Perelman School of Medicine Affiliations
Neurosciences Graduate Group
B.A., Rice University, 1956
M.D., Washington University, 1960
Laskar Award, Basic Science, 1999
John Scott Award, 2000
Gairdner Foundation International Award, 2001
Member, National Academy of Sciences
Jacob Javits Neuroscience Research Award of NIH
American Physiological Society
Society of General Physiologists
Editorial Board, Journal of General Physiology
Editorial Board, Journal of Neurophysiology
Transmembrane ionic channels and membrane potentials are
properties common to all cells. My laboratory works on permeability
mechanisms of ionic channels, the gating processes that open
and close the channels, and the role of channels and membrane
potentials in cell function.
and potassiun channels in excitable membranes are activated
by changes of the membrane
voltage. The laboratory
is examining the gating of these channels in the membranes
of one of the classical excitable cells, the squid giant
axon. In this preparation, the investigator can control
the solution bathing the internal and external surfaces
membrane, and very rapid changes of the membrane potential
can be imposed, allowing excellent time resolution of the
gating processes. Gating current, an important indicator
of gating activity, can best be measured from squid giant
is a property of many cells, including endocrine cells.
Cells derived from the pituitary have
and pacemaking activity, and a full complement of ionic
channels, including sodium channels, 2 or more types
of potassium channels,
and at least 2 types of calcium channels. My research
is examining these cells using the patch clamp technique,
and is attempting to extend studies of this type to neurons
the central nervous system (CNS) to achieve a better
of the cellular electrophysiology of these complex cells.
W., Kehoe, J., Ascher, P., Armstrong, C.M.: Synaptically triggered
action potentials in dendrites.
Neuron 11:145-151, 1993.
F. and Armstrong, C.M.: The relation between ion permeation
and recovery from inaction
of Shaker B channels.
Biophysical Journal 67:1806-1815, 1994.
F. and Armstrong, C.M.: Inactivation of ShakerB K+ channels:
A test for the number of inactivating particles
on each channel. Biophysical Journal 68:89-95, 1995.
K. and Armstrong, C.M. Calcium does not affect Na channel
gating steps uniformly. Biophysical Journal
C.M. and Khodakhah, K. TTX but not STX detectable alters
Na channel gating current. Biophysical
J., Callewerth, G., Armstrong, C.M., and A. Konnerth. Calcium
signalling in a narrow somatic
during synaptic activity in cerebellar Purkinje neurons.
Click here for
a full list of publications
(searches the National Library of Medicine's PubMed database.)