PhD

Assistant Professor Of Physiology

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675 Clinical Research Building

415 Curie Boulevard

Philadelphia, PA 19104

215-746-8178

Lab: 215-746-8177

Fax: 215-573-2273

gekate@mail.med.upenn.edu

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Faculty Spotlight


June 2014

Ekaterina Grishchuk, PhD

The Grishchuk lab focuses on the mechanisms of chromosome motions. Dr. Katya Grishchuk’s initial training was in biophysics. She subsequently received a Ph.D. in biological sciences. During her post-doctoral training, she capitalized on her multidisciplinary background to establish long-term collaborations with biophysicists and computer scientists to build a state-of-the-art laser tweezers system, which allowed the first direct measurements of forces produced by the shortening of microtubules (Grishchuk et al., Nature, 2005). Since she joined the faculty of the Department of Physiology as an Assistant Professor in 2010, she has constructed versatile laser tweezers that are specifically designed to study interactions between dynamic tubulin polymers and kinetochore proteins. Her studies are highly quantitative and she uses advanced mathematical modeling to form novel hypotheses and test their significant predictions. With these multidisciplinary approaches and combination of theoretical and experimental methodologies, she hopes to gain a deep mechanistic understanding of the biophysical mechanisms that ensure high fidelity chromosome segregation in dividing cells; and to learn how pathological chromosomal instability can be prevented.

Katya’s research has been published in top-tier journals, including Nature journals, EMBO. J., Cell journals, PNAS, among others. In 2008, she won the Molecular Biology of the Cell “Paper of the Year” Award.

Katya brings a bit of Russian flavor to the Department. Her early training was in Moscow, and while she was a Senior Research Associate in the Department of Molecular and Cellular Biology at the University of Colorado (following her postdoctoral training there), she was also a Senior and Leading Scientific Researcher at the Institute of General Pathology and Pathophysiology in Moscow.

Since arriving at the University of Pennsylvania, she has become engaged in graduate teaching through her participation in the BMB and CAMB Graduate Programs, and she is an active member of the Pennsylvania Muscle Institute. As a junior member of the Physiology Department in 2011, Katya organized an outstanding annual Department Retreat. It was so successful, that she graciously agreed to organize it again for another 2 years! She is currently funded by two NIH R01 grants, and an American Cancer Society Research Scholar Grant. Since 2012, she has been a recipient of the Kimmel Scholar Award, from The Sidney Kimmel Foundation for Cancer Research.

Поздравляю Katya!

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